| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.161073 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.108976 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0918175 |
| DSPP | dentin sialophosphoprotein | 0.0736611 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0685374 |
| MYOF | myoferlin | 0.0674605 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0672969 |
| HYOU1 | hypoxia up-regulated 1 | 0.0665398 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0619627 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0618116 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0595873 |
| CLDN4 | claudin 4 | 0.0588007 |
| PRELID2 | PRELI domain containing 2 | 0.0573169 |
| AHR | aryl hydrocarbon receptor | 0.0501668 |
| TRAK1 | trafficking protein, kinesin binding 1 | 0.0491614 |
| STK24 | serine/threonine kinase 24 | 0.0478602 |
| TRIM2 | tripartite motif containing 2 | 0.0477099 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0473279 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0467394 |
| ANLN | anillin, actin binding protein | 0.0454059 |
| LYZ | lysozyme | 0.0450525 |
| RAD51B | RAD51 paralog B | 0.0444397 |
| JUP | junction plakoglobin | 0.0438934 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0438824 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0437311 |
| PRSS3 | protease, serine, 3 | 0.0436601 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0433489 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0420501 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0419651 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0412692 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.040738 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0404362 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0401989 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0395106 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0394858 |
| RNF213 | ring finger protein 213 | 0.0391134 |
| MUC17 | mucin 17, cell surface associated | 0.0390788 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0388788 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0388185 |
| CAPN8 | calpain 8 | 0.0386533 |
| PCBP2 | poly(rC) binding protein 2 | 0.0383909 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0373264 |
| SNX9 | sorting nexin 9 | 0.0371364 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.036393 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0363178 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0358336 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0346656 |
| ATXN1 | ataxin 1 | 0.0342844 |
| TES | testin LIM domain protein | 0.0339745 |
| ACTN4 | actinin, alpha 4 | 0.0339467 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0339432 |
| CALR | calreticulin | 0.0337974 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0336579 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.033202 |
| ANXA11 | annexin A11 | 0.0331839 |
| CNKSR3 | CNKSR family member 3 | 0.0331553 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0329535 |
| RBM47 | RNA binding motif protein 47 | 0.0329111 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0326666 |
| LIPH | lipase, member H | 0.0324327 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0324117 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0323669 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.032126 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.031965 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0314658 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0314168 |
| ZNF292 | zinc finger protein 292 | 0.0310604 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0310228 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0308778 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0302155 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0302128 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0300264 |
| GOLGB1 | golgin B1 | 0.029968 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.02984 |
| SPAG9 | sperm associated antigen 9 | 0.029743 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0296133 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0296015 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0294269 |
| MGAM2 | maltase-glucoamylase 2 (putative) | 0.0294154 |
| CTSE | cathepsin E | 0.0292758 |
| EZR | ezrin | 0.0292109 |
| CLINT1 | clathrin interactor 1 | 0.0290269 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0290163 |
| SHROOM3 | shroom family member 3 | 0.0288941 |
| ALPK1 | alpha-kinase 1 | 0.0279416 |
| COG5 | component of oligomeric golgi complex 5 | 0.0278885 |
| TMF1 | TATA element modulatory factor 1 | 0.0277839 |
| CLTC | clathrin, heavy chain (Hc) | 0.0277344 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0276994 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0275541 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0275341 |
| TJP1 | tight junction protein 1 | 0.0275331 |
| FAT1 | FAT atypical cadherin 1 | 0.0274791 |
| ECT2 | epithelial cell transforming 2 | 0.0272133 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0266972 |
| PTEN | phosphatase and tensin homolog | 0.0263534 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0261518 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0260747 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0260027 |
| MUC1 | mucin 1, cell surface associated | 0.0258747 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.184039 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.181914 |
| TMSB10 | thymosin beta 10 | -0.160344 |
| NPSR1 | neuropeptide S receptor 1 | -0.106374 |
| RPS6 | ribosomal protein S6 | -0.0992295 |
| RPL35A | ribosomal protein L35a | -0.0880228 |
| FTL | ferritin, light polypeptide | -0.0817072 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0655134 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0639236 |
| CDK6 | cyclin-dependent kinase 6 | -0.0607946 |
| RPS25 | ribosomal protein S25 | -0.0572905 |
| S100A6 | S100 calcium binding protein A6 | -0.0559618 |
| S100A10 | S100 calcium binding protein A10 | -0.0528183 |
| RPL34 | ribosomal protein L34 | -0.0500237 |
| RPLP1 | ribosomal protein, large, P1 | -0.0483658 |
| AGR2 | anterior gradient 2 | -0.0472588 |
| EHBP1 | EH domain binding protein 1 | -0.0462033 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0459759 |
| HLA-A | major histocompatibility complex, class I, A | -0.0456125 |
| RPL38 | ribosomal protein L38 | -0.045042 |
| RPL36A | ribosomal protein L36a | -0.0448951 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0446857 |
| RPS8 | ribosomal protein S8 | -0.0436406 |
| LCN2 | lipocalin 2 | -0.043431 |
| RPL23 | ribosomal protein L23 | -0.0432207 |
| RPS19 | ribosomal protein S19 | -0.042838 |
| TMSB4X | thymosin beta 4, X-linked | -0.0423871 |
| S100A11 | S100 calcium binding protein A11 | -0.0423686 |
| ATF5 | activating transcription factor 5 | -0.0420514 |
| RPS24 | ribosomal protein S24 | -0.0420461 |
| RPL19 | ribosomal protein L19 | -0.0413923 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.040896 |
| B2M | beta-2-microglobulin | -0.040059 |
| HLA-B | major histocompatibility complex, class I, B | -0.0400351 |
| RPS27A | ribosomal protein S27a | -0.0388291 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0387087 |
| RPL26 | ribosomal protein L26 | -0.0380704 |
| RPS21 | ribosomal protein S21 | -0.038047 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0376249 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0373939 |
| ENO1 | enolase 1, (alpha) | -0.037213 |
| RPS16 | ribosomal protein S16 | -0.0369771 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.03646 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0358115 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0354702 |
| RPS29 | ribosomal protein S29 | -0.0348017 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.034776 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0337359 |
| PGK1 | phosphoglycerate kinase 1 | -0.0335547 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0330244 |
| RPL37A | ribosomal protein L37a | -0.0327615 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.031876 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0317417 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.030442 |
| HLA-C | major histocompatibility complex, class I, C | -0.030393 |
| WDR45B | WD repeat domain 45B | -0.0296772 |
| HLA-E | major histocompatibility complex, class I, E | -0.029558 |
| TMC5 | transmembrane channel-like 5 | -0.0293847 |
| FUS | FUS RNA binding protein | -0.0291173 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0290358 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0285801 |
| FDPS | farnesyl diphosphate synthase | -0.0283243 |
| S100A9 | S100 calcium binding protein A9 | -0.0282223 |
| RPL9 | ribosomal protein L9 | -0.0280709 |
| RPL5 | ribosomal protein L5 | -0.0280571 |
| IER3 | immediate early response 3 | -0.0279729 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0277454 |
| LMNA | lamin A/C | -0.0276915 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.027431 |
| RPL7A | ribosomal protein L7a | -0.0268767 |
| HMGB1 | high mobility group box 1 | -0.026695 |
| CCND1 | cyclin D1 | -0.0266313 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0265907 |
| RPS13 | ribosomal protein S13 | -0.0262081 |
| ASPH | aspartate beta-hydroxylase | -0.0260918 |
| TFRC | transferrin receptor | -0.0260821 |
| AHNAK | AHNAK nucleoprotein | -0.0257239 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0251764 |
| GPATCH8 | G patch domain containing 8 | -0.0248191 |
| RPS14 | ribosomal protein S14 | -0.0246065 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0245948 |
| H3-3B | H3.3 histone B | -0.0243823 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.024345 |
| RPL8 | ribosomal protein L8 | -0.0239002 |
| RPL12 | ribosomal protein L12 | -0.0235907 |
| SEC61G | Sec61 gamma subunit | -0.0234814 |
| RRBP1 | ribosome binding protein 1 | -0.0233631 |
| EPCAM | epithelial cell adhesion molecule | -0.0227835 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0223102 |
| RPL31 | ribosomal protein L31 | -0.0221713 |
| RAI1 | retinoic acid induced 1 | -0.0219343 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0219024 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0217273 |
| THOC2 | THO complex 2 | -0.0213492 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0212068 |
| SERF2 | small EDRK-rich factor 2 | -0.0211513 |
| TRIM56 | tripartite motif containing 56 | -0.0211161 |
| GNAS | GNAS complex locus | -0.0210525 |
| TMEM181 | transmembrane protein 181 | -0.0210336 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0210105 |
