| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.15988 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.149378 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.136235 |
| FAT1 | FAT atypical cadherin 1 | 0.132781 |
| NDRG1 | N-myc downstream regulated 1 | 0.126489 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.114097 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0969332 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.092753 |
| LDHA | lactate dehydrogenase A | 0.0903845 |
| TNS4 | tensin 4 | 0.0869915 |
| FAM13A | family with sequence similarity 13, member A | 0.0861053 |
| TXNIP | thioredoxin interacting protein | 0.0850888 |
| RPS2 | ribosomal protein S2 | 0.0844994 |
| PRELID2 | PRELI domain containing 2 | 0.0783811 |
| FLNB | filamin B, beta | 0.0779662 |
| ITGA6 | integrin, alpha 6 | 0.0761452 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0755547 |
| RPS12 | ribosomal protein S12 | 0.0707775 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0700158 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0697477 |
| EREG | epiregulin | 0.0691791 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0659019 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0646839 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0624315 |
| ANXA2 | annexin A2 | 0.0615765 |
| KIF5B | kinesin family member 5B | 0.0604184 |
| DSPP | dentin sialophosphoprotein | 0.0582029 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0561098 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0543777 |
| MLEC | malectin | 0.0536302 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.053501 |
| GPA33 | glycoprotein A33 (transmembrane) | 0.0527921 |
| PGK1 | phosphoglycerate kinase 1 | 0.0521251 |
| ZNF292 | zinc finger protein 292 | 0.0504695 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.049392 |
| EHF | ets homologous factor | 0.0491578 |
| CALB1 | calbindin 1, 28kDa | 0.0480962 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0473684 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0463695 |
| PTEN | phosphatase and tensin homolog | 0.0444408 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0440778 |
| MUC13 | mucin 13, cell surface associated | 0.04143 |
| RNF43 | ring finger protein 43 | 0.0396605 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0396388 |
| HMGA1 | high mobility group AT-hook 1 | 0.0394828 |
| AREG | amphiregulin | 0.0394424 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0394026 |
| ENO1 | enolase 1, (alpha) | 0.0389454 |
| RPS3 | ribosomal protein S3 | 0.037848 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0378467 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0378322 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0377326 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0376637 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0364494 |
| PKP2 | plakophilin 2 | 0.0358595 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0356801 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0354477 |
| KLF6 | Kruppel-like factor 6 | 0.0352811 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.0343709 |
| FHL2 | four and a half LIM domains 2 | 0.0342414 |
| RACK1 | receptor for activated C kinase 1 | 0.0342351 |
| RPL37A | ribosomal protein L37a | 0.0339631 |
| PCBP2 | poly(rC) binding protein 2 | 0.0337691 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.0326448 |
| SET | SET nuclear proto-oncogene | 0.0323666 |
| PFN1 | profilin 1 | 0.0321254 |
| CCNY | cyclin Y | 0.0321153 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0316593 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0314445 |
| CENPF | centromere protein F, 350/400kDa | 0.0312493 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0310078 |
| SLK | STE20-like kinase | 0.0309769 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0305616 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0305109 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0305094 |
| KRT19 | keratin 19, type I | 0.0304875 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0304125 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0301651 |
| CALR | calreticulin | 0.0301359 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0300973 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0300359 |
| NUP58 | nucleoporin 58 | 0.0299744 |
| CDK19 | cyclin-dependent kinase 19 | 0.0295997 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.029499 |
| EZR | ezrin | 0.0292947 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0292095 |
| RPL18 | ribosomal protein L18 | 0.029177 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0290052 |
| VEGFA | vascular endothelial growth factor A | 0.0288289 |
| RPL23 | ribosomal protein L23 | 0.0285757 |
| CLDN4 | claudin 4 | 0.0284949 |
| EPCAM | epithelial cell adhesion molecule | 0.0281813 |
| ASPH | aspartate beta-hydroxylase | 0.0280355 |
| ATXN1 | ataxin 1 | 0.027756 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0275267 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0274797 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0272797 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0271164 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0270693 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.0270415 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.209144 |
| PTMA | prothymosin, alpha | -0.16731 |
| AHNAK | AHNAK nucleoprotein | -0.132844 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.107373 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0981462 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0729333 |
| H1-0 | H1.0 linker histone | -0.0568938 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0476347 |
| RPS24 | ribosomal protein S24 | -0.0425431 |
| RPS6 | ribosomal protein S6 | -0.0424119 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0386806 |
| CANX | calnexin | -0.0358726 |
| IER3 | immediate early response 3 | -0.0346457 |
| HDLBP | high density lipoprotein binding protein | -0.0333186 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.031739 |
| RRBP1 | ribosome binding protein 1 | -0.0315794 |
| VCL | vinculin | -0.0310931 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0310199 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0310159 |
| AGR2 | anterior gradient 2 | -0.0295797 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0291403 |
| HMGB1 | high mobility group box 1 | -0.0287064 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0282005 |
| RPS21 | ribosomal protein S21 | -0.0273561 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0268234 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0239782 |
| CUX1 | cut-like homeobox 1 | -0.023598 |
| OGA | O-GlcNAcase | -0.023185 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0223638 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0218672 |
| H3-3B | H3.3 histone B | -0.0213276 |
| RPL38 | ribosomal protein L38 | -0.0210597 |
| UBE2I | ubiquitin-conjugating enzyme E2I | -0.0205591 |
| FRMD5 | FERM domain containing 5 | -0.0203938 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0203346 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0201612 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0201353 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.01992 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0195841 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0195707 |
| CTTN | cortactin | -0.0195055 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0193326 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0192462 |
| MYO1E | myosin IE | -0.0192101 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.019145 |
| SDC4 | syndecan 4 | -0.0188517 |
| DEK | DEK proto-oncogene | -0.0187418 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0185439 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0185151 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.018446 |
| S100A10 | S100 calcium binding protein A10 | -0.0183574 |
| COMMD10 | COMM domain containing 10 | -0.0180959 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0177252 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0176115 |
| RAB10 | RAB10, member RAS oncogene family | -0.017593 |
| RPL8 | ribosomal protein L8 | -0.0175442 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0174096 |
| RPL14 | ribosomal protein L14 | -0.0173539 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0172878 |
| MECOM | MDS1 and EVI1 complex locus | -0.0172582 |
| AHI1 | Abelson helper integration site 1 | -0.0172269 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0171127 |
| TMSB4X | thymosin beta 4, X-linked | -0.0170376 |
| CCNL2 | cyclin L2 | -0.0166716 |
| CDK12 | cyclin-dependent kinase 12 | -0.0166275 |
| RPS15 | ribosomal protein S15 | -0.0166186 |
| FUS | FUS RNA binding protein | -0.0166139 |
| PRRC2B | proline-rich coiled-coil 2B | -0.016574 |
| RPL6 | ribosomal protein L6 | -0.016324 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0159117 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0158584 |
| RBM6 | RNA binding motif protein 6 | -0.0156993 |
| TFF1 | trefoil factor 1 | -0.0155805 |
| NPR2 | natriuretic peptide receptor 2 | -0.0154091 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0153998 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0153575 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0152523 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0152376 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0150155 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0149897 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0149592 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0148168 |
| NRN1 | neuritin 1 | -0.0147909 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0143172 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0143054 |
| UBC | ubiquitin C | -0.0142829 |
| MAP4 | microtubule-associated protein 4 | -0.0142335 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0142035 |
| PBRM1 | polybromo 1 | -0.0141924 |
| RPLP2 | ribosomal protein, large, P2 | -0.0141754 |
| RTN3 | reticulon 3 | -0.0141329 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0140665 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.0140656 |
| PALLD | palladin, cytoskeletal associated protein | -0.0140135 |
| RPS23 | ribosomal protein S23 | -0.0139868 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0139861 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0139769 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0139389 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0139138 |
| UBE3C | ubiquitin protein ligase E3C | -0.0138425 |
