| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pexidartinib (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | 0.144318 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.1135 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.102798 |
| RPS2 | ribosomal protein S2 | 0.0941842 |
| CALB1 | calbindin 1, 28kDa | 0.0932448 |
| PKP2 | plakophilin 2 | 0.089241 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0805746 |
| RPS12 | ribosomal protein S12 | 0.0781411 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.07608 |
| RAD51B | RAD51 paralog B | 0.075271 |
| PRELID2 | PRELI domain containing 2 | 0.0729373 |
| RNF213 | ring finger protein 213 | 0.0677661 |
| MYOF | myoferlin | 0.0671176 |
| ANXA2 | annexin A2 | 0.0631635 |
| ACTG1 | actin gamma 1 | 0.0616724 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0586968 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0580886 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0569874 |
| FOXP1 | forkhead box P1 | 0.0555265 |
| LDHA | lactate dehydrogenase A | 0.0553826 |
| PLAC8 | placenta-specific 8 | 0.0549859 |
| KIF5B | kinesin family member 5B | 0.0526157 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0523046 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0522557 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0504858 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0497919 |
| PRSS3 | protease, serine, 3 | 0.0482779 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0480945 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0470132 |
| EGR1 | early growth response 1 | 0.0467378 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0453351 |
| CLDN4 | claudin 4 | 0.0448563 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0442423 |
| RACK1 | receptor for activated C kinase 1 | 0.0430247 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0425306 |
| MKI67 | marker of proliferation Ki-67 | 0.0425222 |
| MUC13 | mucin 13, cell surface associated | 0.0409042 |
| EXOC4 | exocyst complex component 4 | 0.0407504 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0406213 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0401979 |
| SHROOM3 | shroom family member 3 | 0.0399928 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0392557 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0384801 |
| MLEC | malectin | 0.0380622 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0379908 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.037452 |
| FLNB | filamin B, beta | 0.0371946 |
| MX1 | MX dynamin-like GTPase 1 | 0.03716 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0366469 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0363453 |
| VCL | vinculin | 0.0355877 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0344994 |
| DSPP | dentin sialophosphoprotein | 0.0343659 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0341977 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.0339221 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0334346 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0325254 |
| FHIT | fragile histidine triad | 0.0322169 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0322002 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0314843 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0313013 |
| ZNF292 | zinc finger protein 292 | 0.0306644 |
| RIN2 | Ras and Rab interactor 2 | 0.0306306 |
| PGK1 | phosphoglycerate kinase 1 | 0.030544 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0304481 |
| ABHD17C | abhydrolase domain containing 17C | 0.030386 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0297452 |
| KLF6 | Kruppel-like factor 6 | 0.029676 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0294903 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0292177 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0292039 |
| EPHA2 | EPH receptor A2 | 0.0291623 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0290953 |
| FHL2 | four and a half LIM domains 2 | 0.0290132 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0287401 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0286254 |
| SLTM | SAFB-like, transcription modulator | 0.0285047 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0281841 |
| NDRG1 | N-myc downstream regulated 1 | 0.0281542 |
| WWOX | WW domain containing oxidoreductase | 0.0280324 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0277434 |
| WWC1 | WW and C2 domain containing 1 | 0.0276889 |
| NFIA | nuclear factor I/A | 0.0276542 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0271363 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0270544 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0268987 |
| TRIM2 | tripartite motif containing 2 | 0.0268699 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0265791 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0264256 |
| NFIB | nuclear factor I/B | 0.0264078 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0254323 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0248932 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0242 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0240605 |
| HMGA1 | high mobility group AT-hook 1 | 0.0237466 |
| SMYD3 | SET and MYND domain containing 3 | 0.0236611 |
| RPS17 | ribosomal protein S17 | 0.023652 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.023497 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0234298 |
| TLN2 | talin 2 | 0.0232546 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.180447 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.165348 |
| RPS27A | ribosomal protein S27a | -0.129484 |
| UBC | ubiquitin C | -0.120537 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.114709 |
| PTMA | prothymosin, alpha | -0.101041 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0967278 |
| AHNAK | AHNAK nucleoprotein | -0.082314 |
| TMSB10 | thymosin beta 10 | -0.0740006 |
| CANX | calnexin | -0.0670533 |
| RPS6 | ribosomal protein S6 | -0.0627432 |
| RPS23 | ribosomal protein S23 | -0.0612489 |
| RPLP2 | ribosomal protein, large, P2 | -0.0531155 |
| RPS13 | ribosomal protein S13 | -0.0518075 |
| RPS24 | ribosomal protein S24 | -0.0463831 |
| RPS21 | ribosomal protein S21 | -0.0436363 |
| RPS25 | ribosomal protein S25 | -0.0434883 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0428005 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0419405 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.041242 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0402102 |
| RPS11 | ribosomal protein S11 | -0.0380961 |
| RPLP1 | ribosomal protein, large, P1 | -0.0379657 |
| RRBP1 | ribosome binding protein 1 | -0.0368031 |
| RPL8 | ribosomal protein L8 | -0.0363439 |
| HLA-B | major histocompatibility complex, class I, B | -0.0357596 |
| RPL34 | ribosomal protein L34 | -0.0352737 |
| OGA | O-GlcNAcase | -0.0340565 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0334507 |
| HDLBP | high density lipoprotein binding protein | -0.0334438 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0334401 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0330052 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0320823 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0320691 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0309761 |
| RPL36A | ribosomal protein L36a | -0.0309492 |
| RPS15 | ribosomal protein S15 | -0.0309345 |
| CCNI | cyclin I | -0.0307822 |
| RPL32 | ribosomal protein L32 | -0.0304925 |
| FUS | FUS RNA binding protein | -0.0301548 |
| RPS29 | ribosomal protein S29 | -0.0299356 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0296417 |
| RPL38 | ribosomal protein L38 | -0.0271388 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0268092 |
| RPL28 | ribosomal protein L28 | -0.0265214 |
| S100A10 | S100 calcium binding protein A10 | -0.0259472 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0252542 |
| SLC38A2 | solute carrier family 38, member 2 | -0.02513 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0248277 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0248127 |
| CCND2 | cyclin D2 | -0.0247487 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.024585 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0245845 |
| KRT8 | keratin 8, type II | -0.02445 |
| IER3 | immediate early response 3 | -0.0243117 |
| RPL19 | ribosomal protein L19 | -0.0242426 |
| PKM | pyruvate kinase, muscle | -0.0242018 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0241404 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0233644 |
| RPS5 | ribosomal protein S5 | -0.0233133 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0230651 |
| SETD5 | SET domain containing 5 | -0.0228359 |
| IRF1 | interferon regulatory factor 1 | -0.0227975 |
| CTBP2 | C-terminal binding protein 2 | -0.0226946 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0225615 |
| TBCA | tubulin folding cofactor A | -0.0223594 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0223278 |
| RPL4 | ribosomal protein L4 | -0.02205 |
| KRT18 | keratin 18, type I | -0.021884 |
| RPL14 | ribosomal protein L14 | -0.0218057 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.021801 |
| AREG | amphiregulin | -0.0217842 |
| COG5 | component of oligomeric golgi complex 5 | -0.0216498 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0215976 |
| UBE3C | ubiquitin protein ligase E3C | -0.0212277 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.0211625 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.021058 |
| USP3 | ubiquitin specific peptidase 3 | -0.0205527 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0205185 |
| RPS10 | ribosomal protein S10 | -0.0202845 |
| RPL31 | ribosomal protein L31 | -0.0201016 |
| RHEB | Ras homolog enriched in brain | -0.0200114 |
| MYO5B | myosin VB | -0.019987 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0199382 |
| RPL12 | ribosomal protein L12 | -0.0198439 |
| CDK12 | cyclin-dependent kinase 12 | -0.0198121 |
| RPL23 | ribosomal protein L23 | -0.0197156 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0196957 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0195862 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0194375 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0192916 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0192472 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.019171 |
| CTTN | cortactin | -0.0190977 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0190075 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0189635 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0189612 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0189334 |
| PCBP2 | poly(rC) binding protein 2 | -0.0189154 |
| RPL6 | ribosomal protein L6 | -0.0188531 |
