Pexidartinib (hydrochloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.278795
CD44 CD44 molecule (Indian blood group) 0.101153
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0986362
EEF2 eukaryotic translation elongation factor 2 0.0825442
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.08246
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0754716
ERRFI1 ERBB receptor feedback inhibitor 1 0.0718578
SET SET nuclear proto-oncogene 0.0700302
ACTG1 actin gamma 1 0.0684821
RAI1 retinoic acid induced 1 0.0627974
TMSB4X thymosin beta 4, X-linked 0.0627394
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0611757
DST dystonin 0.0571952
CENPF centromere protein F, 350/400kDa 0.0548471
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0536851
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0522596
PGK1 phosphoglycerate kinase 1 0.0511001
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0505182
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0498891
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0492404
LDHA lactate dehydrogenase A 0.0487305
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0475151
MKI67 marker of proliferation Ki-67 0.0467497
RPS12 ribosomal protein S12 0.0455409
RACK1 receptor for activated C kinase 1 0.044974
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0443548
EREG epiregulin 0.0437127
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0435825
KLF6 Kruppel-like factor 6 0.0434167
CXCL8 chemokine (C-X-C motif) ligand 8 0.0432086
PLK2 polo-like kinase 2 0.0416562
KTN1 kinectin 1 (kinesin receptor) 0.0415456
EHBP1 EH domain binding protein 1 0.0414332
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0400442
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0399762
RPS2 ribosomal protein S2 0.0396958
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0387432
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.038517
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0370037
DLG1 discs, large homolog 1 (Drosophila) 0.0363625
CSNK1A1 casein kinase 1, alpha 1 0.0360364
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0354896
RUNX1 runt-related transcription factor 1 0.0350946
BCAR3 breast cancer anti-estrogen resistance 3 0.0329235
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.032598
SLC38A2 solute carrier family 38, member 2 0.0324126
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.03222
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.032165
BIRC3 baculoviral IAP repeat containing 3 0.0318485
RPL37A ribosomal protein L37a 0.0313467
MYOF myoferlin 0.0312394
RPL26 ribosomal protein L26 0.0309227
TRIO trio Rho guanine nucleotide exchange factor 0.0302975
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0299136
ADGRG6 adhesion G protein-coupled receptor G6 0.0298997
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0298772
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0298756
PIAS2 protein inhibitor of activated STAT, 2 0.0291901
ANKRD12 ankyrin repeat domain 12 0.0291064
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0286364
AFF4 AF4/FMR2 family, member 4 0.0286025
RIGI RNA sensor RIG-I 0.028541
PTPRF protein tyrosine phosphatase, receptor type, F 0.028074
CANX calnexin 0.0279559
RPS3 ribosomal protein S3 0.0278951
KIF5B kinesin family member 5B 0.0278923
TSC22D1 TSC22 domain family, member 1 0.027729
PDE10A phosphodiesterase 10A 0.02769
ARHGAP5 Rho GTPase activating protein 5 0.0276558
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0271472
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0270484
RNF213 ring finger protein 213 0.0270272
MACF1 microtubule-actin crosslinking factor 1 0.0269534
TOP2A topoisomerase (DNA) II alpha 170kDa 0.026762
LPP LIM domain containing preferred translocation partner in lipoma 0.0267063
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0265715
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0264581
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.026342
APP amyloid beta (A4) precursor protein 0.0263336
EPHA4 EPH receptor A4 0.0262185
CALR calreticulin 0.0253393
CFAP299 cilia and flagella associated protein 299 0.0251326
LOXL2 lysyl oxidase-like 2 0.0248113
TPR translocated promoter region, nuclear basket protein 0.0246798
NAMPT nicotinamide phosphoribosyltransferase 0.0245354
ESYT2 extended synaptotagmin-like protein 2 0.0245272
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0245263
NAP1L1 nucleosome assembly protein 1-like 1 0.0244624
YEATS2 YEATS domain containing 2 0.024265
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0237698
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0236921
EXOC4 exocyst complex component 4 0.0236902
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0235314
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.023511
MBNL2 muscleblind-like splicing regulator 2 0.0233882
NUP58 nucleoporin 58 0.0229071
SERBP1 SERPINE1 mRNA binding protein 1 0.0228537
SDCCAG8 serologically defined colon cancer antigen 8 0.0226324
EFNA5 ephrin-A5 0.022418
HOOK2 hook microtubule-tethering protein 2 0.0223833

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.264034
MT2A metallothionein 2A -0.0919306
MT1X metallothionein 1X -0.0449854
FTL ferritin, light polypeptide -0.0383482
RPS6 ribosomal protein S6 -0.0292208
RPS23 ribosomal protein S23 -0.0281137
RPLP2 ribosomal protein, large, P2 -0.0259634
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0254715
RPS15 ribosomal protein S15 -0.0248734
S100A10 S100 calcium binding protein A10 -0.0211684
EZR ezrin -0.0201105
TP63 tumor protein p63 -0.0195885
RPL32 ribosomal protein L32 -0.0189189
RPL28 ribosomal protein L28 -0.0180845
TMSB10 thymosin beta 10 -0.0178184
RPS10 ribosomal protein S10 -0.0177352
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0174909
RPS21 ribosomal protein S21 -0.015975
RHOA ras homolog family member A -0.0151479
RTN4 reticulon 4 -0.0148904
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.014558
RPL8 ribosomal protein L8 -0.0143473
RPS13 ribosomal protein S13 -0.0143256
RPS11 ribosomal protein S11 -0.0139276
EMP1 epithelial membrane protein 1 -0.0138468
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0132011
RPLP1 ribosomal protein, large, P1 -0.012824
AREG amphiregulin -0.0125534
EGR1 early growth response 1 -0.0123709
TSC22D2 TSC22 domain family, member 2 -0.0121479
RPS19 ribosomal protein S19 -0.0120818
AHNAK AHNAK nucleoprotein -0.0119823
RPS24 ribosomal protein S24 -0.0119787
TIMP1 TIMP metallopeptidase inhibitor 1 -0.011954
TM4SF1 transmembrane 4 L six family member 1 -0.0117086
LRP10 low density lipoprotein receptor-related protein 10 -0.011265
RPS29 ribosomal protein S29 -0.0112234
TPT1 tumor protein, translationally-controlled 1 -0.0111581
RPS5 ribosomal protein S5 -0.0109759
PLIN2 perilipin 2 -0.0108503
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0105296
S100A9 S100 calcium binding protein A9 -0.0105238
TAPBP TAP binding protein (tapasin) -0.010483
RPL38 ribosomal protein L38 -0.0104511
SDC4 syndecan 4 -0.0104013
UBC ubiquitin C -0.0103783
UBE2H ubiquitin-conjugating enzyme E2H -0.0101183
IER3 immediate early response 3 -0.0100166
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0100134
RHEB Ras homolog enriched in brain -0.00991935
RPL21 ribosomal protein L21 -0.00988595
WASF2 WAS protein family, member 2 -0.00952809
CREB5 cAMP responsive element binding protein 5 -0.00952148
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.00931542
VMP1 vacuole membrane protein 1 -0.00927874
UPP1 uridine phosphorylase 1 -0.00916431
ZFP36L1 ZFP36 ring finger protein-like 1 -0.00888321
ATP5F1B ATP synthase F1 subunit beta -0.00879575
ASTN2 astrotactin 2 -0.00875219
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00860238
CAPN2 calpain 2, (m/II) large subunit -0.00818523
CFLAR CASP8 and FADD-like apoptosis regulator -0.00814451
FOXO3 forkhead box O3 -0.00807458
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.00792782
EXT1 exostosin glycosyltransferase 1 -0.00788766
H1-0 H1.0 linker histone -0.00764892
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.00764305
SBNO2 strawberry notch homolog 2 (Drosophila) -0.00763241
GSK3B glycogen synthase kinase 3 beta -0.00760244
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00758668
CTNND1 catenin (cadherin-associated protein), delta 1 -0.00755884
ZNFX1 zinc finger, NFX1-type containing 1 -0.00750447
S100A11 S100 calcium binding protein A11 -0.00745158
HSPB1 heat shock 27kDa protein 1 -0.00744875
IFITM3 interferon induced transmembrane protein 3 -0.00737945
HMGB1 high mobility group box 1 -0.00731653
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.00729222
NBEAL1 neurobeachin-like 1 -0.0072238
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.00719475
H3-3B H3.3 histone B -0.00715578
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.00713279
KCNK6 potassium channel, two pore domain subfamily K, member 6 -0.00713218
UBE2B ubiquitin-conjugating enzyme E2B -0.00706885
CSNK1D casein kinase 1, delta -0.00705151
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.00700707
HMOX1 heme oxygenase 1 -0.00696904
LPIN1 lipin 1 -0.00696691
ABI1 abl-interactor 1 -0.0069044
IFRD1 interferon-related developmental regulator 1 -0.00687508
MIDN midnolin -0.00687499
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.00686551
RPL19 ribosomal protein L19 -0.00684112
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.00681681
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00677737
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00672079
RICTOR RPTOR independent companion of MTOR, complex 2 -0.00670714
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.00670411
YAP1 Yes-associated protein 1 -0.00667273
CCNL1 cyclin L1 -0.0066705
KLHL24 kelch-like family member 24 -0.00666634