Pexidartinib (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.330166
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0951524
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0936242
NDRG1 N-myc downstream regulated 1 0.0882376
FTH1 ferritin, heavy polypeptide 1 0.0814023
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.065071
CES1 carboxylesterase 1 0.0630305
FAM13A family with sequence similarity 13, member A 0.0606576
CXCL8 chemokine (C-X-C motif) ligand 8 0.0578473
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0549516
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0467376
TBC1D22A TBC1 domain family, member 22A 0.0409491
GRAMD1B GRAM domain containing 1B 0.0388854
PDIA3 protein disulfide isomerase family A, member 3 0.038192
PYGL phosphorylase, glycogen, liver 0.0361198
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0345439
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0343677
PCBP2 poly(rC) binding protein 2 0.034302
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0342958
MKI67 marker of proliferation Ki-67 0.0330451
HYOU1 hypoxia up-regulated 1 0.0327434
DTNA dystrobrevin, alpha 0.0297297
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0285739
ATP11A ATPase, class VI, type 11A 0.0275969
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0273075
NAMPT nicotinamide phosphoribosyltransferase 0.0272987
NGLY1 N-glycanase 1 0.026326
TMEM45B transmembrane protein 45B 0.0260859
ZNF292 zinc finger protein 292 0.0260306
LDHA lactate dehydrogenase A 0.0251514
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0243884
CDCP1 CUB domain containing protein 1 0.0241375
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0236037
SEC24D SEC24 family member D 0.0232226
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0229118
CCNG2 cyclin G2 0.0227393
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0222369
ZNF638 zinc finger protein 638 0.0222054
EEF2 eukaryotic translation elongation factor 2 0.0221485
HOOK2 hook microtubule-tethering protein 2 0.021766
GOLGB1 golgin B1 0.0217165
CEMIP cell migration inducing protein, hyaluronan binding 0.0211687
AKAP9 A kinase (PRKA) anchor protein 9 0.0209776
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0209222
FRY furry homolog (Drosophila) 0.0206448
SLTM SAFB-like, transcription modulator 0.0202387
CCNL1 cyclin L1 0.0200112
NFE2L1 nuclear factor, erythroid 2-like 1 0.0194053
SRRM2 serine/arginine repetitive matrix 2 0.0189429
BLZF1 basic leucine zipper nuclear factor 1 0.0188142
KDM7A lysine (K)-specific demethylase 7A 0.0184841
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0184176
ARRDC3 arrestin domain containing 3 0.0182012
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0181411
GCLC glutamate-cysteine ligase, catalytic subunit 0.0181224
BACE2 beta-site APP-cleaving enzyme 2 0.0181023
SCFD1 sec1 family domain containing 1 0.0180559
C1D C1D nuclear receptor corepressor 0.0177579
RAD51B RAD51 paralog B 0.0174223
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0173344
HM13 histocompatibility (minor) 13 0.0173311
KMT2D lysine (K)-specific methyltransferase 2D 0.0171715
TNIP1 TNFAIP3 interacting protein 1 0.0169128
ZC3H11A zinc finger CCCH-type containing 11A 0.0164545
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0162247
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0161989
RASA2 RAS p21 protein activator 2 0.0161626
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0161092
HELZ helicase with zinc finger 0.0160736
SLC35F5 solute carrier family 35, member F5 0.0159732
MLEC malectin 0.0158856
FAM117B family with sequence similarity 117, member B 0.0157535
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0154251
GPATCH2L G patch domain containing 2-like 0.0150936
MON2 MON2 homolog (S. cerevisiae) 0.0150652
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0150513
PDIA6 protein disulfide isomerase family A, member 6 0.0150351
SEC31A SEC31 homolog A (S. cerevisiae) 0.0149115
MORF4L2 mortality factor 4 like 2 0.0146791
TMF1 TATA element modulatory factor 1 0.014657
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0145852
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0145818
TMED2 transmembrane emp24 domain trafficking protein 2 0.0145382
UBE4A ubiquitination factor E4A 0.0144864
TPR translocated promoter region, nuclear basket protein 0.0144682
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0144645
PRELID2 PRELI domain containing 2 0.0144358
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0144054
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0142722
MIDEAS mitotic deacetylase associated SANT domain protein 0.0142592
MYH9 myosin, heavy chain 9, non-muscle 0.0141683
TMED5 transmembrane emp24 protein transport domain containing 5 0.0141244
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0140178
COG6 component of oligomeric golgi complex 6 0.0139038
TMCO3 transmembrane and coiled-coil domains 3 0.0138624
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.0138514
YEATS2 YEATS domain containing 2 0.0137749
PER2 period circadian clock 2 0.0136537
ATXN1 ataxin 1 0.0136378
PTEN phosphatase and tensin homolog 0.0136003

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.267635
TMSB10 thymosin beta 10 -0.170758
PTPRM protein tyrosine phosphatase, receptor type, M -0.105994
LMO7 LIM domain 7 -0.0811275
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0787453
MT2A metallothionein 2A -0.0730254
TPT1 tumor protein, translationally-controlled 1 -0.0725283
ASPH aspartate beta-hydroxylase -0.0679541
PTMA prothymosin, alpha -0.0667347
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0666558
FTL ferritin, light polypeptide -0.0661544
THSD4 thrombospondin, type I, domain containing 4 -0.0630758
S100A10 S100 calcium binding protein A10 -0.0624575
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0603057
AHNAK AHNAK nucleoprotein -0.0533095
ANXA2 annexin A2 -0.0529456
PDLIM5 PDZ and LIM domain 5 -0.0515159
RPL35A ribosomal protein L35a -0.0513248
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0503912
RPLP1 ribosomal protein, large, P1 -0.0496186
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.046315
PDE4D phosphodiesterase 4D, cAMP-specific -0.0439307
RAB10 RAB10, member RAS oncogene family -0.0436232
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0413336
SEC61G Sec61 gamma subunit -0.040675
TXNRD1 thioredoxin reductase 1 -0.0398669
AKAP12 A kinase (PRKA) anchor protein 12 -0.0393204
KRT7 keratin 7, type II -0.0386367
AKR1C1 aldo-keto reductase family 1, member C1 -0.0380576
OSMR oncostatin M receptor -0.037925
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0376289
CAV1 caveolin 1, caveolae protein, 22kDa -0.0370897
RPL34 ribosomal protein L34 -0.0369416
CST3 cystatin C -0.0367177
RPS24 ribosomal protein S24 -0.0362416
RPS3 ribosomal protein S3 -0.036045
NTN4 netrin 4 -0.0350647
RAB27B RAB27B, member RAS oncogene family -0.0350626
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0350492
LAMC2 laminin, gamma 2 -0.0339398
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.03376
VCL vinculin -0.0336447
MYOF myoferlin -0.0336067
NCOA3 nuclear receptor coactivator 3 -0.0327634
H1-0 H1.0 linker histone -0.0325591
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0325194
RPS6 ribosomal protein S6 -0.0319663
RPS25 ribosomal protein S25 -0.0309962
KRT8 keratin 8, type II -0.0303258
WSB1 WD repeat and SOCS box containing 1 -0.0303144
IER3 immediate early response 3 -0.0298587
RPL19 ribosomal protein L19 -0.0295987
RPL31 ribosomal protein L31 -0.029565
RPL37A ribosomal protein L37a -0.0291034
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0285507
KRT18 keratin 18, type I -0.0283529
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0283111
ACTG1 actin gamma 1 -0.0280288
CCND1 cyclin D1 -0.0275711
RPS23 ribosomal protein S23 -0.0266382
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0265566
RPS27A ribosomal protein S27a -0.025998
RPS19 ribosomal protein S19 -0.0257094
RIMS2 regulating synaptic membrane exocytosis 2 -0.0253003
RPS21 ribosomal protein S21 -0.0251692
MYO1D myosin ID -0.0247391
RPL36 ribosomal protein L36 -0.0244517
DENND5B DENN/MADD domain containing 5B -0.0243378
S100A9 S100 calcium binding protein A9 -0.0242475
SDC4 syndecan 4 -0.0241237
B2M beta-2-microglobulin -0.0239834
IGF1R insulin-like growth factor 1 receptor -0.0239517
ANKRD10 ankyrin repeat domain 10 -0.0238834
RPS8 ribosomal protein S8 -0.0235728
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0233378
RAP1B RAP1B, member of RAS oncogene family -0.0233172
RPL36A ribosomal protein L36a -0.0230905
PATJ PATJ crumbs cell polarity complex component -0.0230417
PARD3 par-3 family cell polarity regulator -0.0228351
AREG amphiregulin -0.0227413
NCOA7 nuclear receptor coactivator 7 -0.0226817
RPL8 ribosomal protein L8 -0.0226438
DOCK5 dedicator of cytokinesis 5 -0.0225631
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0224773
SLC38A1 solute carrier family 38, member 1 -0.022421
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0223861
RPL12 ribosomal protein L12 -0.0223843
RNF145 ring finger protein 145 -0.0223718
RPS29 ribosomal protein S29 -0.0223015
RPLP2 ribosomal protein, large, P2 -0.0222888
TRIO trio Rho guanine nucleotide exchange factor -0.0222712
GSK3B glycogen synthase kinase 3 beta -0.0222288
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0221316
EFNA5 ephrin-A5 -0.0221223
DSCAM Down syndrome cell adhesion molecule -0.0218069
EIF1 eukaryotic translation initiation factor 1 -0.0217126
MCL1 myeloid cell leukemia 1 -0.0215041
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.021489
ENO1 enolase 1, (alpha) -0.0212203
IFI6 interferon, alpha-inducible protein 6 -0.0212056