Pexidartinib (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0912735
FNDC3B fibronectin type III domain containing 3B 0.0745924
IGFBP3 insulin-like growth factor binding protein 3 0.052624
GRB10 growth factor receptor-bound protein 10 0.0482603
PRELID2 PRELI domain containing 2 0.0481721
FAM13A family with sequence similarity 13, member A 0.0467422
CXCL8 chemokine (C-X-C motif) ligand 8 0.0463866
TRIO trio Rho guanine nucleotide exchange factor 0.0406092
PDE4D phosphodiesterase 4D, cAMP-specific 0.0404408
LOX lysyl oxidase 0.040428
PCBP2 poly(rC) binding protein 2 0.0401586
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0383232
RAD51B RAD51 paralog B 0.0376165
ZEB2 zinc finger E-box binding homeobox 2 0.0364356
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.036199
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0344481
GPC6 glypican 6 0.0336999
ATP13A3 ATPase type 13A3 0.0326643
PIAS2 protein inhibitor of activated STAT, 2 0.0323399
RUNX2 runt-related transcription factor 2 0.0320866
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0308423
MEF2A myocyte enhancer factor 2A 0.0305352
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0292499
CD44 CD44 molecule (Indian blood group) 0.0291686
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0283387
RICTOR RPTOR independent companion of MTOR, complex 2 0.0281548
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.028115
EEF2 eukaryotic translation elongation factor 2 0.0280027
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0273425
OSMR oncostatin M receptor 0.0264208
ZNF292 zinc finger protein 292 0.0261189
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0259781
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0258827
GOLGA4 golgin A4 0.0256046
FBXL13 F-box and leucine-rich repeat protein 13 0.0253642
SDK1 sidekick cell adhesion molecule 1 0.0252666
USP34 ubiquitin specific peptidase 34 0.0252545
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0251678
UBA6 ubiquitin-like modifier activating enzyme 6 0.0244801
KMT2C lysine (K)-specific methyltransferase 2C 0.0240626
ETV6 ets variant 6 0.0240196
YEATS2 YEATS domain containing 2 0.0233735
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0232468
SMAD3 SMAD family member 3 0.0232104
DOCK5 dedicator of cytokinesis 5 0.0228495
RPS2 ribosomal protein S2 0.0228265
ITCH itchy E3 ubiquitin protein ligase 0.0227126
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0226689
EFNA5 ephrin-A5 0.0220951
HELZ helicase with zinc finger 0.0219359
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0216809
RBM39 RNA binding motif protein 39 0.0215929
PDIA3 protein disulfide isomerase family A, member 3 0.0214037
LRRC49 leucine rich repeat containing 49 0.0211395
NBAS neuroblastoma amplified sequence 0.0209518
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0204038
HDAC9 histone deacetylase 9 0.02027
LIMCH1 LIM and calponin homology domains 1 0.0202484
DLG1 discs, large homolog 1 (Drosophila) 0.020205
VEGFC vascular endothelial growth factor C 0.0199614
SLTM SAFB-like, transcription modulator 0.019831
SRP54 signal recognition particle 54kDa 0.0196527
COG5 component of oligomeric golgi complex 5 0.0195667
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0195571
PTPRR protein tyrosine phosphatase, receptor type, R 0.0191596
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0190208
DST dystonin 0.0188593
TPR translocated promoter region, nuclear basket protein 0.0187473
BHLHE40 basic helix-loop-helix family, member e40 0.0187428
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0186313
BIRC3 baculoviral IAP repeat containing 3 0.0184906
MRPS6 mitochondrial ribosomal protein S6 0.0184864
RARB retinoic acid receptor, beta 0.0181485
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0181314
NAV2 neuron navigator 2 0.0180201
ANXA1 annexin A1 0.0177704
SIK3 SIK family kinase 3 0.0175297
CD109 CD109 molecule 0.0173265
AKAP9 A kinase (PRKA) anchor protein 9 0.0172407
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0172102
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0170959
STK38L serine/threonine kinase 38 like 0.0170262
SEC23A Sec23 homolog A (S. cerevisiae) 0.0169345
NFE2L1 nuclear factor, erythroid 2-like 1 0.0165769
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.016527
VMP1 vacuole membrane protein 1 0.0164856
CHD1 chromodomain helicase DNA binding protein 1 0.0163993
PSD3 pleckstrin and Sec7 domain containing 3 0.0163496
ZFAND3 zinc finger, AN1-type domain 3 0.0162464
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0162319
METTL15 methyltransferase like 15 0.016134
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0160345
TAS2R14 taste receptor, type 2, member 14 0.015971
SEC31A SEC31 homolog A (S. cerevisiae) 0.0159478
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0157068
PICALM phosphatidylinositol binding clathrin assembly protein 0.0157051
TBK1 TANK-binding kinase 1 0.0156832
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0156536
KDM2A lysine (K)-specific demethylase 2A 0.0155521
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0154715

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.327767
TMSB10 thymosin beta 10 -0.158256
VIM vimentin -0.144696
MT2A metallothionein 2A -0.125456
FTL ferritin, light polypeptide -0.0906199
PTMA prothymosin, alpha -0.0866923
RPLP1 ribosomal protein, large, P1 -0.0853476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0660748
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0635274
RPL32 ribosomal protein L32 -0.0592198
RPL35A ribosomal protein L35a -0.058173
RPS6 ribosomal protein S6 -0.0575525
RPLP2 ribosomal protein, large, P2 -0.0562541
IER3 immediate early response 3 -0.0558003
RPS19 ribosomal protein S19 -0.0557998
AKAP12 A kinase (PRKA) anchor protein 12 -0.0539247
RPS21 ribosomal protein S21 -0.0527714
TPT1 tumor protein, translationally-controlled 1 -0.0506392
RPS29 ribosomal protein S29 -0.050509
RPS24 ribosomal protein S24 -0.0487687
RPL34 ribosomal protein L34 -0.0465947
RPL36 ribosomal protein L36 -0.0457067
RPL31 ribosomal protein L31 -0.0451098
S100A10 S100 calcium binding protein A10 -0.0439587
EIF1 eukaryotic translation initiation factor 1 -0.0436701
RPL23 ribosomal protein L23 -0.0420791
RPS11 ribosomal protein S11 -0.041926
STC1 stanniocalcin 1 -0.0416796
TFPI2 tissue factor pathway inhibitor 2 -0.041605
AHNAK AHNAK nucleoprotein -0.0391335
RPS8 ribosomal protein S8 -0.0381827
RPS13 ribosomal protein S13 -0.0369587
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0368286
RPL28 ribosomal protein L28 -0.0366498
RPL12 ribosomal protein L12 -0.034989
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0346609
B2M beta-2-microglobulin -0.0345163
TM4SF1 transmembrane 4 L six family member 1 -0.0343719
RPS25 ribosomal protein S25 -0.0326339
RPL19 ribosomal protein L19 -0.0325889
RPL38 ribosomal protein L38 -0.0323285
C15ORF48 chromosome 15 open reading frame 48 -0.0319123
RPS23 ribosomal protein S23 -0.0305834
EGR1 early growth response 1 -0.0296828
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0294258
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0291103
FN1 fibronectin 1 -0.0289655
RPLP0 ribosomal protein, large, P0 -0.0288745
RPS16 ribosomal protein S16 -0.0286783
RPL11 ribosomal protein L11 -0.028674
TMSB4X thymosin beta 4, X-linked -0.0281881
RPS15 ribosomal protein S15 -0.0272845
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0271776
S100A9 S100 calcium binding protein A9 -0.0269659
HMGA2 high mobility group AT-hook 2 -0.0265787
RPS5 ribosomal protein S5 -0.026544
HLA-B major histocompatibility complex, class I, B -0.0258374
PKM pyruvate kinase, muscle -0.0253897
RPL8 ribosomal protein L8 -0.0251393
RPL7A ribosomal protein L7a -0.0249465
IFITM3 interferon induced transmembrane protein 3 -0.0235633
LOC102724023 ES1 protein homolog, mitochondrial -0.0232458
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0232065
S100A6 S100 calcium binding protein A6 -0.0231456
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0230065
RPL9 ribosomal protein L9 -0.0228777
RPS27 ribosomal protein S27 -0.0228546
ENO1 enolase 1, (alpha) -0.0227999
RPL37 ribosomal protein L37 -0.0226009
NAP1L1 nucleosome assembly protein 1-like 1 -0.0225942
ANKRD28 ankyrin repeat domain 28 -0.0225534
RPS10 ribosomal protein S10 -0.0225091
CDH13 cadherin 13 -0.022386
RPL37A ribosomal protein L37a -0.0222964
VDAC1 voltage-dependent anion channel 1 -0.0220916
RPS14 ribosomal protein S14 -0.021554
H1-0 H1.0 linker histone -0.0215482
IFI6 interferon, alpha-inducible protein 6 -0.0213896
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0210521
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0208628
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0205193
BTG1 B-cell translocation gene 1, anti-proliferative -0.0202752
CCNI cyclin I -0.0202164
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.020087
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0200067
RPL13A ribosomal protein L13a -0.0198043
UBC ubiquitin C -0.0196093
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0195981
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0192596
GSTP1 glutathione S-transferase pi 1 -0.0191857
RPL15 ribosomal protein L15 -0.0188376
SEC61G Sec61 gamma subunit -0.0187574
H3-3B H3.3 histone B -0.0187519
YBX3 Y box binding protein 3 -0.0185555
EMP1 epithelial membrane protein 1 -0.0182305
RPL5 ribosomal protein L5 -0.0176961
CANX calnexin -0.0176555
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0175269
RPL35 ribosomal protein L35 -0.0174965
RPL36A ribosomal protein L36a -0.0174485