| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.12322 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.10784 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.094553 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0859713 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0854495 |
| VIM | vimentin | 0.0633465 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0493238 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0488569 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0474621 |
| PFN1 | profilin 1 | 0.0457857 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0435445 |
| RAD51B | RAD51 paralog B | 0.0428802 |
| FLNB | filamin B, beta | 0.0413219 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0343989 |
| PCBP1 | poly(rC) binding protein 1 | 0.0337606 |
| TMSB10 | thymosin beta 10 | 0.0336437 |
| FLNA | filamin A, alpha | 0.0331742 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0315906 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0307183 |
| ACTG1 | actin gamma 1 | 0.0293768 |
| PRR16 | proline rich 16 | 0.027468 |
| BICC1 | BicC family RNA binding protein 1 | 0.0271928 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0269648 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0261685 |
| LDHA | lactate dehydrogenase A | 0.0261481 |
| FMNL2 | formin-like 2 | 0.0257014 |
| ITGB5 | integrin, beta 5 | 0.0250038 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.024786 |
| HMGA1 | high mobility group AT-hook 1 | 0.0246217 |
| CMIP | c-Maf inducing protein | 0.0245535 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0239098 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0233481 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0227715 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0219261 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.021882 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0216264 |
| PCBP2 | poly(rC) binding protein 2 | 0.0215441 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0210535 |
| NUP58 | nucleoporin 58 | 0.0205803 |
| ECT2 | epithelial cell transforming 2 | 0.0204492 |
| NEBL | nebulette | 0.0204416 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0203924 |
| RACK1 | receptor for activated C kinase 1 | 0.020001 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0199398 |
| EGR1 | early growth response 1 | 0.0195477 |
| RPS12 | ribosomal protein S12 | 0.0193157 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0192081 |
| GLIS3 | GLIS family zinc finger 3 | 0.0191447 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.0187929 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0185145 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0184413 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0183397 |
| FGG | fibrinogen gamma chain | 0.0179716 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0175319 |
| ACTN1 | actinin, alpha 1 | 0.0174771 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0172354 |
| AUP1 | ancient ubiquitous protein 1 | 0.0171404 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0167691 |
| TGFB2 | transforming growth factor, beta 2 | 0.0166847 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0165169 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0163257 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0162849 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.0161594 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0158775 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0158529 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0155554 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0155254 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0153539 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | 0.0152737 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0150796 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0149058 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0148819 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0148289 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.014765 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0147356 |
| EFNA5 | ephrin-A5 | 0.0146324 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0143258 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.014061 |
| EGFR | epidermal growth factor receptor | 0.0139288 |
| MYO19 | myosin XIX | 0.0138287 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0138164 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0137364 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0135834 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0135406 |
| CABIN1 | calcineurin binding protein 1 | 0.013519 |
| PYGL | phosphorylase, glycogen, liver | 0.0132583 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0132233 |
| TNPO3 | transportin 3 | 0.0131277 |
| FOXP1 | forkhead box P1 | 0.0131091 |
| KLF6 | Kruppel-like factor 6 | 0.012999 |
| HMGA2 | high mobility group AT-hook 2 | 0.0127173 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0127119 |
| DCLK2 | doublecortin-like kinase 2 | 0.0126778 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | 0.0126301 |
| TIMM23B | translocase of inner mitochondrial membrane 23 homolog B (yeast) | 0.0125142 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | 0.0124862 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0122506 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0122377 |
| NFIB | nuclear factor I/B | 0.012213 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.012102 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.251297 |
| MT2A | metallothionein 2A | -0.195262 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.139452 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.120538 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.115641 |
| PTMA | prothymosin, alpha | -0.101919 |
| TXNRD1 | thioredoxin reductase 1 | -0.096168 |
| IER3 | immediate early response 3 | -0.0941363 |
| FTL | ferritin, light polypeptide | -0.0863915 |
| RPL19 | ribosomal protein L19 | -0.0843018 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0840316 |
| RPS6 | ribosomal protein S6 | -0.0682182 |
| RPS21 | ribosomal protein S21 | -0.0668643 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.066131 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0588858 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0574867 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0567012 |
| AHNAK | AHNAK nucleoprotein | -0.051999 |
| DENND4A | DENN/MADD domain containing 4A | -0.0515207 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0506083 |
| TPM3 | tropomyosin 3 | -0.0501514 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0486597 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0465449 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0426708 |
| S100A10 | S100 calcium binding protein A10 | -0.0424734 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0421871 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0411172 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0406136 |
| RPS25 | ribosomal protein S25 | -0.0400799 |
| RPL8 | ribosomal protein L8 | -0.0395106 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0383955 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.037668 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0374762 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0360885 |
| RPS27A | ribosomal protein S27a | -0.0360486 |
| CANX | calnexin | -0.0360309 |
| RBM39 | RNA binding motif protein 39 | -0.0358935 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0355881 |
| ASPH | aspartate beta-hydroxylase | -0.0352691 |
| UBC | ubiquitin C | -0.0352008 |
| RPS15 | ribosomal protein S15 | -0.0343208 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0339907 |
| RTN4 | reticulon 4 | -0.0333715 |
| RPS8 | ribosomal protein S8 | -0.0333046 |
| RPS23 | ribosomal protein S23 | -0.0324194 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0322633 |
| SETD5 | SET domain containing 5 | -0.0316924 |
| RHEB | Ras homolog enriched in brain | -0.031589 |
| RPLP1 | ribosomal protein, large, P1 | -0.0310204 |
| FAM107B | family with sequence similarity 107, member B | -0.0305455 |
| SRGN | serglycin | -0.0305252 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0294714 |
| RPS5 | ribosomal protein S5 | -0.0293252 |
| NOP58 | NOP58 ribonucleoprotein | -0.0291661 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0291604 |
| YBX3 | Y box binding protein 3 | -0.0290744 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0289694 |
| RPL38 | ribosomal protein L38 | -0.02856 |
| FGB | fibrinogen beta chain | -0.0279653 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0278216 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.027801 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0273686 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0272801 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0271726 |
| RPS10 | ribosomal protein S10 | -0.0271319 |
| RPL7 | ribosomal protein L7 | -0.0266138 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0264474 |
| GOLGB1 | golgin B1 | -0.026294 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0259482 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0259271 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0256296 |
| DST | dystonin | -0.0253295 |
| RPS24 | ribosomal protein S24 | -0.0250637 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0246024 |
| B2M | beta-2-microglobulin | -0.0244775 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0244511 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0244487 |
| DEK | DEK proto-oncogene | -0.0243639 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0242915 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0240999 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0240883 |
| ASTN2 | astrotactin 2 | -0.0239849 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0239621 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0239454 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0238297 |
| S100A6 | S100 calcium binding protein A6 | -0.0233514 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0232352 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0229581 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0226116 |
| CAVIN1 | caveolae associated protein 1 | -0.0226046 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0224636 |
| RPL12 | ribosomal protein L12 | -0.0223894 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.0223079 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | -0.0222939 |
| RPL36A | ribosomal protein L36a | -0.0222561 |
| SERF2 | small EDRK-rich factor 2 | -0.0222104 |
| S100A9 | S100 calcium binding protein A9 | -0.022137 |
| RPS11 | ribosomal protein S11 | -0.0221315 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.0220809 |
| SDC4 | syndecan 4 | -0.0220357 |
