| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT17 | keratin 17, type I | 0.1755 |
| NDRG1 | N-myc downstream regulated 1 | 0.168187 |
| FLNB | filamin B, beta | 0.0971417 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0957625 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0953534 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0848311 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0820679 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0790116 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0775424 |
| TXNRD1 | thioredoxin reductase 1 | 0.077502 |
| RPS3 | ribosomal protein S3 | 0.073703 |
| KYNU | kynureninase | 0.0716662 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0708024 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0701443 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0693084 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0687516 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0652145 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.063743 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0625166 |
| OLA1 | Obg-like ATPase 1 | 0.0625064 |
| OGA | O-GlcNAcase | 0.062025 |
| FLNA | filamin A, alpha | 0.0616403 |
| LAMB3 | laminin, beta 3 | 0.0611403 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0610939 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0601392 |
| DTNA | dystrobrevin, alpha | 0.0590797 |
| ANXA2 | annexin A2 | 0.0590592 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0585302 |
| RPL34 | ribosomal protein L34 | 0.0545742 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0531279 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.053004 |
| FN1 | fibronectin 1 | 0.0524238 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0512434 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0509671 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0505929 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0505504 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0492378 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0491142 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0491125 |
| GOLGA4 | golgin A4 | 0.0487243 |
| GPHN | gephyrin | 0.0484447 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0478826 |
| RACK1 | receptor for activated C kinase 1 | 0.0473848 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0471473 |
| USP3 | ubiquitin specific peptidase 3 | 0.0467344 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0463975 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0463468 |
| MYO10 | myosin X | 0.0462054 |
| PTPRA | protein tyrosine phosphatase, receptor type, A | 0.04606 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0460157 |
| ASPH | aspartate beta-hydroxylase | 0.044421 |
| SPAG9 | sperm associated antigen 9 | 0.0442863 |
| FMNL2 | formin-like 2 | 0.0434091 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0432794 |
| TMSB10 | thymosin beta 10 | 0.0413972 |
| RPS8 | ribosomal protein S8 | 0.0413715 |
| COG5 | component of oligomeric golgi complex 5 | 0.0412737 |
| TOP1 | topoisomerase (DNA) I | 0.0412691 |
| EFNA5 | ephrin-A5 | 0.0403705 |
| PGK1 | phosphoglycerate kinase 1 | 0.039821 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0397894 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0388145 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0386827 |
| BBX | bobby sox homolog (Drosophila) | 0.0384743 |
| CLINT1 | clathrin interactor 1 | 0.0379639 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0378305 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0377118 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0376964 |
| HMGA1 | high mobility group AT-hook 1 | 0.0374345 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0371755 |
| RPL37 | ribosomal protein L37 | 0.0367514 |
| CALU | calumenin | 0.0359555 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0354906 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0352859 |
| CDK17 | cyclin-dependent kinase 17 | 0.0351438 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0350317 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0347641 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0343662 |
| GNAS | GNAS complex locus | 0.0336625 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.033562 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0333862 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0333196 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0332918 |
| MSI2 | musashi RNA-binding protein 2 | 0.0330547 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0324302 |
| RPL37A | ribosomal protein L37a | 0.0322409 |
| VCL | vinculin | 0.0319834 |
| RSF1 | remodeling and spacing factor 1 | 0.0318181 |
| SMYD3 | SET and MYND domain containing 3 | 0.0315963 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.031462 |
| INHBA | inhibin, beta A | 0.0306639 |
| RBM33 | RNA binding motif protein 33 | 0.0300387 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0296894 |
| FTL | ferritin, light polypeptide | 0.0293171 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0283538 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.028227 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0279713 |
| HELZ | helicase with zinc finger | 0.0275959 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0275746 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0275051 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.130714 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.124038 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.122814 |
| MUC16 | mucin 16, cell surface associated | -0.117632 |
| LMO7 | LIM domain 7 | -0.112484 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.110805 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0936627 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0905214 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0868512 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0792541 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0779318 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0706097 |
| MYO1E | myosin IE | -0.0704051 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0672201 |
| ZNF292 | zinc finger protein 292 | -0.0667729 |
| ATOSA | atos homolog A | -0.066514 |
| INSIG1 | insulin induced gene 1 | -0.0655452 |
| SVIL | supervillin | -0.0655215 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0646379 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0638521 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0634421 |
| GOLGB1 | golgin B1 | -0.0608099 |
| VGF | VGF nerve growth factor inducible | -0.0604248 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0604037 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0580754 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0580132 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0570656 |
| SRPK2 | SRSF protein kinase 2 | -0.0558658 |
| AHNAK | AHNAK nucleoprotein | -0.0550969 |
| MCL1 | myeloid cell leukemia 1 | -0.054839 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0545288 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0533402 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0533247 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.052543 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0522973 |
| NPTN | neuroplastin | -0.0502896 |
| KIF5B | kinesin family member 5B | -0.0502095 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0478997 |
| MYO5B | myosin VB | -0.0478661 |
| EGFR | epidermal growth factor receptor | -0.047395 |
| ABHD17C | abhydrolase domain containing 17C | -0.0457342 |
| PLK2 | polo-like kinase 2 | -0.044367 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0443058 |
| USP33 | ubiquitin specific peptidase 33 | -0.0442343 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0441445 |
| JUP | junction plakoglobin | -0.0439915 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0435408 |
| CNKSR3 | CNKSR family member 3 | -0.0427549 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0423927 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0406883 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0404891 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.039771 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0392865 |
| AK1 | adenylate kinase 1 | -0.0388729 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0384309 |
| NEK7 | NIMA-related kinase 7 | -0.037529 |
| HLA-B | major histocompatibility complex, class I, B | -0.0371336 |
| SRP72 | signal recognition particle 72kDa | -0.0369535 |
| CUX1 | cut-like homeobox 1 | -0.0363838 |
| RNF145 | ring finger protein 145 | -0.0361922 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0359204 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0358158 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0355342 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.035438 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0349944 |
| RPL8 | ribosomal protein L8 | -0.0349877 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | -0.034574 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0344764 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0343831 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0342817 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0342267 |
| KLF6 | Kruppel-like factor 6 | -0.0338181 |
| ERBIN | erbb2 interacting protein | -0.0337844 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0336748 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0329878 |
| ATXN1 | ataxin 1 | -0.0326515 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0320794 |
| RREB1 | ras responsive element binding protein 1 | -0.0320013 |
| FOXO3 | forkhead box O3 | -0.0313852 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0308895 |
| PRELID2 | PRELI domain containing 2 | -0.0308422 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.030764 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0305492 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0304718 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0303081 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0300589 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0300451 |
| OSMR | oncostatin M receptor | -0.0299498 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0295185 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0294663 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0294638 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0292457 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.028915 |
| SMAD2 | SMAD family member 2 | -0.0288254 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0285942 |
| NUP98 | nucleoporin 98kDa | -0.0280673 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0280004 |
| SMAD3 | SMAD family member 3 | -0.0274229 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0273602 |
| ENO1 | enolase 1, (alpha) | -0.0272265 |
