Pexidartinib (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.161691
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114029
GRAMD1B GRAM domain containing 1B 0.0992571
ERRFI1 ERBB receptor feedback inhibitor 1 0.0962978
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0822939
TFPI2 tissue factor pathway inhibitor 2 0.081977
TRIO trio Rho guanine nucleotide exchange factor 0.0714522
EEF2 eukaryotic translation elongation factor 2 0.0696629
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0678002
ATP11A ATPase, class VI, type 11A 0.0575744
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0545847
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0502651
NIPBL Nipped-B homolog (Drosophila) 0.0474231
RAD51B RAD51 paralog B 0.0472538
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0470429
EXOC4 exocyst complex component 4 0.0456383
YBX3 Y box binding protein 3 0.0446186
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0436919
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.043107
RTN4 reticulon 4 0.0414819
JMJD1C jumonji domain containing 1C 0.0403493
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0396727
MARCHF4 membrane associated ring-CH-type finger 4 0.0396688
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0394143
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.03889
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0376303
DOCK5 dedicator of cytokinesis 5 0.0375744
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0375528
BBX bobby sox homolog (Drosophila) 0.036534
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0361627
WNK1 WNK lysine deficient protein kinase 1 0.0360121
CCNL1 cyclin L1 0.0354775
KTN1 kinectin 1 (kinesin receptor) 0.0352437
ANO6 anoctamin 6 0.0347184
IGF1R insulin-like growth factor 1 receptor 0.034161
CSNK1A1 casein kinase 1, alpha 1 0.0335392
MED13L mediator complex subunit 13-like 0.0328626
PGK1 phosphoglycerate kinase 1 0.0328585
CSDE1 cold shock domain containing E1, RNA-binding 0.0328117
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0324498
XPO1 exportin 1 0.0322978
RICTOR RPTOR independent companion of MTOR, complex 2 0.031851
CLTC clathrin, heavy chain (Hc) 0.031443
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.031364
PHIP pleckstrin homology domain interacting protein 0.0303714
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.029268
TPM3 tropomyosin 3 0.0287479
PCBP2 poly(rC) binding protein 2 0.028704
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.028424
EXOC6B exocyst complex component 6B 0.0281651
ELL2 elongation factor, RNA polymerase II, 2 0.0275436
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0275309
GPHN gephyrin 0.0271943
SFPQ splicing factor proline/glutamine-rich 0.027166
NCKAP1 NCK-associated protein 1 0.0271571
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.02705
ANKRD36 ankyrin repeat domain 36 0.0268175
PTK2 protein tyrosine kinase 2 0.0268079
RBM39 RNA binding motif protein 39 0.0267571
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0266247
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0266006
YAP1 Yes-associated protein 1 0.0264052
IPO7 importin 7 0.0263386
KDM2A lysine (K)-specific demethylase 2A 0.0261221
ZFAND3 zinc finger, AN1-type domain 3 0.0257965
SPAG9 sperm associated antigen 9 0.02567
SET SET nuclear proto-oncogene 0.0254795
LATS2 large tumor suppressor kinase 2 0.0253078
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0252837
WWOX WW domain containing oxidoreductase 0.0251324
OSMR oncostatin M receptor 0.0250865
KLF6 Kruppel-like factor 6 0.0250671
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0247862
PRELID2 PRELI domain containing 2 0.0247573
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0246745
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0245585
NUP155 nucleoporin 155kDa 0.024079
PLCB4 phospholipase C, beta 4 0.0240284
MATR3 matrin 3 0.0239446
TWF1 twinfilin actin binding protein 1 0.023903
ZNF638 zinc finger protein 638 0.0235932
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0235858
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0234709
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0234403
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0233805
BRWD3 bromodomain and WD repeat domain containing 3 0.0233512
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.023267
ZNF292 zinc finger protein 292 0.0232538
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0231145
VMP1 vacuole membrane protein 1 0.0230237
KIF5B kinesin family member 5B 0.0229857
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0229775
BIRC6 baculoviral IAP repeat containing 6 0.0229431
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0229157
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0224257
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0224074
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0224003
FLNA filamin A, alpha 0.0222453
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0220155
ANXA5 annexin A5 0.0217971

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232037
PTMA prothymosin, alpha -0.108699
TMSB10 thymosin beta 10 -0.0814229
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0793504
RPL35A ribosomal protein L35a -0.0566326
HLA-B major histocompatibility complex, class I, B -0.0504275
TPT1 tumor protein, translationally-controlled 1 -0.0478508
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0441107
VIM vimentin -0.0425957
RPL37 ribosomal protein L37 -0.0400655
TPM2 tropomyosin 2 (beta) -0.0392837
RPL31 ribosomal protein L31 -0.0385974
RPS8 ribosomal protein S8 -0.0383036
RPS29 ribosomal protein S29 -0.0378099
RPL37A ribosomal protein L37a -0.0376481
MCL1 myeloid cell leukemia 1 -0.0375598
RPS21 ribosomal protein S21 -0.036712
RPS15 ribosomal protein S15 -0.0362896
RPS10 ribosomal protein S10 -0.0362084
RPS3 ribosomal protein S3 -0.0358122
RPL8 ribosomal protein L8 -0.0358009
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0342115
RPS6 ribosomal protein S6 -0.0335048
RPS19 ribosomal protein S19 -0.0333387
FTL ferritin, light polypeptide -0.0328698
RPLP2 ribosomal protein, large, P2 -0.0320284
RPS27 ribosomal protein S27 -0.0314393
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0305255
RPL23 ribosomal protein L23 -0.0277846
RPL9 ribosomal protein L9 -0.0276385
RPL34 ribosomal protein L34 -0.0274578
RPL36 ribosomal protein L36 -0.0274076
RPL38 ribosomal protein L38 -0.0273331
RPS25 ribosomal protein S25 -0.0273311
RPS13 ribosomal protein S13 -0.0272418
RPL19 ribosomal protein L19 -0.0272376
RPL36A ribosomal protein L36a -0.0272211
RPL11 ribosomal protein L11 -0.0270703
RPLP1 ribosomal protein, large, P1 -0.0264057
RPS27A ribosomal protein S27a -0.026158
MT2A metallothionein 2A -0.0259128
IFI6 interferon, alpha-inducible protein 6 -0.0257225
EIF1 eukaryotic translation initiation factor 1 -0.0247254
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0246169
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0237045
RPS14 ribosomal protein S14 -0.0231875
INTS6 integrator complex subunit 6 -0.0227893
RPL12 ribosomal protein L12 -0.0226668
RPS23 ribosomal protein S23 -0.0225571
CALR calreticulin -0.0223428
RPL32 ribosomal protein L32 -0.0217651
RPS24 ribosomal protein S24 -0.021617
WNT2B wingless-type MMTV integration site family, member 2B -0.0204003
RPL13A ribosomal protein L13a -0.0202106
S100A10 S100 calcium binding protein A10 -0.020164
RPL26 ribosomal protein L26 -0.0199634
HMGA2 high mobility group AT-hook 2 -0.0197429
IER3 immediate early response 3 -0.0196932
AHNAK AHNAK nucleoprotein -0.0193123
VCL vinculin -0.0190988
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0189602
CANX calnexin -0.0188757
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.018796
RPL35 ribosomal protein L35 -0.0186925
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0186154
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0179
RYR3 ryanodine receptor 3 -0.0174509
RPS16 ribosomal protein S16 -0.0165535
CUX1 cut-like homeobox 1 -0.0165375
RPL5 ribosomal protein L5 -0.0165314
RPS11 ribosomal protein S11 -0.0164106
AEBP2 AE binding protein 2 -0.016248
PRH1 proline-rich protein HaeIII subfamily 1 -0.0159737
RSL1D1 ribosomal L1 domain containing 1 -0.0159283
ACTG1 actin gamma 1 -0.0158865
RPS12 ribosomal protein S12 -0.015588
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0155174
RPS5 ribosomal protein S5 -0.0152972
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0152542
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0149426
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0147164
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0147031
RPL7A ribosomal protein L7a -0.0146288
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0145863
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0144319
RPL28 ribosomal protein L28 -0.0143853
RPL27 ribosomal protein L27 -0.0141419
EGR1 early growth response 1 -0.0139458
TPM4 tropomyosin 4 -0.0139269
S100A9 S100 calcium binding protein A9 -0.0137011
FNDC3B fibronectin type III domain containing 3B -0.0135956
WASF2 WAS protein family, member 2 -0.0126156
TBCA tubulin folding cofactor A -0.0125938
RPS17 ribosomal protein S17 -0.0125768
GOLGA4 golgin A4 -0.0123856
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.012343
PATJ PATJ crumbs cell polarity complex component -0.012305
RAB7A RAB7A, member RAS oncogene family -0.0121648
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0121082
H3-3B H3.3 histone B -0.0120647