Pexidartinib (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.150819
HMGA1 high mobility group AT-hook 1 0.0899304
FN1 fibronectin 1 0.0753853
GRB10 growth factor receptor-bound protein 10 0.0614449
TSC22D2 TSC22 domain family, member 2 0.0559413
ELL2 elongation factor, RNA polymerase II, 2 0.0558039
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0542385
UBA6 ubiquitin-like modifier activating enzyme 6 0.0540732
NAMPT nicotinamide phosphoribosyltransferase 0.0538812
FAM13A family with sequence similarity 13, member A 0.0511999
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0487428
PABPC1 poly(A) binding protein, cytoplasmic 1 0.048016
DTNA dystrobrevin, alpha 0.0455497
ERRFI1 ERBB receptor feedback inhibitor 1 0.0449924
IGFBP3 insulin-like growth factor binding protein 3 0.044683
LDHA lactate dehydrogenase A 0.0439175
ARRDC3 arrestin domain containing 3 0.0412535
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0412258
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0401576
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0378549
RNF145 ring finger protein 145 0.0377771
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0368776
FNDC3B fibronectin type III domain containing 3B 0.0368721
ASPH aspartate beta-hydroxylase 0.0364233
LAMC2 laminin, gamma 2 0.0363707
BHLHE40 basic helix-loop-helix family, member e40 0.0358046
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0344178
CD46 CD46 molecule, complement regulatory protein 0.0340451
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0333691
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.032814
ZFP36L1 ZFP36 ring finger protein-like 1 0.0326248
CCNL1 cyclin L1 0.0323147
NUP58 nucleoporin 58 0.0305081
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0296682
RICTOR RPTOR independent companion of MTOR, complex 2 0.0296543
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296274
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0295825
MSN moesin 0.0286993
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0283704
FOSL1 FOS-like antigen 1 0.0283087
POTEF POTE ankyrin domain family, member F 0.0278564
MXD1 MAX dimerization protein 1 0.0278126
NRIP1 nuclear receptor interacting protein 1 0.0277621
TRIO trio Rho guanine nucleotide exchange factor 0.0272494
ATP13A3 ATPase type 13A3 0.0269473
RUNX1 runt-related transcription factor 1 0.0267501
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0264671
TFG TRK-fused gene 0.026278
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0258908
UGCG UDP-glucose ceramide glucosyltransferase 0.0258835
KMT2E lysine (K)-specific methyltransferase 2E 0.0254614
RPS2 ribosomal protein S2 0.0248651
TACSTD2 tumor-associated calcium signal transducer 2 0.0246155
SLTM SAFB-like, transcription modulator 0.0241324
KDM6A lysine (K)-specific demethylase 6A 0.0238995
ALCAM activated leukocyte cell adhesion molecule 0.0236907
AREG amphiregulin 0.0236796
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.023655
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0226771
EEF2 eukaryotic translation elongation factor 2 0.0225026
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0223456
CLDN4 claudin 4 0.0222723
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0221492
ARHGAP29 Rho GTPase activating protein 29 0.0217107
ADAM9 ADAM metallopeptidase domain 9 0.0217002
SEC23A Sec23 homolog A (S. cerevisiae) 0.0215888
HOOK2 hook microtubule-tethering protein 2 0.0207431
NCKAP1 NCK-associated protein 1 0.0206835
PLAU plasminogen activator, urokinase 0.0204433
MSMO1 methylsterol monooxygenase 1 0.0203775
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0200283
CDK17 cyclin-dependent kinase 17 0.019837
PGK1 phosphoglycerate kinase 1 0.0198226
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.019167
ITCH itchy E3 ubiquitin protein ligase 0.019122
NAV2 neuron navigator 2 0.019114
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0190457
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0190456
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0189115
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0185869
QKI QKI, KH domain containing, RNA binding 0.0184914
MCTP2 multiple C2 domains, transmembrane 2 0.0182065
ZNF292 zinc finger protein 292 0.0181017
FTH1 ferritin, heavy polypeptide 1 0.0180489
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0180291
MRPS6 mitochondrial ribosomal protein S6 0.0180246
MBNL1 muscleblind-like splicing regulator 1 0.0177463
EREG epiregulin 0.0176936
ADGRG6 adhesion G protein-coupled receptor G6 0.017482
SACK1A scaffolding CK1 anchoring protein A 0.0173866
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0172208
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0170137
RHOF ras homolog family member F (in filopodia) 0.0164008
FAM3C family with sequence similarity 3, member C 0.0163146
KLF6 Kruppel-like factor 6 0.0162697
RAD23B RAD23 homolog B (S. cerevisiae) 0.0162628
ECT2 epithelial cell transforming 2 0.0162091
FEM1C fem-1 homolog c (C. elegans) 0.0159451
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0156881
CENPF centromere protein F, 350/400kDa 0.0154743

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.239224
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.179866
UBC ubiquitin C -0.176506
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153746
TMSB10 thymosin beta 10 -0.130298
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.119683
TPT1 tumor protein, translationally-controlled 1 -0.11968
AHNAK AHNAK nucleoprotein -0.107421
FTL ferritin, light polypeptide -0.0948188
CANX calnexin -0.0852267
SQSTM1 sequestosome 1 -0.0827237
TMSB4X thymosin beta 4, X-linked -0.0818496
RPS27A ribosomal protein S27a -0.0748671
FBXO32 F-box protein 32 -0.0673326
S100A10 S100 calcium binding protein A10 -0.0650352
EXT1 exostosin glycosyltransferase 1 -0.0624452
RPL34 ribosomal protein L34 -0.0604144
WSB1 WD repeat and SOCS box containing 1 -0.0598241
RPL8 ribosomal protein L8 -0.0584777
RPLP2 ribosomal protein, large, P2 -0.0583457
S100A6 S100 calcium binding protein A6 -0.057532
EIF1 eukaryotic translation initiation factor 1 -0.0569934
TM4SF1 transmembrane 4 L six family member 1 -0.0568007
SAMD4A sterile alpha motif domain containing 4A -0.0539363
RPLP1 ribosomal protein, large, P1 -0.0536051
RPS29 ribosomal protein S29 -0.0506864
SDC4 syndecan 4 -0.0495681
TPM4 tropomyosin 4 -0.0493128
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0487883
HLA-B major histocompatibility complex, class I, B -0.0471599
RPS13 ribosomal protein S13 -0.0467399
RPL23 ribosomal protein L23 -0.0462862
RPS6 ribosomal protein S6 -0.0441444
OGA O-GlcNAcase -0.0440126
IFI16 interferon, gamma-inducible protein 16 -0.043395
CD2AP CD2-associated protein -0.0415685
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0412805
RPS23 ribosomal protein S23 -0.0410398
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0405178
GOLGB1 golgin B1 -0.040202
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0400665
RPS8 ribosomal protein S8 -0.0400418
CAVIN1 caveolae associated protein 1 -0.0398932
ANXA2 annexin A2 -0.0386148
DSCAM Down syndrome cell adhesion molecule -0.0383971
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.037734
LMNA lamin A/C -0.0375008
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0372736
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0369273
RPL36A ribosomal protein L36a -0.0368127
RRBP1 ribosome binding protein 1 -0.0365978
HLA-E major histocompatibility complex, class I, E -0.036518
RPL9 ribosomal protein L9 -0.0363615
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0363551
KDM3A lysine (K)-specific demethylase 3A -0.036313
RPL35A ribosomal protein L35a -0.0357113
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0352483
EIF3A eukaryotic translation initiation factor 3, subunit A -0.034927
MDK midkine (neurite growth-promoting factor 2) -0.0346649
H3-3B H3.3 histone B -0.0343725
HDLBP high density lipoprotein binding protein -0.034354
SOX4 SRY (sex determining region Y)-box 4 -0.0340726
RPL19 ribosomal protein L19 -0.033643
RAD21 RAD21 homolog (S. pombe) -0.0335299
RPS21 ribosomal protein S21 -0.0334088
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0331914
ENO1 enolase 1, (alpha) -0.0323981
BASP1 brain abundant, membrane attached signal protein 1 -0.0320398
CSTB cystatin B (stefin B) -0.0319388
RPL31 ribosomal protein L31 -0.0318241
KRT7 keratin 7, type II -0.0316202
RPS10 ribosomal protein S10 -0.0313941
RPS3 ribosomal protein S3 -0.0310453
RPL38 ribosomal protein L38 -0.0308242
VCL vinculin -0.0303435
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0301229
HMGB2 high mobility group box 2 -0.0299307
PDIA4 protein disulfide isomerase family A, member 4 -0.0298706
FBXL20 F-box and leucine-rich repeat protein 20 -0.0298185
ZFAND3 zinc finger, AN1-type domain 3 -0.0297434
RHEB Ras homolog enriched in brain -0.029723
S100A9 S100 calcium binding protein A9 -0.0297221
LMO7 LIM domain 7 -0.0296176
BZW1 basic leucine zipper and W2 domains 1 -0.0295864
LPP LIM domain containing preferred translocation partner in lipoma -0.029492
RPS24 ribosomal protein S24 -0.029005
RAB1A RAB1A, member RAS oncogene family -0.028879
FBXO34 F-box protein 34 -0.0284712
CALU calumenin -0.0283721
IFI27 interferon, alpha-inducible protein 27 -0.0282638
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0280052
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0274913
RPS16 ribosomal protein S16 -0.0273155
CALR calreticulin -0.0271404
CD63 CD63 molecule -0.0270801
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0270543
F11R F11 receptor -0.0270335
RPS25 ribosomal protein S25 -0.0270209
MYO1E myosin IE -0.0268869
PRRC2C proline-rich coiled-coil 2C -0.0267538