| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.196395 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.16239 |
| EFNA5 | ephrin-A5 | 0.145943 |
| ASPH | aspartate beta-hydroxylase | 0.145746 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.117806 |
| TXNRD1 | thioredoxin reductase 1 | 0.108501 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0961012 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0945037 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0902431 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0862044 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0833641 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0765119 |
| MYOF | myoferlin | 0.0745418 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0740499 |
| GRAMD1B | GRAM domain containing 1B | 0.0728122 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0724424 |
| NEK7 | NIMA-related kinase 7 | 0.0722862 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0707594 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0703406 |
| COL5A2 | collagen, type V, alpha 2 | 0.0678195 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0664996 |
| CTSC | cathepsin C | 0.0661049 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0636875 |
| CENPF | centromere protein F, 350/400kDa | 0.0632764 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0621076 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0610468 |
| PGK1 | phosphoglycerate kinase 1 | 0.0590892 |
| NRCAM | neuronal cell adhesion molecule | 0.0581686 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0565357 |
| LDHA | lactate dehydrogenase A | 0.0555966 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0554388 |
| GDA | guanine deaminase | 0.0534561 |
| RTN4 | reticulon 4 | 0.053243 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0523098 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0509005 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0505776 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0500808 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0498625 |
| MKI67 | marker of proliferation Ki-67 | 0.0492599 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0482804 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0472224 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0454765 |
| PCBP2 | poly(rC) binding protein 2 | 0.0440369 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0430525 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0424097 |
| PDE10A | phosphodiesterase 10A | 0.0422048 |
| SET | SET nuclear proto-oncogene | 0.0420844 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0411618 |
| CD109 | CD109 molecule | 0.0410366 |
| FLNB | filamin B, beta | 0.0408979 |
| TNPO1 | transportin 1 | 0.0407183 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0402408 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0397527 |
| ANXA1 | annexin A1 | 0.0386935 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0383455 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0376411 |
| PTEN | phosphatase and tensin homolog | 0.0370452 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0364651 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0360112 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0359398 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0355613 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0352619 |
| ZNF292 | zinc finger protein 292 | 0.0348353 |
| PTGR1 | prostaglandin reductase 1 | 0.0344139 |
| MFF | mitochondrial fission factor | 0.0342147 |
| FAM13A | family with sequence similarity 13, member A | 0.0341214 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0336713 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.03338 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0332236 |
| NDRG1 | N-myc downstream regulated 1 | 0.032894 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0328905 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0328302 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0327229 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0322131 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0319665 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0319475 |
| RPS2 | ribosomal protein S2 | 0.0319251 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0316451 |
| ENAH | enabled homolog (Drosophila) | 0.0316 |
| TPR | translocated promoter region, nuclear basket protein | 0.0313937 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0313324 |
| FTL | ferritin, light polypeptide | 0.0311717 |
| ENO1 | enolase 1, (alpha) | 0.0309184 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0308205 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0304261 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0301466 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0299327 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0298191 |
| NUP58 | nucleoporin 58 | 0.0296012 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.02959 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0292225 |
| EZR | ezrin | 0.0291939 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0291207 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0289693 |
| ACTG1 | actin gamma 1 | 0.0289483 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0284829 |
| B2M | beta-2-microglobulin | 0.0283674 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0279116 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0278303 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0276665 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.211873 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.103837 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0731144 |
| CDH13 | cadherin 13 | -0.0661101 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0613261 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0584796 |
| AUTS2 | autism susceptibility candidate 2 | -0.0526434 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0443869 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0374687 |
| VCL | vinculin | -0.0373186 |
| SMAD2 | SMAD family member 2 | -0.0304251 |
| CUX1 | cut-like homeobox 1 | -0.0303993 |
| RPS24 | ribosomal protein S24 | -0.0300825 |
| PCBP3 | poly(rC) binding protein 3 | -0.0291849 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0291096 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.028053 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0260486 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0260412 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0256467 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0243446 |
| RAB31 | RAB31, member RAS oncogene family | -0.024088 |
| DENND1A | DENN/MADD domain containing 1A | -0.0240674 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0240053 |
| INTS6 | integrator complex subunit 6 | -0.0229849 |
| SQSTM1 | sequestosome 1 | -0.0226704 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0225864 |
| XYLT1 | xylosyltransferase I | -0.0225027 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0220354 |
| AHNAK | AHNAK nucleoprotein | -0.0216955 |
| AEBP2 | AE binding protein 2 | -0.021638 |
| MAP7 | microtubule-associated protein 7 | -0.0213877 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0213443 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.021063 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0207512 |
| PCDH9 | protocadherin 9 | -0.0202465 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0202348 |
| NCKAP5 | NCK-associated protein 5 | -0.0195657 |
| NTN4 | netrin 4 | -0.0191271 |
| LSAMP | limbic system-associated membrane protein | -0.0190175 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0184419 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0180014 |
| FMNL2 | formin-like 2 | -0.0175413 |
| SVIL | supervillin | -0.0169152 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0164302 |
| RPL31 | ribosomal protein L31 | -0.0162542 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0160562 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0158581 |
| FAM107B | family with sequence similarity 107, member B | -0.0158292 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0155354 |
| FOXK1 | forkhead box K1 | -0.0151506 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.015033 |
| BMP6 | bone morphogenetic protein 6 | -0.0148385 |
| CHL1 | cell adhesion molecule L1-like | -0.0147791 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0145182 |
| GLCCI1 | glucocorticoid induced 1 | -0.0144941 |
| AADAC | arylacetamide deacetylase | -0.0140367 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.0139496 |
| OXSR1 | oxidative stress responsive 1 | -0.0139321 |
| FSTL4 | follistatin-like 4 | -0.013918 |
| RPL38 | ribosomal protein L38 | -0.0137129 |
| C9ORF153 | chromosome 9 open reading frame 153 | -0.0137115 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0136378 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0136254 |
| HMGA2 | high mobility group AT-hook 2 | -0.0136104 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0136098 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0134389 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.013401 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0133572 |
| CLMP | CXADR-like membrane protein | -0.0132564 |
| LAMB4 | laminin, beta 4 | -0.0131027 |
| ZNF644 | zinc finger protein 644 | -0.0130567 |
| RPL36A | ribosomal protein L36a | -0.0130008 |
| SLCO1C1 | solute carrier organic anion transporter family, member 1C1 | -0.0128598 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0126926 |
| GLRX | glutaredoxin (thioltransferase) | -0.0125003 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0123259 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0122396 |
| MYPN | myopalladin | -0.012232 |
| RPS6 | ribosomal protein S6 | -0.0121604 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0119979 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | -0.0118787 |
| RANBP17 | RAN binding protein 17 | -0.0118328 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0116491 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0116459 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0116271 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0115935 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0115758 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0113997 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0112424 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0112342 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0111814 |
| FOXC1 | forkhead box C1 | -0.0110747 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0110652 |
| PCDH15 | protocadherin-related 15 | -0.010981 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0109709 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0107817 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0107431 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0106841 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0106811 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.010645 |
