| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PEG10 | paternally expressed 10 | 0.134496 |
| ZNF292 | zinc finger protein 292 | 0.119735 |
| TSC22D2 | TSC22 domain family, member 2 | 0.11384 |
| COL5A2 | collagen, type V, alpha 2 | 0.112313 |
| HDAC9 | histone deacetylase 9 | 0.0913405 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0872486 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.083184 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0689117 |
| NCKAP1 | NCK-associated protein 1 | 0.0631751 |
| ENAH | enabled homolog (Drosophila) | 0.0629156 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0617213 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0612614 |
| ANXA1 | annexin A1 | 0.0579724 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0561281 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0558334 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0541019 |
| USP25 | ubiquitin specific peptidase 25 | 0.0526633 |
| DST | dystonin | 0.047307 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0463053 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0451804 |
| CENPF | centromere protein F, 350/400kDa | 0.0450941 |
| RPS2 | ribosomal protein S2 | 0.0431912 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0431082 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0426524 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0425018 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0407034 |
| MED13L | mediator complex subunit 13-like | 0.040689 |
| ZNF608 | zinc finger protein 608 | 0.0404991 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0401341 |
| ANK2 | ankyrin 2, neuronal | 0.0400189 |
| DOCK5 | dedicator of cytokinesis 5 | 0.039847 |
| ITGAV | integrin, alpha V | 0.0395331 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0383567 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0380348 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0373599 |
| RHOH | ras homolog family member H | 0.0370126 |
| FOXP2 | forkhead box P2 | 0.0360001 |
| PLPP1 | phospholipid phosphatase 1 | 0.0356002 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0355867 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0352606 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0352194 |
| RBM20 | RNA binding motif protein 20 | 0.0348491 |
| TENM3 | teneurin transmembrane protein 3 | 0.0345129 |
| FLNA | filamin A, alpha | 0.033983 |
| TLK1 | tousled-like kinase 1 | 0.033522 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0333806 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0332128 |
| MEIS2 | Meis homeobox 2 | 0.0329904 |
| PCDH18 | protocadherin 18 | 0.0326983 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.032495 |
| CFL2 | cofilin 2 (muscle) | 0.0323887 |
| RPS12 | ribosomal protein S12 | 0.0322718 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.03224 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0321817 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0319793 |
| CRY1 | cryptochrome circadian clock 1 | 0.0316508 |
| UPP1 | uridine phosphorylase 1 | 0.030891 |
| PFN1 | profilin 1 | 0.0306288 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0304349 |
| PRTG | protogenin | 0.0302187 |
| MTF2 | metal response element binding transcription factor 2 | 0.0300458 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0298826 |
| PDGFC | platelet derived growth factor C | 0.0297176 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0292514 |
| PDS5B | PDS5 cohesin associated factor B | 0.0290449 |
| STAG2 | stromal antigen 2 | 0.028713 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0285995 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0285492 |
| USP3 | ubiquitin specific peptidase 3 | 0.0283825 |
| NEK7 | NIMA-related kinase 7 | 0.0281539 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0280373 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0278845 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0277823 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0277289 |
| NFIB | nuclear factor I/B | 0.027548 |
| MEF2C | myocyte enhancer factor 2C | 0.0272396 |
| TLK2 | tousled-like kinase 2 | 0.0269977 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0269421 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0266645 |
| USP53 | ubiquitin specific peptidase 53 | 0.0265896 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0264344 |
| SLK | STE20-like kinase | 0.0264176 |
| MDFIC | MyoD family inhibitor domain containing | 0.0263942 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0256225 |
| PREPL | prolyl endopeptidase-like | 0.0256115 |
| NEBL | nebulette | 0.0254111 |
| TPM3 | tropomyosin 3 | 0.0253366 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0253172 |
| GPC4 | glypican 4 | 0.0252717 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0250671 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0250077 |
| SET | SET nuclear proto-oncogene | 0.0249922 |
| FAT1 | FAT atypical cadherin 1 | 0.0249686 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0249005 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0248886 |
| TJP1 | tight junction protein 1 | 0.0248098 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0243679 |
| UTRN | utrophin | 0.0243213 |
| FOXJ3 | forkhead box J3 | 0.0241123 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0237348 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.210268 |
| PTMA | prothymosin, alpha | -0.157331 |
| VIM | vimentin | -0.100016 |
| AHNAK | AHNAK nucleoprotein | -0.0927848 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.086141 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.084059 |
| TMSB10 | thymosin beta 10 | -0.0775679 |
| RPL19 | ribosomal protein L19 | -0.072425 |
| RPS16 | ribosomal protein S16 | -0.065291 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0644095 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0619044 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0548561 |
| H1-0 | H1.0 linker histone | -0.0499182 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0496556 |
| CADM2 | cell adhesion molecule 2 | -0.0482908 |
| HMGB1 | high mobility group box 1 | -0.0479602 |
| NOP58 | NOP58 ribonucleoprotein | -0.0477489 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0464541 |
| MAP4 | microtubule-associated protein 4 | -0.0443592 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0434708 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.042907 |
| SETD5 | SET domain containing 5 | -0.0423605 |
| RPL34 | ribosomal protein L34 | -0.0420812 |
| RPS6 | ribosomal protein S6 | -0.0420012 |
| TMSB4X | thymosin beta 4, X-linked | -0.0408472 |
| RPS21 | ribosomal protein S21 | -0.0401131 |
| RPL35A | ribosomal protein L35a | -0.0389892 |
| FTL | ferritin, light polypeptide | -0.0383962 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.037572 |
| RPL31 | ribosomal protein L31 | -0.0373621 |
| EMP1 | epithelial membrane protein 1 | -0.0352991 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0330344 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0321868 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0320918 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0320734 |
| RPS8 | ribosomal protein S8 | -0.0319133 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0314323 |
| DEK | DEK proto-oncogene | -0.0313045 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0306605 |
| BRDT | bromodomain, testis-specific | -0.030445 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0298534 |
| GNAS | GNAS complex locus | -0.0287291 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0284402 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0275338 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0274935 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0274714 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0272565 |
| EAPP | E2F-associated phosphoprotein | -0.0270859 |
| RPS24 | ribosomal protein S24 | -0.0269843 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0268126 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0266747 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0263779 |
| RPS25 | ribosomal protein S25 | -0.0263466 |
| RSF1 | remodeling and spacing factor 1 | -0.0263338 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0261326 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.026132 |
| RPL18 | ribosomal protein L18 | -0.0260687 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0258343 |
| RPS27A | ribosomal protein S27a | -0.0256702 |
| BBX | bobby sox homolog (Drosophila) | -0.0256645 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0253772 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0252469 |
| KIAA1958 | KIAA1958 | -0.0252215 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0251049 |
| CANX | calnexin | -0.0250464 |
| RPL36A | ribosomal protein L36a | -0.0250111 |
| PRR11 | proline rich 11 | -0.0248689 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0247984 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0245816 |
| ZNF385D | zinc finger protein 385D | -0.0245528 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0245001 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0244703 |
| HDLBP | high density lipoprotein binding protein | -0.0242274 |
| ZNF609 | zinc finger protein 609 | -0.0241878 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0241419 |
| RPLP2 | ribosomal protein, large, P2 | -0.0239497 |
| GPATCH8 | G patch domain containing 8 | -0.0239371 |
| ASTN2 | astrotactin 2 | -0.0238232 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0236776 |
| B2M | beta-2-microglobulin | -0.0235916 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0234446 |
| DPPA4 | developmental pluripotency associated 4 | -0.0232777 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0232703 |
| SCFD1 | sec1 family domain containing 1 | -0.023267 |
| RPL12 | ribosomal protein L12 | -0.0229884 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.022886 |
| RHOA | ras homolog family member A | -0.0227718 |
| INTS6 | integrator complex subunit 6 | -0.0227714 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0226304 |
| RPS11 | ribosomal protein S11 | -0.0223063 |
| TPM4 | tropomyosin 4 | -0.0222571 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0222311 |
| NDRG1 | N-myc downstream regulated 1 | -0.0222268 |
| THRAP3 | thyroid hormone receptor associated protein 3 | -0.0221182 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0220871 |
| SGO2 | shugoshin 2 | -0.0220369 |
| RPL11 | ribosomal protein L11 | -0.0220211 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0219289 |
| S100A10 | S100 calcium binding protein A10 | -0.0219219 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0218834 |
