Pexidartinib (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0894341
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0837382
SMAD3 SMAD family member 3 0.0755462
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.075496
CD44 CD44 molecule (Indian blood group) 0.0716647
JMJD1C jumonji domain containing 1C 0.0715041
SEPTIN9 septin 9 0.0648649
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0600746
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0594393
PRELID2 PRELI domain containing 2 0.0576087
WWTR1 WW domain containing transcription regulator 1 0.0575362
KTN1 kinectin 1 (kinesin receptor) 0.0566058
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.056073
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0554008
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0552892
MYH9 myosin, heavy chain 9, non-muscle 0.0548817
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0538648
TXNRD1 thioredoxin reductase 1 0.0529262
EEF2 eukaryotic translation elongation factor 2 0.051333
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0480594
RPS2 ribosomal protein S2 0.0479372
ICAM1 intercellular adhesion molecule 1 0.0476834
ZNF292 zinc finger protein 292 0.0471341
ARRDC3 arrestin domain containing 3 0.0465832
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0462139
APLP2 amyloid beta (A4) precursor-like protein 2 0.0461781
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0460733
FOSL1 FOS-like antigen 1 0.0456932
DST dystonin 0.0451233
SMYD3 SET and MYND domain containing 3 0.0448219
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0447614
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0446638
RPS12 ribosomal protein S12 0.0443971
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0440782
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0438216
ASPH aspartate beta-hydroxylase 0.0427851
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0427415
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0424781
EFNA5 ephrin-A5 0.0424098
PDE10A phosphodiesterase 10A 0.042371
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0416868
PCBP2 poly(rC) binding protein 2 0.0413494
SET SET nuclear proto-oncogene 0.0412486
MYOF myoferlin 0.0403882
ERRFI1 ERBB receptor feedback inhibitor 1 0.0403367
CSNK1A1 casein kinase 1, alpha 1 0.0398884
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0393878
TRIO trio Rho guanine nucleotide exchange factor 0.0386758
NFE2L1 nuclear factor, erythroid 2-like 1 0.0386425
SFTPA2 surfactant protein A2 0.0373045
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0372986
ANXA2 annexin A2 0.0370736
ACTN4 actinin, alpha 4 0.0370311
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0367584
CENPF centromere protein F, 350/400kDa 0.0366364
SRRM2 serine/arginine repetitive matrix 2 0.0361811
NCOR2 nuclear receptor corepressor 2 0.036069
RTN4 reticulon 4 0.0351157
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0343693
WNK1 WNK lysine deficient protein kinase 1 0.033547
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0334971
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0333955
MED13L mediator complex subunit 13-like 0.0330691
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.03292
ZFP36 ZFP36 ring finger protein 0.0327666
LDHA lactate dehydrogenase A 0.0326519
SDK1 sidekick cell adhesion molecule 1 0.0324807
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0319713
FLNA filamin A, alpha 0.0313592
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.031171
VMP1 vacuole membrane protein 1 0.0311345
SPTBN1 spectrin, beta, non-erythrocytic 1 0.031052
ADGRG6 adhesion G protein-coupled receptor G6 0.0310492
FAT1 FAT atypical cadherin 1 0.0309628
ATXN1 ataxin 1 0.03052
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0300936
MBNL1 muscleblind-like splicing regulator 1 0.029948
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0296999
IPO7 importin 7 0.0295715
ACTG1 actin gamma 1 0.0294964
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0294816
YAP1 Yes-associated protein 1 0.0294281
ITGAV integrin, alpha V 0.0293866
HPCAL1 hippocalcin-like 1 0.0291144
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0288904
L1CAM L1 cell adhesion molecule 0.0287897
DGKD diacylglycerol kinase, delta 130kDa 0.0287586
CARD18 caspase recruitment domain family, member 18 0.0286606
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.028582
EPAS1 endothelial PAS domain protein 1 0.0283024
MKI67 marker of proliferation Ki-67 0.0280964
ANGPTL4 angiopoietin-like 4 0.0278946
PXDN peroxidasin 0.0277552
SEPTIN7 septin 7 0.0275468
PNISR PNN-interacting serine/arginine-rich protein 0.0274833
KMT2E lysine (K)-specific methyltransferase 2E 0.0274361
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0270927
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0270219
RACK1 receptor for activated C kinase 1 0.0269292
SLC38A2 solute carrier family 38, member 2 0.026929

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.280004
AHNAK AHNAK nucleoprotein -0.185602
PTMA prothymosin, alpha -0.171575
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126846
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111287
RPS16 ribosomal protein S16 -0.108964
TMSB10 thymosin beta 10 -0.0958311
FBL fibrillarin -0.0781773
TM4SF1 transmembrane 4 L six family member 1 -0.0675209
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0653685
VIM vimentin -0.051134
H1-0 H1.0 linker histone -0.0465638
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0431717
CANX calnexin -0.0410801
RPS24 ribosomal protein S24 -0.0391825
RPLP0 ribosomal protein, large, P0 -0.0375746
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0354963
SLC35F3 solute carrier family 35, member F3 -0.0343553
S100A6 S100 calcium binding protein A6 -0.0331025
VCL vinculin -0.0328988
CTSD cathepsin D -0.0328176
HMGA2 high mobility group AT-hook 2 -0.031744
HDLBP high density lipoprotein binding protein -0.0313199
RSL1D1 ribosomal L1 domain containing 1 -0.0309662
TPT1 tumor protein, translationally-controlled 1 -0.0309587
ATG7 autophagy related 7 -0.0299149
RPS21 ribosomal protein S21 -0.0290148
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.028024
CAVIN1 caveolae associated protein 1 -0.025245
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0250364
PDIA4 protein disulfide isomerase family A, member 4 -0.0243276
FTL ferritin, light polypeptide -0.0242497
LMNA lamin A/C -0.0233121
RPLP2 ribosomal protein, large, P2 -0.0228067
THSD4 thrombospondin, type I, domain containing 4 -0.0216419
EXT1 exostosin glycosyltransferase 1 -0.0216011
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0213237
ATP5F1B ATP synthase F1 subunit beta -0.0209873
CTTN cortactin -0.0208968
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0207465
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0201795
ASTN2 astrotactin 2 -0.0194182
RPL8 ribosomal protein L8 -0.0193632
CARS1 cysteinyl-tRNA synthetase 1 -0.0192779
MYL12B myosin, light chain 12B, regulatory -0.0191086
TPM1 tropomyosin 1 (alpha) -0.0188924
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0185887
PRSS23 protease, serine, 23 -0.0185492
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0185488
WASF2 WAS protein family, member 2 -0.0184183
RPL36A ribosomal protein L36a -0.0183108
MDK midkine (neurite growth-promoting factor 2) -0.0177206
ZMYND8 zinc finger, MYND-type containing 8 -0.0172777
ZNF546 zinc finger protein 546 -0.0170183
PTPRF protein tyrosine phosphatase, receptor type, F -0.0169516
RPL27A ribosomal protein L27a -0.0168647
DEK DEK proto-oncogene -0.0167044
SERF2 small EDRK-rich factor 2 -0.0165136
UBC ubiquitin C -0.0164554
HMGB1 high mobility group box 1 -0.0163007
RPL32 ribosomal protein L32 -0.0162176
MAP1B microtubule-associated protein 1B -0.0161098
CSTB cystatin B (stefin B) -0.0160586
FBXO27 F-box protein 27 -0.0158047
RPS5 ribosomal protein S5 -0.0157956
TMEM123 transmembrane protein 123 -0.0156488
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0155296
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0155134
GOSR1 golgi SNAP receptor complex member 1 -0.0152949
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0150321
SOD2 superoxide dismutase 2, mitochondrial -0.0149004
MAP4 microtubule-associated protein 4 -0.0147868
FRMD5 FERM domain containing 5 -0.0147077
RAB7A RAB7A, member RAS oncogene family -0.0144354
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0143549
EHBP1 EH domain binding protein 1 -0.0142649
S100A9 S100 calcium binding protein A9 -0.0142297
IER3 immediate early response 3 -0.0139554
RPS25 ribosomal protein S25 -0.0134091
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.01335
PRR13 proline rich 13 -0.0132613
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) -0.0130665
RPL12 ribosomal protein L12 -0.0129289
KPNB1 karyopherin (importin) beta 1 -0.0128421
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0128316
MUSK muscle, skeletal, receptor tyrosine kinase -0.0127742
RPL34 ribosomal protein L34 -0.0127383
RHEB Ras homolog enriched in brain -0.0126379
GOLGA4 golgin A4 -0.0126102
CD2AP CD2-associated protein -0.0124612
UBE2I ubiquitin-conjugating enzyme E2I -0.0124359
REEP3 receptor accessory protein 3 -0.0124216
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -0.012321
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0123126
PLIN2 perilipin 2 -0.0122893
ZNF407 zinc finger protein 407 -0.0122632
RSU1 Ras suppressor protein 1 -0.0122381
BMAL2 basic helix-loop-helix ARNT like 2 -0.0122157
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.0121856
RPS13 ribosomal protein S13 -0.0121181