| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0893793 |
| MUC16 | mucin 16, cell surface associated | 0.0584338 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0512606 |
| HMGA1 | high mobility group AT-hook 1 | 0.0466155 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0409524 |
| LAMB3 | laminin, beta 3 | 0.0408333 |
| PLAU | plasminogen activator, urokinase | 0.0397665 |
| TGM2 | transglutaminase 2 | 0.0375407 |
| RUNX1 | runt-related transcription factor 1 | 0.0371596 |
| FOSL1 | FOS-like antigen 1 | 0.0360266 |
| NDRG1 | N-myc downstream regulated 1 | 0.0328253 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0326626 |
| MYO6 | myosin VI | 0.0321648 |
| NAV2 | neuron navigator 2 | 0.0317079 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0315459 |
| MUC4 | mucin 4, cell surface associated | 0.0265791 |
| C3 | complement component 3 | 0.0265144 |
| CLDN4 | claudin 4 | 0.0265091 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.025737 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0254327 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.0244681 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0239836 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0238204 |
| ARRDC3 | arrestin domain containing 3 | 0.0231378 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0230232 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0229629 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0225298 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0222057 |
| ECT2 | epithelial cell transforming 2 | 0.0221571 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0218278 |
| CDC27 | cell division cycle 27 | 0.0209165 |
| JUP | junction plakoglobin | 0.0209043 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0202982 |
| RACK1 | receptor for activated C kinase 1 | 0.020118 |
| ITGB4 | integrin, beta 4 | 0.0200599 |
| NFIB | nuclear factor I/B | 0.0199554 |
| LDHA | lactate dehydrogenase A | 0.0197941 |
| KLF10 | Kruppel-like factor 10 | 0.0191406 |
| MTCH1 | mitochondrial carrier 1 | 0.018139 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 0.0175929 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0173878 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0172026 |
| PCDH1 | protocadherin 1 | 0.0167133 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0166696 |
| PFN1 | profilin 1 | 0.0163845 |
| RPS12 | ribosomal protein S12 | 0.0162763 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0159584 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0159553 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0158206 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0157946 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0156734 |
| CCNL1 | cyclin L1 | 0.0155511 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 0.0155158 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.0153635 |
| KLF6 | Kruppel-like factor 6 | 0.015362 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0153501 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0150601 |
| FLNA | filamin A, alpha | 0.0148607 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0145535 |
| CALR | calreticulin | 0.0143818 |
| RPN1 | ribophorin I | 0.0142942 |
| PCBP2 | poly(rC) binding protein 2 | 0.0141805 |
| NUP58 | nucleoporin 58 | 0.0141588 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0139114 |
| LSR | lipolysis stimulated lipoprotein receptor | 0.0138917 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 | 0.0138797 |
| SRP54 | signal recognition particle 54kDa | 0.0137223 |
| TBC1D5 | TBC1 domain family, member 5 | 0.013698 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0136131 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.013422 |
| PCBP1 | poly(rC) binding protein 1 | 0.0133115 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.013173 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0130172 |
| PATL1 | protein associated with topoisomerase II homolog 1 (yeast) | 0.0129309 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0126792 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0126475 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0123901 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0123774 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0122993 |
| MYOF | myoferlin | 0.0122886 |
| SLTM | SAFB-like, transcription modulator | 0.0121516 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0121162 |
| LONP1 | lon peptidase 1, mitochondrial | 0.0120836 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0120278 |
| RBM26 | RNA binding motif protein 26 | 0.0119919 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0117664 |
| LAMA5 | laminin, alpha 5 | 0.0116534 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0114367 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0114269 |
| SMC4 | structural maintenance of chromosomes 4 | 0.011319 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0111844 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0109592 |
| PLXNB2 | plexin B2 | 0.010959 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0109252 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0109119 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.0109106 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0108043 |
| GRN | granulin | 0.0107424 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.0106035 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0105385 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.24963 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.199509 |
| RPS6 | ribosomal protein S6 | -0.123502 |
| PTMA | prothymosin, alpha | -0.121079 |
| AHNAK | AHNAK nucleoprotein | -0.113879 |
| TMSB4X | thymosin beta 4, X-linked | -0.0981388 |
| LMO7 | LIM domain 7 | -0.0973042 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0939408 |
| DSG2 | desmoglein 2 | -0.0920481 |
| CANX | calnexin | -0.085635 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0749726 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0666277 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0656326 |
| GOLGB1 | golgin B1 | -0.065167 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0607695 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0601231 |
| RPS13 | ribosomal protein S13 | -0.0601192 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0586486 |
| SQSTM1 | sequestosome 1 | -0.057764 |
| TPM4 | tropomyosin 4 | -0.0567175 |
| ACTG1 | actin gamma 1 | -0.0567075 |
| RPS15 | ribosomal protein S15 | -0.0560032 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0550982 |
| RPL19 | ribosomal protein L19 | -0.0545553 |
| FN1 | fibronectin 1 | -0.0539147 |
| RPS21 | ribosomal protein S21 | -0.0532695 |
| PLSCR1 | phospholipid scramblase 1 | -0.0514264 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0501846 |
| VCL | vinculin | -0.0495335 |
| RPS8 | ribosomal protein S8 | -0.0472742 |
| RPS24 | ribosomal protein S24 | -0.0467639 |
| RPL8 | ribosomal protein L8 | -0.0463677 |
| INTS6 | integrator complex subunit 6 | -0.0460282 |
| CD2AP | CD2-associated protein | -0.0454554 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0447644 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0444942 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0437973 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0432677 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0425165 |
| RPS27A | ribosomal protein S27a | -0.0424502 |
| RPS23 | ribosomal protein S23 | -0.0414196 |
| MYO1E | myosin IE | -0.0414026 |
| H1-0 | H1.0 linker histone | -0.0411361 |
| RPL38 | ribosomal protein L38 | -0.0404834 |
| PATJ | PATJ crumbs cell polarity complex component | -0.040483 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0403384 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0401739 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0400175 |
| TJP1 | tight junction protein 1 | -0.0399935 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0394522 |
| UBC | ubiquitin C | -0.0394251 |
| KRT18 | keratin 18, type I | -0.0393548 |
| MX2 | MX dynamin-like GTPase 2 | -0.0392013 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.039178 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0385683 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0384879 |
| RPS25 | ribosomal protein S25 | -0.0378975 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.036765 |
| EMP1 | epithelial membrane protein 1 | -0.0361397 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0352997 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0352183 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0350807 |
| SVIL | supervillin | -0.0349347 |
| SP100 | SP100 nuclear antigen | -0.0345015 |
| LAMA4 | laminin, alpha 4 | -0.0344274 |
| RPL32 | ribosomal protein L32 | -0.034293 |
| SYT14 | synaptotagmin XIV | -0.0339355 |
| HLA-B | major histocompatibility complex, class I, B | -0.0338868 |
| MX1 | MX dynamin-like GTPase 1 | -0.0338326 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0337168 |
| TAOK1 | TAO kinase 1 | -0.0337096 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0336593 |
| S100A10 | S100 calcium binding protein A10 | -0.0336047 |
| RPL12 | ribosomal protein L12 | -0.0335852 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0333776 |
| RPS5 | ribosomal protein S5 | -0.0332848 |
| RPL34 | ribosomal protein L34 | -0.0328571 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0328443 |
| RPL36A | ribosomal protein L36a | -0.0327414 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0324872 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.031961 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0317251 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.031675 |
| B2M | beta-2-microglobulin | -0.0316268 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0316095 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0314915 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0312905 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0310225 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0304832 |
| RPS29 | ribosomal protein S29 | -0.030441 |
| CTTN | cortactin | -0.0303719 |
| H3-3B | H3.3 histone B | -0.030033 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0299792 |
| RPL28 | ribosomal protein L28 | -0.0297691 |
| RPS10 | ribosomal protein S10 | -0.0296136 |
| RPLP2 | ribosomal protein, large, P2 | -0.0295798 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0295414 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0293889 |
| RPL31 | ribosomal protein L31 | -0.0290017 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0288804 |
