| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.133286 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.106795 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.103142 |
| SET | SET nuclear proto-oncogene | 0.0850889 |
| NAV3 | neuron navigator 3 | 0.0798421 |
| HDAC9 | histone deacetylase 9 | 0.0684125 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0682083 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0642024 |
| RPS2 | ribosomal protein S2 | 0.0582696 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0580127 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.057832 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0578296 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0562859 |
| RPS12 | ribosomal protein S12 | 0.0539728 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0534187 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0527385 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0527265 |
| NUP58 | nucleoporin 58 | 0.0525442 |
| CALD1 | caldesmon 1 | 0.0485375 |
| HMGA1 | high mobility group AT-hook 1 | 0.0455349 |
| STC1 | stanniocalcin 1 | 0.043954 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.042416 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.041328 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0413117 |
| LAMB3 | laminin, beta 3 | 0.0412258 |
| WDR43 | WD repeat domain 43 | 0.0400176 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0363087 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0341023 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0336052 |
| ZNF438 | zinc finger protein 438 | 0.0332785 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0331285 |
| RBM26 | RNA binding motif protein 26 | 0.0329992 |
| ACTG1 | actin gamma 1 | 0.0329332 |
| NCKAP1 | NCK-associated protein 1 | 0.0324105 |
| NF1 | neurofibromin 1 | 0.0309195 |
| CLTC | clathrin, heavy chain (Hc) | 0.0308955 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0307459 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0303334 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0301032 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0296769 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0294605 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0292107 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0285232 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0282686 |
| TMF1 | TATA element modulatory factor 1 | 0.0282578 |
| DGKI | diacylglycerol kinase, iota | 0.0280292 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0270619 |
| FAM120A | family with sequence similarity 120A | 0.0268653 |
| ANK2 | ankyrin 2, neuronal | 0.0266788 |
| PFN1 | profilin 1 | 0.0265883 |
| LDHA | lactate dehydrogenase A | 0.0265728 |
| DIAPH3 | diaphanous-related formin 3 | 0.0260369 |
| POTEF | POTE ankyrin domain family, member F | 0.0256829 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0253769 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.025216 |
| JMJD1C | jumonji domain containing 1C | 0.0251131 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0250548 |
| RBM25 | RNA binding motif protein 25 | 0.0250007 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.024808 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0245938 |
| EXOC4 | exocyst complex component 4 | 0.0245877 |
| RACK1 | receptor for activated C kinase 1 | 0.0241753 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0240687 |
| NUDCD1 | NudC domain containing 1 | 0.0240403 |
| RPS3 | ribosomal protein S3 | 0.0240315 |
| TTR | transthyretin | 0.0239984 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0235269 |
| RPL37A | ribosomal protein L37a | 0.023526 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0234681 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0233186 |
| ATP13A3 | ATPase type 13A3 | 0.0231478 |
| FLNB | filamin B, beta | 0.0228326 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0227784 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0227671 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.022764 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0226185 |
| ZNF292 | zinc finger protein 292 | 0.0225352 |
| YEATS2 | YEATS domain containing 2 | 0.0222975 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0219745 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.0218887 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0218073 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0216597 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0214757 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0213788 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0213161 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0212919 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0211356 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0210917 |
| BNC2 | basonuclin 2 | 0.0209801 |
| TCF12 | transcription factor 12 | 0.0209209 |
| FRMD6 | FERM domain containing 6 | 0.0207061 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | 0.0205304 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.020366 |
| PCBP2 | poly(rC) binding protein 2 | 0.0203354 |
| ZNF451 | zinc finger protein 451 | 0.0199049 |
| FHIT | fragile histidine triad | 0.0196777 |
| CDC27 | cell division cycle 27 | 0.0196751 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0195893 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0195484 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0195232 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.155808 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114203 |
| RPL8 | ribosomal protein L8 | -0.0827215 |
| RPS6 | ribosomal protein S6 | -0.0786755 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.072494 |
| RPLP1 | ribosomal protein, large, P1 | -0.0553395 |
| RPS21 | ribosomal protein S21 | -0.054533 |
| RPLP2 | ribosomal protein, large, P2 | -0.0530962 |
| AHNAK | AHNAK nucleoprotein | -0.0479501 |
| RPL35A | ribosomal protein L35a | -0.0469136 |
| RPL12 | ribosomal protein L12 | -0.0459469 |
| MT2A | metallothionein 2A | -0.0438181 |
| PTMA | prothymosin, alpha | -0.0412891 |
| RPL32 | ribosomal protein L32 | -0.0390729 |
| RPS24 | ribosomal protein S24 | -0.0386519 |
| TMSB10 | thymosin beta 10 | -0.0381745 |
| RPS29 | ribosomal protein S29 | -0.0369782 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0365835 |
| RPL38 | ribosomal protein L38 | -0.0344907 |
| RPL7A | ribosomal protein L7a | -0.0343894 |
| RPS15 | ribosomal protein S15 | -0.0332689 |
| RPL34 | ribosomal protein L34 | -0.0326065 |
| RPL35 | ribosomal protein L35 | -0.0313335 |
| RPS13 | ribosomal protein S13 | -0.0309038 |
| RPL36 | ribosomal protein L36 | -0.030686 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0296844 |
| RPL23 | ribosomal protein L23 | -0.02776 |
| RPS16 | ribosomal protein S16 | -0.0275909 |
| RPL31 | ribosomal protein L31 | -0.0269175 |
| RPL19 | ribosomal protein L19 | -0.0268849 |
| RPLP0 | ribosomal protein, large, P0 | -0.0268255 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0264812 |
| RPS5 | ribosomal protein S5 | -0.0253222 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0252592 |
| RPS23 | ribosomal protein S23 | -0.0251335 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0246402 |
| RPS11 | ribosomal protein S11 | -0.0244384 |
| RPS27A | ribosomal protein S27a | -0.0242667 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0239812 |
| RPS25 | ribosomal protein S25 | -0.0238436 |
| RRBP1 | ribosome binding protein 1 | -0.0237906 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0220695 |
| S100A9 | S100 calcium binding protein A9 | -0.0219552 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0216974 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0215006 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0210097 |
| RPS19 | ribosomal protein S19 | -0.0209555 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0205053 |
| RPS10 | ribosomal protein S10 | -0.0204797 |
| HDLBP | high density lipoprotein binding protein | -0.0203278 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0199221 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0199024 |
| RPL14 | ribosomal protein L14 | -0.0197828 |
| RPL28 | ribosomal protein L28 | -0.0197546 |
| G0S2 | G0/G1 switch 2 | -0.0194758 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0194502 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0191814 |
| SGMS2 | sphingomyelin synthase 2 | -0.0188974 |
| RPL36A | ribosomal protein L36a | -0.018344 |
| CAVIN1 | caveolae associated protein 1 | -0.018207 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0180907 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0180496 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.0178934 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0176222 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0172998 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0172951 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0172178 |
| CCNI | cyclin I | -0.0170663 |
| JUN | jun proto-oncogene | -0.0166059 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0164914 |
| RPL36AL | ribosomal protein L36a-like | -0.016473 |
| UPP1 | uridine phosphorylase 1 | -0.0162246 |
| S100A10 | S100 calcium binding protein A10 | -0.016146 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0160044 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0159739 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0157799 |
| EGR1 | early growth response 1 | -0.0155407 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0152207 |
| UBC | ubiquitin C | -0.0150655 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0150011 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0148159 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0146539 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0146354 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.014474 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0141624 |
| RHEB | Ras homolog enriched in brain | -0.0141225 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0140708 |
| MT1X | metallothionein 1X | -0.0137576 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0136131 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0134105 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0133575 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0133557 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.0132441 |
| RECQL | RecQ helicase-like | -0.0130998 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0130181 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | -0.0129796 |
| FUS | FUS RNA binding protein | -0.0129785 |
| TXNRD1 | thioredoxin reductase 1 | -0.0128321 |
| RPL13A | ribosomal protein L13a | -0.0128067 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0126076 |
