| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pexidartinib (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.405308 |
| FN1 | fibronectin 1 | 0.261464 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.206934 |
| PGK1 | phosphoglycerate kinase 1 | 0.140551 |
| NDRG1 | N-myc downstream regulated 1 | 0.138151 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0995025 |
| LDHA | lactate dehydrogenase A | 0.0897308 |
| B2M | beta-2-microglobulin | 0.0891969 |
| CD44 | CD44 molecule (Indian blood group) | 0.0864233 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0808696 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0791452 |
| COL1A2 | collagen, type I, alpha 2 | 0.070698 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0655206 |
| ZNF292 | zinc finger protein 292 | 0.0631915 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0586126 |
| ENO1 | enolase 1, (alpha) | 0.0554102 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0550334 |
| CALR | calreticulin | 0.0530354 |
| HLA-B | major histocompatibility complex, class I, B | 0.0527864 |
| TGM2 | transglutaminase 2 | 0.0514419 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.051257 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0511522 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0499183 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0474978 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0469257 |
| YEATS2 | YEATS domain containing 2 | 0.0468361 |
| ANXA2 | annexin A2 | 0.0466724 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0460298 |
| MEF2A | myocyte enhancer factor 2A | 0.0455053 |
| FAM13A | family with sequence similarity 13, member A | 0.0451931 |
| GOLGA4 | golgin A4 | 0.0446492 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0436346 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0425572 |
| CD109 | CD109 molecule | 0.0421387 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0418722 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.040529 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0402842 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0398384 |
| FLNB | filamin B, beta | 0.0392686 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0387452 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0386356 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0378188 |
| CENPF | centromere protein F, 350/400kDa | 0.0372971 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0364343 |
| ATP13A3 | ATPase type 13A3 | 0.0355528 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0352823 |
| NAV2 | neuron navigator 2 | 0.035276 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0351042 |
| HELZ | helicase with zinc finger | 0.0349763 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0347832 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0344376 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0343734 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0341732 |
| RTN4 | reticulon 4 | 0.0341728 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0337003 |
| POTEF | POTE ankyrin domain family, member F | 0.0335884 |
| STC1 | stanniocalcin 1 | 0.0335145 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0331089 |
| MYO1B | myosin IB | 0.0330213 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0326934 |
| LOX | lysyl oxidase | 0.0325372 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0321961 |
| FTL | ferritin, light polypeptide | 0.0320635 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0319902 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0319714 |
| MMP2 | matrix metallopeptidase 2 | 0.0319531 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0312624 |
| RBM39 | RNA binding motif protein 39 | 0.0311518 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0309811 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0305353 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0304623 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0303432 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0300865 |
| INHBA | inhibin, beta A | 0.0298711 |
| COPA | coatomer protein complex, subunit alpha | 0.0296751 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0294052 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0290549 |
| NUP58 | nucleoporin 58 | 0.0287629 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0285027 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0279326 |
| HM13 | histocompatibility (minor) 13 | 0.0278944 |
| RAB6A | RAB6A, member RAS oncogene family | 0.027796 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.027756 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0276339 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.027442 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0273303 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0272337 |
| CDC73 | cell division cycle 73 | 0.027012 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0269391 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0267257 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.0265361 |
| ANLN | anillin, actin binding protein | 0.0265083 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0264317 |
| CALU | calumenin | 0.0264311 |
| MKI67 | marker of proliferation Ki-67 | 0.0263659 |
| SET | SET nuclear proto-oncogene | 0.0262318 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.026113 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0260233 |
| ZNF148 | zinc finger protein 148 | 0.0256288 |
| NCKAP1 | NCK-associated protein 1 | 0.0256061 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.143019 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0645715 |
| CDH13 | cadherin 13 | -0.0443915 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0378581 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0357661 |
| AHNAK | AHNAK nucleoprotein | -0.0347461 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.032703 |
| SP100 | SP100 nuclear antigen | -0.0273414 |
| GLIS3 | GLIS family zinc finger 3 | -0.026713 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0253777 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0246266 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0226831 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0216422 |
| RPS21 | ribosomal protein S21 | -0.0209712 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0207824 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0203056 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0199652 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0195886 |
| TMSB10 | thymosin beta 10 | -0.0189156 |
| MT1X | metallothionein 1X | -0.0188831 |
| IER3 | immediate early response 3 | -0.0188203 |
| CCND1 | cyclin D1 | -0.0187126 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0186001 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0183282 |
| RPLP2 | ribosomal protein, large, P2 | -0.0176348 |
| HDAC9 | histone deacetylase 9 | -0.0174014 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0173063 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0172621 |
| PLSCR1 | phospholipid scramblase 1 | -0.0172033 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0169643 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0169383 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0165091 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0164123 |
| SLC38A2 | solute carrier family 38, member 2 | -0.016143 |
| TENM4 | teneurin transmembrane protein 4 | -0.0158523 |
| FAM20C | family with sequence similarity 20, member C | -0.0155943 |
| IL1B | interleukin 1, beta | -0.0151163 |
| IPO9 | importin 9 | -0.015009 |
| HDLBP | high density lipoprotein binding protein | -0.0147768 |
| AEBP2 | AE binding protein 2 | -0.014654 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0146212 |
| PARD3 | par-3 family cell polarity regulator | -0.0145841 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0145352 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0145317 |
| NABP1 | nucleic acid binding protein 1 | -0.014522 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0144829 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0143424 |
| RBM6 | RNA binding motif protein 6 | -0.0141737 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0140761 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0139411 |
| OXR1 | oxidation resistance 1 | -0.0138522 |
| RPS15 | ribosomal protein S15 | -0.013803 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.013794 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0136644 |
| DOCK10 | dedicator of cytokinesis 10 | -0.013649 |
| RPS19 | ribosomal protein S19 | -0.0131849 |
| POU2F2 | POU class 2 homeobox 2 | -0.0130492 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0130263 |
| RCC1 | regulator of chromosome condensation 1 | -0.0130235 |
| INTS6 | integrator complex subunit 6 | -0.0129073 |
| VCL | vinculin | -0.0128053 |
| MCL1 | myeloid cell leukemia 1 | -0.0127888 |
| COL5A1 | collagen, type V, alpha 1 | -0.0127425 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | -0.0127063 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0124162 |
| DPYD | dihydropyrimidine dehydrogenase | -0.012364 |
| CCDC138 | coiled-coil domain containing 138 | -0.012262 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0122226 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0122154 |
| RIGI | RNA sensor RIG-I | -0.0120797 |
| IRF1 | interferon regulatory factor 1 | -0.0119613 |
| COL1A1 | collagen, type I, alpha 1 | -0.011929 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0118477 |
| NKTR | natural killer cell triggering receptor | -0.0117284 |
| RND3 | Rho family GTPase 3 | -0.0114401 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0114293 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0113321 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.011315 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0112149 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0111807 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0109692 |
| CDK6 | cyclin-dependent kinase 6 | -0.0109689 |
| TMEM230 | transmembrane protein 230 | -0.0109012 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0108583 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0108282 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0107688 |
| TET3 | tet methylcytosine dioxygenase 3 | -0.010729 |
| OAZ1 | ornithine decarboxylase antizyme 1 | -0.0106583 |
| CST3 | cystatin C | -0.0106404 |
| FHIT | fragile histidine triad | -0.0105701 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0105551 |
| RPL28 | ribosomal protein L28 | -0.0105278 |
| EEA1 | early endosome antigen 1 | -0.010453 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0104253 |
| HMGB1 | high mobility group box 1 | -0.0104142 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0104022 |
| SDC4 | syndecan 4 | -0.0103794 |
| ATP9A | ATPase, class II, type 9A | -0.0103135 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.0103112 |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | -0.010291 |
