| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.323546 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.161679 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.135938 |
| PEG10 | paternally expressed 10 | 0.126822 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.104728 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0915199 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0753138 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0731002 |
| NCKAP5 | NCK-associated protein 5 | 0.0628984 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0619784 |
| CENPF | centromere protein F, 350/400kDa | 0.0577156 |
| WWOX | WW domain containing oxidoreductase | 0.0561724 |
| RAD51B | RAD51 paralog B | 0.0560417 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0550805 |
| ESRRG | estrogen-related receptor gamma | 0.0539767 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0523376 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0516767 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0506462 |
| TENM1 | teneurin transmembrane protein 1 | 0.0505095 |
| SNTG1 | syntrophin, gamma 1 | 0.0504937 |
| NDRG1 | N-myc downstream regulated 1 | 0.0495152 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0490311 |
| CNTNAP2 | contactin associated protein-like 2 | 0.0488976 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0488187 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.048703 |
| SMYD3 | SET and MYND domain containing 3 | 0.0468402 |
| LSAMP | limbic system-associated membrane protein | 0.0446101 |
| RNF213 | ring finger protein 213 | 0.0435155 |
| NAV1 | neuron navigator 1 | 0.0431854 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | 0.0429449 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.04092 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0398146 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0397732 |
| EPHA6 | EPH receptor A6 | 0.0394733 |
| ASPH | aspartate beta-hydroxylase | 0.0389945 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0382824 |
| ADAR | adenosine deaminase, RNA-specific | 0.0372377 |
| NRG1 | neuregulin 1 | 0.0370838 |
| SMAD9 | SMAD family member 9 | 0.0368423 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0366337 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0359183 |
| TOX | thymocyte selection-associated high mobility group box | 0.034665 |
| RORA | RAR-related orphan receptor A | 0.0341011 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.0336164 |
| FHIT | fragile histidine triad | 0.0335311 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | 0.0332382 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0328035 |
| ZNF407 | zinc finger protein 407 | 0.0325805 |
| AGBL4 | ATP/GTP binding protein-like 4 | 0.0325011 |
| SET | SET nuclear proto-oncogene | 0.0322738 |
| RIT2 | Ras-like without CAAX 2 | 0.0321643 |
| EPHA3 | EPH receptor A3 | 0.032003 |
| DTNA | dystrobrevin, alpha | 0.0317792 |
| HMGB3 | high mobility group box 3 | 0.0317155 |
| NFIB | nuclear factor I/B | 0.0314158 |
| GPC6 | glypican 6 | 0.0303479 |
| FAT1 | FAT atypical cadherin 1 | 0.0301323 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0298958 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0294912 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0294746 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0291975 |
| NRXN1 | neurexin 1 | 0.0290637 |
| ENO1 | enolase 1, (alpha) | 0.0288313 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0287674 |
| NLGN1 | neuroligin 1 | 0.0285162 |
| FAM13A | family with sequence similarity 13, member A | 0.0281173 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0280405 |
| MACROD2 | MACRO domain containing 2 | 0.0268978 |
| EFNA5 | ephrin-A5 | 0.026677 |
| RIGI | RNA sensor RIG-I | 0.0262911 |
| PCDH9 | protocadherin 9 | 0.0259728 |
| NELL1 | NEL-like 1 (chicken) | 0.0258169 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0255245 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.0251981 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.02505 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0250137 |
| YEATS2 | YEATS domain containing 2 | 0.0245586 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0239127 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0236876 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.023656 |
| PRELID2 | PRELI domain containing 2 | 0.0234231 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0232686 |
| PEX5L | peroxisomal biogenesis factor 5-like | 0.0231846 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0231434 |
| SYT1 | synaptotagmin I | 0.0230626 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0230334 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0229947 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0229426 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.022807 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0220421 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.021978 |
| MAP1B | microtubule-associated protein 1B | 0.0218801 |
| GPRIN3 | GPRIN family member 3 | 0.0217887 |
| DACH1 | dachshund family transcription factor 1 | 0.0216648 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0214951 |
| KCTD8 | potassium channel tetramerization domain containing 8 | 0.0213073 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.021261 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 0.0211862 |
| VEGFA | vascular endothelial growth factor A | 0.0211645 |
| DST | dystonin | 0.0211601 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.187671 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.123156 |
| FTL | ferritin, light polypeptide | -0.0616133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0584909 |
| CALCA | calcitonin-related polypeptide alpha | -0.0578458 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0531278 |
| UBB | ubiquitin B | -0.0441715 |
| RPS6 | ribosomal protein S6 | -0.0426114 |
| RPL8 | ribosomal protein L8 | -0.0408931 |
| RPLP1 | ribosomal protein, large, P1 | -0.0397467 |
| RPS21 | ribosomal protein S21 | -0.0397422 |
| CHGA | chromogranin A | -0.0370425 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.03394 |
| S100A9 | S100 calcium binding protein A9 | -0.0334254 |
| RPS27A | ribosomal protein S27a | -0.032109 |
| FOXC1 | forkhead box C1 | -0.0319994 |
| NOP58 | NOP58 ribonucleoprotein | -0.0319935 |
| H1-0 | H1.0 linker histone | -0.0316393 |
| RPL37 | ribosomal protein L37 | -0.0316387 |
| RPL11 | ribosomal protein L11 | -0.0308555 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0308036 |
| SQSTM1 | sequestosome 1 | -0.0303295 |
| RPS25 | ribosomal protein S25 | -0.029919 |
| MT2A | metallothionein 2A | -0.0291955 |
| RPL5 | ribosomal protein L5 | -0.0288001 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0286351 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0284793 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0280783 |
| INHBA | inhibin, beta A | -0.027972 |
| RRBP1 | ribosome binding protein 1 | -0.0274296 |
| RPL19 | ribosomal protein L19 | -0.0272677 |
| GNAS | GNAS complex locus | -0.0263657 |
| FUS | FUS RNA binding protein | -0.0262781 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.026011 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0257207 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0257129 |
| RPL12 | ribosomal protein L12 | -0.0257019 |
| RPL7A | ribosomal protein L7a | -0.0256503 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.025633 |
| RPL6 | ribosomal protein L6 | -0.0251892 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0251534 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0249093 |
| RPL23 | ribosomal protein L23 | -0.0244706 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0241755 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0241175 |
| RPS8 | ribosomal protein S8 | -0.0238658 |
| RPS19 | ribosomal protein S19 | -0.0238162 |
| TPM4 | tropomyosin 4 | -0.0234065 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0232611 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.023156 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0230981 |
| RPS3 | ribosomal protein S3 | -0.0229912 |
| JAM3 | junctional adhesion molecule 3 | -0.022691 |
| DEK | DEK proto-oncogene | -0.0226511 |
| LMNA | lamin A/C | -0.0223589 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.022259 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0221316 |
| RPS29 | ribosomal protein S29 | -0.0219269 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0219146 |
| TMSB10 | thymosin beta 10 | -0.021913 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0218626 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0217204 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0216705 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0216326 |
| RPL36 | ribosomal protein L36 | -0.0215706 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0215584 |
| RPS5 | ribosomal protein S5 | -0.0214581 |
| RPL31 | ribosomal protein L31 | -0.0214184 |
| FAM162A | family with sequence similarity 162, member A | -0.0212983 |
| RPL38 | ribosomal protein L38 | -0.0212413 |
| RPL32 | ribosomal protein L32 | -0.0209336 |
| RPS11 | ribosomal protein S11 | -0.0207817 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.020737 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0204703 |
| YBX1 | Y box binding protein 1 | -0.0204336 |
| RPL37A | ribosomal protein L37a | -0.0204311 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0203985 |
| RPL7 | ribosomal protein L7 | -0.0203811 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0201774 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0200761 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0198824 |
| RHEB | Ras homolog enriched in brain | -0.01987 |
| RPS15 | ribosomal protein S15 | -0.0198092 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0194561 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0194118 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0193134 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0191362 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0190468 |
| RPLP2 | ribosomal protein, large, P2 | -0.0190275 |
| JUN | jun proto-oncogene | -0.0190246 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.019005 |
| RPL35 | ribosomal protein L35 | -0.0189257 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0184534 |
| HMGB1 | high mobility group box 1 | -0.0184147 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0184042 |
| TUFM | Tu translation elongation factor, mitochondrial | -0.0183739 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0183689 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0183526 |
| SERF2 | small EDRK-rich factor 2 | -0.0183015 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0182738 |
