Pexidartinib (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.174852
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.105246
FNDC3B fibronectin type III domain containing 3B 0.0986229
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.078391
NRG3 neuregulin 3 0.0712656
FMN1 formin 1 0.0660369
PRELID2 PRELI domain containing 2 0.063793
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.062091
RAD51B RAD51 paralog B 0.0560024
FHIT fragile histidine triad 0.0465566
TENM1 teneurin transmembrane protein 1 0.0398964
IGFBP3 insulin-like growth factor binding protein 3 0.037685
LSAMP limbic system-associated membrane protein 0.0354286
LEF1 lymphoid enhancer-binding factor 1 0.0342382
LINGO2 leucine rich repeat and Ig domain containing 2 0.0314799
KAZN kazrin, periplakin interacting protein 0.0312554
YEATS2 YEATS domain containing 2 0.0309406
FLNA filamin A, alpha 0.02751
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0268203
ICAM1 intercellular adhesion molecule 1 0.0265245
CLEC2D C-type lectin domain family 2, member D 0.0243254
MAML3 mastermind-like 3 (Drosophila) 0.0228547
PHF21A PHD finger protein 21A 0.0227768
FRMD4A FERM domain containing 4A 0.0227056
IL1RAP interleukin 1 receptor accessory protein 0.0220509
MACROD2 MACRO domain containing 2 0.0219067
BIRC6 baculoviral IAP repeat containing 6 0.0216216
BRWD3 bromodomain and WD repeat domain containing 3 0.0213752
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0213279
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0211635
INPP5F inositol polyphosphate-5-phosphatase F 0.0209396
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0209178
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0208716
KMT2C lysine (K)-specific methyltransferase 2C 0.0208588
EXOC4 exocyst complex component 4 0.0207618
FGGY FGGY carbohydrate kinase domain containing 0.0200166
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0193878
PRKCSH protein kinase C substrate 80K-H 0.0192414
BHLHE40 basic helix-loop-helix family, member e40 0.019184
ITGB5 integrin, beta 5 0.0190833
BABAM2 BRISC and BRCA1 A complex member 2 0.0189814
WDPCP WD repeat containing planar cell polarity effector 0.0189639
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0188166
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0185596
LRMDA leucine rich melanocyte differentiation associated 0.0181217
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0179735
SREBF2 sterol regulatory element binding transcription factor 2 0.0178342
WWOX WW domain containing oxidoreductase 0.017828
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0175194
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0174597
CCDC14 coiled-coil domain containing 14 0.0173193
ZNF292 zinc finger protein 292 0.0168744
NPAS2 neuronal PAS domain protein 2 0.0168207
BACE2 beta-site APP-cleaving enzyme 2 0.0167959
CDH13 cadherin 13 0.0166433
FAM13A family with sequence similarity 13, member A 0.0159683
LPP LIM domain containing preferred translocation partner in lipoma 0.0159324
HPCAL1 hippocalcin-like 1 0.0157526
FNIP1 folliculin interacting protein 1 0.0157272
CNKSR3 CNKSR family member 3 0.0157249
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0156066
CCDC91 coiled-coil domain containing 91 0.0154635
CAPRIN1 cell cycle associated protein 1 0.0153095
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0153061
CDK6 cyclin-dependent kinase 6 0.0152858
ACSS3 acyl-CoA synthetase short-chain family member 3 0.0152226
CADM1 cell adhesion molecule 1 0.0151992
MSI2 musashi RNA-binding protein 2 0.0148965
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0147536
NDRG1 N-myc downstream regulated 1 0.0146011
HDAC9 histone deacetylase 9 0.0145093
MEF2A myocyte enhancer factor 2A 0.0143951
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0143473
SEPTIN9 septin 9 0.0140429
PIAS2 protein inhibitor of activated STAT, 2 0.0140331
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0139876
TBC1D5 TBC1 domain family, member 5 0.0139766
SMAD3 SMAD family member 3 0.0138072
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0135838
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0135154
CEP85L centrosomal protein 85kDa-like 0.0132968
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0132699
RPS2 ribosomal protein S2 0.0131661
PEA15 phosphoprotein enriched in astrocytes 15 0.0129387
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0128043
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0128012
DST dystonin 0.0127379
CFAP20DC CFAP20 domain containing 0.0127212
AMPD3 adenosine monophosphate deaminase 3 0.0125268
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0124349
SPTBN1 spectrin, beta, non-erythrocytic 1 0.012307
SEC24A SEC24 family member A 0.0122845
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0122784
MBD5 methyl-CpG binding domain protein 5 0.0122019
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0120876
GPR137B G protein-coupled receptor 137B 0.0120138
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0119808
FAM78B family with sequence similarity 78, member B 0.0119193
AKAP9 A kinase (PRKA) anchor protein 9 0.0119118
TMEM45A transmembrane protein 45A 0.0118918

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.277603
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180486
UBC ubiquitin C -0.150105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.142628
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.113273
TM4SF1 transmembrane 4 L six family member 1 -0.0810736
PTMA prothymosin, alpha -0.0810065
ENO1 enolase 1, (alpha) -0.077846
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0737486
TMSB10 thymosin beta 10 -0.0727547
RPS27A ribosomal protein S27a -0.0717527
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0670816
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0653472
SQSTM1 sequestosome 1 -0.0649183
PKM pyruvate kinase, muscle -0.0550821
RPS3 ribosomal protein S3 -0.0549034
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0545654
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0529102
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.052157
RPS6 ribosomal protein S6 -0.0509898
AHNAK AHNAK nucleoprotein -0.050963
RPL23 ribosomal protein L23 -0.0473023
CANX calnexin -0.0456161
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0450362
RHOA ras homolog family member A -0.0442506
CTTN cortactin -0.0435801
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0410264
TPM3 tropomyosin 3 -0.0386199
RPLP1 ribosomal protein, large, P1 -0.037243
EMP1 epithelial membrane protein 1 -0.0367929
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0364043
RPS13 ribosomal protein S13 -0.0351151
PRRC2C proline-rich coiled-coil 2C -0.0349498
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0348022
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0344709
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0342546
POTEF POTE ankyrin domain family, member F -0.0334815
PCBP2 poly(rC) binding protein 2 -0.0326831
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0324477
APOD apolipoprotein D -0.032354
MT2A metallothionein 2A -0.0322449
RPL36A ribosomal protein L36a -0.0319757
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0319154
TXNRD1 thioredoxin reductase 1 -0.0317438
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0310465
RASAL2 RAS protein activator like 2 -0.0309341
NAP1L1 nucleosome assembly protein 1-like 1 -0.0307641
S100A9 S100 calcium binding protein A9 -0.0306494
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0304892
RPS21 ribosomal protein S21 -0.0303484
RPLP2 ribosomal protein, large, P2 -0.0300896
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.03003
RPL34 ribosomal protein L34 -0.029726
TPT1 tumor protein, translationally-controlled 1 -0.0295784
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.02947
MCL1 myeloid cell leukemia 1 -0.0294312
LOC112694756 uncharaterized LOC112694756 -0.0292902
RPS24 ribosomal protein S24 -0.0284358
ZFAND3 zinc finger, AN1-type domain 3 -0.0282365
MAP4 microtubule-associated protein 4 -0.0279298
RPL19 ribosomal protein L19 -0.0279108
B2M beta-2-microglobulin -0.027765
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0270103
RPS8 ribosomal protein S8 -0.0267489
RPS23 ribosomal protein S23 -0.0264229
CALU calumenin -0.0260385
RPS15 ribosomal protein S15 -0.0259568
S100A10 S100 calcium binding protein A10 -0.0256632
RPL31 ribosomal protein L31 -0.0253999
RPL15 ribosomal protein L15 -0.0253755
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0251208
IER3 immediate early response 3 -0.0250238
RPL12 ribosomal protein L12 -0.0249195
RHEB Ras homolog enriched in brain -0.0248766
HLA-E major histocompatibility complex, class I, E -0.0248344
LMNA lamin A/C -0.0246674
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0246141
GOLGA4 golgin A4 -0.0244298
VMP1 vacuole membrane protein 1 -0.0242096
MYH9 myosin, heavy chain 9, non-muscle -0.024134
ANXA2 annexin A2 -0.0241041
RPL8 ribosomal protein L8 -0.0238901
RPL32 ribosomal protein L32 -0.0237742
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0237735
CLIC4 chloride intracellular channel 4 -0.0236758
SP100 SP100 nuclear antigen -0.0235887
DEK DEK proto-oncogene -0.0227862
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0225234
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0225028
H3-3B H3.3 histone B -0.022428
EIF1 eukaryotic translation initiation factor 1 -0.0217503
ACTN4 actinin, alpha 4 -0.0215412
TPI1 triosephosphate isomerase 1 -0.0213005
IPO7 importin 7 -0.0211353
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0209216
RPL38 ribosomal protein L38 -0.0207697
RPL28 ribosomal protein L28 -0.0207309
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0206631
RSL1D1 ribosomal L1 domain containing 1 -0.0204905
CHD4 chromodomain helicase DNA binding protein 4 -0.0203285