Pexidartinib (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.0948323
HDAC9 histone deacetylase 9 0.08802
ADAM10 ADAM metallopeptidase domain 10 0.0800024
ZNF292 zinc finger protein 292 0.077476
PDE4B phosphodiesterase 4B, cAMP-specific 0.077006
SOX6 SRY (sex determining region Y)-box 6 0.0765345
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0731356
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0730731
TJP1 tight junction protein 1 0.0717434
EEF2 eukaryotic translation elongation factor 2 0.0655067
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0653916
PDGFC platelet derived growth factor C 0.0633579
TXNRD1 thioredoxin reductase 1 0.0586404
GOLGA4 golgin A4 0.0560146
TGFBR3 transforming growth factor, beta receptor III 0.0559762
PYGB phosphorylase, glycogen; brain 0.0537061
TFG TRK-fused gene 0.0511276
EVI5 ecotropic viral integration site 5 0.0503253
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0488027
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0486314
RBM39 RNA binding motif protein 39 0.0486195
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0481066
KMT2E lysine (K)-specific methyltransferase 2E 0.046231
PICALM phosphatidylinositol binding clathrin assembly protein 0.0458449
TMEM65 transmembrane protein 65 0.0458175
FNDC3B fibronectin type III domain containing 3B 0.0442417
NBAS neuroblastoma amplified sequence 0.0441421
SSBP2 single-stranded DNA binding protein 2 0.0434742
RAB6A RAB6A, member RAS oncogene family 0.0432693
ZMYM2 zinc finger, MYM-type 2 0.0427018
ZNF608 zinc finger protein 608 0.0423208
SBF2 SET binding factor 2 0.0414599
ANK2 ankyrin 2, neuronal 0.0413207
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0400717
YEATS2 YEATS domain containing 2 0.0398264
NAMPT nicotinamide phosphoribosyltransferase 0.0397997
ECT2 epithelial cell transforming 2 0.039175
HELZ helicase with zinc finger 0.0387263
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0384963
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0384228
EZR ezrin 0.0379829
EML4 echinoderm microtubule associated protein like 4 0.0370733
PTBP2 polypyrimidine tract binding protein 2 0.0363435
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0362559
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0360481
TXNIP thioredoxin interacting protein 0.0356785
UBA6 ubiquitin-like modifier activating enzyme 6 0.0352295
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0349363
PCBP2 poly(rC) binding protein 2 0.0339829
FAM13A family with sequence similarity 13, member A 0.0325219
BRWD1 bromodomain and WD repeat domain containing 1 0.0325201
NCKAP1 NCK-associated protein 1 0.0321602
LPP LIM domain containing preferred translocation partner in lipoma 0.0319565
COG5 component of oligomeric golgi complex 5 0.0318916
PRELID2 PRELI domain containing 2 0.0311358
ZBTB20 zinc finger and BTB domain containing 20 0.0305759
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0303828
PNISR PNN-interacting serine/arginine-rich protein 0.0296605
TMEM41B transmembrane protein 41B 0.0295978
PLPP3 phospholipid phosphatase 3 0.0291028
CENPF centromere protein F, 350/400kDa 0.0284224
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0283544
PHF21A PHD finger protein 21A 0.0283214
FHIT fragile histidine triad 0.0282326
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0281574
SEC23A Sec23 homolog A (S. cerevisiae) 0.028099
NUP58 nucleoporin 58 0.0275245
WDFY3 WD repeat and FYVE domain containing 3 0.0274105
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0273223
BIRC6 baculoviral IAP repeat containing 6 0.0273161
RNF145 ring finger protein 145 0.0271818
MSI2 musashi RNA-binding protein 2 0.0271408
PCGF5 polycomb group ring finger 5 0.0270349
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0267694
MON2 MON2 homolog (S. cerevisiae) 0.0262593
ZMIZ1 zinc finger, MIZ-type containing 1 0.0260531
TBC1D5 TBC1 domain family, member 5 0.0260515
SRP54 signal recognition particle 54kDa 0.0260095
SEC24D SEC24 family member D 0.0259611
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0258645
KDM6A lysine (K)-specific demethylase 6A 0.0258545
CDC73 cell division cycle 73 0.0258352
RBM25 RNA binding motif protein 25 0.0255141
FAM91A1 family with sequence similarity 91, member A1 0.0255054
ANKRD11 ankyrin repeat domain 11 0.0254971
DOCK3 dedicator of cytokinesis 3 0.0252995
XPO1 exportin 1 0.0252373
PHIP pleckstrin homology domain interacting protein 0.0252307
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0251537
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0250171
FOXJ3 forkhead box J3 0.0249099
NFIA nuclear factor I/A 0.0248435
AHCYL2 adenosylhomocysteinase-like 2 0.0248002
KDM3A lysine (K)-specific demethylase 3A 0.024767
SEC31A SEC31 homolog A (S. cerevisiae) 0.0247135
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0246966
ADAM9 ADAM metallopeptidase domain 9 0.0246118
FER fer (fps/fes related) tyrosine kinase 0.0243045
DSCAM Down syndrome cell adhesion molecule 0.0242549
USP34 ubiquitin specific peptidase 34 0.024198

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.325265
PTMA prothymosin, alpha -0.245634
AHNAK AHNAK nucleoprotein -0.13786
TPT1 tumor protein, translationally-controlled 1 -0.0996434
RPS6 ribosomal protein S6 -0.0972254
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0773741
BMP10 bone morphogenetic protein 10 -0.0768118
RPS8 ribosomal protein S8 -0.0727648
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.06911
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0677074
ARL4C ADP-ribosylation factor-like 4C -0.065196
TMSB4X thymosin beta 4, X-linked -0.0649273
PKM pyruvate kinase, muscle -0.0605292
RPLP1 ribosomal protein, large, P1 -0.0562593
RPL31 ribosomal protein L31 -0.0543897
TM4SF1 transmembrane 4 L six family member 1 -0.0510418
RPL34 ribosomal protein L34 -0.0509817
RPL12 ribosomal protein L12 -0.0496118
RPL19 ribosomal protein L19 -0.0495749
ACTG1 actin gamma 1 -0.0488255
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0443227
VCL vinculin -0.0439067
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0392236
ENO1 enolase 1, (alpha) -0.0389545
RPL26 ribosomal protein L26 -0.0382833
RPS23 ribosomal protein S23 -0.0357241
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0356834
RPS13 ribosomal protein S13 -0.0356592
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0352714
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0349939
IFI16 interferon, gamma-inducible protein 16 -0.0344815
CCND1 cyclin D1 -0.0344077
LOC112694756 uncharaterized LOC112694756 -0.0339334
RPLP2 ribosomal protein, large, P2 -0.0337136
RPL7A ribosomal protein L7a -0.0331927
RPS19 ribosomal protein S19 -0.033126
S100A9 S100 calcium binding protein A9 -0.0330069
RPL9 ribosomal protein L9 -0.0328878
RPS27A ribosomal protein S27a -0.0316442
RPL35A ribosomal protein L35a -0.031279
RPL32 ribosomal protein L32 -0.0301689
EBNA1BP2 EBNA1 binding protein 2 -0.0294409
SP100 SP100 nuclear antigen -0.0294054
S100A10 S100 calcium binding protein A10 -0.0282966
RPS21 ribosomal protein S21 -0.0280251
GLI3 GLI family zinc finger 3 -0.0277855
RPL7 ribosomal protein L7 -0.0277375
RPL37A ribosomal protein L37a -0.0275457
RPS14 ribosomal protein S14 -0.0275208
RSL1D1 ribosomal L1 domain containing 1 -0.0274606
RFC3 replication factor C (activator 1) 3, 38kDa -0.026457
RPS16 ribosomal protein S16 -0.0263999
CAMKMT calmodulin-lysine N-methyltransferase -0.0263459
RPS25 ribosomal protein S25 -0.0263277
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0263065
ZNF217 zinc finger protein 217 -0.0258912
RPS24 ribosomal protein S24 -0.0257271
TPI1 triosephosphate isomerase 1 -0.0254793
INTS6 integrator complex subunit 6 -0.0253003
RPS5 ribosomal protein S5 -0.0249509
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0244404
TMSB10 thymosin beta 10 -0.0238429
RPL8 ribosomal protein L8 -0.0238398
HSPB1 heat shock 27kDa protein 1 -0.0234642
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0233753
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0230017
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0229925
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0229891
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0229861
TUBA1B tubulin, alpha 1b -0.0228944
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.022718
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0225736
NPAS2 neuronal PAS domain protein 2 -0.0223565
RPS3 ribosomal protein S3 -0.0223089
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0219421
MYO5C myosin VC -0.0218471
BPTF bromodomain PHD finger transcription factor -0.0218134
EEF1G eukaryotic translation elongation factor 1 gamma -0.0216063
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0215779
SETX senataxin -0.0212556
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0212514
RPL23 ribosomal protein L23 -0.0212082
TPM4 tropomyosin 4 -0.0210427
TAS2R14 taste receptor, type 2, member 14 -0.0207567
TBCA tubulin folding cofactor A -0.0207263
FER1L6 fer-1-like family member 6 -0.0207009
RPS11 ribosomal protein S11 -0.0203678
RPL38 ribosomal protein L38 -0.0202842
RPL35 ribosomal protein L35 -0.0201017
RPL4 ribosomal protein L4 -0.0200006
NAP1L1 nucleosome assembly protein 1-like 1 -0.0199412
ZNF438 zinc finger protein 438 -0.0197695
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0196375
DIAPH3 diaphanous-related formin 3 -0.0192952
S100A4 S100 calcium binding protein A4 -0.0191123
MYL12B myosin, light chain 12B, regulatory -0.018979
RPL10A ribosomal protein L10a -0.0188285
RACK1 receptor for activated C kinase 1 -0.0188058
RPL36A ribosomal protein L36a -0.0187891
RALY RALY heterogeneous nuclear ribonucleoprotein -0.018594