Pexidartinib (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.147209
TRIO trio Rho guanine nucleotide exchange factor 0.143487
COL6A3 collagen, type VI, alpha 3 0.134956
FNDC3B fibronectin type III domain containing 3B 0.113332
VCAN versican 0.111643
NAV2 neuron navigator 2 0.0937269
CADM1 cell adhesion molecule 1 0.0868687
FRMD4A FERM domain containing 4A 0.0848675
FTH1 ferritin, heavy polypeptide 1 0.0797299
MYH9 myosin, heavy chain 9, non-muscle 0.0730377
DST dystonin 0.0722492
EEF2 eukaryotic translation elongation factor 2 0.0700981
CD44 CD44 molecule (Indian blood group) 0.0657617
MYOF myoferlin 0.0648623
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0635506
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0633924
SOD2 superoxide dismutase 2, mitochondrial 0.0630461
IGFBP3 insulin-like growth factor binding protein 3 0.0606906
AKAP12 A kinase (PRKA) anchor protein 12 0.058021
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0577107
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0553412
PLIN2 perilipin 2 0.0545184
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.053464
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0518203
ZMIZ1 zinc finger, MIZ-type containing 1 0.0516244
FN1 fibronectin 1 0.0475046
MXI1 MAX interactor 1, dimerization protein 0.0458613
FMNL2 formin-like 2 0.0448634
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0448622
UGCG UDP-glucose ceramide glucosyltransferase 0.0447646
HDAC9 histone deacetylase 9 0.0441984
SDK1 sidekick cell adhesion molecule 1 0.0438636
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0436697
ELL2 elongation factor, RNA polymerase II, 2 0.0433893
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0430221
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0430175
MSN moesin 0.0424123
LOXL2 lysyl oxidase-like 2 0.0405419
CD109 CD109 molecule 0.0379194
ZNF292 zinc finger protein 292 0.037913
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0370654
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0357943
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0354937
CDH13 cadherin 13 0.0349552
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0348279
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0341534
FLNA filamin A, alpha 0.033458
USP9X ubiquitin specific peptidase 9, X-linked 0.0333949
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0332973
NAV1 neuron navigator 1 0.0328432
CCBE1 collagen and calcium binding EGF domains 1 0.0328274
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0324494
TNS3 tensin 3 0.0324428
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0320636
COL8A1 collagen, type VIII, alpha 1 0.0313627
RPS2 ribosomal protein S2 0.0312603
SPAG9 sperm associated antigen 9 0.030917
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0307249
ICAM1 intercellular adhesion molecule 1 0.0301853
PRELID2 PRELI domain containing 2 0.0301796
RAD51B RAD51 paralog B 0.0301553
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0296872
EPAS1 endothelial PAS domain protein 1 0.0295582
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0294352
MMP12 matrix metallopeptidase 12 0.0294186
NAMPT nicotinamide phosphoribosyltransferase 0.0291908
EGFR epidermal growth factor receptor 0.0291159
UBA6 ubiquitin-like modifier activating enzyme 6 0.0289556
AFDN afadin, adherens junction formation factor 0.0289194
STC2 stanniocalcin 2 0.0285456
ATP13A3 ATPase type 13A3 0.0285064
TGFBI transforming growth factor, beta-induced, 68kDa 0.0280804
HELZ helicase with zinc finger 0.0280594
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0275451
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0271752
FRMPD4 FERM and PDZ domain containing 4 0.027033
AFF3 AF4/FMR2 family, member 3 0.0269852
LAMP2 lysosomal-associated membrane protein 2 0.0269788
C3 complement component 3 0.0267066
BACE2 beta-site APP-cleaving enzyme 2 0.0266509
TMEM178B transmembrane protein 178B 0.0264155
FLNB filamin B, beta 0.0261378
SYNJ2 synaptojanin 2 0.0259376
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0254474
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0254
TRAM2 translocation associated membrane protein 2 0.0247175
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0244658
PSD3 pleckstrin and Sec7 domain containing 3 0.0243648
LOX lysyl oxidase 0.0243156
LPP LIM domain containing preferred translocation partner in lipoma 0.0240937
PPARD peroxisome proliferator-activated receptor delta 0.0238481
SEPTIN9 septin 9 0.0238381
WDFY1 WD repeat and FYVE domain containing 1 0.0234578
FNIP1 folliculin interacting protein 1 0.0234148
RND3 Rho family GTPase 3 0.023323
RNF213 ring finger protein 213 0.0231753
NDRG1 N-myc downstream regulated 1 0.022842
RUNX1 runt-related transcription factor 1 0.0223743
JMJD1C jumonji domain containing 1C 0.022273
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0221857

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201668
TMSB10 thymosin beta 10 -0.107441
MT2A metallothionein 2A -0.100197
TPT1 tumor protein, translationally-controlled 1 -0.0917562
VIM vimentin -0.0837213
RPS6 ribosomal protein S6 -0.0819765
HLA-B major histocompatibility complex, class I, B -0.0773581
PTMA prothymosin, alpha -0.0744846
FTL ferritin, light polypeptide -0.0712461
RPS24 ribosomal protein S24 -0.0678431
RPL36A ribosomal protein L36a -0.0561419
RPS23 ribosomal protein S23 -0.0551847
RPL32 ribosomal protein L32 -0.0549525
RPLP2 ribosomal protein, large, P2 -0.0523573
RPL19 ribosomal protein L19 -0.05077
RPS13 ribosomal protein S13 -0.0489198
RPLP1 ribosomal protein, large, P1 -0.0459281
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.045403
RPS21 ribosomal protein S21 -0.0445614
TXNIP thioredoxin interacting protein -0.0439413
DEK DEK proto-oncogene -0.0417975
IER3 immediate early response 3 -0.0413503
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0402288
RPS19 ribosomal protein S19 -0.0395975
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0366055
RPS8 ribosomal protein S8 -0.0364026
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0361868
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0358125
RPL7A ribosomal protein L7a -0.0357513
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0348017
RPL35A ribosomal protein L35a -0.0346424
COL1A1 collagen, type I, alpha 1 -0.0345195
EIF1 eukaryotic translation initiation factor 1 -0.0337386
RPL36 ribosomal protein L36 -0.0324774
RPS10 ribosomal protein S10 -0.0322909
RPL11 ribosomal protein L11 -0.0319083
S100A9 S100 calcium binding protein A9 -0.0306063
AHNAK AHNAK nucleoprotein -0.0303774
RPS15 ribosomal protein S15 -0.0303276
RPL12 ribosomal protein L12 -0.0299473
SDC4 syndecan 4 -0.029861
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0297565
RPS3 ribosomal protein S3 -0.0296314
RPL8 ribosomal protein L8 -0.029564
LOC112694756 uncharaterized LOC112694756 -0.029425
RPL35 ribosomal protein L35 -0.0280207
EGR1 early growth response 1 -0.0278963
RPS27A ribosomal protein S27a -0.0278744
VDAC1 voltage-dependent anion channel 1 -0.0277145
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0269693
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0269441
RPL38 ribosomal protein L38 -0.026775
IFITM3 interferon induced transmembrane protein 3 -0.0267703
RPS25 ribosomal protein S25 -0.026404
RPS5 ribosomal protein S5 -0.0262426
RPS11 ribosomal protein S11 -0.0255126
RBMX RNA binding motif protein, X-linked -0.0252112
RPL9 ribosomal protein L9 -0.0251512
ASTN2 astrotactin 2 -0.0250837
RPL31 ribosomal protein L31 -0.0249861
RPL28 ribosomal protein L28 -0.0247639
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0242964
WSB1 WD repeat and SOCS box containing 1 -0.0241112
TXNRD1 thioredoxin reductase 1 -0.0240969
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0238845
RPS16 ribosomal protein S16 -0.023627
LMNA lamin A/C -0.0232198
H3-3B H3.3 histone B -0.023167
WASF2 WAS protein family, member 2 -0.0231421
RPS4X ribosomal protein S4, X-linked -0.0229526
RPL23 ribosomal protein L23 -0.0228299
RPL34 ribosomal protein L34 -0.0227855
RPL5 ribosomal protein L5 -0.022402
CAVIN1 caveolae associated protein 1 -0.0221064
KDM3A lysine (K)-specific demethylase 3A -0.0219396
FUS FUS RNA binding protein -0.021686
UBC ubiquitin C -0.0216716
RPL26 ribosomal protein L26 -0.0216346
RPS14 ribosomal protein S14 -0.0210767
HDLBP high density lipoprotein binding protein -0.0206293
RPS29 ribosomal protein S29 -0.020604
CCNI cyclin I -0.0204385
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0203071
DIAPH3 diaphanous-related formin 3 -0.0202505
RPLP0 ribosomal protein, large, P0 -0.0200248
GLIS3 GLIS family zinc finger 3 -0.0198329
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0193589
RPL13A ribosomal protein L13a -0.0187946
CDK12 cyclin-dependent kinase 12 -0.0187448
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0187313
KMT2A lysine (K)-specific methyltransferase 2A -0.0186707
UBE2B ubiquitin-conjugating enzyme E2B -0.0185056
BICC1 BicC family RNA binding protein 1 -0.0183558
THOC2 THO complex 2 -0.0181763
RRBP1 ribosome binding protein 1 -0.0178753
NAP1L1 nucleosome assembly protein 1-like 1 -0.0177613
RPL37 ribosomal protein L37 -0.017747
HDAC8 histone deacetylase 8 -0.0177148
NAP1L4 nucleosome assembly protein 1-like 4 -0.0175886
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.017432