| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.191769 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.183902 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.178967 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.158187 |
| VIM | vimentin | 0.13038 |
| LOX | lysyl oxidase | 0.123646 |
| CDH13 | cadherin 13 | 0.119891 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.1106 |
| STC1 | stanniocalcin 1 | 0.10997 |
| EGFR | epidermal growth factor receptor | 0.107874 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.102106 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0935877 |
| NDRG1 | N-myc downstream regulated 1 | 0.0874293 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0870711 |
| TMSB10 | thymosin beta 10 | 0.0827223 |
| NRXN3 | neurexin 3 | 0.081893 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0807407 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0787241 |
| COL1A2 | collagen, type I, alpha 2 | 0.0740173 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0725917 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.068248 |
| EFNA5 | ephrin-A5 | 0.0653712 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0648904 |
| HLA-B | major histocompatibility complex, class I, B | 0.061622 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0610812 |
| CALR | calreticulin | 0.0596798 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0581571 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0572204 |
| VEGFC | vascular endothelial growth factor C | 0.0566214 |
| HLA-A | major histocompatibility complex, class I, A | 0.0566083 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0559117 |
| PRSS23 | protease, serine, 23 | 0.0548566 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0537124 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0507845 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0494455 |
| MYO1E | myosin IE | 0.04872 |
| PGK1 | phosphoglycerate kinase 1 | 0.0476289 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0466225 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0461356 |
| FAM13A | family with sequence similarity 13, member A | 0.0435051 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0434755 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0424234 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0424043 |
| IL6 | interleukin 6 | 0.0422074 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0421164 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.041815 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0417068 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0417045 |
| WASF2 | WAS protein family, member 2 | 0.0415714 |
| FRMD4A | FERM domain containing 4A | 0.0412557 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0403467 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0401697 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0396351 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0391223 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0380407 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0372225 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0371215 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0370434 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.037037 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0365944 |
| PDGFC | platelet derived growth factor C | 0.0363918 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0361765 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0358811 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0355889 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.035568 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0349296 |
| LOXL2 | lysyl oxidase-like 2 | 0.0346614 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0337587 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.033417 |
| RNF145 | ring finger protein 145 | 0.0332809 |
| HLA-C | major histocompatibility complex, class I, C | 0.032828 |
| RPLP1 | ribosomal protein, large, P1 | 0.0326903 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0324775 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0324105 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0319025 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0317719 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0317461 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0312268 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0307968 |
| CD44 | CD44 molecule (Indian blood group) | 0.0306948 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0302744 |
| COG6 | component of oligomeric golgi complex 6 | 0.0302027 |
| CA12 | carbonic anhydrase XII | 0.0302025 |
| SYNPO | synaptopodin | 0.030104 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0300496 |
| ANO6 | anoctamin 6 | 0.0299342 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0295571 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0294371 |
| KAZN | kazrin, periplakin interacting protein | 0.0292234 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0290883 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0290227 |
| C1D | C1D nuclear receptor corepressor | 0.0289639 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0289093 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0288986 |
| FTO | fat mass and obesity associated | 0.0287948 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0285091 |
| HIP1 | huntingtin interacting protein 1 | 0.0284683 |
| GOLGB1 | golgin B1 | 0.0280016 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0277748 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0275647 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.168315 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.149613 |
| PTMA | prothymosin, alpha | -0.0891702 |
| SETD5 | SET domain containing 5 | -0.0621996 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.061926 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.056219 |
| SMYD3 | SET and MYND domain containing 3 | -0.0561511 |
| MEF2A | myocyte enhancer factor 2A | -0.0549137 |
| CALD1 | caldesmon 1 | -0.0530832 |
| H3-3B | H3.3 histone B | -0.0516728 |
| AHNAK | AHNAK nucleoprotein | -0.0514837 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0491512 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0480712 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0469716 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0460845 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0447016 |
| PHF21A | PHD finger protein 21A | -0.0416686 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0415759 |
| WAC | WW domain containing adaptor with coiled-coil | -0.040264 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0402317 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0396558 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0386542 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0384079 |
| SEC24D | SEC24 family member D | -0.0376543 |
| ANLN | anillin, actin binding protein | -0.0364581 |
| SRPK2 | SRSF protein kinase 2 | -0.0362827 |
| HDLBP | high density lipoprotein binding protein | -0.0361821 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0356148 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0352079 |
| ANKRD12 | ankyrin repeat domain 12 | -0.034799 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.0347263 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0344902 |
| RNF24 | ring finger protein 24 | -0.034048 |
| MTPN | myotrophin | -0.0333436 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.033336 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0332668 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0332041 |
| RPL11 | ribosomal protein L11 | -0.0328561 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0323085 |
| UBC | ubiquitin C | -0.0322668 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0321119 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0319903 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0318748 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0313095 |
| CFDP1 | craniofacial development protein 1 | -0.0312971 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0310074 |
| TFG | TRK-fused gene | -0.0308353 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0307555 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0305614 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0305455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0304215 |
| RPL32 | ribosomal protein L32 | -0.0302796 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0302505 |
| DENND4C | DENN/MADD domain containing 4C | -0.0300885 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0300859 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0300289 |
| SDC4 | syndecan 4 | -0.0299026 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0297631 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0297573 |
| TXNIP | thioredoxin interacting protein | -0.0294565 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0293391 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0292775 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.029083 |
| FUS | FUS RNA binding protein | -0.029043 |
| RTN4 | reticulon 4 | -0.0289037 |
| RSRP1 | arginine/serine-rich protein 1 | -0.0288649 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0286681 |
| MED13 | mediator complex subunit 13 | -0.0284431 |
| JMJD1C | jumonji domain containing 1C | -0.0281182 |
| SMAD3 | SMAD family member 3 | -0.0279994 |
| CABIN1 | calcineurin binding protein 1 | -0.0278654 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0278536 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0278445 |
| TCERG1 | transcription elongation regulator 1 | -0.0277639 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0274578 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0274524 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | -0.0274121 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0273786 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0272489 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0270217 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0269877 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0269849 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0267922 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0267025 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.0266981 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0266078 |
| RAD21 | RAD21 homolog (S. pombe) | -0.026303 |
| APP | amyloid beta (A4) precursor protein | -0.0262823 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0261498 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0259269 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0258701 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0258492 |
| OGA | O-GlcNAcase | -0.0256226 |
| RPLP2 | ribosomal protein, large, P2 | -0.0255336 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0254816 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0254777 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0254127 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.025398 |
| ATRN | attractin | -0.0253495 |
| PTN | pleiotrophin | -0.0253455 |
