| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.112266 |
| LDHA | lactate dehydrogenase A | 0.107525 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.103899 |
| DSCAM | Down syndrome cell adhesion molecule | 0.075543 |
| DNER | delta/notch-like EGF repeat containing | 0.0729258 |
| ZNF292 | zinc finger protein 292 | 0.0668677 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0644742 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0616876 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0616039 |
| NUP58 | nucleoporin 58 | 0.0597049 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0596749 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.053777 |
| KIAA1328 | KIAA1328 | 0.0536605 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0527238 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0514574 |
| ATP13A3 | ATPase type 13A3 | 0.0505745 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0480772 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.047382 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0471726 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0457179 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0454168 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.045058 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0446883 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0442453 |
| PYGL | phosphorylase, glycogen, liver | 0.0441437 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0436269 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0435906 |
| ATXN1 | ataxin 1 | 0.041952 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0417872 |
| HJURP | Holliday junction recognition protein | 0.0417858 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0412543 |
| KIF5B | kinesin family member 5B | 0.0409856 |
| ANLN | anillin, actin binding protein | 0.0408578 |
| CENPF | centromere protein F, 350/400kDa | 0.0405024 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0404902 |
| KIAA1958 | KIAA1958 | 0.0391209 |
| MKI67 | marker of proliferation Ki-67 | 0.0390443 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0372586 |
| METTL15 | methyltransferase like 15 | 0.0360133 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0358245 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0355147 |
| SMAD3 | SMAD family member 3 | 0.0354808 |
| DIAPH3 | diaphanous-related formin 3 | 0.0353854 |
| ATRN | attractin | 0.0352992 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0348502 |
| MTREX | Mtr4 exosome RNA helicase | 0.0347194 |
| TPX2 | TPX2, microtubule-associated | 0.0343864 |
| CEP250 | centrosomal protein 250kDa | 0.0340471 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0340092 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0337677 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0337545 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0335014 |
| AFDN | afadin, adherens junction formation factor | 0.03316 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0331372 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0328068 |
| ENO1 | enolase 1, (alpha) | 0.0323931 |
| CFH | complement factor H | 0.0322849 |
| VIM | vimentin | 0.031882 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0317443 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0316499 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0316148 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0314436 |
| SMYD3 | SET and MYND domain containing 3 | 0.0311807 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0308358 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0307629 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0304904 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0302443 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0300968 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0299342 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0298963 |
| SUGP2 | SURP and G patch domain containing 2 | 0.0298161 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0296874 |
| OXSR1 | oxidative stress responsive 1 | 0.029542 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0294221 |
| ARRDC3 | arrestin domain containing 3 | 0.0294218 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0293361 |
| CAPRIN2 | caprin family member 2 | 0.029293 |
| PCBP2 | poly(rC) binding protein 2 | 0.0289199 |
| PDE8A | phosphodiesterase 8A | 0.0285767 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0285608 |
| ANKRD36 | ankyrin repeat domain 36 | 0.02851 |
| RAD51B | RAD51 paralog B | 0.0279746 |
| KIF20B | kinesin family member 20B | 0.0279217 |
| CUL3 | cullin 3 | 0.0279182 |
| SLC35F2 | solute carrier family 35, member F2 | 0.0277977 |
| NF1 | neurofibromin 1 | 0.0275486 |
| NCKAP1 | NCK-associated protein 1 | 0.0274691 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0272912 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0272468 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0271656 |
| CENPE | centromere protein E, 312kDa | 0.0271243 |
| TTK | TTK protein kinase | 0.0270944 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0270871 |
| TUBB | tubulin, beta class I | 0.027074 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0270208 |
| SGO2 | shugoshin 2 | 0.0269498 |
| RAD18 | RAD18 E3 ubiquitin protein ligase | 0.0263431 |
| UBQLN1 | ubiquilin 1 | 0.026202 |
| RB1 | retinoblastoma 1 | 0.0261227 |
| PIKFYVE | phosphoinositide kinase, FYVE finger containing | 0.0261167 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.078112 |
| AHNAK | AHNAK nucleoprotein | -0.0667133 |
| INTS6 | integrator complex subunit 6 | -0.0640921 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0601172 |
| HMGA2 | high mobility group AT-hook 2 | -0.0587254 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0554499 |
| RPLP1 | ribosomal protein, large, P1 | -0.0543823 |
| PTMA | prothymosin, alpha | -0.0528863 |
| PRSS23 | protease, serine, 23 | -0.0494292 |
| RIGI | RNA sensor RIG-I | -0.0436813 |
| SVIL | supervillin | -0.0425472 |
| FUS | FUS RNA binding protein | -0.0411595 |
| DST | dystonin | -0.041115 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0409541 |
| TMSB10 | thymosin beta 10 | -0.0409263 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0388477 |
| SDC4 | syndecan 4 | -0.0380477 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0362534 |
| ZNF609 | zinc finger protein 609 | -0.0360207 |
| TRIM44 | tripartite motif containing 44 | -0.0359839 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0358342 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0353464 |
| IER3 | immediate early response 3 | -0.0351312 |
| RAI14 | retinoic acid induced 14 | -0.034343 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0321951 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0315734 |
| S100A9 | S100 calcium binding protein A9 | -0.0313559 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0310204 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0307066 |
| VCL | vinculin | -0.0291882 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0291772 |
| SKIL | SKI-like proto-oncogene | -0.0290466 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0287118 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0280103 |
| ETFA | electron-transfer-flavoprotein, alpha polypeptide | -0.0278542 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.027806 |
| POTEF | POTE ankyrin domain family, member F | -0.0274568 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.027312 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0270209 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0267666 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0267265 |
| NAV3 | neuron navigator 3 | -0.0265606 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0262386 |
| PCNX2 | pecanex 2 | -0.0262134 |
| NINL | ninein-like | -0.0261996 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0260477 |
| SP100 | SP100 nuclear antigen | -0.0260458 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0253208 |
| AK1 | adenylate kinase 1 | -0.0252866 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.025234 |
| TAOK1 | TAO kinase 1 | -0.0251357 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0250625 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0248593 |
| ANXA2 | annexin A2 | -0.024758 |
| RPL36AL | ribosomal protein L36a-like | -0.0246518 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0244343 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0243462 |
| SEPTIN9 | septin 9 | -0.0242624 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0242567 |
| COLEC11 | collectin sub-family member 11 | -0.0241438 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0241115 |
| CMIP | c-Maf inducing protein | -0.0238287 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0234835 |
| PRR16 | proline rich 16 | -0.0233978 |
| LMNA | lamin A/C | -0.0233558 |
| KLHL29 | kelch-like family member 29 | -0.0232756 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0230993 |
| ATG7 | autophagy related 7 | -0.0229703 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0229436 |
| H1-0 | H1.0 linker histone | -0.0224513 |
| ABR | active BCR-related | -0.0222955 |
| ITGA6 | integrin, alpha 6 | -0.0220385 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0218828 |
| CCNYL1 | cyclin Y-like 1 | -0.0218815 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0218294 |
| CCND1 | cyclin D1 | -0.0218089 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0217865 |
| FOXK1 | forkhead box K1 | -0.0217462 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0217094 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0216793 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0216019 |
| SEM1 | SEM1 26S proteasome subunit | -0.0215007 |
| PHF14 | PHD finger protein 14 | -0.0214446 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0212192 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.021202 |
| PARD3 | par-3 family cell polarity regulator | -0.0211147 |
| KIAA0319L | KIAA0319-like | -0.0209594 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0208755 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0207674 |
| CLIC4 | chloride intracellular channel 4 | -0.0207416 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0206498 |
| TMEM44 | transmembrane protein 44 | -0.0205623 |
| MED17 | mediator complex subunit 17 | -0.020471 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0204052 |
| PERP | PERP, TP53 apoptosis effector | -0.0203776 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.0203036 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0202508 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0200143 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0199831 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0199219 |
