Pexidartinib (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.11435
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0912791
MACC1 metastasis associated in colon cancer 1 0.0869633
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0820219
FTH1 ferritin, heavy polypeptide 1 0.080071
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0723191
SNX9 sorting nexin 9 0.0702611
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0683726
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0661034
PRELID2 PRELI domain containing 2 0.0630069
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0575299
FAM3C family with sequence similarity 3, member C 0.0520752
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0517071
EEF2 eukaryotic translation elongation factor 2 0.051698
UBE2H ubiquitin-conjugating enzyme E2H 0.0514184
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0499147
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0495932
NCKAP1 NCK-associated protein 1 0.0480249
CTNND1 catenin (cadherin-associated protein), delta 1 0.0466359
CDCP1 CUB domain containing protein 1 0.0451963
COG5 component of oligomeric golgi complex 5 0.0447021
MYO5B myosin VB 0.0443593
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0440262
USP3 ubiquitin specific peptidase 3 0.0435792
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0402314
FAT1 FAT atypical cadherin 1 0.040086
GARS1 glycyl-tRNA synthetase 1 0.0400192
ADAM17 ADAM metallopeptidase domain 17 0.0393795
PLAUR plasminogen activator, urokinase receptor 0.03884
RBM39 RNA binding motif protein 39 0.0384948
EPS8 epidermal growth factor receptor pathway substrate 8 0.038365
EZR ezrin 0.0381853
MYO10 myosin X 0.0381396
LDHA lactate dehydrogenase A 0.0380168
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0375676
KDM7A lysine (K)-specific demethylase 7A 0.0368553
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0367757
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0365734
JMJD1C jumonji domain containing 1C 0.0360822
TMEM123 transmembrane protein 123 0.0346241
MED13L mediator complex subunit 13-like 0.0340858
KMT2C lysine (K)-specific methyltransferase 2C 0.0339607
AFDN afadin, adherens junction formation factor 0.033892
ARHGAP32 Rho GTPase activating protein 32 0.0330671
ZNF292 zinc finger protein 292 0.0328026
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0327514
ARHGAP26 Rho GTPase activating protein 26 0.0321592
RICTOR RPTOR independent companion of MTOR, complex 2 0.0318717
ZNRF3 zinc and ring finger 3 0.0316958
SESTD1 SEC14 and spectrin domains 1 0.0316681
ACTN4 actinin, alpha 4 0.031303
LMTK2 lemur tyrosine kinase 2 0.031211
RNF149 ring finger protein 149 0.0307108
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0299628
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0298846
FXR1 fragile X mental retardation, autosomal homolog 1 0.0296965
TGFBI transforming growth factor, beta-induced, 68kDa 0.0295253
ZFAND6 zinc finger, AN1-type domain 6 0.0293901
ARRDC3 arrestin domain containing 3 0.0290919
TFG TRK-fused gene 0.0286602
FAR1 fatty acyl CoA reductase 1 0.0284862
MYOF myoferlin 0.0283736
PCBP2 poly(rC) binding protein 2 0.0282495
FNDC3B fibronectin type III domain containing 3B 0.0275155
DPY19L1 dpy-19-like 1 (C. elegans) 0.0274441
PTBP3 polypyrimidine tract binding protein 3 0.0270508
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0268503
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0265193
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0263039
PELI1 pellino E3 ubiquitin protein ligase 1 0.0262166
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0257882
PDS5B PDS5 cohesin associated factor B 0.025653
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0256322
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0254729
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0254716
CERS6 ceramide synthase 6 0.0254549
TNPO3 transportin 3 0.025398
PTK2 protein tyrosine kinase 2 0.025342
NBAS neuroblastoma amplified sequence 0.0252298
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0251935
SERINC5 serine incorporator 5 0.0248779
NEK7 NIMA-related kinase 7 0.0247933
PUM2 pumilio RNA-binding family member 2 0.0244716
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0242441
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0241087
ARL5B ADP-ribosylation factor-like 5B 0.0239501
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0238371
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0238131
DENND4C DENN/MADD domain containing 4C 0.0237242
ANXA11 annexin A11 0.0236174
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0233151
UBQLN1 ubiquilin 1 0.023152
RREB1 ras responsive element binding protein 1 0.022975
OSBPL3 oxysterol binding protein-like 3 0.02291
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0228823
CCDC6 coiled-coil domain containing 6 0.0228138
MARCHF6 membrane associated ring-CH-type finger 6 0.0225482
TMEM41B transmembrane protein 41B 0.022537
ITCH itchy E3 ubiquitin protein ligase 0.0225001
STAG2 stromal antigen 2 0.0224978

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.221973
FTL ferritin, light polypeptide -0.106
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102614
TMSB10 thymosin beta 10 -0.0904072
MAML2 mastermind-like 2 (Drosophila) -0.0810522
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0660322
GNAS GNAS complex locus -0.0655242
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0639753
RPS6 ribosomal protein S6 -0.0611072
RPL35A ribosomal protein L35a -0.0605824
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0600929
SDK1 sidekick cell adhesion molecule 1 -0.0591533
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0583888
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0568285
GOLGB1 golgin B1 -0.053507
CANX calnexin -0.0534739
CDK13 cyclin-dependent kinase 13 -0.0531758
INTS6 integrator complex subunit 6 -0.052168
GMDS GDP-mannose 4,6-dehydratase -0.050404
DLG1 discs, large homolog 1 (Drosophila) -0.0501123
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0499049
ACTG1 actin gamma 1 -0.0498787
TPT1 tumor protein, translationally-controlled 1 -0.0462385
SAMD4A sterile alpha motif domain containing 4A -0.0459094
RPLP1 ribosomal protein, large, P1 -0.045759
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0457406
RPS21 ribosomal protein S21 -0.0432955
RPS27A ribosomal protein S27a -0.0431609
NEBL nebulette -0.0405345
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0404292
RPL31 ribosomal protein L31 -0.0394775
EHBP1 EH domain binding protein 1 -0.0391952
IER3 immediate early response 3 -0.0385295
PTPRK protein tyrosine phosphatase, receptor type, K -0.0378933
RPLP2 ribosomal protein, large, P2 -0.0365617
RPS3 ribosomal protein S3 -0.0365072
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0362502
RPL37A ribosomal protein L37a -0.0359366
TOP1 topoisomerase (DNA) I -0.0358628
RIGI RNA sensor RIG-I -0.0351428
NABP1 nucleic acid binding protein 1 -0.0347992
FAM107B family with sequence similarity 107, member B -0.0347314
RPS19 ribosomal protein S19 -0.034523
IFRD1 interferon-related developmental regulator 1 -0.0342279
SMAD3 SMAD family member 3 -0.0333059
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0331776
RPL18 ribosomal protein L18 -0.0331307
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0331156
LMNA lamin A/C -0.0325726
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0324641
RPL12 ribosomal protein L12 -0.0316304
RPS8 ribosomal protein S8 -0.0313821
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0311936
RPL23 ribosomal protein L23 -0.0309744
ZBTB20 zinc finger and BTB domain containing 20 -0.0309519
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0307492
LOC102724023 ES1 protein homolog, mitochondrial -0.0304134
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0301562
NCEH1 neutral cholesterol ester hydrolase 1 -0.0297257
EXT1 exostosin glycosyltransferase 1 -0.0293601
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0292464
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.027789
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.027674
VCL vinculin -0.0271438
SOX4 SRY (sex determining region Y)-box 4 -0.0269777
RPL19 ribosomal protein L19 -0.026791
KDM5B lysine (K)-specific demethylase 5B -0.0267316
PKP4 plakophilin 4 -0.0261727
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0257611
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0256823
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0249911
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0249889
HMGB1 high mobility group box 1 -0.0249688
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0248981
HMGA2 high mobility group AT-hook 2 -0.024865
AHNAK AHNAK nucleoprotein -0.0248453
RPL34 ribosomal protein L34 -0.0247766
THOC2 THO complex 2 -0.0247277
CCND1 cyclin D1 -0.0247174
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0246454
RPS14 ribosomal protein S14 -0.0242103
RTN3 reticulon 3 -0.0241444
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0239802
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0238748
SET SET nuclear proto-oncogene -0.0237213
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0237085
ZBTB38 zinc finger and BTB domain containing 38 -0.0233898
HDLBP high density lipoprotein binding protein -0.0230492
EIF5B eukaryotic translation initiation factor 5B -0.0230382
BZW2 basic leucine zipper and W2 domains 2 -0.0229189
MED13 mediator complex subunit 13 -0.0229014
ASPH aspartate beta-hydroxylase -0.0227734
RPL26 ribosomal protein L26 -0.0223377
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0223368
B2M beta-2-microglobulin -0.0219073
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0218438
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0217752
NKD1 naked cuticle homolog 1 (Drosophila) -0.0217097
HDAC4 histone deacetylase 4 -0.0215773
RPS5 ribosomal protein S5 -0.0215399