Pexidartinib (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pexidartinib (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pexidartinib (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.199249
AREG amphiregulin 0.113784
ANXA1 annexin A1 0.105492
EEF2 eukaryotic translation elongation factor 2 0.104646
LMO7 LIM domain 7 0.0948216
OXR1 oxidation resistance 1 0.0917426
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0894567
FAT1 FAT atypical cadherin 1 0.0860991
RNF43 ring finger protein 43 0.085361
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0852497
PDE4B phosphodiesterase 4B, cAMP-specific 0.0833235
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0790815
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0771253
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0759227
EGFR epidermal growth factor receptor 0.0753305
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0732314
EREG epiregulin 0.0672448
KMT2C lysine (K)-specific methyltransferase 2C 0.0642485
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0622499
RUNX2 runt-related transcription factor 2 0.0621399
GOLGA4 golgin A4 0.0585058
KITLG KIT ligand 0.0583741
ATXN1 ataxin 1 0.0558509
NDRG1 N-myc downstream regulated 1 0.0517098
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0511847
BIRC3 baculoviral IAP repeat containing 3 0.0499654
LDHA lactate dehydrogenase A 0.049803
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0494346
RPS2 ribosomal protein S2 0.0484693
NEK7 NIMA-related kinase 7 0.0451638
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0449724
ZNF292 zinc finger protein 292 0.0442571
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0438573
TOP1 topoisomerase (DNA) I 0.0438038
KDM6A lysine (K)-specific demethylase 6A 0.0436484
MBNL1 muscleblind-like splicing regulator 1 0.0434868
NAMPT nicotinamide phosphoribosyltransferase 0.0422506
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0414568
GARS1 glycyl-tRNA synthetase 1 0.0413565
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.040809
PTBP2 polypyrimidine tract binding protein 2 0.0399966
COG5 component of oligomeric golgi complex 5 0.0391836
STRN3 striatin, calmodulin binding protein 3 0.0391132
AXIN2 axin 2 0.0389148
SLTM SAFB-like, transcription modulator 0.0388958
TXNRD1 thioredoxin reductase 1 0.0386422
PUM2 pumilio RNA-binding family member 2 0.0386026
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0383584
SLMAP sarcolemma associated protein 0.0378685
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0376412
NUP58 nucleoporin 58 0.0372346
ITPRID2 ITPR interacting domain containing 2 0.0371969
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0370865
HILPDA hypoxia inducible lipid droplet-associated 0.0369455
ARRDC3 arrestin domain containing 3 0.0369193
ZMYM2 zinc finger, MYM-type 2 0.0367264
TSC22D2 TSC22 domain family, member 2 0.0363245
RNF145 ring finger protein 145 0.0360249
MSI2 musashi RNA-binding protein 2 0.035742
CLTC clathrin, heavy chain (Hc) 0.0356448
DDIT4 DNA-damage-inducible transcript 4 0.0356022
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0347312
NCKAP1 NCK-associated protein 1 0.0346995
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0337337
FAR1 fatty acyl CoA reductase 1 0.0335892
BBX bobby sox homolog (Drosophila) 0.033395
KTN1 kinectin 1 (kinesin receptor) 0.0333891
ECT2 epithelial cell transforming 2 0.0330386
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0328716
USP6NL USP6 N-terminal like 0.0328604
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0322888
TES testin LIM domain protein 0.0319809
USP3 ubiquitin specific peptidase 3 0.0319549
WAC WW domain containing adaptor with coiled-coil 0.0317216
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0314198
DSCAM Down syndrome cell adhesion molecule 0.0314182
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0311584
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0310798
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0309512
LAMC2 laminin, gamma 2 0.0309145
ESYT2 extended synaptotagmin-like protein 2 0.0303889
RAB6A RAB6A, member RAS oncogene family 0.0300489
MED13L mediator complex subunit 13-like 0.0298125
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.029788
TPR translocated promoter region, nuclear basket protein 0.0294499
RBM39 RNA binding motif protein 39 0.0289634
UBA6 ubiquitin-like modifier activating enzyme 6 0.0288412
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0287065
CENPF centromere protein F, 350/400kDa 0.0283875
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0279788
GPHN gephyrin 0.0277966
EZR ezrin 0.0276273
ARHGAP32 Rho GTPase activating protein 32 0.0276051
NEMF nuclear export mediator factor 0.0275302
SFXN1 sideroflexin 1 0.0274979
OGA O-GlcNAcase 0.0272659
FNDC3A fibronectin type III domain containing 3A 0.0272471
TXNIP thioredoxin interacting protein 0.0268162
NCEH1 neutral cholesterol ester hydrolase 1 0.0267752
PDLIM5 PDZ and LIM domain 5 0.026672

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.122138
ACTG1 actin gamma 1 -0.102629
LAMA4 laminin, alpha 4 -0.0836102
HMGA2 high mobility group AT-hook 2 -0.0812804
RCOR1 REST corepressor 1 -0.0771957
IER3 immediate early response 3 -0.0682754
RPS6 ribosomal protein S6 -0.0658906
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0654579
EGR1 early growth response 1 -0.0566781
FERMT1 fermitin family member 1 -0.0561764
TPT1 tumor protein, translationally-controlled 1 -0.0557021
VCL vinculin -0.0523494
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0467969
MPRIP myosin phosphatase Rho interacting protein -0.038599
GPC5 glypican 5 -0.0384457
CUX1 cut-like homeobox 1 -0.0339775
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0320172
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0307564
S100A6 S100 calcium binding protein A6 -0.0294342
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0292579
RPL35A ribosomal protein L35a -0.0289622
ABR active BCR-related -0.028685
KRT18 keratin 18, type I -0.0286724
AHNAK AHNAK nucleoprotein -0.0280127
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.027644
RPS24 ribosomal protein S24 -0.0275275
CMIP c-Maf inducing protein -0.026372
RPL31 ribosomal protein L31 -0.0262025
LOC102724023 ES1 protein homolog, mitochondrial -0.0255618
ITPKC inositol-trisphosphate 3-kinase C -0.0255581
ITGB4 integrin, beta 4 -0.0250793
RPS13 ribosomal protein S13 -0.0249404
AKAP12 A kinase (PRKA) anchor protein 12 -0.0248187
CD9 CD9 molecule -0.0246731
RPS25 ribosomal protein S25 -0.024502
RPL34 ribosomal protein L34 -0.0241892
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0232897
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0230708
NTSR1 neurotensin receptor 1 (high affinity) -0.0227753
DEK DEK proto-oncogene -0.0222885
SGMS2 sphingomyelin synthase 2 -0.0215995
RPS21 ribosomal protein S21 -0.0215623
TMSB10 thymosin beta 10 -0.0214715
SEPTIN9 septin 9 -0.0211155
RPL8 ribosomal protein L8 -0.0209579
CDK13 cyclin-dependent kinase 13 -0.0208346
GATAD2A GATA zinc finger domain containing 2A -0.0208272
RPS29 ribosomal protein S29 -0.0208193
FLOT1 flotillin 1 -0.0207072
RPS15 ribosomal protein S15 -0.0205973
RPL12 ribosomal protein L12 -0.0203368
CREB5 cAMP responsive element binding protein 5 -0.0202591
ATP5F1B ATP synthase F1 subunit beta -0.020236
FHIT fragile histidine triad -0.0200421
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0198394
FRMD8 FERM domain containing 8 -0.01944
KLK6 kallikrein-related peptidase 6 -0.0191782
PATJ PATJ crumbs cell polarity complex component -0.0187002
HDLBP high density lipoprotein binding protein -0.0183214
RRM2 ribonucleotide reductase M2 -0.0181345
CCND1 cyclin D1 -0.0180097
RPS8 ribosomal protein S8 -0.0177666
LEMD1 LEM domain containing 1 -0.0173988
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0173955
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0169072
RPS23 ribosomal protein S23 -0.0168917
RPS10 ribosomal protein S10 -0.0167745
PCNX4 pecanex 4 -0.0166777
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0166334
KRT19 keratin 19, type I -0.0165672
HDAC4 histone deacetylase 4 -0.0165533
RPS14 ribosomal protein S14 -0.0165122
RPS5 ribosomal protein S5 -0.0165079
RPL38 ribosomal protein L38 -0.0164245
RPL9 ribosomal protein L9 -0.0162359
RPS27A ribosomal protein S27a -0.0161792
RPLP2 ribosomal protein, large, P2 -0.0161706
BICD1 bicaudal D homolog 1 (Drosophila) -0.0159423
RPL19 ribosomal protein L19 -0.015913
CDHR3 cadherin-related family member 3 -0.0158394
RASAL2 RAS protein activator like 2 -0.0155888
AKAP13 A kinase (PRKA) anchor protein 13 -0.0155658
MCL1 myeloid cell leukemia 1 -0.0154917
EHBP1 EH domain binding protein 1 -0.0154499
CANX calnexin -0.0154322
EXOC4 exocyst complex component 4 -0.0153087
HMGB1 high mobility group box 1 -0.0151732
CLCF1 cardiotrophin-like cytokine factor 1 -0.0151148
S100A9 S100 calcium binding protein A9 -0.0150199
SNED1 sushi, nidogen and EGF-like domains 1 -0.0150006
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.014908
KRT8 keratin 8, type II -0.0148382
LSMEM2 leucine-rich single-pass membrane protein 2 -0.0147748
POTEF POTE ankyrin domain family, member F -0.0145458
CLIP2 CAP-GLY domain containing linker protein 2 -0.0144363
SETD5 SET domain containing 5 -0.0143545
KLK10 kallikrein-related peptidase 10 -0.0142194
ZSWIM6 zinc finger, SWIM-type containing 6 -0.013839
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0137961
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0137253