| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.181875 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.165338 |
| WWOX | WW domain containing oxidoreductase | 0.0887574 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0815295 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0765281 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0688235 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0669043 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0650688 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0606201 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0590189 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0552433 |
| CENPF | centromere protein F, 350/400kDa | 0.0529764 |
| NAV2 | neuron navigator 2 | 0.0506009 |
| RUNX1 | runt-related transcription factor 1 | 0.0484718 |
| RAD51B | RAD51 paralog B | 0.0477183 |
| RPS2 | ribosomal protein S2 | 0.0447334 |
| DSPP | dentin sialophosphoprotein | 0.044414 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0439911 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0404003 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0375389 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0348235 |
| MKI67 | marker of proliferation Ki-67 | 0.0346638 |
| PGK1 | phosphoglycerate kinase 1 | 0.0346174 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0337101 |
| LDHA | lactate dehydrogenase A | 0.0331981 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0331657 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0331168 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0320595 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0307428 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0297397 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0296461 |
| PRELID2 | PRELI domain containing 2 | 0.0281324 |
| TNS3 | tensin 3 | 0.0274599 |
| ATXN1 | ataxin 1 | 0.0268842 |
| AOPEP | aminopeptidase O (putative) | 0.0266485 |
| EXOC4 | exocyst complex component 4 | 0.0266161 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0262647 |
| RACK1 | receptor for activated C kinase 1 | 0.0258901 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0250429 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0241588 |
| ECT2 | epithelial cell transforming 2 | 0.0233376 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.023143 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0229858 |
| ACTG1 | actin gamma 1 | 0.0229731 |
| EGR1 | early growth response 1 | 0.0228434 |
| EFNB2 | ephrin-B2 | 0.0228414 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.0227599 |
| ANLN | anillin, actin binding protein | 0.0219686 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0216357 |
| TMEM123 | transmembrane protein 123 | 0.0210246 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0209693 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0209607 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0209362 |
| SET | SET nuclear proto-oncogene | 0.020597 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0204357 |
| DST | dystonin | 0.0203352 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0196962 |
| BMP5 | bone morphogenetic protein 5 | 0.0196284 |
| RPS12 | ribosomal protein S12 | 0.0194763 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0190662 |
| SMYD3 | SET and MYND domain containing 3 | 0.0189504 |
| SMOC2 | SPARC related modular calcium binding 2 | 0.0189218 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0187861 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0187301 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | 0.0187025 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0187012 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0186554 |
| PHF14 | PHD finger protein 14 | 0.0186539 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0185656 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0181319 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0181157 |
| FOXP1 | forkhead box P1 | 0.0180627 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0179057 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0178568 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0175954 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0175504 |
| KLF6 | Kruppel-like factor 6 | 0.0173901 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0173345 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0173189 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0173156 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0172296 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0168725 |
| CDK6 | cyclin-dependent kinase 6 | 0.0168445 |
| CCDC88A | coiled-coil domain containing 88A | 0.0164593 |
| RBM26 | RNA binding motif protein 26 | 0.0164078 |
| SYT1 | synaptotagmin I | 0.0163285 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0162448 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0160792 |
| FLNA | filamin A, alpha | 0.0159121 |
| UTRN | utrophin | 0.0158743 |
| PROX1 | prospero homeobox 1 | 0.015868 |
| AIG1 | androgen-induced 1 | 0.0157749 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0157567 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0157341 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0157296 |
| CDH13 | cadherin 13 | 0.015719 |
| FAT1 | FAT atypical cadherin 1 | 0.0156003 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0155953 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0154542 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0152839 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.129194 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125553 |
| AHNAK | AHNAK nucleoprotein | -0.125075 |
| TMSB10 | thymosin beta 10 | -0.0968317 |
| RPS27A | ribosomal protein S27a | -0.0953625 |
| UBC | ubiquitin C | -0.0866952 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0712445 |
| RPS6 | ribosomal protein S6 | -0.0706711 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0700249 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0589711 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0566148 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0537295 |
| CANX | calnexin | -0.0528676 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0431322 |
| FLNB | filamin B, beta | -0.0424493 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0416401 |
| GOLGA4 | golgin A4 | -0.0408072 |
| RPS13 | ribosomal protein S13 | -0.0398321 |
| RPS24 | ribosomal protein S24 | -0.0388753 |
| ENO1 | enolase 1, (alpha) | -0.0388685 |
| RPL36A | ribosomal protein L36a | -0.0377346 |
| RPS5 | ribosomal protein S5 | -0.0368267 |
| RPLP2 | ribosomal protein, large, P2 | -0.0361064 |
| RPL23 | ribosomal protein L23 | -0.0358888 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0354143 |
| PKM | pyruvate kinase, muscle | -0.0349063 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0347344 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.0345698 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0333372 |
| OGA | O-GlcNAcase | -0.0331753 |
| VMP1 | vacuole membrane protein 1 | -0.0327152 |
| RPS23 | ribosomal protein S23 | -0.0322736 |
| RPS21 | ribosomal protein S21 | -0.0322722 |
| RPS19 | ribosomal protein S19 | -0.0319579 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0315464 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0313668 |
| PCBP2 | poly(rC) binding protein 2 | -0.0308599 |
| RPL7A | ribosomal protein L7a | -0.0302971 |
| RPL8 | ribosomal protein L8 | -0.0294888 |
| SRPK2 | SRSF protein kinase 2 | -0.0291205 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.028911 |
| GLG1 | golgi glycoprotein 1 | -0.0288209 |
| RPS11 | ribosomal protein S11 | -0.0284081 |
| S100A10 | S100 calcium binding protein A10 | -0.0282371 |
| SETD5 | SET domain containing 5 | -0.0280919 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0276646 |
| RPS25 | ribosomal protein S25 | -0.0276013 |
| RPL19 | ribosomal protein L19 | -0.0275942 |
| FTL | ferritin, light polypeptide | -0.0275328 |
| RPS15 | ribosomal protein S15 | -0.0274407 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0269657 |
| RPL31 | ribosomal protein L31 | -0.0268787 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0268698 |
| H1-0 | H1.0 linker histone | -0.0267543 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0266426 |
| VIM | vimentin | -0.0264723 |
| NKTR | natural killer cell triggering receptor | -0.0264642 |
| KRT8 | keratin 8, type II | -0.0264247 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0261028 |
| SDC4 | syndecan 4 | -0.0257927 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0255777 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0253964 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0250146 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0245316 |
| WASF2 | WAS protein family, member 2 | -0.0242228 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0242052 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0238308 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.023805 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0234823 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0232372 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0230423 |
| COG5 | component of oligomeric golgi complex 5 | -0.0227764 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.022717 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0226611 |
| RHOA | ras homolog family member A | -0.0226329 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0225856 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0225017 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0221792 |
| RPL28 | ribosomal protein L28 | -0.0220927 |
| PERP | PERP, TP53 apoptosis effector | -0.0220091 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0217586 |
| UBE3C | ubiquitin protein ligase E3C | -0.021543 |
| RPS10 | ribosomal protein S10 | -0.0214578 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0213616 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0211782 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0210505 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0208704 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0207809 |
| RPL5 | ribosomal protein L5 | -0.0206286 |
| HDLBP | high density lipoprotein binding protein | -0.0205896 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.020569 |
| PDE8A | phosphodiesterase 8A | -0.0205535 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0205324 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0203806 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0203784 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0203368 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0202257 |
| RBM6 | RNA binding motif protein 6 | -0.0201642 |
| RPS29 | ribosomal protein S29 | -0.019909 |
| RHEB | Ras homolog enriched in brain | -0.0198943 |
