| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pexidartinib (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pexidartinib (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.0861803 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0703428 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0618769 |
| NDRG1 | N-myc downstream regulated 1 | 0.0584447 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0578309 |
| FAM13A | family with sequence similarity 13, member A | 0.0566724 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0529143 |
| RUNX1 | runt-related transcription factor 1 | 0.0488404 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0474745 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0416841 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0408828 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0371611 |
| MT2A | metallothionein 2A | 0.0361183 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.035264 |
| ZNF292 | zinc finger protein 292 | 0.0349227 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0346005 |
| SMAD3 | SMAD family member 3 | 0.033282 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.03283 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0303439 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0291416 |
| CENPF | centromere protein F, 350/400kDa | 0.028546 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0279925 |
| FLNA | filamin A, alpha | 0.0276636 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0264278 |
| NAV2 | neuron navigator 2 | 0.0264106 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0260533 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0257702 |
| PTEN | phosphatase and tensin homolog | 0.0255298 |
| RPS12 | ribosomal protein S12 | 0.0254839 |
| NOTCH2 | notch 2 | 0.0254832 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0253308 |
| RPS2 | ribosomal protein S2 | 0.025183 |
| VEGFA | vascular endothelial growth factor A | 0.0251075 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0248321 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0244147 |
| ARRDC3 | arrestin domain containing 3 | 0.0238586 |
| PCBP2 | poly(rC) binding protein 2 | 0.0231669 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0223771 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0223024 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0220182 |
| PFN1 | profilin 1 | 0.0218359 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0216963 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0215926 |
| NUP58 | nucleoporin 58 | 0.0212826 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0210522 |
| YEATS2 | YEATS domain containing 2 | 0.0207307 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0206449 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0206355 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0204131 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0203683 |
| PRELID2 | PRELI domain containing 2 | 0.0203269 |
| MYOF | myoferlin | 0.0202935 |
| ZNF638 | zinc finger protein 638 | 0.0202371 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0196011 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0193198 |
| COL5A2 | collagen, type V, alpha 2 | 0.0191983 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0191315 |
| MSN | moesin | 0.0191278 |
| C1D | C1D nuclear receptor corepressor | 0.0189447 |
| SPAG9 | sperm associated antigen 9 | 0.0184417 |
| METTL15 | methyltransferase like 15 | 0.0183112 |
| RPL37A | ribosomal protein L37a | 0.0178812 |
| LDHA | lactate dehydrogenase A | 0.0178364 |
| TFG | TRK-fused gene | 0.0176283 |
| TNS1 | tensin 1 | 0.0175621 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0175613 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0175509 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0174469 |
| CCNL1 | cyclin L1 | 0.0170512 |
| CUL3 | cullin 3 | 0.0169941 |
| HMGA1 | high mobility group AT-hook 1 | 0.0165857 |
| SET | SET nuclear proto-oncogene | 0.0165773 |
| HELZ | helicase with zinc finger | 0.016369 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0163596 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0161211 |
| RPL23 | ribosomal protein L23 | 0.0161084 |
| MXI1 | MAX interactor 1, dimerization protein | 0.016037 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0159199 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0159069 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0158529 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0156411 |
| KIF5B | kinesin family member 5B | 0.0155991 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0155594 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0155459 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0155218 |
| PKM | pyruvate kinase, muscle | 0.0153162 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0152188 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0151763 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0149868 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0149755 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0149259 |
| OGA | O-GlcNAcase | 0.0146386 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0142671 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0142624 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0142325 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0141424 |
| PLPP3 | phospholipid phosphatase 3 | 0.0141148 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0139373 |
| HMGB2 | high mobility group box 2 | 0.0138427 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0137812 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.255924 |
| INHBA | inhibin, beta A | -0.245663 |
| COL1A1 | collagen, type I, alpha 1 | -0.182919 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.152893 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.151519 |
| MMP1 | matrix metallopeptidase 1 | -0.130495 |
| HMGA2 | high mobility group AT-hook 2 | -0.130088 |
| STC1 | stanniocalcin 1 | -0.121073 |
| AHNAK | AHNAK nucleoprotein | -0.108854 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.102052 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0913219 |
| EMP1 | epithelial membrane protein 1 | -0.0882118 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0863571 |
| COL1A2 | collagen, type I, alpha 2 | -0.0843818 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0790356 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0762472 |
| CAVIN1 | caveolae associated protein 1 | -0.0762188 |
| FN1 | fibronectin 1 | -0.0750095 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0747775 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0703056 |
| FBN1 | fibrillin 1 | -0.0671613 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0654904 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0588366 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0565303 |
| RAI14 | retinoic acid induced 14 | -0.0524085 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0523155 |
| HLA-B | major histocompatibility complex, class I, B | -0.0508185 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0503045 |
| CDH13 | cadherin 13 | -0.0494977 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0456882 |
| CANX | calnexin | -0.0451674 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0436116 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0421175 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.04207 |
| TMSB10 | thymosin beta 10 | -0.0420568 |
| CCND1 | cyclin D1 | -0.041351 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0409939 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0404711 |
| CLMP | CXADR-like membrane protein | -0.0380661 |
| VIM | vimentin | -0.0374276 |
| COL3A1 | collagen, type III, alpha 1 | -0.0372404 |
| PRRX1 | paired related homeobox 1 | -0.0371959 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0370948 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0367696 |
| TPM4 | tropomyosin 4 | -0.0364445 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0357291 |
| HDLBP | high density lipoprotein binding protein | -0.0355468 |
| OXR1 | oxidation resistance 1 | -0.0345459 |
| NPTX1 | neuronal pentraxin I | -0.0339265 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0334841 |
| NCKAP5 | NCK-associated protein 5 | -0.0330019 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0306772 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0302684 |
| H1-0 | H1.0 linker histone | -0.0301158 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0298867 |
| PTMA | prothymosin, alpha | -0.0295617 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0292253 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0291926 |
| DIAPH2 | diaphanous-related formin 2 | -0.0290069 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0289287 |
| MMP12 | matrix metallopeptidase 12 | -0.0284222 |
| MAP1B | microtubule-associated protein 1B | -0.0280593 |
| DNER | delta/notch-like EGF repeat containing | -0.0254961 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0253369 |
| IER3 | immediate early response 3 | -0.0253119 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0250944 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0246474 |
| FSTL1 | follistatin-like 1 | -0.0245345 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0242551 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0242242 |
| KIAA1549L | KIAA1549-like | -0.0238 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0236024 |
| PRSS23 | protease, serine, 23 | -0.0234021 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.0229855 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0227167 |
| HLA-A | major histocompatibility complex, class I, A | -0.0225182 |
| MAP4 | microtubule-associated protein 4 | -0.0215484 |
| ATP13A3 | ATPase type 13A3 | -0.0213765 |
| FRMD4A | FERM domain containing 4A | -0.0213686 |
| TMSB4X | thymosin beta 4, X-linked | -0.0212936 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0211714 |
| HHIP | hedgehog interacting protein | -0.0199875 |
| INSIG1 | insulin induced gene 1 | -0.0198453 |
| FOXP1 | forkhead box P1 | -0.0198122 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0197719 |
| CTSB | cathepsin B | -0.0196868 |
| COL5A3 | collagen, type V, alpha 3 | -0.0196593 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0192877 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0189134 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0188371 |
| COL5A1 | collagen, type V, alpha 1 | -0.0187651 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0182537 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0182367 |
| RRBP1 | ribosome binding protein 1 | -0.0182267 |
| LOXL2 | lysyl oxidase-like 2 | -0.0181518 |
| AEBP2 | AE binding protein 2 | -0.0181084 |
| NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit | -0.0180804 |
| SASH1 | SAM and SH3 domain containing 1 | -0.018 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.017932 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0178116 |
