Phenobarbital Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. (Chemical Entities of Biological Interest Ontology, CHEBI_8069)
External Link http://ctdbase.org/detail.go?type=chem&acc=D010634
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Genes

213 genes/proteins interacting with the chemical Phenobarbital from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACHE acetylcholinesterase (Yt blood group)
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
AHR aryl hydrocarbon receptor
ALB albumin
ANXA1 annexin A1
ANXA2 annexin A2
ANXA4 annexin A4
ANXA5 annexin A5
APOA1 apolipoprotein A-I
APOE apolipoprotein E
ASS1 argininosuccinate synthase 1
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BTBD11 BTB (POZ) domain containing 11
C3 complement component 3
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC134 coiled-coil domain containing 134
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCNE1 cyclin E1
CCR4 chemokine (C-C motif) receptor 4
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDK2 cyclin-dependent kinase 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CES3 carboxylesterase 3
CHN2 chimerin 2
CLSTN2 calsyntenin 2
COX6C cytochrome c oxidase subunit VIc
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CYB5A cytochrome b5 type A (microsomal)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A cytochrome P450, family 3, subfamily A
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCX doublecortin
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DPP10 dipeptidyl-peptidase 10 (non-functional)
EFNB2 ephrin-B2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXOSC2 exosome component 2
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FABP1 fatty acid binding protein 1, liver
FAM84A family with sequence similarity 84, member A
FGF1 fibroblast growth factor 1 (acidic)
FLCN folliculin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXM1 forkhead box M1
G6PD glucose-6-phosphate dehydrogenase
GADL1 glutamate decarboxylase-like 1
GH1 growth hormone 1
GJB1 gap junction protein, beta 1, 32kDa
GJB2 gap junction protein, beta 2, 26kDa
GLB1 galactosidase, beta 1
GLUL glutamate-ammonia ligase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX1 glutathione peroxidase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
GSTA4 glutathione S-transferase alpha 4
GSTA5 glutathione S-transferase alpha 5
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GUSB glucuronidase, beta
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
IGF2R insulin-like growth factor 2 receptor
IGFBP1 insulin-like growth factor binding protein 1
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INS insulin
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LARGE like-glycosyltransferase
LEP leptin
LINGO2 leucine rich repeat and Ig domain containing 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MGST1 microsomal glutathione S-transferase 1
MKI67 marker of proliferation Ki-67
MUC2 mucin 2, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUDCD3 NudC domain containing 3
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OTC ornithine carbamoyltransferase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PDRG1 p53 and DNA-damage regulated 1
PHB prohibitin
PHB2 prohibitin 2
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
PPARA peroxisome proliferator-activated receptor alpha
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRICKLE2 prickle homolog 2 (Drosophila)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCE protein kinase C, epsilon
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RXRA retinoid X receptor, alpha
SCGB2A2 secretoglobin, family 2A, member 2
SEPT9 septin 9
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SIX3 SIX homeobox 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A9 solute carrier family 38, member 9
SOD1 superoxide dismutase 1, soluble
SPATA21 spermatogenesis associated 21
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TBXAS1 thromboxane A synthase 1 (platelet)
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TMEM132D transmembrane protein 132D
TNF tumor necrosis factor
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNK2 tyrosine kinase, non-receptor, 2
TP53 tumor protein p53
TRIO trio Rho guanine nucleotide exchange factor
TSHB thyroid stimulating hormone, beta
TSLIG1 tRNA splicing ligase complex subunit 1
TTLL9 tubulin tyrosine ligase-like family member 9
UGDH UDP-glucose 6-dehydrogenase
UGP2 UDP-glucose pyrophosphorylase 2
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
VEGFA vascular endothelial growth factor A
VIM vimentin
WDR17 WD repeat domain 17
WSCD1 WSC domain containing 1
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZSCAN22 zinc finger and SCAN domain containing 22