| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Phenylephrine (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.235381 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0903283 |
| MMP12 | matrix metallopeptidase 12 | 0.076026 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0640127 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0600562 |
| TMEM41B | transmembrane protein 41B | 0.0457097 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0449719 |
| KIF5B | kinesin family member 5B | 0.0436147 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0429879 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0422575 |
| TXNRD1 | thioredoxin reductase 1 | 0.0389098 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0386534 |
| XPO1 | exportin 1 | 0.037957 |
| TPM3 | tropomyosin 3 | 0.0370206 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0366861 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0349181 |
| ANXA1 | annexin A1 | 0.0330612 |
| BCHE | butyrylcholinesterase | 0.0315645 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0313382 |
| CCNL1 | cyclin L1 | 0.0301767 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0287909 |
| RTN4 | reticulon 4 | 0.0285448 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0277802 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0272818 |
| CLDN1 | claudin 1 | 0.02553 |
| ASPH | aspartate beta-hydroxylase | 0.0246954 |
| CLDND1 | claudin domain containing 1 | 0.0235949 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0231358 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0225458 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0221786 |
| TNPO1 | transportin 1 | 0.0219777 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0218077 |
| IPO7 | importin 7 | 0.0217764 |
| SET | SET nuclear proto-oncogene | 0.0214846 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.021464 |
| IL6ST | interleukin 6 signal transducer | 0.0213176 |
| NEBL | nebulette | 0.0211738 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0209841 |
| SSR1 | signal sequence receptor, alpha | 0.0207141 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0205538 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.020533 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0204782 |
| TPX2 | TPX2, microtubule-associated | 0.0204421 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0203615 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0199575 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0197899 |
| THOC1 | THO complex 1 | 0.0197574 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0197242 |
| MKI67 | marker of proliferation Ki-67 | 0.0193185 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0191103 |
| NEK7 | NIMA-related kinase 7 | 0.0190807 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0189056 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0188577 |
| CEP192 | centrosomal protein 192kDa | 0.0186221 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0184677 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0182823 |
| PNN | pinin, desmosome associated protein | 0.0182635 |
| VMP1 | vacuole membrane protein 1 | 0.0182468 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0180662 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0174702 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0173002 |
| ENAH | enabled homolog (Drosophila) | 0.0170434 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.01701 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0168974 |
| MEMO1 | mediator of cell motility 1 | 0.0168851 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0167095 |
| RAB10 | RAB10, member RAS oncogene family | 0.0166179 |
| TPR | translocated promoter region, nuclear basket protein | 0.0164661 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0164349 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0163513 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0163449 |
| NDC80 | NDC80 kinetochore complex component | 0.0163354 |
| FAT1 | FAT atypical cadherin 1 | 0.0163239 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0162962 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0162943 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0162048 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0161897 |
| NKTR | natural killer cell triggering receptor | 0.0160435 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0160022 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0158726 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0157228 |
| ZNF146 | zinc finger protein 146 | 0.0155353 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0153735 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0153314 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0151778 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0150092 |
| KIAA1328 | KIAA1328 | 0.014758 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0145548 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.014514 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0144148 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 0.0143697 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0143462 |
| CFAP97 | cilia and flagella associated protein 97 | 0.0142826 |
| PANK3 | pantothenate kinase 3 | 0.0142813 |
| AFG3L2 | AFG3-like AAA ATPase 2 | 0.0142615 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0141726 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0141524 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0140977 |
| PGK1 | phosphoglycerate kinase 1 | 0.0139798 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0139789 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.108881 |
| TMSB10 | thymosin beta 10 | -0.100755 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.090713 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0669489 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0656002 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0573118 |
| RPL23 | ribosomal protein L23 | -0.0486035 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0468622 |
| VIM | vimentin | -0.0463765 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0456007 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0447531 |
| RPLP1 | ribosomal protein, large, P1 | -0.0447388 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0433333 |
| FTL | ferritin, light polypeptide | -0.0413379 |
| RPL35A | ribosomal protein L35a | -0.0393556 |
| HMGA2 | high mobility group AT-hook 2 | -0.0373752 |
| RPL36 | ribosomal protein L36 | -0.0354179 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0345296 |
| ZNF804A | zinc finger protein 804A | -0.0339033 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0324793 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0321475 |
| RPS19 | ribosomal protein S19 | -0.0320477 |
| YAP1 | Yes-associated protein 1 | -0.0311715 |
| TPI1 | triosephosphate isomerase 1 | -0.0311103 |
| SYT1 | synaptotagmin I | -0.0305626 |
| RPL26 | ribosomal protein L26 | -0.0299427 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0296635 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0295192 |
| TENM3 | teneurin transmembrane protein 3 | -0.0290381 |
| S100A10 | S100 calcium binding protein A10 | -0.0289522 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0288193 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0286855 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0285271 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0282947 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0279022 |
| ACTG1 | actin gamma 1 | -0.0272367 |
| HMGA1 | high mobility group AT-hook 1 | -0.0271857 |
| CCND1 | cyclin D1 | -0.0271026 |
| RASAL2 | RAS protein activator like 2 | -0.0269094 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0267683 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0264069 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0263779 |
| RPL9 | ribosomal protein L9 | -0.0260331 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0260126 |
| RPL11 | ribosomal protein L11 | -0.0256418 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0254823 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0252448 |
| SQSTM1 | sequestosome 1 | -0.0248632 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0246715 |
| DTNA | dystrobrevin, alpha | -0.0241698 |
| NHSL1 | NHS-like 1 | -0.0240009 |
| NFIB | nuclear factor I/B | -0.023992 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0237919 |
| ETV6 | ets variant 6 | -0.023356 |
| EXOC4 | exocyst complex component 4 | -0.0233527 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0232964 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.022739 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0225118 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0224466 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.022322 |
| FUS | FUS RNA binding protein | -0.0216721 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0216668 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0215882 |
| CUX1 | cut-like homeobox 1 | -0.0211629 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0210958 |
| SSH2 | slingshot protein phosphatase 2 | -0.0210189 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0206283 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.020596 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0205761 |
| RPL31 | ribosomal protein L31 | -0.0204138 |
| SBF2 | SET binding factor 2 | -0.0204136 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0202229 |
| FSTL5 | follistatin-like 5 | -0.0201992 |
| EDARADD | EDAR-associated death domain | -0.0201663 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0200957 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0200381 |
| RPL34 | ribosomal protein L34 | -0.0198093 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0197808 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0197438 |
| RPS14 | ribosomal protein S14 | -0.0196796 |
| RPS6 | ribosomal protein S6 | -0.0196266 |
| GCG | glucagon | -0.0193881 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0193716 |
| GNAS | GNAS complex locus | -0.0192803 |
| CBFB | core-binding factor, beta subunit | -0.0192482 |
| RAD51B | RAD51 paralog B | -0.0191879 |
| RPS5 | ribosomal protein S5 | -0.0191157 |
| PFN1 | profilin 1 | -0.0190973 |
| RPS21 | ribosomal protein S21 | -0.0189605 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0188033 |
| DST | dystonin | -0.0187297 |
| NAV3 | neuron navigator 3 | -0.0184917 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0183798 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0182675 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.018 |
| RPL28 | ribosomal protein L28 | -0.0179572 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0177498 |
| EML6 | echinoderm microtubule associated protein like 6 | -0.0177392 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0176998 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0176864 |
