Phenylephrine (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0756729
PLK2 polo-like kinase 2 0.0662461
TPM3 tropomyosin 3 0.0644167
ATP13A3 ATPase type 13A3 0.0632378
MSN moesin 0.056789
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0566059
GLS2 glutaminase 2 (liver, mitochondrial) 0.0561593
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0554673
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0520397
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0512039
ADAM17 ADAM metallopeptidase domain 17 0.0472229
SPAG9 sperm associated antigen 9 0.0472142
XPO1 exportin 1 0.0457216
ITGAV integrin, alpha V 0.0456782
B2M beta-2-microglobulin 0.0454491
UBA6 ubiquitin-like modifier activating enzyme 6 0.0445138
ARRDC3 arrestin domain containing 3 0.0430017
NRIP1 nuclear receptor interacting protein 1 0.0426929
MARCHF6 membrane associated ring-CH-type finger 6 0.0411647
ANKRD33B ankyrin repeat domain 33B 0.0405895
ACBD3 acyl-CoA binding domain containing 3 0.0402823
NRP2 neuropilin 2 0.0401997
WDR43 WD repeat domain 43 0.0399461
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0399398
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0398604
FMNL2 formin-like 2 0.0396444
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0394307
RIPK2 receptor-interacting serine-threonine kinase 2 0.039345
UGCG UDP-glucose ceramide glucosyltransferase 0.0392386
RB1CC1 RB1-inducible coiled-coil 1 0.0392218
RBM39 RNA binding motif protein 39 0.0386718
BIRC6 baculoviral IAP repeat containing 6 0.0383769
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0382694
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0380756
ZFP36L1 ZFP36 ring finger protein-like 1 0.037462
DDIT4 DNA-damage-inducible transcript 4 0.0370516
DENND4A DENN/MADD domain containing 4A 0.0364729
PDIA3 protein disulfide isomerase family A, member 3 0.0362378
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0358471
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0357497
ANXA5 annexin A5 0.0347496
GOLGA4 golgin A4 0.0344741
ZFAND3 zinc finger, AN1-type domain 3 0.0342854
JMJD1C jumonji domain containing 1C 0.0329142
PAX8 paired box 8 0.0323603
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0323197
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0323012
CCNL1 cyclin L1 0.0318465
CRY1 cryptochrome circadian clock 1 0.0312405
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0310824
NAV2 neuron navigator 2 0.0310806
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0309492
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.030441
MBNL2 muscleblind-like splicing regulator 2 0.0303147
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0301535
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.029865
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0297447
NCKAP1 NCK-associated protein 1 0.0297076
FAT1 FAT atypical cadherin 1 0.0294967
KMT2E lysine (K)-specific methyltransferase 2E 0.0294775
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0293775
ADAM9 ADAM metallopeptidase domain 9 0.0293577
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0292367
SET SET nuclear proto-oncogene 0.0290376
NAP1L1 nucleosome assembly protein 1-like 1 0.0287968
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0283141
WAC WW domain containing adaptor with coiled-coil 0.0278434
SKIC3 SKI3 subunit of superkiller complex 0.0275947
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.027288
SUCO SUN domain containing ossification factor 0.0270683
MYH9 myosin, heavy chain 9, non-muscle 0.0269937
PTK2 protein tyrosine kinase 2 0.0269841
JAK1 Janus kinase 1 0.0266645
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.026639
CHD1 chromodomain helicase DNA binding protein 1 0.026585
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0263895
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0263706
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0263524
TGFB2 transforming growth factor, beta 2 0.0262602
CSF1 colony stimulating factor 1 (macrophage) 0.0262564
FXR1 fragile X mental retardation, autosomal homolog 1 0.0262304
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026082
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0259596
RTN4 reticulon 4 0.0258572
FNDC3B fibronectin type III domain containing 3B 0.0255935
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0252741
ZFC3H1 zinc finger, C3H1-type containing 0.025231
USP3 ubiquitin specific peptidase 3 0.0251263
VMP1 vacuole membrane protein 1 0.0250542
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0249135
SLMAP sarcolemma associated protein 0.0248264
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0248166
ECPAS Ecm29 proteasome adaptor and scaffold 0.0245994
EXT1 exostosin glycosyltransferase 1 0.0244403
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0244106
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0243231
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0242937
BAIAP2L1 BAI1-associated protein 2-like 1 0.0242603
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.023991
COPB1 coatomer protein complex, subunit beta 1 0.0239272

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.138953
IGFBP3 insulin-like growth factor binding protein 3 -0.132836
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1023
VIM vimentin -0.0876187
FRMD4A FERM domain containing 4A -0.0871237
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0709655
HLA-B major histocompatibility complex, class I, B -0.0631564
HIPK2 homeodomain interacting protein kinase 2 -0.0627058
MT2A metallothionein 2A -0.0622816
FTL ferritin, light polypeptide -0.061042
CP ceruloplasmin (ferroxidase) -0.0575738
RPS6 ribosomal protein S6 -0.0571482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0543262
RNF213 ring finger protein 213 -0.0534664
TPT1 tumor protein, translationally-controlled 1 -0.0508932
RRBP1 ribosome binding protein 1 -0.049925
RPLP1 ribosomal protein, large, P1 -0.0497206
RPL35A ribosomal protein L35a -0.0474073
RPL23 ribosomal protein L23 -0.0463059
RPS8 ribosomal protein S8 -0.0459862
RPL26 ribosomal protein L26 -0.0430765
MAP1B microtubule-associated protein 1B -0.0422904
MT1X metallothionein 1X -0.0408112
SP100 SP100 nuclear antigen -0.0404938
EHBP1 EH domain binding protein 1 -0.0397659
GLIS3 GLIS family zinc finger 3 -0.0393951
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0393876
LOC112694756 uncharaterized LOC112694756 -0.0378434
FKBP5 FK506 binding protein 5 -0.0375375
CTSD cathepsin D -0.0370896
TSHZ2 teashirt zinc finger homeobox 2 -0.0364275
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0353795
RIGI RNA sensor RIG-I -0.0349721
RPL34 ribosomal protein L34 -0.033671
PBX1 pre-B-cell leukemia homeobox 1 -0.0329856
PLIN2 perilipin 2 -0.0326971
IFITM3 interferon induced transmembrane protein 3 -0.0326704
EEF2 eukaryotic translation elongation factor 2 -0.0321166
RPS5 ribosomal protein S5 -0.0305303
RPL28 ribosomal protein L28 -0.0302768
HLA-C major histocompatibility complex, class I, C -0.0301829
ZMYND8 zinc finger, MYND-type containing 8 -0.0298705
RPL8 ribosomal protein L8 -0.0297718
CUX1 cut-like homeobox 1 -0.0297349
ARF1 ADP-ribosylation factor 1 -0.0295844
RPL19 ribosomal protein L19 -0.0292524
GPC6 glypican 6 -0.0289986
HMGB1 high mobility group box 1 -0.0289081
ZBTB20 zinc finger and BTB domain containing 20 -0.0288274
S100A10 S100 calcium binding protein A10 -0.0284132
RPL12 ribosomal protein L12 -0.0273074
CAVIN1 caveolae associated protein 1 -0.0272393
RPS14 ribosomal protein S14 -0.0271103
ANXA4 annexin A4 -0.0265759
FLNA filamin A, alpha -0.0255047
RPS20 ribosomal protein S20 -0.025482
CLMP CXADR-like membrane protein -0.0252065
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0250545
LMNA lamin A/C -0.0244559
RPL30 ribosomal protein L30 -0.0240172
RPL31 ribosomal protein L31 -0.0237106
RPLP0 ribosomal protein, large, P0 -0.0236837
ADAR adenosine deaminase, RNA-specific -0.0235509
LDHA lactate dehydrogenase A -0.0233344
RPL9 ribosomal protein L9 -0.0232279
RPL35 ribosomal protein L35 -0.023054
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0228831
RPS24 ribosomal protein S24 -0.0224962
RRM2 ribonucleotide reductase M2 -0.0222619
S100A6 S100 calcium binding protein A6 -0.0219804
HLA-E major histocompatibility complex, class I, E -0.0218381
RPL27A ribosomal protein L27a -0.02167
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0214284
ETV6 ets variant 6 -0.0213651
ICAM1 intercellular adhesion molecule 1 -0.020861
EXOC4 exocyst complex component 4 -0.0206989
RPS21 ribosomal protein S21 -0.020541
SERF2 small EDRK-rich factor 2 -0.0204965
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0204509
LPP LIM domain containing preferred translocation partner in lipoma -0.020443
RPS19 ribosomal protein S19 -0.0202913
FLNC filamin C, gamma -0.0202861
XAF1 XIAP associated factor 1 -0.0201683
ACTG1 actin gamma 1 -0.0201237
TXNRD1 thioredoxin reductase 1 -0.0201
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0198063
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0197838
RACK1 receptor for activated C kinase 1 -0.0196688
RPS15 ribosomal protein S15 -0.0195894
MMP7 matrix metallopeptidase 7 -0.0192087
RPS17 ribosomal protein S17 -0.0191427
UGDH UDP-glucose 6-dehydrogenase -0.0189795
HM13 histocompatibility (minor) 13 -0.0187875
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0187393
SDK1 sidekick cell adhesion molecule 1 -0.018561
GNAS GNAS complex locus -0.0184421
LAMB3 laminin, beta 3 -0.0183872
RPLP2 ribosomal protein, large, P2 -0.0183436
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.018341
RPS16 ribosomal protein S16 -0.0181815