| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Phenylephrine (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.125187 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.118658 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0954361 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0687528 |
| NDRG1 | N-myc downstream regulated 1 | 0.0665964 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0658819 |
| PTMA | prothymosin, alpha | 0.0651663 |
| B2M | beta-2-microglobulin | 0.0576413 |
| GRB7 | growth factor receptor-bound protein 7 | 0.0566486 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0556722 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0536019 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0529061 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0477325 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0467347 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0460878 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0436556 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.0397728 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0391059 |
| ENO1 | enolase 1, (alpha) | 0.0388246 |
| INSIG1 | insulin induced gene 1 | 0.0379453 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0372529 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0370111 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0365214 |
| SLC38A1 | solute carrier family 38, member 1 | 0.036448 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0344638 |
| TMEM165 | transmembrane protein 165 | 0.0338978 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0333231 |
| KIF16B | kinesin family member 16B | 0.0330426 |
| FDPS | farnesyl diphosphate synthase | 0.0329671 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0321073 |
| TPM3 | tropomyosin 3 | 0.031757 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.031403 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | 0.0310375 |
| FOXO3 | forkhead box O3 | 0.0304719 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0298287 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0295065 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0288361 |
| LASP1 | LIM and SH3 protein 1 | 0.0285507 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0276619 |
| TMSB4X | thymosin beta 4, X-linked | 0.0273923 |
| WASL | Wiskott-Aldrich syndrome-like | 0.027237 |
| SET | SET nuclear proto-oncogene | 0.0270752 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0263308 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0262742 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0257905 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.0256743 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0255948 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.0254038 |
| AREG | amphiregulin | 0.0246079 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0244625 |
| FAM13A | family with sequence similarity 13, member A | 0.0242984 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0242486 |
| MSMO1 | methylsterol monooxygenase 1 | 0.023993 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0239463 |
| TOB1 | transducer of ERBB2, 1 | 0.0239334 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0239004 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0233396 |
| SMAD3 | SMAD family member 3 | 0.0230567 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0230024 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0227653 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0223077 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0222653 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0220221 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0219847 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0219727 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0219005 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0215844 |
| TENM2 | teneurin transmembrane protein 2 | 0.0215349 |
| RNF24 | ring finger protein 24 | 0.0215035 |
| USO1 | USO1 vesicle transport factor | 0.0213519 |
| TMEM41B | transmembrane protein 41B | 0.021132 |
| S100A6 | S100 calcium binding protein A6 | 0.0210765 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0209678 |
| ANXA5 | annexin A5 | 0.0209285 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0208018 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.020671 |
| TPD52 | tumor protein D52 | 0.0206132 |
| BBX | bobby sox homolog (Drosophila) | 0.02061 |
| FNBP1 | formin binding protein 1 | 0.0205812 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0199729 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 0.019908 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0198927 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0198346 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0197112 |
| CALR | calreticulin | 0.0197068 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0196795 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0196312 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0195244 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0193527 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.019242 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0192312 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0192035 |
| VEGFA | vascular endothelial growth factor A | 0.0191123 |
| DSTN | destrin (actin depolymerizing factor) | 0.0190872 |
| SEC24A | SEC24 family member A | 0.0189591 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0187825 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0186759 |
| MYO6 | myosin VI | 0.0185363 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0184187 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0184072 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CATSPERB | catsper channel auxiliary subunit beta | -0.142916 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.131076 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.102774 |
| CDK12 | cyclin-dependent kinase 12 | -0.0879132 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0758687 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0719134 |
| CEP250 | centrosomal protein 250kDa | -0.0666095 |
| ACACA | acetyl-CoA carboxylase alpha | -0.062191 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0609017 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0590111 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0552755 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0529646 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0527566 |
| NEBL | nebulette | -0.0509057 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0473306 |
| EFNA5 | ephrin-A5 | -0.046018 |
| RPL23 | ribosomal protein L23 | -0.0455834 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.0453172 |
| PTK2 | protein tyrosine kinase 2 | -0.0453152 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0448929 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.042591 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0423314 |
| S100P | S100 calcium binding protein P | -0.0408033 |
| SHROOM3 | shroom family member 3 | -0.0405344 |
| CLTC | clathrin, heavy chain (Hc) | -0.0402302 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0399268 |
| RUNX1 | runt-related transcription factor 1 | -0.0392512 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.037594 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0365654 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0351243 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0347877 |
| VMP1 | vacuole membrane protein 1 | -0.0338143 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0337859 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0337531 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0333699 |
| EXOC4 | exocyst complex component 4 | -0.0326663 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0324841 |
| RPL19 | ribosomal protein L19 | -0.0320445 |
| WWC1 | WW and C2 domain containing 1 | -0.0319091 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.030726 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0286948 |
| SEPTIN9 | septin 9 | -0.0280786 |
| PATJ | PATJ crumbs cell polarity complex component | -0.028044 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.0279814 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0279234 |
| OSMR | oncostatin M receptor | -0.0278329 |
| UBAP1 | ubiquitin associated protein 1 | -0.0274447 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0267459 |
| OLA1 | Obg-like ATPase 1 | -0.0266519 |
| TMC5 | transmembrane channel-like 5 | -0.0261329 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0258556 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0257598 |
| SMYD3 | SET and MYND domain containing 3 | -0.0254086 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0253837 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0252057 |
| ANXA2 | annexin A2 | -0.0250647 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0246248 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0241709 |
| GLCCI1 | glucocorticoid induced 1 | -0.0240478 |
| CCND1 | cyclin D1 | -0.023948 |
| ASPH | aspartate beta-hydroxylase | -0.0239088 |
| TC2N | tandem C2 domains, nuclear | -0.0234566 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0234506 |
| SGMS1 | sphingomyelin synthase 1 | -0.023193 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0230763 |
| MED13L | mediator complex subunit 13-like | -0.022576 |
| MT2A | metallothionein 2A | -0.0224836 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0222323 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0221648 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.02216 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0220512 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0219798 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0219249 |
| KRT86 | keratin 86, type II | -0.0217024 |
| ARF1 | ADP-ribosylation factor 1 | -0.0216129 |
| ZBTB16 | zinc finger and BTB domain containing 16 | -0.0215437 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0214873 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0214658 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0214069 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.0210164 |
| YAP1 | Yes-associated protein 1 | -0.0207344 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0207276 |
| NTN4 | netrin 4 | -0.0206407 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0203859 |
| DIAPH1 | diaphanous-related formin 1 | -0.0203446 |
| DENND1B | DENN/MADD domain containing 1B | -0.0201838 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0201122 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0200885 |
| GPHN | gephyrin | -0.0200305 |
| SETX | senataxin | -0.0200236 |
| INTS6 | integrator complex subunit 6 | -0.0195998 |
| NFIA | nuclear factor I/A | -0.0193943 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0193923 |
| MCL1 | myeloid cell leukemia 1 | -0.019134 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0189707 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0189394 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0188571 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0187264 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.018469 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | -0.0184309 |
