Phenylephrine (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0886952
COL5A2 collagen, type V, alpha 2 0.081463
NEBL nebulette 0.0790851
NGLY1 N-glycanase 1 0.0771749
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0770639
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0743028
FMNL2 formin-like 2 0.0680496
ZNF292 zinc finger protein 292 0.0634411
ZNF608 zinc finger protein 608 0.0633398
JMJD1C jumonji domain containing 1C 0.0572417
PIAS2 protein inhibitor of activated STAT, 2 0.0526032
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0513805
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0512604
ADGRG6 adhesion G protein-coupled receptor G6 0.050476
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0475379
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0472661
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0469711
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.046923
NFIA nuclear factor I/A 0.0463215
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0461642
ZNF638 zinc finger protein 638 0.0454039
HILPDA hypoxia inducible lipid droplet-associated 0.0453718
ARFGEF3 ARFGEF family member 3 0.0453088
CENPF centromere protein F, 350/400kDa 0.0450274
TOX thymocyte selection-associated high mobility group box 0.0438497
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0435647
USP34 ubiquitin specific peptidase 34 0.0427452
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0425362
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0401264
ATRN attractin 0.0395573
ATP11A ATPase, class VI, type 11A 0.0395454
SRSF4 serine/arginine-rich splicing factor 4 0.0386755
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0381584
SLIT2 slit homolog 2 (Drosophila) 0.0378142
TENM3 teneurin transmembrane protein 3 0.0366978
DST dystonin 0.0360828
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0351594
RAB6A RAB6A, member RAS oncogene family 0.0348736
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0346104
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0341705
SEC63 SEC63 homolog (S. cerevisiae) 0.0338007
SLF1 SMC5-SMC6 complex localization factor 1 0.0337839
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0335958
MED13L mediator complex subunit 13-like 0.0333312
SOX5 SRY (sex determining region Y)-box 5 0.033154
AKAP9 A kinase (PRKA) anchor protein 9 0.0328802
ATXN2 ataxin 2 0.0323536
PDS5B PDS5 cohesin associated factor B 0.0319024
CHD7 chromodomain helicase DNA binding protein 7 0.0318663
PDE8A phosphodiesterase 8A 0.0309874
KMT2C lysine (K)-specific methyltransferase 2C 0.0307082
ZCCHC7 zinc finger, CCHC domain containing 7 0.0303428
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.030223
MED13 mediator complex subunit 13 0.0301653
STRN3 striatin, calmodulin binding protein 3 0.0299872
NRG1 neuregulin 1 0.0298659
PGAP1 post-GPI attachment to proteins 1 0.0293603
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0292422
KDM6A lysine (K)-specific demethylase 6A 0.0287208
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.028593
PCNX1 pecanex 1 0.028407
GYS1 glycogen synthase 1 (muscle) 0.0282943
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281965
SPATS2 spermatogenesis associated, serine-rich 2 0.0280762
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0280037
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.027866
NBEAL1 neurobeachin-like 1 0.0277264
SREBF2 sterol regulatory element binding transcription factor 2 0.0275276
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0273444
ARHGAP32 Rho GTPase activating protein 32 0.0272022
YEATS2 YEATS domain containing 2 0.0270421
THOC2 THO complex 2 0.0269108
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0265892
CELF2 CUGBP, Elav-like family member 2 0.0264434
RLF rearranged L-myc fusion 0.0264117
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0264085
ZEB1 zinc finger E-box binding homeobox 1 0.0263319
EIF4A2 eukaryotic translation initiation factor 4A2 0.0262562
ANKRD36 ankyrin repeat domain 36 0.0262412
JARID2 jumonji, AT rich interactive domain 2 0.0260898
MXI1 MAX interactor 1, dimerization protein 0.0260522
KMT2E lysine (K)-specific methyltransferase 2E 0.0260477
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0259716
HELZ helicase with zinc finger 0.0257774
RPL4 ribosomal protein L4 0.0256944
FXR1 fragile X mental retardation, autosomal homolog 1 0.0256892
ESYT2 extended synaptotagmin-like protein 2 0.0254519
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0253804
GLS2 glutaminase 2 (liver, mitochondrial) 0.0252725
CDK8 cyclin-dependent kinase 8 0.0243868
ACACA acetyl-CoA carboxylase alpha 0.0242477
HDAC9 histone deacetylase 9 0.0238321
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0237839
TASOR2 transcription activation suppressor family member 2 0.0237747
HSPA8 heat shock 70kDa protein 8 0.0237336
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0236864
TOP2B topoisomerase (DNA) II beta 180kDa 0.02354
SCAF11 SR-related CTD-associated factor 11 0.0234423
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0234255
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0234132

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116952
IFI6 interferon, alpha-inducible protein 6 -0.111862
TMSB10 thymosin beta 10 -0.088727
RPS6 ribosomal protein S6 -0.0848418
RAD51B RAD51 paralog B -0.0822038
RPLP1 ribosomal protein, large, P1 -0.0818339
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0797323
NPAS3 neuronal PAS domain protein 3 -0.0778873
RPL28 ribosomal protein L28 -0.0750885
EGR1 early growth response 1 -0.0746192
PTMA prothymosin, alpha -0.0659949
RPS21 ribosomal protein S21 -0.0649646
RPL23 ribosomal protein L23 -0.0641515
ACTG1 actin gamma 1 -0.0623426
RPL37A ribosomal protein L37a -0.061989
RPS19 ribosomal protein S19 -0.0611965
RPL11 ribosomal protein L11 -0.0598012
RPL26 ribosomal protein L26 -0.0570655
RPS8 ribosomal protein S8 -0.055398
RPL34 ribosomal protein L34 -0.054649
RPL36 ribosomal protein L36 -0.054094
RPL13A ribosomal protein L13a -0.0517156
RPLP2 ribosomal protein, large, P2 -0.0503191
RPL32 ribosomal protein L32 -0.0494931
MT2A metallothionein 2A -0.0494929
HMGB1 high mobility group box 1 -0.0481727
RPS29 ribosomal protein S29 -0.0478476
ISG15 ISG15 ubiquitin-like modifier -0.0473674
RPL9 ribosomal protein L9 -0.046398
RPL12 ribosomal protein L12 -0.0460016
RPS24 ribosomal protein S24 -0.045096
RIGI RNA sensor RIG-I -0.0443056
SOX4 SRY (sex determining region Y)-box 4 -0.0432882
TPT1 tumor protein, translationally-controlled 1 -0.0415577
RPL35A ribosomal protein L35a -0.0414571
H1-0 H1.0 linker histone -0.0408332
FBXL7 F-box and leucine-rich repeat protein 7 -0.0402774
TPI1 triosephosphate isomerase 1 -0.0401931
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0400472
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0394806
PDE4D phosphodiesterase 4D, cAMP-specific -0.0393748
EXOC6B exocyst complex component 6B -0.0393665
GNAS GNAS complex locus -0.0392568
PFN1 profilin 1 -0.0382444
RPS16 ribosomal protein S16 -0.038126
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0380166
HLA-B major histocompatibility complex, class I, B -0.0365988
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0365014
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0364099
RPL37 ribosomal protein L37 -0.0361588
RPL5 ribosomal protein L5 -0.0355794
WLS wntless Wnt ligand secretion mediator -0.0353917
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0352377
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.034792
FTL ferritin, light polypeptide -0.0347132
EEF2 eukaryotic translation elongation factor 2 -0.0342163
RPS11 ribosomal protein S11 -0.0341315
MYL12B myosin, light chain 12B, regulatory -0.0340363
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0338073
RPS17 ribosomal protein S17 -0.03373
VCL vinculin -0.032922
NAP1L1 nucleosome assembly protein 1-like 1 -0.0326074
RAP1B RAP1B, member of RAS oncogene family -0.0324524
ZNFX1 zinc finger, NFX1-type containing 1 -0.0318394
RPLP0 ribosomal protein, large, P0 -0.031366
MIDN midnolin -0.0313262
NALF1 NALCN channel auxiliary factor 1 -0.031097
VIM vimentin -0.0310189
ATP5F1E ATP synthase F1 subunit epsilon -0.0308119
RPS28 ribosomal protein S28 -0.030422
RPS15 ribosomal protein S15 -0.0295669
PRRC2B proline-rich coiled-coil 2B -0.0292062
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0287978
TXNRD1 thioredoxin reductase 1 -0.0287823
RBBP6 retinoblastoma binding protein 6 -0.0285645
RPS5 ribosomal protein S5 -0.028487
RRBP1 ribosome binding protein 1 -0.0279068
LOC112694756 uncharaterized LOC112694756 -0.0276851
SEPTIN7 septin 7 -0.0276657
TUBB4B tubulin, beta 4B class IVb -0.0276299
RPL7A ribosomal protein L7a -0.0274339
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0271128
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0265023
PABPN1 poly(A) binding protein, nuclear 1 -0.0264099
RPS27 ribosomal protein S27 -0.0264022
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0263901
RPS3 ribosomal protein S3 -0.0261992
SETX senataxin -0.0260457
BCAS3 breast carcinoma amplified sequence 3 -0.0259146
RPL18 ribosomal protein L18 -0.0257454
RPL27A ribosomal protein L27a -0.0254709
RPL8 ribosomal protein L8 -0.025227
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0250064
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0242275
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0241556
EXT1 exostosin glycosyltransferase 1 -0.0240357
DOCK3 dedicator of cytokinesis 3 -0.0238092
RPL19 ribosomal protein L19 -0.0237571
TUBB tubulin, beta class I -0.0235985
RAB7A RAB7A, member RAS oncogene family -0.0235509