Phenylephrine (hydrochloride)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.170229
NAMPT nicotinamide phosphoribosyltransferase 0.169
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0856145
CD109 CD109 molecule 0.0833584
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0784454
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0782122
CDC73 cell division cycle 73 0.0768045
KMT2E lysine (K)-specific methyltransferase 2E 0.0763806
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0699043
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0638998
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0606171
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0590564
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0572769
EPS8 epidermal growth factor receptor pathway substrate 8 0.0559955
ZNF292 zinc finger protein 292 0.0543369
HELZ helicase with zinc finger 0.0515298
FNDC3B fibronectin type III domain containing 3B 0.051244
RNF145 ring finger protein 145 0.0472933
APP amyloid beta (A4) precursor protein 0.046738
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0459618
SPRED1 sprouty-related, EVH1 domain containing 1 0.0452702
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0441416
RBM33 RNA binding motif protein 33 0.0440512
PGK1 phosphoglycerate kinase 1 0.0435601
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0404939
A2M alpha-2-macroglobulin 0.0395536
NUP58 nucleoporin 58 0.0388941
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0384016
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0381013
TNNC1 troponin C type 1 (slow) 0.0380663
RLF rearranged L-myc fusion 0.0379413
MRTFA myocardin related transcription factor A 0.0377441
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0365391
AHR aryl hydrocarbon receptor 0.0362899
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0357974
BIRC2 baculoviral IAP repeat containing 2 0.0355978
VMP1 vacuole membrane protein 1 0.0351739
PI15 peptidase inhibitor 15 0.0350906
WWTR1 WW domain containing transcription regulator 1 0.03459
LEF1 lymphoid enhancer-binding factor 1 0.0342941
SRPK2 SRSF protein kinase 2 0.0337825
MED13L mediator complex subunit 13-like 0.0334857
NEK7 NIMA-related kinase 7 0.0334748
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0332615
RICTOR RPTOR independent companion of MTOR, complex 2 0.0331902
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0324728
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0324055
DSCAM Down syndrome cell adhesion molecule 0.0314978
KDM3A lysine (K)-specific demethylase 3A 0.0313708
FOXJ3 forkhead box J3 0.0302718
PNPLA8 patatin-like phospholipase domain containing 8 0.0300163
RAD23B RAD23 homolog B (S. cerevisiae) 0.0299087
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0295888
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0292398
PUM1 pumilio RNA-binding family member 1 0.0291508
INSIG2 insulin induced gene 2 0.0289673
NOP58 NOP58 ribonucleoprotein 0.0289551
SYPL1 synaptophysin-like 1 0.0285988
HBP1 HMG-box transcription factor 1 0.0282827
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0281414
RAD21 RAD21 homolog (S. pombe) 0.0274618
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0271497
CCNL1 cyclin L1 0.0270245
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0268212
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0266901
CHSY1 chondroitin sulfate synthase 1 0.0262854
ARRDC3 arrestin domain containing 3 0.0262666
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0259544
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.025614
PPME1 protein phosphatase methylesterase 1 0.0244998
ICAM1 intercellular adhesion molecule 1 0.0242306
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0238685
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0237069
STRN3 striatin, calmodulin binding protein 3 0.0236826
XPO1 exportin 1 0.0232969
RAB8B RAB8B, member RAS oncogene family 0.0232292
PHF21A PHD finger protein 21A 0.0230849
MATR3 matrin 3 0.0229927
IFI16 interferon, gamma-inducible protein 16 0.0228983
PUM2 pumilio RNA-binding family member 2 0.0228262
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0227256
GSK3B glycogen synthase kinase 3 beta 0.0226151
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0225863
NPEPPS aminopeptidase puromycin sensitive 0.0225298
GTF2I general transcription factor IIi 0.0219937
RBM39 RNA binding motif protein 39 0.0219443
CD59 CD59 molecule, complement regulatory protein 0.0218273
TM9SF3 transmembrane 9 superfamily member 3 0.0217321
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0216771
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0215659
IL6ST interleukin 6 signal transducer 0.0215091
ATP13A3 ATPase type 13A3 0.0214572
YBX3 Y box binding protein 3 0.0213546
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0213333
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0213177
RNMT RNA (guanine-7-) methyltransferase 0.0212439
KDM6A lysine (K)-specific demethylase 6A 0.021017
RCAN1 regulator of calcineurin 1 0.0208897
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0208889
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0208607

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.322043
VIM vimentin -0.193756
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.13638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115456
TMSB10 thymosin beta 10 -0.113713
MT2A metallothionein 2A -0.102433
HLA-B major histocompatibility complex, class I, B -0.10049
NLGN1 neuroligin 1 -0.0839859
PTMA prothymosin, alpha -0.0824772
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0658525
HILPDA hypoxia inducible lipid droplet-associated -0.0642792
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0641984
CALD1 caldesmon 1 -0.0620998
RPL37A ribosomal protein L37a -0.0596011
FTL ferritin, light polypeptide -0.0566561
RPLP1 ribosomal protein, large, P1 -0.0553617
RPS8 ribosomal protein S8 -0.0543886
AKAP12 A kinase (PRKA) anchor protein 12 -0.0538451
AKAP9 A kinase (PRKA) anchor protein 9 -0.0535243
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0533579
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0528973
PTCHD4 patched domain containing 4 -0.0502174
TRIM2 tripartite motif containing 2 -0.0501843
GDF15 growth differentiation factor 15 -0.0497549
CUX1 cut-like homeobox 1 -0.0497425
RPL35A ribosomal protein L35a -0.048356
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0465484
EGR1 early growth response 1 -0.0456073
IGFBP5 insulin-like growth factor binding protein 5 -0.0447753
ACTG1 actin gamma 1 -0.0447716
LDHA lactate dehydrogenase A -0.0443578
CALR calreticulin -0.0436196
ENO2 enolase 2 (gamma, neuronal) -0.0433046
TBC1D22A TBC1 domain family, member 22A -0.0423507
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0409422
RPS6 ribosomal protein S6 -0.040084
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0381793
NPAS2 neuronal PAS domain protein 2 -0.0378765
NDRG1 N-myc downstream regulated 1 -0.0378519
CENPF centromere protein F, 350/400kDa -0.0372911
S100A6 S100 calcium binding protein A6 -0.0365039
CALU calumenin -0.0364663
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0359276
GPC6 glypican 6 -0.0358717
RPL9 ribosomal protein L9 -0.0358336
VGF VGF nerve growth factor inducible -0.0358176
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0349649
POTEF POTE ankyrin domain family, member F -0.0334927
TLE4 transducin-like enhancer of split 4 -0.0334519
RPS23 ribosomal protein S23 -0.0331939
MAML3 mastermind-like 3 (Drosophila) -0.032898
S100A10 S100 calcium binding protein A10 -0.0327487
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0327009
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0324133
ZSWIM6 zinc finger, SWIM-type containing 6 -0.032222
NRCAM neuronal cell adhesion molecule -0.0321651
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0315494
TPT1 tumor protein, translationally-controlled 1 -0.0315259
RPS19 ribosomal protein S19 -0.0313708
HSPB1 heat shock 27kDa protein 1 -0.0310186
IRS2 insulin receptor substrate 2 -0.0306221
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0305411
EEF2 eukaryotic translation elongation factor 2 -0.0305054
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0297648
RPS13 ribosomal protein S13 -0.0296445
CYB5R3 cytochrome b5 reductase 3 -0.029486
S100A9 S100 calcium binding protein A9 -0.0293761
CABIN1 calcineurin binding protein 1 -0.0293105
LMNA lamin A/C -0.0289918
CTSD cathepsin D -0.0289216
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0287176
VDAC1 voltage-dependent anion channel 1 -0.0286749
RPLP2 ribosomal protein, large, P2 -0.0281583
IFITM3 interferon induced transmembrane protein 3 -0.0273949
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0271646
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0271509
IFI6 interferon, alpha-inducible protein 6 -0.0270411
PDIA4 protein disulfide isomerase family A, member 4 -0.0268107
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0266084
PLIN2 perilipin 2 -0.0265135
MRPS6 mitochondrial ribosomal protein S6 -0.0264661
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.026194
RPL28 ribosomal protein L28 -0.0255277
ATF4 activating transcription factor 4 -0.0253321
FHIT fragile histidine triad -0.0252001
PARVB parvin, beta -0.0251634
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0251266
BZW2 basic leucine zipper and W2 domains 2 -0.0250169
IGF2 insulin-like growth factor 2 -0.0247144
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0241305
NAV3 neuron navigator 3 -0.0240421
KTN1 kinectin 1 (kinesin receptor) -0.0239429
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0239211
RPL19 ribosomal protein L19 -0.0237421
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0237055
TAGLN2 transgelin 2 -0.0236821
RPS15 ribosomal protein S15 -0.0236337
NAV1 neuron navigator 1 -0.0235813
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0234354
ANO10 anoctamin 10 -0.0234157