Phenylephrine (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0653742
APP amyloid beta (A4) precursor protein 0.0635804
ZNF292 zinc finger protein 292 0.0593612
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0491735
TMSB4X thymosin beta 4, X-linked 0.0471981
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0440457
MATR3 matrin 3 0.0430061
FXR1 fragile X mental retardation, autosomal homolog 1 0.0425515
WAC WW domain containing adaptor with coiled-coil 0.041149
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0406266
ANKRD10 ankyrin repeat domain 10 0.0399747
KDM3A lysine (K)-specific demethylase 3A 0.0393748
RNF145 ring finger protein 145 0.0387522
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0373394
CCNL1 cyclin L1 0.0368929
NCKAP1 NCK-associated protein 1 0.0365515
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0363703
AHNAK AHNAK nucleoprotein 0.0349845
USP9X ubiquitin specific peptidase 9, X-linked 0.034636
KMT2E lysine (K)-specific methyltransferase 2E 0.0315937
OGA O-GlcNAcase 0.0311796
SLMAP sarcolemma associated protein 0.030643
PGK1 phosphoglycerate kinase 1 0.0304816
KIF5B kinesin family member 5B 0.0298043
NPEPPS aminopeptidase puromycin sensitive 0.0296874
CDC73 cell division cycle 73 0.0293296
BHLHE40 basic helix-loop-helix family, member e40 0.0292751
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0292339
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.029215
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0291671
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0289722
EIF4A2 eukaryotic translation initiation factor 4A2 0.0280381
TOP2B topoisomerase (DNA) II beta 180kDa 0.0280219
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0276208
TNPO1 transportin 1 0.0274628
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0268045
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0266096
PUM1 pumilio RNA-binding family member 1 0.0263278
AFDN afadin, adherens junction formation factor 0.0259758
PDS5B PDS5 cohesin associated factor B 0.0259604
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0256286
PTBP2 polypyrimidine tract binding protein 2 0.0251622
RBM39 RNA binding motif protein 39 0.0249151
RTN4 reticulon 4 0.0247313
IPO7 importin 7 0.0229687
SPOPL speckle-type POZ protein-like 0.0227549
RSL1D1 ribosomal L1 domain containing 1 0.0226168
KDM6A lysine (K)-specific demethylase 6A 0.0225937
RAD23B RAD23 homolog B (S. cerevisiae) 0.0225246
ZNF148 zinc finger protein 148 0.0224775
PAWR PRKC, apoptosis, WT1, regulator 0.0223601
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0223565
PUM2 pumilio RNA-binding family member 2 0.0222095
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.022008
NDFIP1 Nedd4 family interacting protein 1 0.0219155
SET SET nuclear proto-oncogene 0.0217948
CCNT2 cyclin T2 0.0216845
RLF rearranged L-myc fusion 0.0214963
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0213243
USP3 ubiquitin specific peptidase 3 0.0213066
RPL14 ribosomal protein L14 0.021062
RANBP2 RAN binding protein 2 0.0210132
FUBP1 far upstream element (FUSE) binding protein 1 0.0208856
XPO1 exportin 1 0.0208835
TM9SF3 transmembrane 9 superfamily member 3 0.0208678
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0206938
CSDE1 cold shock domain containing E1, RNA-binding 0.0206368
WDR43 WD repeat domain 43 0.0206242
B2M beta-2-microglobulin 0.0203206
CCNY cyclin Y 0.0202652
FNBP1L formin binding protein 1-like 0.0202444
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0202279
CAMTA1 calmodulin binding transcription activator 1 0.0202015
NCOR1 nuclear receptor corepressor 1 0.0200898
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.020044
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0198246
NEK7 NIMA-related kinase 7 0.0198038
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0197974
NAMPT nicotinamide phosphoribosyltransferase 0.0196858
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0196801
EMP1 epithelial membrane protein 1 0.0196105
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0195236
CLINT1 clathrin interactor 1 0.0194379
HELZ helicase with zinc finger 0.0193528
OSBPL9 oxysterol binding protein-like 9 0.0192253
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.019185
LAMB3 laminin, beta 3 0.0190544
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0190343
MARCHF6 membrane associated ring-CH-type finger 6 0.0189156
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0188973
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0188957
PNN pinin, desmosome associated protein 0.0188904
JMJD1C jumonji domain containing 1C 0.0188826
PAPOLA poly(A) polymerase alpha 0.0186905
CUL3 cullin 3 0.018566
MTF2 metal response element binding transcription factor 2 0.0185128
TRA2A transformer 2 alpha homolog (Drosophila) 0.0185084
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0184507
FAM13B family with sequence similarity 13, member B 0.0184345
HDAC2 histone deacetylase 2 0.0182988

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.211005
TMSB10 thymosin beta 10 -0.114515
MT2A metallothionein 2A -0.108594
FTL ferritin, light polypeptide -0.0970425
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.091806
NDRG1 N-myc downstream regulated 1 -0.0744992
RPL35A ribosomal protein L35a -0.0651818
ACTG1 actin gamma 1 -0.061214
RPS6 ribosomal protein S6 -0.0553796
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0515923
PKM pyruvate kinase, muscle -0.0504409
POTEF POTE ankyrin domain family, member F -0.049323
CCND1 cyclin D1 -0.0479035
RPL31 ribosomal protein L31 -0.0478254
RPS8 ribosomal protein S8 -0.0477631
HMGA1 high mobility group AT-hook 1 -0.0466285
IGFBP3 insulin-like growth factor binding protein 3 -0.0455036
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0429523
RAD51B RAD51 paralog B -0.0427656
RPS19 ribosomal protein S19 -0.0410035
LDHA lactate dehydrogenase A -0.0397257
RPL23 ribosomal protein L23 -0.0375676
RPL28 ribosomal protein L28 -0.0362641
LOC112694756 uncharaterized LOC112694756 -0.0360584
RPL9 ribosomal protein L9 -0.0349086
RPLP1 ribosomal protein, large, P1 -0.0345194
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0343777
BPTF bromodomain PHD finger transcription factor -0.0340206
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0339698
ENO1 enolase 1, (alpha) -0.0337333
EEF2 eukaryotic translation elongation factor 2 -0.0319056
S100A10 S100 calcium binding protein A10 -0.0318427
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0318414
EGFR epidermal growth factor receptor -0.0312302
ZBTB20 zinc finger and BTB domain containing 20 -0.0311485
RPS29 ribosomal protein S29 -0.0308435
FLNA filamin A, alpha -0.0307196
TPT1 tumor protein, translationally-controlled 1 -0.0300811
FLNB filamin B, beta -0.0299183
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0294299
RPS14 ribosomal protein S14 -0.0293772
MACROD2 MACRO domain containing 2 -0.0290923
RPL12 ribosomal protein L12 -0.0289439
RPL37A ribosomal protein L37a -0.0287762
RPS16 ribosomal protein S16 -0.0276396
RACK1 receptor for activated C kinase 1 -0.0276141
VDAC1 voltage-dependent anion channel 1 -0.0271393
RPS11 ribosomal protein S11 -0.0269015
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0267929
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0259244
RPL19 ribosomal protein L19 -0.025904
TTC3 tetratricopeptide repeat domain 3 -0.0257898
SVIL supervillin -0.0254398
RPS23 ribosomal protein S23 -0.025162
CDCP1 CUB domain containing protein 1 -0.0245226
RPS17 ribosomal protein S17 -0.0241385
RPS10 ribosomal protein S10 -0.0241302
RPLP2 ribosomal protein, large, P2 -0.0240736
RPL34 ribosomal protein L34 -0.0240177
ENO2 enolase 2 (gamma, neuronal) -0.0240154
RPS12 ribosomal protein S12 -0.0238088
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.023785
S100A6 S100 calcium binding protein A6 -0.023591
TPI1 triosephosphate isomerase 1 -0.0227558
RPS5 ribosomal protein S5 -0.0226079
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0215884
EGR1 early growth response 1 -0.0213106
FNDC3B fibronectin type III domain containing 3B -0.0211384
RPL37 ribosomal protein L37 -0.0209004
GOLGB1 golgin B1 -0.0205186
RPL7A ribosomal protein L7a -0.020424
PRELID2 PRELI domain containing 2 -0.0202833
RPS15 ribosomal protein S15 -0.0202676
INTS6 integrator complex subunit 6 -0.0202617
DLC1 DLC1 Rho GTPase activating protein -0.020067
RPL27 ribosomal protein L27 -0.0200057
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0199567
SEPTIN9 septin 9 -0.019906
RPS25 ribosomal protein S25 -0.0198459
RPL36 ribosomal protein L36 -0.0198103
ATXN1 ataxin 1 -0.0196499
OSBPL10 oxysterol binding protein-like 10 -0.0194699
RPL11 ribosomal protein L11 -0.0192715
TUBB4B tubulin, beta 4B class IVb -0.0192235
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0191556
HM13 histocompatibility (minor) 13 -0.0189982
RPS24 ribosomal protein S24 -0.0188158
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0186572
PAX8 paired box 8 -0.0184671
WWOX WW domain containing oxidoreductase -0.0184182
ZFHX3 zinc finger homeobox 3 -0.0182979
FHIT fragile histidine triad -0.0182869
TPM4 tropomyosin 4 -0.0182067
AKAP9 A kinase (PRKA) anchor protein 9 -0.0180394
S100A9 S100 calcium binding protein A9 -0.0178192
BBS9 Bardet-Biedl syndrome 9 -0.017697
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0176263
RPS13 ribosomal protein S13 -0.0175343
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0175296
RPS20 ribosomal protein S20 -0.017522