Phenylephrine (hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.0527076
ERRFI1 ERBB receptor feedback inhibitor 1 0.051347
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0425148
ASPH aspartate beta-hydroxylase 0.0366333
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0364422
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0334955
MSN moesin 0.0322953
CDCP1 CUB domain containing protein 1 0.0301532
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0294441
CENPF centromere protein F, 350/400kDa 0.0293378
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0284677
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0279683
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.025259
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.025112
STC1 stanniocalcin 1 0.0250905
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0239489
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0231185
ANTXR2 anthrax toxin receptor 2 0.0222946
RASA2 RAS p21 protein activator 2 0.0219237
PGK1 phosphoglycerate kinase 1 0.0215544
TUBB6 tubulin, beta 6 class V 0.0215109
ZNF148 zinc finger protein 148 0.0214408
RFWD3 ring finger and WD repeat domain 3 0.0210762
CKAP5 cytoskeleton associated protein 5 0.020463
NGLY1 N-glycanase 1 0.0200591
VMP1 vacuole membrane protein 1 0.0198981
TPX2 TPX2, microtubule-associated 0.0197514
RB1CC1 RB1-inducible coiled-coil 1 0.0195489
TM4SF1 transmembrane 4 L six family member 1 0.0195194
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0193018
TPM3 tropomyosin 3 0.0190362
TRIO trio Rho guanine nucleotide exchange factor 0.0190041
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0187167
MYO10 myosin X 0.0180089
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0179307
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0178181
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.017811
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0177635
KIF5B kinesin family member 5B 0.0174781
DIAPH3 diaphanous-related formin 3 0.017367
PLAUR plasminogen activator, urokinase receptor 0.0166341
CLIC4 chloride intracellular channel 4 0.0165311
MKI67 marker of proliferation Ki-67 0.016517
MIS18BP1 MIS18 binding protein 1 0.0157046
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0155026
RTN4 reticulon 4 0.0151019
SMC4 structural maintenance of chromosomes 4 0.0149042
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0148627
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0146837
ZC3H11A zinc finger CCCH-type containing 11A 0.0145212
CEP95 centrosomal protein 95kDa 0.0144679
SON SON DNA binding protein 0.0144296
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0144237
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0142448
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0142115
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0141685
CDC27 cell division cycle 27 0.0140473
HIPK3 homeodomain interacting protein kinase 3 0.0139398
KIF18B kinesin family member 18B 0.0139359
NDC80 NDC80 kinetochore complex component 0.013913
CHD1 chromodomain helicase DNA binding protein 1 0.0138741
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0135149
AKAP12 A kinase (PRKA) anchor protein 12 0.0134987
TOP1 topoisomerase (DNA) I 0.0134691
CENPE centromere protein E, 312kDa 0.0134074
COL4A1 collagen, type IV, alpha 1 0.0133306
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0133232
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0132682
KIF4A kinesin family member 4A 0.0130937
RRM2 ribonucleotide reductase M2 0.0130933
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0130525
RICTOR RPTOR independent companion of MTOR, complex 2 0.0128944
RNF145 ring finger protein 145 0.0128286
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0127034
SMAP1 small ArfGAP 1 0.0125737
SPRED1 sprouty-related, EVH1 domain containing 1 0.0125651
ANLN anillin, actin binding protein 0.0124734
ECT2 epithelial cell transforming 2 0.0123495
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0123096
BUB3 BUB3 mitotic checkpoint protein 0.0123002
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0122472
CCNL1 cyclin L1 0.0121892
CLTC clathrin, heavy chain (Hc) 0.0121827
ZFC3H1 zinc finger, C3H1-type containing 0.0121783
SRRM1 serine/arginine repetitive matrix 1 0.0121166
KIAA1549L KIAA1549-like 0.0119711
CRLS1 cardiolipin synthase 1 0.0119418
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0118562
SFPQ splicing factor proline/glutamine-rich 0.0118549
KIF11 kinesin family member 11 0.0118342
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0117585
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0117467
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0116878
RBM39 RNA binding motif protein 39 0.0116308
CENPC centromere protein C 0.0116165
ITPRID2 ITPR interacting domain containing 2 0.0115682
CEP350 centrosomal protein 350kDa 0.0115146
EGR1 early growth response 1 0.0114802
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0113719
BCAR3 breast cancer anti-estrogen resistance 3 0.0113527

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.503929
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144448
TMSB10 thymosin beta 10 -0.125046
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117099
MT2A metallothionein 2A -0.109644
FN1 fibronectin 1 -0.0900912
VIM vimentin -0.0874541
PTMA prothymosin, alpha -0.0806386
RPLP1 ribosomal protein, large, P1 -0.0653953
FTL ferritin, light polypeptide -0.0608138
IER3 immediate early response 3 -0.0564256
NDRG1 N-myc downstream regulated 1 -0.055822
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0516886
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0490876
LOC112694756 uncharaterized LOC112694756 -0.0488181
RPL12 ribosomal protein L12 -0.0486926
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0468507
LOX lysyl oxidase -0.0446946
RPS6 ribosomal protein S6 -0.0441183
CDH13 cadherin 13 -0.0423426
FAM13A family with sequence similarity 13, member A -0.0408999
CCND1 cyclin D1 -0.0399671
RPS8 ribosomal protein S8 -0.0390662
ANXA2 annexin A2 -0.0383302
RPL23 ribosomal protein L23 -0.0381287
TPT1 tumor protein, translationally-controlled 1 -0.0371751
FNDC3B fibronectin type III domain containing 3B -0.0366792
RPL28 ribosomal protein L28 -0.0350556
RPS19 ribosomal protein S19 -0.0345421
WSB1 WD repeat and SOCS box containing 1 -0.034119
YBX1 Y box binding protein 1 -0.0338947
IGFBP3 insulin-like growth factor binding protein 3 -0.0336267
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0334007
RUNX1 runt-related transcription factor 1 -0.0331373
RPS20 ribosomal protein S20 -0.0330115
ACTG1 actin gamma 1 -0.032144
ADM adrenomedullin -0.0315538
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0311252
COL5A1 collagen, type V, alpha 1 -0.030903
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0307734
EFNA5 ephrin-A5 -0.0305532
RPL35A ribosomal protein L35a -0.0304443
S100A10 S100 calcium binding protein A10 -0.0300745
RLF rearranged L-myc fusion -0.0297022
GNAS GNAS complex locus -0.0296317
HMGA2 high mobility group AT-hook 2 -0.0287929
RPS14 ribosomal protein S14 -0.0287415
TGFBI transforming growth factor, beta-induced, 68kDa -0.0283263
JUN jun proto-oncogene -0.0283198
FTH1 ferritin, heavy polypeptide 1 -0.0279983
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0278188
HDLBP high density lipoprotein binding protein -0.0273312
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0272459
IRS2 insulin receptor substrate 2 -0.0270788
CANX calnexin -0.0268019
PCBP3 poly(rC) binding protein 3 -0.0267642
RPL19 ribosomal protein L19 -0.0265834
RACK1 receptor for activated C kinase 1 -0.0263755
PKM pyruvate kinase, muscle -0.0262377
RPLP2 ribosomal protein, large, P2 -0.02507
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.024637
RAB1A RAB1A, member RAS oncogene family -0.0245703
RPS24 ribosomal protein S24 -0.0245143
USP3 ubiquitin specific peptidase 3 -0.02433
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0241509
RPS16 ribosomal protein S16 -0.0241385
TGFB1 transforming growth factor, beta 1 -0.0238321
FAM162A family with sequence similarity 162, member A -0.0236066
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0235159
ZNF292 zinc finger protein 292 -0.0234611
RPL9 ribosomal protein L9 -0.0233809
FLNA filamin A, alpha -0.0230217
ASTN2 astrotactin 2 -0.0228781
RPL7 ribosomal protein L7 -0.0227929
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0226894
LMNA lamin A/C -0.0224976
RPLP0 ribosomal protein, large, P0 -0.022467
RPL34 ribosomal protein L34 -0.0224294
RPL8 ribosomal protein L8 -0.0221256
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0219157
HM13 histocompatibility (minor) 13 -0.0218072
UGCG UDP-glucose ceramide glucosyltransferase -0.0216066
EEF2 eukaryotic translation elongation factor 2 -0.0215466
SQSTM1 sequestosome 1 -0.0215449
MYOF myoferlin -0.0211539
INTS6 integrator complex subunit 6 -0.0209839
HILPDA hypoxia inducible lipid droplet-associated -0.020583
LDHA lactate dehydrogenase A -0.0205702
RPS27A ribosomal protein S27a -0.0205642
NAV1 neuron navigator 1 -0.020501
BTG1 B-cell translocation gene 1, anti-proliferative -0.0204663
IGF1R insulin-like growth factor 1 receptor -0.0204069
KDM3A lysine (K)-specific demethylase 3A -0.0203034
RPL37 ribosomal protein L37 -0.0199943
CAVIN1 caveolae associated protein 1 -0.0199135
HIP1 huntingtin interacting protein 1 -0.0198982
RPL30 ribosomal protein L30 -0.0198585
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0195356
ANKRD11 ankyrin repeat domain 11 -0.019454
GLIS3 GLIS family zinc finger 3 -0.0193833