| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Phenylephrine (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.146311 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.134436 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.120742 |
| MT2A | metallothionein 2A | 0.09805 |
| STC1 | stanniocalcin 1 | 0.0913916 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0816778 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0768829 |
| MT1X | metallothionein 1X | 0.0742244 |
| VCAN | versican | 0.0695686 |
| LOX | lysyl oxidase | 0.0652267 |
| ATP13A3 | ATPase type 13A3 | 0.0640871 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0596403 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0536144 |
| CANX | calnexin | 0.0491428 |
| B2M | beta-2-microglobulin | 0.0488087 |
| CALR | calreticulin | 0.0476425 |
| COL1A2 | collagen, type I, alpha 2 | 0.0455656 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0447624 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0422106 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0412675 |
| TMF1 | TATA element modulatory factor 1 | 0.0412472 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0410223 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.040691 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0402825 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0396798 |
| TPM4 | tropomyosin 4 | 0.0383531 |
| ARRDC3 | arrestin domain containing 3 | 0.0381941 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0376157 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0362044 |
| CD109 | CD109 molecule | 0.0354184 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0347703 |
| ENO1 | enolase 1, (alpha) | 0.0346861 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0345054 |
| SETD5 | SET domain containing 5 | 0.0339586 |
| ADM | adrenomedullin | 0.033461 |
| TBC1D23 | TBC1 domain family, member 23 | 0.033405 |
| RBM39 | RNA binding motif protein 39 | 0.0325255 |
| GOLGA4 | golgin A4 | 0.031314 |
| POSTN | periostin, osteoblast specific factor | 0.0309703 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0303521 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0286689 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0285815 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.028073 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0276649 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0275182 |
| COL3A1 | collagen, type III, alpha 1 | 0.0274707 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0268458 |
| VMP1 | vacuole membrane protein 1 | 0.0260579 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0257029 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0254109 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.025069 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0248434 |
| FBN1 | fibrillin 1 | 0.0245301 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0241314 |
| ARF4 | ADP-ribosylation factor 4 | 0.0233806 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0232291 |
| SFTPA2 | surfactant protein A2 | 0.0230705 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0229692 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0227462 |
| DCAF13 | DDB1 and CUL4 associated factor 13 | 0.0227456 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0226501 |
| MLEC | malectin | 0.0225541 |
| WASHC4 | WASH complex subunit 4 | 0.0224144 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0223143 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0223049 |
| TPM2 | tropomyosin 2 (beta) | 0.0221612 |
| INSIG2 | insulin induced gene 2 | 0.0221333 |
| MSN | moesin | 0.0221241 |
| SUCO | SUN domain containing ossification factor | 0.0220717 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0218788 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0218685 |
| NKTR | natural killer cell triggering receptor | 0.0215858 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0213702 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0213004 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0211504 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0209467 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0208396 |
| FAM107B | family with sequence similarity 107, member B | 0.0207921 |
| NBAS | neuroblastoma amplified sequence | 0.0207175 |
| COG6 | component of oligomeric golgi complex 6 | 0.0207091 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0206082 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0202111 |
| MAP4 | microtubule-associated protein 4 | 0.0201428 |
| CCNL1 | cyclin L1 | 0.0200746 |
| VIRMA | vir like m6A methyltransferase associated | 0.0200729 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0200183 |
| WASF2 | WAS protein family, member 2 | 0.0197932 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0197319 |
| SEC24A | SEC24 family member A | 0.0196895 |
| TPM3 | tropomyosin 3 | 0.0195659 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0195279 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0194853 |
| FNIP1 | folliculin interacting protein 1 | 0.0194759 |
| AHNAK | AHNAK nucleoprotein | 0.0194585 |
| TMEM165 | transmembrane protein 165 | 0.0194284 |
| HYOU1 | hypoxia up-regulated 1 | 0.0194135 |
| JAK1 | Janus kinase 1 | 0.0192259 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0191568 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0190749 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.0189896 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.298298 |
| COL1A1 | collagen, type I, alpha 1 | -0.112964 |
| NDRG1 | N-myc downstream regulated 1 | -0.103655 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.102026 |
| TMSB10 | thymosin beta 10 | -0.0875753 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0855647 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0850344 |
| CDH13 | cadherin 13 | -0.0832182 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0668219 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0603511 |
| RPL35A | ribosomal protein L35a | -0.0600082 |
| CD44 | CD44 molecule (Indian blood group) | -0.0599337 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0561421 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0546017 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0543687 |
| PLEC | plectin | -0.0453065 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0443616 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0435338 |
| OSMR | oncostatin M receptor | -0.0430146 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0429627 |
| RIGI | RNA sensor RIG-I | -0.0407559 |
| ASPH | aspartate beta-hydroxylase | -0.0401036 |
| GLIS3 | GLIS family zinc finger 3 | -0.0398005 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0393728 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0390912 |
| RRBP1 | ribosome binding protein 1 | -0.0386499 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0365455 |
| COL5A1 | collagen, type V, alpha 1 | -0.0357965 |
| PDE10A | phosphodiesterase 10A | -0.0352652 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0348707 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0338651 |
| NAV1 | neuron navigator 1 | -0.0335491 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0335289 |
| RACK1 | receptor for activated C kinase 1 | -0.0333173 |
| FLNA | filamin A, alpha | -0.0329769 |
| RUNX1 | runt-related transcription factor 1 | -0.0323748 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0313062 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0311948 |
| RPL26 | ribosomal protein L26 | -0.0305576 |
| HLA-B | major histocompatibility complex, class I, B | -0.0300116 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0296405 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0292283 |
| MAP1B | microtubule-associated protein 1B | -0.0284105 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.028137 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0273866 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0273003 |
| RPL30 | ribosomal protein L30 | -0.02713 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0269343 |
| CNTN5 | contactin 5 | -0.0267804 |
| RPL12 | ribosomal protein L12 | -0.0265007 |
| RPL28 | ribosomal protein L28 | -0.0264303 |
| RTN4 | reticulon 4 | -0.0263732 |
| RPLP0 | ribosomal protein, large, P0 | -0.0259368 |
| ACTG1 | actin gamma 1 | -0.0256542 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.025468 |
| RPS6 | ribosomal protein S6 | -0.0243326 |
| CALD1 | caldesmon 1 | -0.0242927 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0241007 |
| RPLP1 | ribosomal protein, large, P1 | -0.0239886 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0239385 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0238495 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0234389 |
| VIM | vimentin | -0.0234012 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0231476 |
| NAV3 | neuron navigator 3 | -0.0231435 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0228573 |
| RPS8 | ribosomal protein S8 | -0.0227185 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0224041 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.022296 |
| PRELID2 | PRELI domain containing 2 | -0.0222784 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0221517 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0220892 |
| SVIL | supervillin | -0.021832 |
| ATXN1 | ataxin 1 | -0.0216858 |
| RPL35 | ribosomal protein L35 | -0.0215033 |
| KIAA1217 | KIAA1217 | -0.0213886 |
| RPL23 | ribosomal protein L23 | -0.0212903 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0212294 |
| RPL8 | ribosomal protein L8 | -0.0211487 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0210125 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0209645 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0207625 |
| SP100 | SP100 nuclear antigen | -0.0205086 |
| RPL9 | ribosomal protein L9 | -0.0203145 |
| CAVIN1 | caveolae associated protein 1 | -0.020288 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0202222 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0201617 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.020029 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0196005 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0195659 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0195456 |
| IL6 | interleukin 6 | -0.0193604 |
| RPL36 | ribosomal protein L36 | -0.0193048 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0189422 |
| ARF1 | ADP-ribosylation factor 1 | -0.0187134 |
| VCL | vinculin | -0.018658 |
| TENM3 | teneurin transmembrane protein 3 | -0.01864 |
| RPL13A | ribosomal protein L13a | -0.0185848 |
| RPL11 | ribosomal protein L11 | -0.0185792 |
| SMYD3 | SET and MYND domain containing 3 | -0.018425 |
