Phenylephrine (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.194601
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.11218
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0841319
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0804234
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0799314
ENO1 enolase 1, (alpha) 0.0728569
TF transferrin 0.0712549
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0677786
ZNF292 zinc finger protein 292 0.0570296
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0564034
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0563993
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0527804
DSPP dentin sialophosphoprotein 0.0510779
FBF1 Fas (TNFRSF6) binding factor 1 0.0508593
FNDC3B fibronectin type III domain containing 3B 0.0484648
CCNL1 cyclin L1 0.0465618
INSIG2 insulin induced gene 2 0.0465093
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0454496
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0439061
CPE carboxypeptidase E 0.042523
ESYT2 extended synaptotagmin-like protein 2 0.0419263
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0410341
PCGF5 polycomb group ring finger 5 0.0406626
GRK3 G protein-coupled receptor kinase 3 0.0401282
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0401009
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0395445
RAB6A RAB6A, member RAS oncogene family 0.039285
AFDN afadin, adherens junction formation factor 0.0391667
DDIT4 DNA-damage-inducible transcript 4 0.0390795
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.038945
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0388085
BHLHE40 basic helix-loop-helix family, member e40 0.0363313
PLIN2 perilipin 2 0.0348662
ARRDC3 arrestin domain containing 3 0.0342114
FAM13A family with sequence similarity 13, member A 0.0341962
ELL2 elongation factor, RNA polymerase II, 2 0.0340412
FGG fibrinogen gamma chain 0.0331732
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0329016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0324245
CANX calnexin 0.0322757
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0322332
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0320905
DSCAM Down syndrome cell adhesion molecule 0.0315061
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0312096
PDE8A phosphodiesterase 8A 0.0311459
CFB complement factor B 0.0311092
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0302374
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0301997
NDRG1 N-myc downstream regulated 1 0.0301187
KDM3A lysine (K)-specific demethylase 3A 0.0293728
RNF149 ring finger protein 149 0.0285048
IPO5 importin 5 0.0283272
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0282659
MXI1 MAX interactor 1, dimerization protein 0.0278699
SRRM1 serine/arginine repetitive matrix 1 0.0278394
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0276843
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0272519
AHSG alpha-2-HS-glycoprotein 0.026846
MTSS1 metastasis suppressor 1 0.0267827
KIF1B kinesin family member 1B 0.0266691
EIF4B eukaryotic translation initiation factor 4B 0.0263444
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0255738
BBX bobby sox homolog (Drosophila) 0.0253653
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0250618
SCAF11 SR-related CTD-associated factor 11 0.0250498
KMT2E lysine (K)-specific methyltransferase 2E 0.0248846
UBA6 ubiquitin-like modifier activating enzyme 6 0.0248273
RYBP RING1 and YY1 binding protein 0.0247903
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0247093
MAP2K1 mitogen-activated protein kinase kinase 1 0.0246901
RICTOR RPTOR independent companion of MTOR, complex 2 0.0245354
LCOR ligand dependent nuclear receptor corepressor 0.0243719
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0242633
PDS5B PDS5 cohesin associated factor B 0.0242147
HELZ helicase with zinc finger 0.0241531
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0241053
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0238713
STRN3 striatin, calmodulin binding protein 3 0.0237576
ADM adrenomedullin 0.0237466
RIOK3 RIO kinase 3 0.0235251
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0235124
PIAS2 protein inhibitor of activated STAT, 2 0.0234444
ARFGEF3 ARFGEF family member 3 0.0233141
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0232561
OXR1 oxidation resistance 1 0.0230744
SMAP1 small ArfGAP 1 0.0230003
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0228423
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0228104
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.0225822
TOR1AIP2 torsin A interacting protein 2 0.0224457
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0223862
SELENOP selenoprotein P 0.0223237
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0223055
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0220912
HOOK2 hook microtubule-tethering protein 2 0.0219968
RANBP9 RAN binding protein 9 0.0219521
TNS1 tensin 1 0.021731
PDIA3 protein disulfide isomerase family A, member 3 0.0214163
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0211273
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0211179

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.148607
NKD1 naked cuticle homolog 1 (Drosophila) -0.141084
IGF2 insulin-like growth factor 2 -0.127342
C3 complement component 3 -0.11901
EHBP1 EH domain binding protein 1 -0.0988083
SAMD4A sterile alpha motif domain containing 4A -0.0976227
GPC6 glypican 6 -0.0954556
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0884923
NPAS2 neuronal PAS domain protein 2 -0.0823082
MAML2 mastermind-like 2 (Drosophila) -0.0809828
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0798216
DLC1 DLC1 Rho GTPase activating protein -0.0763103
PTCHD4 patched domain containing 4 -0.0721321
TM4SF1 transmembrane 4 L six family member 1 -0.0719357
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0691796
VCL vinculin -0.0684384
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0668028
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0661222
BCL2L1 BCL2-like 1 -0.0660727
ATXN1 ataxin 1 -0.0638997
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0638828
EXT1 exostosin glycosyltransferase 1 -0.0636006
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0630621
DST dystonin -0.0601193
LMCD1 LIM and cysteine-rich domains 1 -0.0598587
MT2A metallothionein 2A -0.0573834
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0555862
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0548247
DNAH17 dynein, axonemal, heavy chain 17 -0.0543346
FRMD5 FERM domain containing 5 -0.0533483
EGR1 early growth response 1 -0.0529353
RPLP1 ribosomal protein, large, P1 -0.0510562
UBASH3B ubiquitin associated and SH3 domain containing B -0.0469476
SMAD3 SMAD family member 3 -0.0462245
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0461213
ZBTB20 zinc finger and BTB domain containing 20 -0.045904
DOCK4 dedicator of cytokinesis 4 -0.0452859
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0442892
PATJ PATJ crumbs cell polarity complex component -0.0434162
STK17A serine/threonine kinase 17a -0.0432971
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0430887
TIMP1 TIMP metallopeptidase inhibitor 1 -0.042859
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0426459
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0425949
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.042158
FAM107B family with sequence similarity 107, member B -0.0409918
PEG3 paternally expressed 3 -0.0398211
ITGAV integrin, alpha V -0.0388414
MRTFA myocardin related transcription factor A -0.0379533
KRT23 keratin 23, type I -0.0375912
CP ceruloplasmin (ferroxidase) -0.0375902
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0368756
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0358201
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0357363
FILIP1L filamin A interacting protein 1-like -0.0355462
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0352438
PDGFB platelet-derived growth factor beta polypeptide -0.0339071
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0338945
PTPRF protein tyrosine phosphatase, receptor type, F -0.0334969
MBNL2 muscleblind-like splicing regulator 2 -0.033283
KLF6 Kruppel-like factor 6 -0.0330912
HDAC4 histone deacetylase 4 -0.0326347
LRMDA leucine rich melanocyte differentiation associated -0.0322327
TRIO trio Rho guanine nucleotide exchange factor -0.0319753
MAPK8 mitogen-activated protein kinase 8 -0.0318816
OSBPL10 oxysterol binding protein-like 10 -0.031853
FAM135A family with sequence similarity 135, member A -0.0309065
TMSB10 thymosin beta 10 -0.0307982
RNF213 ring finger protein 213 -0.0307202
COMMD10 COMM domain containing 10 -0.0307098
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0302759
ITGB5 integrin, beta 5 -0.0301162
SEPTIN9 septin 9 -0.0300058
SVIL supervillin -0.0299894
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0297421
TBC1D22A TBC1 domain family, member 22A -0.0296001
RPL35A ribosomal protein L35a -0.0294876
ZFAND3 zinc finger, AN1-type domain 3 -0.0294639
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0292802
CLTC clathrin, heavy chain (Hc) -0.0292592
RPS24 ribosomal protein S24 -0.0291577
CCDC146 coiled-coil domain containing 146 -0.0290047
LOC112694756 uncharaterized LOC112694756 -0.0285414
RUNX1 runt-related transcription factor 1 -0.0284656
TPM1 tropomyosin 1 (alpha) -0.0284218
PRRC2B proline-rich coiled-coil 2B -0.0284115
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0283201
THBS1 thrombospondin 1 -0.0282884
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0282654
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0280779
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0279223
PTPRK protein tyrosine phosphatase, receptor type, K -0.0277354
CNKSR3 CNKSR family member 3 -0.027655
RIGI RNA sensor RIG-I -0.0274632
GNAS GNAS complex locus -0.0273645
RRBP1 ribosome binding protein 1 -0.0272382
GPC3 glypican 3 -0.0266163
IGF1R insulin-like growth factor 1 receptor -0.0264307
CLIP2 CAP-GLY domain containing linker protein 2 -0.026367
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0263456