| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Phenylephrine (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.131318 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.125883 |
| VCL | vinculin | 0.0784261 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0693768 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.066824 |
| CALB1 | calbindin 1, 28kDa | 0.0662734 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0657627 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0651323 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0642264 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0596965 |
| TXNRD1 | thioredoxin reductase 1 | 0.0561291 |
| EZR | ezrin | 0.0561137 |
| RPL4 | ribosomal protein L4 | 0.0551959 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0543426 |
| DSPP | dentin sialophosphoprotein | 0.0540088 |
| FLNB | filamin B, beta | 0.0539796 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0514497 |
| CANX | calnexin | 0.0493607 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0443969 |
| GOLGA4 | golgin A4 | 0.0442148 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0437239 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0435692 |
| SHROOM3 | shroom family member 3 | 0.0432787 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0426536 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0421868 |
| LMO7 | LIM domain 7 | 0.0419025 |
| AREG | amphiregulin | 0.0395612 |
| EREG | epiregulin | 0.0384604 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0376777 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0372318 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0369975 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0354722 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0351689 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0350306 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0349948 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0348319 |
| YME1L1 | YME1-like 1 ATPase | 0.0347231 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0336473 |
| PTEN | phosphatase and tensin homolog | 0.0335696 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.033331 |
| MYO6 | myosin VI | 0.032542 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0325159 |
| OGA | O-GlcNAcase | 0.0324848 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0324049 |
| CALU | calumenin | 0.0316387 |
| ATXN1 | ataxin 1 | 0.0312735 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.031031 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0308039 |
| ITGA6 | integrin, alpha 6 | 0.0299563 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.0295919 |
| TJP1 | tight junction protein 1 | 0.0295135 |
| TRIM31 | tripartite motif containing 31 | 0.0289362 |
| PGK1 | phosphoglycerate kinase 1 | 0.0288275 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0284227 |
| TSPAN8 | tetraspanin 8 | 0.0282257 |
| TMF1 | TATA element modulatory factor 1 | 0.028102 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0278809 |
| FAT1 | FAT atypical cadherin 1 | 0.0277588 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.027676 |
| LRRC1 | leucine rich repeat containing 1 | 0.0275275 |
| KIF5B | kinesin family member 5B | 0.0273854 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0272347 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0271721 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0270564 |
| SUCO | SUN domain containing ossification factor | 0.0265093 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0263771 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.026359 |
| AFDN | afadin, adherens junction formation factor | 0.0259661 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0259213 |
| XPOT | exportin, tRNA | 0.0258341 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0257625 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0256639 |
| DSG3 | desmoglein 3 | 0.0253218 |
| ACTN4 | actinin, alpha 4 | 0.0251101 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0250645 |
| USP34 | ubiquitin specific peptidase 34 | 0.0249234 |
| USP15 | ubiquitin specific peptidase 15 | 0.0249169 |
| CLTC | clathrin, heavy chain (Hc) | 0.0247032 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0245819 |
| CORO1C | coronin, actin binding protein, 1C | 0.0245036 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0243483 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0243138 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0237079 |
| FOXO1 | forkhead box O1 | 0.0236607 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0235263 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0232591 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0232336 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0230961 |
| GLG1 | golgi glycoprotein 1 | 0.0230141 |
| PHF3 | PHD finger protein 3 | 0.022971 |
| SRP54 | signal recognition particle 54kDa | 0.0229232 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0228373 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.022533 |
| CCNG1 | cyclin G1 | 0.0223865 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0223564 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0221251 |
| TMEM41B | transmembrane protein 41B | 0.0215288 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0214402 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0214164 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0213763 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPLP1 | ribosomal protein, large, P1 | -0.0925144 |
| RPS6 | ribosomal protein S6 | -0.0871018 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0860849 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0828549 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0688322 |
| TMSB10 | thymosin beta 10 | -0.0622076 |
| RPL23 | ribosomal protein L23 | -0.048859 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0459524 |
| CTBP2 | C-terminal binding protein 2 | -0.0440651 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0430142 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0410752 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0405585 |
| PTMA | prothymosin, alpha | -0.0390937 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0383971 |
| RPL37A | ribosomal protein L37a | -0.0379502 |
| RPS19 | ribosomal protein S19 | -0.0364398 |
| RPS14 | ribosomal protein S14 | -0.0354398 |
| SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative) | -0.034611 |
| RPL34 | ribosomal protein L34 | -0.0343768 |
| MSI2 | musashi RNA-binding protein 2 | -0.033178 |
| RPS17 | ribosomal protein S17 | -0.0325663 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0314175 |
| RPS24 | ribosomal protein S24 | -0.0310183 |
| RPS8 | ribosomal protein S8 | -0.0301279 |
| MT2A | metallothionein 2A | -0.0300479 |
| RPLP2 | ribosomal protein, large, P2 | -0.0299423 |
| RPL35A | ribosomal protein L35a | -0.0295481 |
| HMGA1 | high mobility group AT-hook 1 | -0.0295238 |
| RPL28 | ribosomal protein L28 | -0.0284843 |
| RPS29 | ribosomal protein S29 | -0.0284315 |
| RPL36 | ribosomal protein L36 | -0.0280768 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0278968 |
| PCBP2 | poly(rC) binding protein 2 | -0.0273814 |
| RPS20 | ribosomal protein S20 | -0.0270563 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0260477 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0259084 |
| SPON1 | spondin 1, extracellular matrix protein | -0.0255358 |
| S100A9 | S100 calcium binding protein A9 | -0.0254169 |
| WWOX | WW domain containing oxidoreductase | -0.0251563 |
| RPS25 | ribosomal protein S25 | -0.0251077 |
| RPS3 | ribosomal protein S3 | -0.0247891 |
| CUX1 | cut-like homeobox 1 | -0.0246922 |
| RPL9 | ribosomal protein L9 | -0.0246282 |
| RPS23 | ribosomal protein S23 | -0.0244667 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0228083 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0224787 |
| ITGB4 | integrin, beta 4 | -0.0224316 |
| DIAPH1 | diaphanous-related formin 1 | -0.0223356 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0216776 |
| RPS21 | ribosomal protein S21 | -0.0216638 |
| POTEF | POTE ankyrin domain family, member F | -0.0212076 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0207827 |
| FOXP1 | forkhead box P1 | -0.0205911 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0204885 |
| RPL31 | ribosomal protein L31 | -0.0204674 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0202095 |
| PYGB | phosphorylase, glycogen; brain | -0.020208 |
| RAD51B | RAD51 paralog B | -0.0201398 |
| SP100 | SP100 nuclear antigen | -0.0200327 |
| RPL35 | ribosomal protein L35 | -0.019974 |
| NRXN3 | neurexin 3 | -0.0195946 |
| RPS11 | ribosomal protein S11 | -0.0191905 |
| RPL38 | ribosomal protein L38 | -0.0189176 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0186401 |
| FOXK1 | forkhead box K1 | -0.0185594 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0185286 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0184561 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0182614 |
| GNAS | GNAS complex locus | -0.0182576 |
| NPSR1 | neuropeptide S receptor 1 | -0.0180798 |
| YBX1 | Y box binding protein 1 | -0.0179921 |
| RACK1 | receptor for activated C kinase 1 | -0.0176608 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0176384 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0175704 |
| RCOR1 | REST corepressor 1 | -0.0174786 |
| RPS12 | ribosomal protein S12 | -0.0174776 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0174626 |
| RPL19 | ribosomal protein L19 | -0.0171859 |
| FRMD5 | FERM domain containing 5 | -0.0171541 |
| RPL13A | ribosomal protein L13a | -0.0170967 |
| RPS5 | ribosomal protein S5 | -0.0170467 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0168119 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0167016 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0161601 |
| MX1 | MX dynamin-like GTPase 1 | -0.0161037 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0160195 |
| NABP1 | nucleic acid binding protein 1 | -0.0156471 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0156281 |
| RPL27 | ribosomal protein L27 | -0.0155959 |
| OLA1 | Obg-like ATPase 1 | -0.0154311 |
| ADAR | adenosine deaminase, RNA-specific | -0.0154019 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0153952 |
| GAB2 | GRB2-associated binding protein 2 | -0.0153544 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0151055 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0151029 |
| EGR1 | early growth response 1 | -0.0150232 |
| RBM25 | RNA binding motif protein 25 | -0.0148231 |
| FHIT | fragile histidine triad | -0.0148066 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0147435 |
| RPL36A | ribosomal protein L36a | -0.0147189 |
