Phenylephrine (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0595974
SPAG9 sperm associated antigen 9 0.0591427
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0523817
DSCAM Down syndrome cell adhesion molecule 0.0370023
RNF145 ring finger protein 145 0.0360092
GCLC glutamate-cysteine ligase, catalytic subunit 0.0347542
NAMPT nicotinamide phosphoribosyltransferase 0.0332972
ERRFI1 ERBB receptor feedback inhibitor 1 0.0311334
CCNL1 cyclin L1 0.0297515
FNIP1 folliculin interacting protein 1 0.0295604
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0293011
FAM13A family with sequence similarity 13, member A 0.0287569
ARRDC3 arrestin domain containing 3 0.0282174
ADAM17 ADAM metallopeptidase domain 17 0.0280353
USP34 ubiquitin specific peptidase 34 0.0272848
SOD2 superoxide dismutase 2, mitochondrial 0.0256774
RICTOR RPTOR independent companion of MTOR, complex 2 0.0256205
JMJD1C jumonji domain containing 1C 0.0248171
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0240149
MCTP1 multiple C2 domains, transmembrane 1 0.0236301
DENND4A DENN/MADD domain containing 4A 0.022854
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0228047
USP9X ubiquitin specific peptidase 9, X-linked 0.0222215
AGO2 argonaute RISC catalytic component 2 0.0221719
PUM2 pumilio RNA-binding family member 2 0.0219913
NPC1 Niemann-Pick disease, type C1 0.0218483
ZC3H11A zinc finger CCCH-type containing 11A 0.0215182
NGLY1 N-glycanase 1 0.021472
BIRC3 baculoviral IAP repeat containing 3 0.0205552
ANKRD10 ankyrin repeat domain 10 0.020341
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0199946
CAMTA1 calmodulin binding transcription activator 1 0.0199392
MKI67 marker of proliferation Ki-67 0.0194842
MSMO1 methylsterol monooxygenase 1 0.0194727
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0194644
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0194083
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0187902
ATG14 autophagy related 14 0.0184531
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0182524
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0181238
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0178677
ARL5B ADP-ribosylation factor-like 5B 0.0177177
MARF1 meiosis regulator and mRNA stability factor 1 0.0175179
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0174096
ARGLU1 arginine and glutamate rich 1 0.0171963
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0170918
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0170347
RAP1B RAP1B, member of RAS oncogene family 0.0169316
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0167682
ZC3H15 zinc finger CCCH-type containing 15 0.0167366
TXNRD1 thioredoxin reductase 1 0.0166938
B2M beta-2-microglobulin 0.0165729
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0164645
KTN1 kinectin 1 (kinesin receptor) 0.0160959
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0160662
KDM6A lysine (K)-specific demethylase 6A 0.0159967
MYO1B myosin IB 0.0154883
GLS2 glutaminase 2 (liver, mitochondrial) 0.0154841
CCNH cyclin H 0.0150781
PAPOLA poly(A) polymerase alpha 0.0150767
USP53 ubiquitin specific peptidase 53 0.0150451
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0149676
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0146183
SUCO SUN domain containing ossification factor 0.0145891
ZFC3H1 zinc finger, C3H1-type containing 0.014475
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0142445
NDE1 nudE neurodevelopment protein 1 0.0136632
MYO6 myosin VI 0.0134866
VMP1 vacuole membrane protein 1 0.0134233
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.0132793
CUL3 cullin 3 0.013204
BIRC2 baculoviral IAP repeat containing 2 0.0131683
SERINC3 serine incorporator 3 0.0131669
CHD1 chromodomain helicase DNA binding protein 1 0.013125
ITPRID2 ITPR interacting domain containing 2 0.013114
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.01311
ESYT2 extended synaptotagmin-like protein 2 0.0130592
TENT5A terminal nucleotidyltransferase 5A 0.0130471
NSUN6 NOP2/Sun domain family, member 6 0.0128299
SRSF5 serine/arginine-rich splicing factor 5 0.0127379
GSK3B glycogen synthase kinase 3 beta 0.0126966
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0125817
AGFG1 ArfGAP with FG repeats 1 0.0124544
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0123335
NUP58 nucleoporin 58 0.0122859
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0122456
UBA6 ubiquitin-like modifier activating enzyme 6 0.0121189
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0120547
NCKAP1 NCK-associated protein 1 0.0119856
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0119782
ABLIM1 actin binding LIM protein 1 0.0119021
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0117477
KIAA1217 KIAA1217 0.0117296
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0116459
NCOA3 nuclear receptor coactivator 3 0.0116407
CCL20 chemokine (C-C motif) ligand 20 0.0116237
JAK1 Janus kinase 1 0.0115712
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.0115524
CNOT1 CCR4-NOT transcription complex, subunit 1 0.011524
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0114919

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.394169
EGFR epidermal growth factor receptor -0.179246
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.144399
TMSB10 thymosin beta 10 -0.129806
MT2A metallothionein 2A -0.122761
S100A10 S100 calcium binding protein A10 -0.0772435
GRAMD1B GRAM domain containing 1B -0.0707743
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0677527
ASPH aspartate beta-hydroxylase -0.0660508
THSD4 thrombospondin, type I, domain containing 4 -0.063316
LOC112694756 uncharaterized LOC112694756 -0.0599787
RPLP1 ribosomal protein, large, P1 -0.0598276
PTMA prothymosin, alpha -0.0587293
SEC61G Sec61 gamma subunit -0.0578022
TPT1 tumor protein, translationally-controlled 1 -0.0552837
MYOF myoferlin -0.0519866
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0509789
FTL ferritin, light polypeptide -0.0487998
ACTG1 actin gamma 1 -0.0487089
LDHA lactate dehydrogenase A -0.0431757
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0421603
NDRG1 N-myc downstream regulated 1 -0.041374
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0408963
RPL35A ribosomal protein L35a -0.0406483
PKM pyruvate kinase, muscle -0.040603
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0398034
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0385456
S100P S100 calcium binding protein P -0.0375928
LMO7 LIM domain 7 -0.0375795
CAV1 caveolin 1, caveolae protein, 22kDa -0.0368667
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0351516
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0348059
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0339613
MAML3 mastermind-like 3 (Drosophila) -0.033003
RPS25 ribosomal protein S25 -0.0328386
FNDC3B fibronectin type III domain containing 3B -0.0327414
RPL37A ribosomal protein L37a -0.0309102
IGFBP3 insulin-like growth factor binding protein 3 -0.0301682
INTS6 integrator complex subunit 6 -0.0299069
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0296117
SCEL sciellin -0.0294099
CST3 cystatin C -0.0290707
MT1X metallothionein 1X -0.0289781
RPS24 ribosomal protein S24 -0.0283514
RIMS2 regulating synaptic membrane exocytosis 2 -0.0278176
ENO1 enolase 1, (alpha) -0.0270116
SMYD3 SET and MYND domain containing 3 -0.026939
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0267895
SLC38A1 solute carrier family 38, member 1 -0.0267893
SAMD4A sterile alpha motif domain containing 4A -0.0265851
CD163L1 CD163 molecule-like 1 -0.0263569
GNAS GNAS complex locus -0.0261092
IER3 immediate early response 3 -0.0255767
H1-0 H1.0 linker histone -0.025539
RPS3 ribosomal protein S3 -0.0252519
S100A11 S100 calcium binding protein A11 -0.0247636
FTH1 ferritin, heavy polypeptide 1 -0.0246989
RPS8 ribosomal protein S8 -0.0244733
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0244432
NPAS2 neuronal PAS domain protein 2 -0.0243322
PYGL phosphorylase, glycogen, liver -0.0242761
RPS29 ribosomal protein S29 -0.0242237
C15ORF48 chromosome 15 open reading frame 48 -0.0236541
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0236285
RPL30 ribosomal protein L30 -0.0236147
RPS6 ribosomal protein S6 -0.023417
RPS19 ribosomal protein S19 -0.0234021
MORF4L2 mortality factor 4 like 2 -0.0233862
S100A6 S100 calcium binding protein A6 -0.0232913
KRT18 keratin 18, type I -0.0226401
CSTB cystatin B (stefin B) -0.0224253
ANXA2 annexin A2 -0.0223932
LAMA4 laminin, alpha 4 -0.0222465
CCND1 cyclin D1 -0.0221217
KRT7 keratin 7, type II -0.0217348
AHNAK AHNAK nucleoprotein -0.0217091
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0216597
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0215937
RPL12 ribosomal protein L12 -0.0214996
RPL23 ribosomal protein L23 -0.0213008
HMGA1 high mobility group AT-hook 1 -0.0212322
PM20D1 peptidase M20 domain containing 1 -0.0211658
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0209867
LAMB3 laminin, beta 3 -0.0208688
BPTF bromodomain PHD finger transcription factor -0.020706
ANKRD12 ankyrin repeat domain 12 -0.0201629
NTSR1 neurotensin receptor 1 (high affinity) -0.0201329
RPL34 ribosomal protein L34 -0.0201294
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0198829
CMIP c-Maf inducing protein -0.0193365
TPI1 triosephosphate isomerase 1 -0.0192687
CTBP2 C-terminal binding protein 2 -0.0190673
CUX1 cut-like homeobox 1 -0.0190143
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0190137
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0189408
RPL28 ribosomal protein L28 -0.018906
RACK1 receptor for activated C kinase 1 -0.018626
RPS14 ribosomal protein S14 -0.0186147
RPL31 ribosomal protein L31 -0.0185822
RPS27A ribosomal protein S27a -0.0183512