Phenylephrine (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.19534
NAMPT nicotinamide phosphoribosyltransferase 0.139824
CXCL8 chemokine (C-X-C motif) ligand 8 0.114741
GOLGA4 golgin A4 0.0890169
FAM13A family with sequence similarity 13, member A 0.0754681
RBM39 RNA binding motif protein 39 0.0703958
RICTOR RPTOR independent companion of MTOR, complex 2 0.0653685
USP34 ubiquitin specific peptidase 34 0.0614615
STC1 stanniocalcin 1 0.0568307
ESYT2 extended synaptotagmin-like protein 2 0.0551835
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0529711
KDM2A lysine (K)-specific demethylase 2A 0.0521755
RIOK3 RIO kinase 3 0.0456934
NGLY1 N-glycanase 1 0.0445153
ATP13A3 ATPase type 13A3 0.0438022
SDK1 sidekick cell adhesion molecule 1 0.0437279
PIAS2 protein inhibitor of activated STAT, 2 0.0436375
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0405406
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0399012
EIF1 eukaryotic translation initiation factor 1 0.0398097
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0383095
WAC WW domain containing adaptor with coiled-coil 0.0381305
BASP1 brain abundant, membrane attached signal protein 1 0.0376511
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0373143
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0367348
DLG1 discs, large homolog 1 (Drosophila) 0.0363675
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0354186
BHLHE40 basic helix-loop-helix family, member e40 0.0353307
RAB1A RAB1A, member RAS oncogene family 0.0350667
JMJD1C jumonji domain containing 1C 0.034818
ARHGAP5 Rho GTPase activating protein 5 0.0347134
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0344493
FMNL2 formin-like 2 0.0343856
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0343292
JARID2 jumonji, AT rich interactive domain 2 0.0341427
KMT2C lysine (K)-specific methyltransferase 2C 0.0337549
COG5 component of oligomeric golgi complex 5 0.033465
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.033145
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0330078
SRP54 signal recognition particle 54kDa 0.0329422
MXI1 MAX interactor 1, dimerization protein 0.0328035
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0322048
USP15 ubiquitin specific peptidase 15 0.0316679
ELL2 elongation factor, RNA polymerase II, 2 0.031091
PELI1 pellino E3 ubiquitin protein ligase 1 0.0307585
KPNB1 karyopherin (importin) beta 1 0.0306786
TTC3 tetratricopeptide repeat domain 3 0.0306688
KIF5B kinesin family member 5B 0.030297
KTN1 kinectin 1 (kinesin receptor) 0.0301742
RAB8B RAB8B, member RAS oncogene family 0.0300396
SETD5 SET domain containing 5 0.0300317
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0296495
SEC31A SEC31 homolog A (S. cerevisiae) 0.0295462
CHD1 chromodomain helicase DNA binding protein 1 0.0295201
ITCH itchy E3 ubiquitin protein ligase 0.0289738
RAB5A RAB5A, member RAS oncogene family 0.0288171
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0286018
MIS18BP1 MIS18 binding protein 1 0.0283493
SPAG9 sperm associated antigen 9 0.0282829
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0281789
RAB6A RAB6A, member RAS oncogene family 0.0280999
BIRC3 baculoviral IAP repeat containing 3 0.027991
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0276575
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0270046
USP3 ubiquitin specific peptidase 3 0.0266883
RNF145 ring finger protein 145 0.0265091
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0260732
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0260145
WDR43 WD repeat domain 43 0.0259957
DENND4A DENN/MADD domain containing 4A 0.0258068
PICALM phosphatidylinositol binding clathrin assembly protein 0.025674
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.025555
TPR translocated promoter region, nuclear basket protein 0.0253311
LMAN1 lectin, mannose-binding, 1 0.0252029
BIRC6 baculoviral IAP repeat containing 6 0.0248524
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0248282
MAP2K1 mitogen-activated protein kinase kinase 1 0.0247758
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0244673
BZW1 basic leucine zipper and W2 domains 1 0.0242972
BTG1 B-cell translocation gene 1, anti-proliferative 0.0240749
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0237517
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.023625
MEF2A myocyte enhancer factor 2A 0.0233908
MAP4 microtubule-associated protein 4 0.0233699
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0229238
ZNF292 zinc finger protein 292 0.0228641
EPS8 epidermal growth factor receptor pathway substrate 8 0.022739
RSL1D1 ribosomal L1 domain containing 1 0.0227081
TFRC transferrin receptor 0.02256
ADM adrenomedullin 0.0225431
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0225284
NUP58 nucleoporin 58 0.0225254
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0222177
RAI1 retinoic acid induced 1 0.0221965
ZCCHC7 zinc finger, CCHC domain containing 7 0.0221409
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0219849
TFPI2 tissue factor pathway inhibitor 2 0.0219671
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0219279
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0219267
UBA6 ubiquitin-like modifier activating enzyme 6 0.0218448

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -0.150193
VIM vimentin -0.0933045
PCBP2 poly(rC) binding protein 2 -0.0926267
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0885841
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0763792
TMSB10 thymosin beta 10 -0.0730735
EEF2 eukaryotic translation elongation factor 2 -0.0716179
GLCCI1 glucocorticoid induced 1 -0.07149
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0597963
NRG1 neuregulin 1 -0.0593503
UBC ubiquitin C -0.0538754
EGFR epidermal growth factor receptor -0.0504669
FN1 fibronectin 1 -0.0504378
ETV6 ets variant 6 -0.049917
GPC6 glypican 6 -0.0466999
CDH13 cadherin 13 -0.0448199
LRMDA leucine rich melanocyte differentiation associated -0.0431871
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0428732
NRP1 neuropilin 1 -0.042816
OSMR oncostatin M receptor -0.0413408
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.03987
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0398037
EFNA5 ephrin-A5 -0.0387137
NTN4 netrin 4 -0.0380304
TNNC1 troponin C type 1 (slow) -0.0378731
MCL1 myeloid cell leukemia 1 -0.0373547
NCOA7 nuclear receptor coactivator 7 -0.0364265
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0348094
DPYD dihydropyrimidine dehydrogenase -0.0346635
MSRB3 methionine sulfoxide reductase B3 -0.0344844
EXOC6B exocyst complex component 6B -0.0344323
ZBTB20 zinc finger and BTB domain containing 20 -0.0340849
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0335449
MYH9 myosin, heavy chain 9, non-muscle -0.0326276
ANTXR2 anthrax toxin receptor 2 -0.03162
MAP1B microtubule-associated protein 1B -0.0311849
ATXN1 ataxin 1 -0.030903
RNF213 ring finger protein 213 -0.0301271
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0294788
MAML2 mastermind-like 2 (Drosophila) -0.0283557
GLIS3 GLIS family zinc finger 3 -0.0272019
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0264742
BCAS3 breast carcinoma amplified sequence 3 -0.0264018
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0261864
KSR1 kinase suppressor of ras 1 -0.0260745
RAD51B RAD51 paralog B -0.0257622
SVIL supervillin -0.025564
R3HDM2 R3H domain containing 2 -0.0254611
FRMD4A FERM domain containing 4A -0.024953
PTPRK protein tyrosine phosphatase, receptor type, K -0.024867
RPL23 ribosomal protein L23 -0.0235856
SMAD3 SMAD family member 3 -0.0233435
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0228976
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0227706
KIAA1217 KIAA1217 -0.0227647
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.022695
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0226594
ECE1 endothelin converting enzyme 1 -0.0223321
TRPS1 trichorhinophalangeal syndrome I -0.0220967
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0218025
ANTXR1 anthrax toxin receptor 1 -0.0216635
EXOC4 exocyst complex component 4 -0.0215688
ATF7 activating transcription factor 7 -0.021387
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0213657
SRRM2 serine/arginine repetitive matrix 2 -0.0213165
SYT1 synaptotagmin I -0.0212967
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0210791
PKM pyruvate kinase, muscle -0.0209252
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0208648
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.020373
ATG7 autophagy related 7 -0.0203692
VCL vinculin -0.020316
UTRN utrophin -0.0202382
ZNF804A zinc finger protein 804A -0.0199239
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.019909
ANKRD28 ankyrin repeat domain 28 -0.0198782
IL1R1 interleukin 1 receptor, type I -0.0198163
PHF14 PHD finger protein 14 -0.0198011
WLS wntless Wnt ligand secretion mediator -0.0196307
DUSP16 dual specificity phosphatase 16 -0.0194542
STK38L serine/threonine kinase 38 like -0.0194008
DCLK2 doublecortin-like kinase 2 -0.0189718
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.018959
NAV2 neuron navigator 2 -0.0188267
HEG1 heart development protein with EGF-like domains 1 -0.0184694
MAML3 mastermind-like 3 (Drosophila) -0.0179866
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0176268
TNRC18 trinucleotide repeat containing 18 -0.0174608
FLNB filamin B, beta -0.0174597
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0173988
ASPH aspartate beta-hydroxylase -0.0170586
TGFB1 transforming growth factor, beta 1 -0.0169702
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0169217
TBC1D5 TBC1 domain family, member 5 -0.0168863
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0168628
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0168516
TBL1X transducin (beta)-like 1X-linked -0.0167574
EGR1 early growth response 1 -0.0167565
BPTF bromodomain PHD finger transcription factor -0.0165059
GLIPR1 GLI pathogenesis-related 1 -0.0164321