Phenylephrine (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0800334
AKAP12 A kinase (PRKA) anchor protein 12 0.0765618
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0628196
TM4SF1 transmembrane 4 L six family member 1 0.0615273
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.057964
FGB fibrinogen beta chain 0.0482854
PTK2 protein tyrosine kinase 2 0.0479332
ERRFI1 ERBB receptor feedback inhibitor 1 0.0463211
CXCL8 chemokine (C-X-C motif) ligand 8 0.0440904
DENND4A DENN/MADD domain containing 4A 0.0414721
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0405246
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0391999
NAMPT nicotinamide phosphoribosyltransferase 0.0380843
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.036477
RPL4 ribosomal protein L4 0.0360548
FAM168A family with sequence similarity 168, member A 0.0353071
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0346967
WDR43 WD repeat domain 43 0.033809
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0332782
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0326727
KTN1 kinectin 1 (kinesin receptor) 0.0322551
TPM3 tropomyosin 3 0.0320137
TXNRD1 thioredoxin reductase 1 0.031229
SLC38A1 solute carrier family 38, member 1 0.0306857
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0305424
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0304621
CANX calnexin 0.0292131
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0288956
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.028106
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0279791
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0268216
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.025969
PDIA3 protein disulfide isomerase family A, member 3 0.0259586
TFPI2 tissue factor pathway inhibitor 2 0.0255213
BCLAF1 BCL2-associated transcription factor 1 0.0253556
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0253031
USP34 ubiquitin specific peptidase 34 0.0251731
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0249872
BIRC6 baculoviral IAP repeat containing 6 0.0243921
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0242098
GARS1 glycyl-tRNA synthetase 1 0.0240538
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.024035
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0239884
FGA fibrinogen alpha chain 0.0232635
PCNX1 pecanex 1 0.0231835
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0229787
CLU clusterin 0.022857
YME1L1 YME1-like 1 ATPase 0.0228537
PTBP2 polypyrimidine tract binding protein 2 0.0226044
FGG fibrinogen gamma chain 0.0225602
CRY1 cryptochrome circadian clock 1 0.0224992
SRRM2 serine/arginine repetitive matrix 2 0.0222576
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0220906
ENO1 enolase 1, (alpha) 0.0220364
TLK1 tousled-like kinase 1 0.0217485
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0217026
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0215225
BZW1 basic leucine zipper and W2 domains 1 0.0212291
RBM39 RNA binding motif protein 39 0.0211256
SNX9 sorting nexin 9 0.0208121
ADAM17 ADAM metallopeptidase domain 17 0.0208093
FXR1 fragile X mental retardation, autosomal homolog 1 0.0207791
CSDE1 cold shock domain containing E1, RNA-binding 0.0207699
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0207215
KDM3A lysine (K)-specific demethylase 3A 0.0206893
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0205592
NUP58 nucleoporin 58 0.020537
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0204707
ANKRD28 ankyrin repeat domain 28 0.0204262
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0202073
SDC4 syndecan 4 0.0200665
HSPA8 heat shock 70kDa protein 8 0.019976
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0199707
DGKD diacylglycerol kinase, delta 130kDa 0.0198529
BIRC2 baculoviral IAP repeat containing 2 0.0198408
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0196769
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0196192
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.01957
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0194023
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0193506
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0193126
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0192915
CAMTA1 calmodulin binding transcription activator 1 0.0192859
MATR3 matrin 3 0.0190828
CCNL1 cyclin L1 0.0189941
CHD1 chromodomain helicase DNA binding protein 1 0.0189853
CEP95 centrosomal protein 95kDa 0.0189057
MT1X metallothionein 1X 0.018578
HYOU1 hypoxia up-regulated 1 0.0185523
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0182961
USP15 ubiquitin specific peptidase 15 0.0181967
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0180113
APLP2 amyloid beta (A4) precursor-like protein 2 0.01791
GOLT1B golgi transport 1B 0.017826
TTC3 tetratricopeptide repeat domain 3 0.017807
CDC73 cell division cycle 73 0.0177761
WRN Werner syndrome, RecQ helicase-like 0.0177434
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0175633
RASAL2 RAS protein activator like 2 0.017467
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.01741

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.217347
TMSB10 thymosin beta 10 -0.131669
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114189
FTL ferritin, light polypeptide -0.102739
RPL23 ribosomal protein L23 -0.0856301
THSD4 thrombospondin, type I, domain containing 4 -0.0790281
PARD3 par-3 family cell polarity regulator -0.0774813
GRAMD1B GRAM domain containing 1B -0.0723651
MT2A metallothionein 2A -0.0712459
RPLP1 ribosomal protein, large, P1 -0.0671321
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0544409
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0480008
DOCK4 dedicator of cytokinesis 4 -0.0471709
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0462031
RPL35A ribosomal protein L35a -0.0455642
CMIP c-Maf inducing protein -0.0438576
WWOX WW domain containing oxidoreductase -0.0437869
IGF2 insulin-like growth factor 2 -0.0430589
RPS12 ribosomal protein S12 -0.0424148
S100A6 S100 calcium binding protein A6 -0.0416601
MAML3 mastermind-like 3 (Drosophila) -0.0411197
ACTG1 actin gamma 1 -0.0404221
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0396531
BICC1 BicC family RNA binding protein 1 -0.0389562
ANKRD11 ankyrin repeat domain 11 -0.0389376
PDE4D phosphodiesterase 4D, cAMP-specific -0.0383904
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0374755
TRIO trio Rho guanine nucleotide exchange factor -0.0363888
RPS8 ribosomal protein S8 -0.0361461
DOCK5 dedicator of cytokinesis 5 -0.0360187
RPL19 ribosomal protein L19 -0.0354824
RPS19 ribosomal protein S19 -0.0351327
IGFBP3 insulin-like growth factor binding protein 3 -0.0344757
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.03433
NEGR1 neuronal growth regulator 1 -0.0342292
RPL36 ribosomal protein L36 -0.0335959
VIM vimentin -0.0329311
EGR1 early growth response 1 -0.0312957
EHBP1 EH domain binding protein 1 -0.0312382
DST dystonin -0.0306422
SVIL supervillin -0.0300772
EGFR epidermal growth factor receptor -0.0296432
FNDC3B fibronectin type III domain containing 3B -0.0294183
MCL1 myeloid cell leukemia 1 -0.0294094
RPS17 ribosomal protein S17 -0.0294047
RPL26 ribosomal protein L26 -0.0290773
SMOC1 SPARC related modular calcium binding 1 -0.0285277
RPL28 ribosomal protein L28 -0.0284651
RPL31 ribosomal protein L31 -0.0282699
PRKCE protein kinase C, epsilon -0.0280931
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0280189
HMGA1 high mobility group AT-hook 1 -0.0278163
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0277531
RPL37A ribosomal protein L37a -0.0277309
RPS6 ribosomal protein S6 -0.0274273
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.027365
MYOF myoferlin -0.0269505
HLA-A major histocompatibility complex, class I, A -0.026763
ZBTB20 zinc finger and BTB domain containing 20 -0.0266062
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0261049
UBASH3B ubiquitin associated and SH3 domain containing B -0.0258126
SAMD4A sterile alpha motif domain containing 4A -0.0256055
SERF2 small EDRK-rich factor 2 -0.0255262
RPS16 ribosomal protein S16 -0.0254236
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0248413
RAD51B RAD51 paralog B -0.024684
ANKRD12 ankyrin repeat domain 12 -0.0241896
RPL9 ribosomal protein L9 -0.0236562
NEBL nebulette -0.0236525
RPS21 ribosomal protein S21 -0.0235557
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0235411
ITGB5 integrin, beta 5 -0.0234732
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0233494
RIGI RNA sensor RIG-I -0.0232574
ATP5F1E ATP synthase F1 subunit epsilon -0.0231656
GLIS3 GLIS family zinc finger 3 -0.0230658
APP amyloid beta (A4) precursor protein -0.0225484
RCC1 regulator of chromosome condensation 1 -0.0225413
RPL34 ribosomal protein L34 -0.0223848
ERBIN erbb2 interacting protein -0.02229
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0222492
ALCAM activated leukocyte cell adhesion molecule -0.0220862
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0217672
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0217108
RPLP0 ribosomal protein, large, P0 -0.0216656
ZNF804A zinc finger protein 804A -0.0215126
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0212716
RPS23 ribosomal protein S23 -0.0212691
RPLP2 ribosomal protein, large, P2 -0.0210957
ARHGAP26 Rho GTPase activating protein 26 -0.0208885
UGCG UDP-glucose ceramide glucosyltransferase -0.0207882
PTPRM protein tyrosine phosphatase, receptor type, M -0.0207594
FLNB filamin B, beta -0.0206589
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0202424
RPS15 ribosomal protein S15 -0.0199346
TRPS1 trichorhinophalangeal syndrome I -0.0199239
NCOA2 nuclear receptor coactivator 2 -0.019904
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0197306
MEF2D myocyte enhancer factor 2D -0.0196526
LRMDA leucine rich melanocyte differentiation associated -0.0195463