| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Phenylephrine (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.129195 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.12332 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0978606 |
| ZNF292 | zinc finger protein 292 | 0.0896881 |
| CALU | calumenin | 0.0760056 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0758047 |
| RBM25 | RNA binding motif protein 25 | 0.0753437 |
| ENO1 | enolase 1, (alpha) | 0.0746359 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0713223 |
| PGK1 | phosphoglycerate kinase 1 | 0.0693836 |
| RNF145 | ring finger protein 145 | 0.0681393 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0669615 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0664715 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0661472 |
| RTN4 | reticulon 4 | 0.063088 |
| RAD51B | RAD51 paralog B | 0.0624123 |
| GPC6 | glypican 6 | 0.0620805 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0613445 |
| APP | amyloid beta (A4) precursor protein | 0.061164 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0575206 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0574589 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.056916 |
| ZNF638 | zinc finger protein 638 | 0.056362 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0563433 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0559385 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0558272 |
| NAV2 | neuron navigator 2 | 0.0551179 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0539093 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0527834 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.052095 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0516147 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0514958 |
| NUP58 | nucleoporin 58 | 0.0505334 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0502435 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0499392 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0491212 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0483081 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0482353 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0476437 |
| FN1 | fibronectin 1 | 0.0469619 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0467568 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0458907 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0458292 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0458057 |
| B2M | beta-2-microglobulin | 0.0454935 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.044935 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0448804 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0446995 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0446774 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0443078 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0440185 |
| CEP350 | centrosomal protein 350kDa | 0.0437856 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0436137 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0430953 |
| KIF1B | kinesin family member 1B | 0.0430927 |
| MATR3 | matrin 3 | 0.0430064 |
| PEG10 | paternally expressed 10 | 0.042432 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0419952 |
| USP3 | ubiquitin specific peptidase 3 | 0.041698 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0412698 |
| OGA | O-GlcNAcase | 0.0408569 |
| AK1 | adenylate kinase 1 | 0.0404304 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0401889 |
| S100A8 | S100 calcium binding protein A8 | 0.0397011 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0390448 |
| TMSB4X | thymosin beta 4, X-linked | 0.0387673 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0384224 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0380143 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0379719 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0371262 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0368978 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0365306 |
| SUCO | SUN domain containing ossification factor | 0.0365169 |
| WDR7 | WD repeat domain 7 | 0.0364429 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0363479 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0360855 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0360592 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0352917 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0352645 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0351719 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0351536 |
| CCNY | cyclin Y | 0.0351284 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0351081 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0350374 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0347259 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0346001 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.033856 |
| TMF1 | TATA element modulatory factor 1 | 0.0337144 |
| JMJD1C | jumonji domain containing 1C | 0.0335738 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0335561 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0333544 |
| RLF | rearranged L-myc fusion | 0.0328469 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0327664 |
| TTLL10 | tubulin tyrosine ligase-like family member 10 | 0.0327162 |
| RBM39 | RNA binding motif protein 39 | 0.0324007 |
| PHF3 | PHD finger protein 3 | 0.0319421 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.031909 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.031568 |
| XPO1 | exportin 1 | 0.0314238 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0312716 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT17 | keratin 17, type I | -0.117249 |
| MUC16 | mucin 16, cell surface associated | -0.111344 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.105196 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0918636 |
| MYO1E | myosin IE | -0.0911312 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0895233 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0883996 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0878421 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0867745 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0854839 |
| TPM4 | tropomyosin 4 | -0.0804152 |
| LMO7 | LIM domain 7 | -0.0803144 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0787704 |
| SVIL | supervillin | -0.0770904 |
| POTEF | POTE ankyrin domain family, member F | -0.076734 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0766806 |
| ATOSA | atos homolog A | -0.0730892 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0681141 |
| LAMC2 | laminin, gamma 2 | -0.0678473 |
| STC1 | stanniocalcin 1 | -0.0669664 |
| RPL37A | ribosomal protein L37a | -0.0640916 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.063426 |
| NABP1 | nucleic acid binding protein 1 | -0.0629841 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0626208 |
| EFNA5 | ephrin-A5 | -0.0596114 |
| LAMB3 | laminin, beta 3 | -0.0584849 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0584048 |
| RPL12 | ribosomal protein L12 | -0.0568692 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0564159 |
| TJP1 | tight junction protein 1 | -0.0548491 |
| RPS16 | ribosomal protein S16 | -0.0518539 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0516376 |
| S100A9 | S100 calcium binding protein A9 | -0.0515896 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0514523 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0507534 |
| TMSB10 | thymosin beta 10 | -0.0496827 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0489811 |
| MCL1 | myeloid cell leukemia 1 | -0.0488684 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0474193 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0472194 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0442914 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0441224 |
| LCN2 | lipocalin 2 | -0.0439664 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0439569 |
| RPL15 | ribosomal protein L15 | -0.0439316 |
| S100A6 | S100 calcium binding protein A6 | -0.0437514 |
| NDRG1 | N-myc downstream regulated 1 | -0.0435548 |
| RCOR1 | REST corepressor 1 | -0.0435357 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0431677 |
| ERBIN | erbb2 interacting protein | -0.0431074 |
| RPL31 | ribosomal protein L31 | -0.0426554 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0423098 |
| RPS24 | ribosomal protein S24 | -0.0421441 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0416737 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0413033 |
| PARD3 | par-3 family cell polarity regulator | -0.0408883 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.040273 |
| RBM47 | RNA binding motif protein 47 | -0.0395765 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0392985 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0392813 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0390186 |
| RPS25 | ribosomal protein S25 | -0.0390179 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0383128 |
| RPL28 | ribosomal protein L28 | -0.0375306 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0373472 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0372223 |
| NCOR2 | nuclear receptor corepressor 2 | -0.036993 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0369754 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0369541 |
| RPLP0 | ribosomal protein, large, P0 | -0.0362497 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0361944 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0359209 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0358029 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.035654 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0348613 |
| BPTF | bromodomain PHD finger transcription factor | -0.0348213 |
| KIF13B | kinesin family member 13B | -0.0344511 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0343421 |
| FA2H | fatty acid 2-hydroxylase | -0.0338836 |
| WASF2 | WAS protein family, member 2 | -0.0338607 |
| INTS6 | integrator complex subunit 6 | -0.0338578 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0333593 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0332694 |
| ABHD17C | abhydrolase domain containing 17C | -0.0331049 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0330885 |
| CNKSR3 | CNKSR family member 3 | -0.0325541 |
| EZR | ezrin | -0.0322405 |
| SEPTIN9 | septin 9 | -0.0318301 |
| RHOA | ras homolog family member A | -0.0317473 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0315691 |
| EXOC6B | exocyst complex component 6B | -0.0313384 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0310417 |
| RPLP2 | ribosomal protein, large, P2 | -0.0308828 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0308101 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0303737 |
| RPL26 | ribosomal protein L26 | -0.0298243 |
| RPL35A | ribosomal protein L35a | -0.0297728 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0290839 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0289139 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0288703 |
