| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Phenylephrine (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.116655 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.113997 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0942599 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0876733 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0832705 |
| ASPH | aspartate beta-hydroxylase | 0.082357 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0792426 |
| RNF145 | ring finger protein 145 | 0.0683566 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.066404 |
| CCNL1 | cyclin L1 | 0.0637142 |
| RBM39 | RNA binding motif protein 39 | 0.0623576 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0613849 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0605468 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0565673 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0561287 |
| FAM13A | family with sequence similarity 13, member A | 0.0545425 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.052605 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0523699 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.051524 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0489029 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0488835 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0481683 |
| CANX | calnexin | 0.0478099 |
| HMGB2 | high mobility group box 2 | 0.0475527 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0472733 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0469045 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0467974 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0461294 |
| TPM3 | tropomyosin 3 | 0.0460652 |
| NCKAP1 | NCK-associated protein 1 | 0.045751 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.045507 |
| TOP1 | topoisomerase (DNA) I | 0.0446288 |
| TFG | TRK-fused gene | 0.0446244 |
| SPAG9 | sperm associated antigen 9 | 0.044558 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0443023 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0432096 |
| CALR | calreticulin | 0.042763 |
| MATR3 | matrin 3 | 0.0425752 |
| ZNF292 | zinc finger protein 292 | 0.0421803 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0416899 |
| PAPOLA | poly(A) polymerase alpha | 0.0416076 |
| USP3 | ubiquitin specific peptidase 3 | 0.0405247 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0405059 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0403889 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0401918 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0401739 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0401012 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0397799 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0387625 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0386364 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0383863 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0379437 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0378527 |
| PGK1 | phosphoglycerate kinase 1 | 0.0377978 |
| RLF | rearranged L-myc fusion | 0.0376066 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0375994 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0372852 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0369057 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.036207 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0353663 |
| TMSB4X | thymosin beta 4, X-linked | 0.0352538 |
| RYBP | RING1 and YY1 binding protein | 0.0351555 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.035146 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0350159 |
| RTN4 | reticulon 4 | 0.0348763 |
| SET | SET nuclear proto-oncogene | 0.034278 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0341341 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0335265 |
| NUP58 | nucleoporin 58 | 0.032794 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0322048 |
| TNPO1 | transportin 1 | 0.0320565 |
| ANXA5 | annexin A5 | 0.0320093 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0319103 |
| PTK2 | protein tyrosine kinase 2 | 0.0319086 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0316969 |
| YTHDC1 | YTH domain containing 1 | 0.0316119 |
| UBC | ubiquitin C | 0.0312954 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0305034 |
| ATP13A3 | ATPase type 13A3 | 0.0299083 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0298722 |
| QKI | QKI, KH domain containing, RNA binding | 0.0294908 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0293964 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0290647 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0288478 |
| ECT2 | epithelial cell transforming 2 | 0.0286751 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0286261 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0283648 |
| AHNAK | AHNAK nucleoprotein | 0.0283489 |
| FAM3C | family with sequence similarity 3, member C | 0.0282433 |
| SLMAP | sarcolemma associated protein | 0.027967 |
| IL6ST | interleukin 6 signal transducer | 0.0278835 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0278126 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0277574 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0276675 |
| FN1 | fibronectin 1 | 0.0275567 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0274998 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.027182 |
| ZNF207 | zinc finger protein 207 | 0.0271571 |
| CDC73 | cell division cycle 73 | 0.0271048 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.027061 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.191984 |
| FTL | ferritin, light polypeptide | -0.118884 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.105672 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.102194 |
| TMSB10 | thymosin beta 10 | -0.0918426 |
| ACTG1 | actin gamma 1 | -0.076903 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0722282 |
| EFNA5 | ephrin-A5 | -0.064743 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0628164 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0612457 |
| NDRG1 | N-myc downstream regulated 1 | -0.0578665 |
| FBXO32 | F-box protein 32 | -0.0577137 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0569671 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0566931 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0554496 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0537711 |
| RPLP1 | ribosomal protein, large, P1 | -0.0500311 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0480593 |
| NAV2 | neuron navigator 2 | -0.0479806 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0457821 |
| RNF213 | ring finger protein 213 | -0.042429 |
| HLA-B | major histocompatibility complex, class I, B | -0.0416919 |
| RPL34 | ribosomal protein L34 | -0.0404025 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0389193 |
| RPS19 | ribosomal protein S19 | -0.0373509 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0366646 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0364392 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0362641 |
| RPLP2 | ribosomal protein, large, P2 | -0.0354236 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0346467 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0335886 |
| RPL35A | ribosomal protein L35a | -0.0321746 |
| MYO1E | myosin IE | -0.0321097 |
| GOLGB1 | golgin B1 | -0.0314262 |
| MX2 | MX dynamin-like GTPase 2 | -0.0312704 |
| ETV6 | ets variant 6 | -0.0311693 |
| RBM47 | RNA binding motif protein 47 | -0.0298963 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0296468 |
| FNIP1 | folliculin interacting protein 1 | -0.0292655 |
| RPL9 | ribosomal protein L9 | -0.0289609 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0287987 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0287564 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0287204 |
| RAD51B | RAD51 paralog B | -0.0285815 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0284246 |
| RIGI | RNA sensor RIG-I | -0.0282856 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0279913 |
| ATXN1 | ataxin 1 | -0.0271733 |
| RPL23 | ribosomal protein L23 | -0.0270497 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0270019 |
| FBXO34 | F-box protein 34 | -0.0260507 |
| MX1 | MX dynamin-like GTPase 1 | -0.0258761 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0256311 |
| PLSCR1 | phospholipid scramblase 1 | -0.0253031 |
| RPS16 | ribosomal protein S16 | -0.024859 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0248158 |
| SMAD3 | SMAD family member 3 | -0.0247659 |
| CSTB | cystatin B (stefin B) | -0.024521 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0239177 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0238935 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0236891 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0232434 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0230023 |
| RPL28 | ribosomal protein L28 | -0.0224471 |
| PLEC | plectin | -0.0223596 |
| RPS13 | ribosomal protein S13 | -0.0220705 |
| RRBP1 | ribosome binding protein 1 | -0.0220301 |
| VCL | vinculin | -0.022023 |
| RPL37 | ribosomal protein L37 | -0.021934 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0218272 |
| RPL37A | ribosomal protein L37a | -0.0217271 |
| RPS29 | ribosomal protein S29 | -0.0216759 |
| NF1 | neurofibromin 1 | -0.0216563 |
| RPL30 | ribosomal protein L30 | -0.0216439 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0215302 |
| LAMB3 | laminin, beta 3 | -0.0214864 |
| LMO7 | LIM domain 7 | -0.0214847 |
| TXNIP | thioredoxin interacting protein | -0.0214241 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0210878 |
| FHIT | fragile histidine triad | -0.0210631 |
| BPTF | bromodomain PHD finger transcription factor | -0.020999 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.020941 |
| HMGA1 | high mobility group AT-hook 1 | -0.0208961 |
| GNAS | GNAS complex locus | -0.02089 |
| HLA-A | major histocompatibility complex, class I, A | -0.0207551 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0205929 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0205312 |
| HLA-E | major histocompatibility complex, class I, E | -0.0204853 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0201641 |
| S100A10 | S100 calcium binding protein A10 | -0.0199086 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0198693 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0197714 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0197706 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0196705 |
| RPL19 | ribosomal protein L19 | -0.0196678 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0195649 |
| RPL35 | ribosomal protein L35 | -0.0195483 |
| SP100 | SP100 nuclear antigen | -0.0194518 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0194509 |
| RPL36 | ribosomal protein L36 | -0.0194112 |
