Phenylephrine (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.256778
FN1 fibronectin 1 0.0860912
FNDC3A fibronectin type III domain containing 3A 0.0763898
ERRFI1 ERBB receptor feedback inhibitor 1 0.0701586
SPAG9 sperm associated antigen 9 0.0629776
STC1 stanniocalcin 1 0.0616168
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0557381
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.055285
MCL1 myeloid cell leukemia 1 0.0531857
PDLIM5 PDZ and LIM domain 5 0.0531289
NAMPT nicotinamide phosphoribosyltransferase 0.0521963
ITPRID2 ITPR interacting domain containing 2 0.0517282
ELL2 elongation factor, RNA polymerase II, 2 0.05027
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.04676
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0457151
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0453578
CD109 CD109 molecule 0.0440826
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0433252
CANX calnexin 0.0431102
AKAP13 A kinase (PRKA) anchor protein 13 0.0422671
PDE4D phosphodiesterase 4D, cAMP-specific 0.0417081
PGK1 phosphoglycerate kinase 1 0.0416804
IFIH1 interferon induced with helicase C domain 1 0.0389815
FMNL2 formin-like 2 0.0385126
ESYT2 extended synaptotagmin-like protein 2 0.037597
AUTS2 autism susceptibility candidate 2 0.0375532
B2M beta-2-microglobulin 0.037507
WARS1 tryptophanyl-tRNA synthetase 1 0.0364784
PDIA6 protein disulfide isomerase family A, member 6 0.0360825
BZW1 basic leucine zipper and W2 domains 1 0.0345209
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0338355
PM20D1 peptidase M20 domain containing 1 0.0338187
SMAD2 SMAD family member 2 0.0315781
SOD2 superoxide dismutase 2, mitochondrial 0.0308528
TFPI2 tissue factor pathway inhibitor 2 0.0306627
DNER delta/notch-like EGF repeat containing 0.0297234
GDA guanine deaminase 0.0297054
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0292987
CXCL8 chemokine (C-X-C motif) ligand 8 0.028153
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0278983
OXSR1 oxidative stress responsive 1 0.0277421
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.027608
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0270488
USP9X ubiquitin specific peptidase 9, X-linked 0.026638
KYNU kynureninase 0.0266138
NCAM1 neural cell adhesion molecule 1 0.0265193
SFTPA2 surfactant protein A2 0.0264477
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0262733
SLC16A6 solute carrier family 16, member 6 0.0260587
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0260109
TENT5A terminal nucleotidyltransferase 5A 0.0258997
ZC3H11A zinc finger CCCH-type containing 11A 0.0256118
CTSL cathepsin L 0.0254632
ATP13A3 ATPase type 13A3 0.024991
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.024619
FNIP1 folliculin interacting protein 1 0.0242086
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0241828
USP34 ubiquitin specific peptidase 34 0.0240421
TM4SF1 transmembrane 4 L six family member 1 0.0238071
RGS2 regulator of G-protein signaling 2 0.0237559
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0236181
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0233059
RAB31 RAB31, member RAS oncogene family 0.0230959
PCBP3 poly(rC) binding protein 3 0.0230918
PDIA3 protein disulfide isomerase family A, member 3 0.0227551
BASP1 brain abundant, membrane attached signal protein 1 0.0226135
PICALM phosphatidylinositol binding clathrin assembly protein 0.0224691
BMP6 bone morphogenetic protein 6 0.0222657
PDGFA platelet-derived growth factor alpha polypeptide 0.0221562
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0220745
CHD1 chromodomain helicase DNA binding protein 1 0.022053
TGFBR1 transforming growth factor, beta receptor 1 0.0218545
COPA coatomer protein complex, subunit alpha 0.0217806
KMT2C lysine (K)-specific methyltransferase 2C 0.0215429
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0215317
SET SET nuclear proto-oncogene 0.0214341
UBC ubiquitin C 0.021385
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0211504
TPM3 tropomyosin 3 0.0211114
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0205549
RSL1D1 ribosomal L1 domain containing 1 0.0205435
CHL1 cell adhesion molecule L1-like 0.0203335
BMERB1 bMERB domain containing 1 0.0203267
SAMD4A sterile alpha motif domain containing 4A 0.0201467
ZEB2 zinc finger E-box binding homeobox 2 0.0201256
KMT2E lysine (K)-specific methyltransferase 2E 0.0200485
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0200049
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0199996
IL6 interleukin 6 0.0196374
SAR1A secretion associated, Ras related GTPase 1A 0.0195031
NT5C2 5'-nucleotidase, cytosolic II 0.0193524
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0191993
CCDC68 coiled-coil domain containing 68 0.0191183
KDM6A lysine (K)-specific demethylase 6A 0.0187647
TPM4 tropomyosin 4 0.0186076
AKAP12 A kinase (PRKA) anchor protein 12 0.0185007
APLP2 amyloid beta (A4) precursor-like protein 2 0.018364
MYOF myoferlin 0.018272
CTBP2 C-terminal binding protein 2 0.0181969
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0181352

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144448
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0930695
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0905518
EFNA5 ephrin-A5 -0.0862579
TMSB10 thymosin beta 10 -0.0860986
PSD3 pleckstrin and Sec7 domain containing 3 -0.0770853
FTL ferritin, light polypeptide -0.0741268
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0723446
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0674532
RPLP1 ribosomal protein, large, P1 -0.0667137
TXNRD1 thioredoxin reductase 1 -0.0663116
EEF2 eukaryotic translation elongation factor 2 -0.0611639
NALF1 NALCN channel auxiliary factor 1 -0.0593756
SMYD3 SET and MYND domain containing 3 -0.0582019
RPS6 ribosomal protein S6 -0.0557125
MT2A metallothionein 2A -0.0546822
PDE10A phosphodiesterase 10A -0.0543616
COL5A2 collagen, type V, alpha 2 -0.0529073
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.050607
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0493894
GRAMD1B GRAM domain containing 1B -0.049242
RPS8 ribosomal protein S8 -0.0478442
RPL23 ribosomal protein L23 -0.0474308
PRKN parkin RBR E3 ubiquitin protein ligase -0.0449153
RPL26 ribosomal protein L26 -0.0447351
ASPH aspartate beta-hydroxylase -0.0426866
ACTG1 actin gamma 1 -0.0412698
CENPF centromere protein F, 350/400kDa -0.0411852
RPL35A ribosomal protein L35a -0.0410002
RPL37A ribosomal protein L37a -0.0384736
RPL9 ribosomal protein L9 -0.0379476
LOC112694756 uncharaterized LOC112694756 -0.037675
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0374668
COL8A1 collagen, type VIII, alpha 1 -0.0373537
RPS19 ribosomal protein S19 -0.0373118
RPS24 ribosomal protein S24 -0.0353799
GNAS GNAS complex locus -0.0352527
NRCAM neuronal cell adhesion molecule -0.0347778
RPL12 ribosomal protein L12 -0.0341959
MAP1B microtubule-associated protein 1B -0.03121
RPL13A ribosomal protein L13a -0.0310981
RPL19 ribosomal protein L19 -0.0307196
RPL36 ribosomal protein L36 -0.0305788
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0295614
MAML3 mastermind-like 3 (Drosophila) -0.029019
RPS29 ribosomal protein S29 -0.0288477
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0288143
RPL34 ribosomal protein L34 -0.0283459
RPL37 ribosomal protein L37 -0.0282961
RPL31 ribosomal protein L31 -0.0276734
RPS23 ribosomal protein S23 -0.0267332
TRIO trio Rho guanine nucleotide exchange factor -0.0267092
ANTXR1 anthrax toxin receptor 1 -0.0265707
RPL5 ribosomal protein L5 -0.0264366
PRDX1 peroxiredoxin 1 -0.0263639
RPS4X ribosomal protein S4, X-linked -0.0257887
TUSC3 tumor suppressor candidate 3 -0.0254103
RPL35 ribosomal protein L35 -0.0253624
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0251701
RPS21 ribosomal protein S21 -0.0251163
AKR1C1 aldo-keto reductase family 1, member C1 -0.0245931
RACK1 receptor for activated C kinase 1 -0.0244399
RPLP2 ribosomal protein, large, P2 -0.024313
RPS14 ribosomal protein S14 -0.0234105
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0230467
RPL32 ribosomal protein L32 -0.022861
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0228029
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0226221
YBX1 Y box binding protein 1 -0.0224561
RPS5 ribosomal protein S5 -0.0224189
RPS20 ribosomal protein S20 -0.0216724
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0215543
S100A10 S100 calcium binding protein A10 -0.0212829
CENPE centromere protein E, 312kDa -0.0210937
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0210686
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0210062
ATP5F1B ATP synthase F1 subunit beta -0.0208013
COL4A5 collagen, type IV, alpha 5 -0.0207816
RPL27 ribosomal protein L27 -0.0206802
FTH1 ferritin, heavy polypeptide 1 -0.020375
RPS17 ribosomal protein S17 -0.0203422
PBX1 pre-B-cell leukemia homeobox 1 -0.0202908
PALLD palladin, cytoskeletal associated protein -0.0202408
NCOA7 nuclear receptor coactivator 7 -0.0201448
RPL11 ribosomal protein L11 -0.0199862
PKM pyruvate kinase, muscle -0.0198863
RPS15 ribosomal protein S15 -0.0198855
RPLP0 ribosomal protein, large, P0 -0.0195432
RPL28 ribosomal protein L28 -0.0194355
RPS12 ribosomal protein S12 -0.0194019
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0193777
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0192491
RPL38 ribosomal protein L38 -0.0188174
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0188025
PTGR1 prostaglandin reductase 1 -0.0186939
CADM2 cell adhesion molecule 2 -0.01866
DOCK4 dedicator of cytokinesis 4 -0.0186545
FLNA filamin A, alpha -0.0186292
SRGN serglycin -0.0183788
PRRC2B proline-rich coiled-coil 2B -0.0183568