| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Phenylephrine (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNA5 | ephrin-A5 | 0.273251 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.206944 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.107711 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.105936 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0950461 |
| KYNU | kynureninase | 0.0928282 |
| COL5A2 | collagen, type V, alpha 2 | 0.0921726 |
| PDE10A | phosphodiesterase 10A | 0.0813515 |
| USP34 | ubiquitin specific peptidase 34 | 0.0766207 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0759043 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.073376 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0722771 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0659127 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0654686 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0648204 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0630063 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0612967 |
| DST | dystonin | 0.0600579 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0595989 |
| GDA | guanine deaminase | 0.0585507 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0585089 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0574843 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0573505 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0554166 |
| CCDC88A | coiled-coil domain containing 88A | 0.0547694 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0540786 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0531884 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.052689 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0520265 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0504735 |
| ATXN1 | ataxin 1 | 0.0496708 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0486518 |
| RLF | rearranged L-myc fusion | 0.0485917 |
| RBM39 | RNA binding motif protein 39 | 0.0483929 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0481808 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0470986 |
| RPS6 | ribosomal protein S6 | 0.0470734 |
| RUNX1 | runt-related transcription factor 1 | 0.0468831 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0467837 |
| SETD5 | SET domain containing 5 | 0.0428337 |
| MTF2 | metal response element binding transcription factor 2 | 0.0425972 |
| ZNF292 | zinc finger protein 292 | 0.0417719 |
| PKM | pyruvate kinase, muscle | 0.0415365 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.040279 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0400031 |
| TOP1 | topoisomerase (DNA) I | 0.0387132 |
| RPS12 | ribosomal protein S12 | 0.0382707 |
| PTK2 | protein tyrosine kinase 2 | 0.0377607 |
| RTN4 | reticulon 4 | 0.0370542 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0360946 |
| TJP1 | tight junction protein 1 | 0.0356843 |
| ASPH | aspartate beta-hydroxylase | 0.0343949 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.034075 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0338206 |
| PGK1 | phosphoglycerate kinase 1 | 0.0334199 |
| FTL | ferritin, light polypeptide | 0.033239 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0321115 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0308067 |
| RNF145 | ring finger protein 145 | 0.0306592 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0303124 |
| FN1 | fibronectin 1 | 0.0297302 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0296045 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0284982 |
| FAM13A | family with sequence similarity 13, member A | 0.0271085 |
| MED13L | mediator complex subunit 13-like | 0.0268719 |
| VMP1 | vacuole membrane protein 1 | 0.0259993 |
| MEF2A | myocyte enhancer factor 2A | 0.0258707 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0246867 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0243778 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0241175 |
| B2M | beta-2-microglobulin | 0.0227738 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0226027 |
| JMJD1C | jumonji domain containing 1C | 0.0221086 |
| SPAG9 | sperm associated antigen 9 | 0.0215034 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0210445 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0210008 |
| ERBIN | erbb2 interacting protein | 0.0208634 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0207954 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0195122 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0183997 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0183901 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0182983 |
| HELZ | helicase with zinc finger | 0.0170271 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0161157 |
| CEP350 | centrosomal protein 350kDa | 0.0155298 |
| ANXA2 | annexin A2 | 0.0116995 |
| PARD3 | par-3 family cell polarity regulator | 0.0114885 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0114799 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0110843 |
| ACTG1 | actin gamma 1 | 0.0105281 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.00956224 |
| DSCAM | Down syndrome cell adhesion molecule | 0.00948122 |
| RYBP | RING1 and YY1 binding protein | 0.00914389 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.00854959 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.00827858 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00663136 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.00633308 |
| NCOR1 | nuclear receptor corepressor 1 | 0.00538565 |
| LDHA | lactate dehydrogenase A | 0.00451494 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.00415943 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.18732 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.175137 |
| LMO7 | LIM domain 7 | -0.113905 |
| SNX9 | sorting nexin 9 | -0.110056 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.10695 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.09174 |
| RPS16 | ribosomal protein S16 | -0.091107 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.089803 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0892383 |
| NAV2 | neuron navigator 2 | -0.0805046 |
| STAG2 | stromal antigen 2 | -0.0778725 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0734101 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0730005 |
| EGR1 | early growth response 1 | -0.0689185 |
| RPL37 | ribosomal protein L37 | -0.0666967 |
| ITGA6 | integrin, alpha 6 | -0.0632885 |
| MYO5B | myosin VB | -0.063122 |
| SPATA13 | spermatogenesis associated 13 | -0.0619508 |
| LAMB3 | laminin, beta 3 | -0.0611802 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0604675 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0603927 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0595976 |
| UBE2Z | ubiquitin-conjugating enzyme E2Z | -0.057512 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.057377 |
| RBM25 | RNA binding motif protein 25 | -0.0568951 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0568839 |
| RPLP1 | ribosomal protein, large, P1 | -0.0558964 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.054545 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.053235 |
| VIM | vimentin | -0.0526727 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.050652 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0494137 |
| RPLP2 | ribosomal protein, large, P2 | -0.0486601 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0481536 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0477771 |
| WASF2 | WAS protein family, member 2 | -0.0473889 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0471326 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0452142 |
| RPL26 | ribosomal protein L26 | -0.0450839 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0444737 |
| MXD1 | MAX dimerization protein 1 | -0.044463 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0440452 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0433669 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0429286 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0424984 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0418038 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0415146 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.041367 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0409268 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0401944 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0401662 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.037954 |
| TMSB10 | thymosin beta 10 | -0.0365834 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0349134 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0339267 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0339197 |
| CDK6 | cyclin-dependent kinase 6 | -0.0338101 |
| EZR | ezrin | -0.0328789 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0326799 |
| FNIP1 | folliculin interacting protein 1 | -0.0323906 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0316088 |
| NDRG1 | N-myc downstream regulated 1 | -0.0303833 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0290006 |
| KRT8 | keratin 8, type II | -0.0287885 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0285624 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0256702 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0248047 |
| CANX | calnexin | -0.0247799 |
| RPS3 | ribosomal protein S3 | -0.0236094 |
| MT2A | metallothionein 2A | -0.0230108 |
| MED13 | mediator complex subunit 13 | -0.0217224 |
| UBC | ubiquitin C | -0.0213182 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0210669 |
| FMNL2 | formin-like 2 | -0.0207892 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0207654 |
| HMGA2 | high mobility group AT-hook 2 | -0.0206901 |
| RPL35A | ribosomal protein L35a | -0.0205403 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.019367 |
| MCL1 | myeloid cell leukemia 1 | -0.0188134 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0178089 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0174 |
| TPM4 | tropomyosin 4 | -0.0171045 |
| SP100 | SP100 nuclear antigen | -0.0165615 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0163577 |
| RPL23 | ribosomal protein L23 | -0.0163365 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0153218 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0150904 |
| PTMA | prothymosin, alpha | -0.0144398 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0142467 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0120656 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0110136 |
| TNS3 | tensin 3 | -0.0105531 |
| CARD16 | caspase recruitment domain family, member 16 | -0.00970871 |
| MYOF | myoferlin | -0.00776567 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.00706947 |
| RPS8 | ribosomal protein S8 | -0.00686972 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00521718 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0042198 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.00400892 |
| GOLGA4 | golgin A4 | -0.00357007 |
