Phenylephrine (hydrochloride)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.278086
PGK1 phosphoglycerate kinase 1 0.104277
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0970413
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0915202
NAMPT nicotinamide phosphoribosyltransferase 0.0885837
FNDC3B fibronectin type III domain containing 3B 0.0847942
CXCL8 chemokine (C-X-C motif) ligand 8 0.0736144
FAM20C family with sequence similarity 20, member C 0.0676475
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0594401
GOLGA4 golgin A4 0.0572103
DSCAM Down syndrome cell adhesion molecule 0.0570417
ERRFI1 ERBB receptor feedback inhibitor 1 0.0548706
RBM39 RNA binding motif protein 39 0.0528867
H1-0 H1.0 linker histone 0.0508556
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0496432
RLF rearranged L-myc fusion 0.0467714
ATP13A3 ATPase type 13A3 0.0460389
TFPI2 tissue factor pathway inhibitor 2 0.0451472
SETD5 SET domain containing 5 0.0418679
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0412102
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0398824
ZNF292 zinc finger protein 292 0.0398169
TPM4 tropomyosin 4 0.0394292
MT2A metallothionein 2A 0.0389916
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0388855
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383442
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0382539
SMC4 structural maintenance of chromosomes 4 0.0382424
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0376252
ARRDC3 arrestin domain containing 3 0.0375456
TMF1 TATA element modulatory factor 1 0.037428
MCTP2 multiple C2 domains, transmembrane 2 0.0369842
YME1L1 YME1-like 1 ATPase 0.0366707
COL1A2 collagen, type I, alpha 2 0.036124
CD109 CD109 molecule 0.0360359
CLIC4 chloride intracellular channel 4 0.0360165
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0358192
ADAM17 ADAM metallopeptidase domain 17 0.0357198
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0356627
CENPF centromere protein F, 350/400kDa 0.035498
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0354337
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0353811
INHBA inhibin, beta A 0.0346262
ANKRD28 ankyrin repeat domain 28 0.0343404
ZNF654 zinc finger protein 654 0.0336343
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0336163
NIPBL Nipped-B homolog (Drosophila) 0.0332666
TBC1D23 TBC1 domain family, member 23 0.0327212
FMNL2 formin-like 2 0.0324229
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0324008
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0323986
USP9X ubiquitin specific peptidase 9, X-linked 0.0322386
ENO1 enolase 1, (alpha) 0.0322313
MKI67 marker of proliferation Ki-67 0.0320811
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0304462
MYO1B myosin IB 0.0304019
ESYT2 extended synaptotagmin-like protein 2 0.0298865
ITCH itchy E3 ubiquitin protein ligase 0.0298751
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0296021
SDC4 syndecan 4 0.0289509
SOD2 superoxide dismutase 2, mitochondrial 0.0289066
COPA coatomer protein complex, subunit alpha 0.0288998
ANLN anillin, actin binding protein 0.028847
LDHA lactate dehydrogenase A 0.0287648
FAM13A family with sequence similarity 13, member A 0.0287249
CENPE centromere protein E, 312kDa 0.0281864
TOP2B topoisomerase (DNA) II beta 180kDa 0.0279911
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0278038
UBA6 ubiquitin-like modifier activating enzyme 6 0.0277914
CSDE1 cold shock domain containing E1, RNA-binding 0.0277308
CSNK1A1 casein kinase 1, alpha 1 0.0272905
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0272446
IQGAP1 IQ motif containing GTPase activating protein 1 0.0263515
CALU calumenin 0.0261326
ELL2 elongation factor, RNA polymerase II, 2 0.0258427
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0257353
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0254886
CERT1 ceramide transporter 1 0.0254864
RAD21 RAD21 homolog (S. pombe) 0.0251652
MBNL1 muscleblind-like splicing regulator 1 0.0251462
KDM6A lysine (K)-specific demethylase 6A 0.0249808
SNAP25 synaptosomal-associated protein, 25kDa 0.0249153
EMP1 epithelial membrane protein 1 0.0248182
GPSM2 G-protein signaling modulator 2 0.0246526
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0245799
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0245443
WTAP Wilms tumor 1 associated protein 0.0244531
NRP2 neuropilin 2 0.0244022
RAB6A RAB6A, member RAS oncogene family 0.0243242
LMAN1 lectin, mannose-binding, 1 0.024217
THBS1 thrombospondin 1 0.0241533
ACBD3 acyl-CoA binding domain containing 3 0.0238266
PPME1 protein phosphatase methylesterase 1 0.0236985
FXR1 fragile X mental retardation, autosomal homolog 1 0.023653
SEPTIN2 septin 2 0.0235681
SRP54 signal recognition particle 54kDa 0.0234905
NF1 neurofibromin 1 0.0234831
B2M beta-2-microglobulin 0.0232647
TPM3 tropomyosin 3 0.0232099
NGLY1 N-glycanase 1 0.0231861

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.107348
HLA-B major histocompatibility complex, class I, B -0.0867279
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0837262
FRMD4A FERM domain containing 4A -0.064072
TMSB10 thymosin beta 10 -0.0632281
RPLP1 ribosomal protein, large, P1 -0.0581849
COL1A1 collagen, type I, alpha 1 -0.0546585
CDH13 cadherin 13 -0.0441517
RPL35A ribosomal protein L35a -0.0424181
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0420525
NAV1 neuron navigator 1 -0.0415586
IFI6 interferon, alpha-inducible protein 6 -0.0388279
RPS6 ribosomal protein S6 -0.038272
RPL37A ribosomal protein L37a -0.0380269
COL5A3 collagen, type V, alpha 3 -0.0375666
TGFBI transforming growth factor, beta-induced, 68kDa -0.0372989
EGR1 early growth response 1 -0.0372774
SP100 SP100 nuclear antigen -0.0371359
IGFBP3 insulin-like growth factor binding protein 3 -0.0370343
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0349685
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0345292
RPS19 ribosomal protein S19 -0.0342983
COL6A1 collagen, type VI, alpha 1 -0.0340063
HLA-A major histocompatibility complex, class I, A -0.0321758
EEF2 eukaryotic translation elongation factor 2 -0.0320266
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0317582
RPL11 ribosomal protein L11 -0.0294851
EPSTI1 epithelial stromal interaction 1 (breast) -0.0283924
PSD3 pleckstrin and Sec7 domain containing 3 -0.0280974
RNF213 ring finger protein 213 -0.0280843
RPLP2 ribosomal protein, large, P2 -0.0278859
COL6A2 collagen, type VI, alpha 2 -0.0271165
RPL36 ribosomal protein L36 -0.0270172
RPS8 ribosomal protein S8 -0.0266899
FTH1 ferritin, heavy polypeptide 1 -0.0256475
RPL9 ribosomal protein L9 -0.0254575
TNNC1 troponin C type 1 (slow) -0.0254382
IFITM3 interferon induced transmembrane protein 3 -0.0251805
EGFR epidermal growth factor receptor -0.0247163
RPL31 ribosomal protein L31 -0.0243041
TGFB1 transforming growth factor, beta 1 -0.0240259
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0239852
RPS25 ribosomal protein S25 -0.0237199
TPT1 tumor protein, translationally-controlled 1 -0.0233031
RPS5 ribosomal protein S5 -0.0230472
COL5A1 collagen, type V, alpha 1 -0.0229569
HLA-C major histocompatibility complex, class I, C -0.0229331
EML5 echinoderm microtubule associated protein like 5 -0.0224662
FHIT fragile histidine triad -0.0222728
RPS13 ribosomal protein S13 -0.0214026
ACTG1 actin gamma 1 -0.021228
SHISA5 shisa family member 5 -0.0211896
RPL23 ribosomal protein L23 -0.0209379
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0206424
S100A10 S100 calcium binding protein A10 -0.0206106
CUX1 cut-like homeobox 1 -0.0205714
PTPRG protein tyrosine phosphatase, receptor type, G -0.0205074
NDRG1 N-myc downstream regulated 1 -0.0204917
CADM1 cell adhesion molecule 1 -0.0204045
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0200685
RPL8 ribosomal protein L8 -0.0199661
RPL28 ribosomal protein L28 -0.0197689
RPL30 ribosomal protein L30 -0.0192848
COLEC10 collectin sub-family member 10 (C-type lectin) -0.0189814
RPL35 ribosomal protein L35 -0.0187321
RPS12 ribosomal protein S12 -0.0187155
TNS3 tensin 3 -0.0186266
RPS14 ribosomal protein S14 -0.0184848
LOC112694756 uncharaterized LOC112694756 -0.018441
ENO2 enolase 2 (gamma, neuronal) -0.0184123
MX1 MX dynamin-like GTPase 1 -0.0183883
MMP2 matrix metallopeptidase 2 -0.0180001
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0179659
LOC102724023 ES1 protein homolog, mitochondrial -0.0179471
EXT1 exostosin glycosyltransferase 1 -0.0176691
RPL34 ribosomal protein L34 -0.0176513
RPS21 ribosomal protein S21 -0.0175803
HMGA1 high mobility group AT-hook 1 -0.0175088
TAOK3 TAO kinase 3 -0.0172718
SVIL supervillin -0.0172577
GLMN glomulin, FKBP associated protein -0.0172082
IFITM1 interferon induced transmembrane protein 1 -0.0171684
SMAD3 SMAD family member 3 -0.0171408
RPS29 ribosomal protein S29 -0.0171025
RPL26 ribosomal protein L26 -0.0169663
SLIT2 slit homolog 2 (Drosophila) -0.0168735
ATXN1 ataxin 1 -0.0166254
EPAS1 endothelial PAS domain protein 1 -0.0161543
GLIS3 GLIS family zinc finger 3 -0.0158761
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0158743
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0157684
PKM pyruvate kinase, muscle -0.0156734
HDAC9 histone deacetylase 9 -0.0156412
COMMD10 COMM domain containing 10 -0.0156256
EIF1 eukaryotic translation initiation factor 1 -0.0156087
HPCAL1 hippocalcin-like 1 -0.0154726
RAD51B RAD51 paralog B -0.0153392
IGFBP5 insulin-like growth factor binding protein 5 -0.0151989
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.015185
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0151806