| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenylephrine (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Phenylephrine (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0619936 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0586292 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0570985 |
| PTMA | prothymosin, alpha | 0.0508967 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0480847 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.046184 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0443097 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0415226 |
| PEG10 | paternally expressed 10 | 0.0414287 |
| ZNF292 | zinc finger protein 292 | 0.0379645 |
| ENO1 | enolase 1, (alpha) | 0.033336 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0332334 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0320579 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0309645 |
| CENPF | centromere protein F, 350/400kDa | 0.0305908 |
| SET | SET nuclear proto-oncogene | 0.0304031 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0296182 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0290231 |
| TPM3 | tropomyosin 3 | 0.0288065 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0282793 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0276047 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0273916 |
| XPO1 | exportin 1 | 0.0264894 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0258886 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0256802 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0255082 |
| PGK1 | phosphoglycerate kinase 1 | 0.0249194 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0247338 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0243822 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0239642 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0239371 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0238548 |
| TXNIP | thioredoxin interacting protein | 0.0232116 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0231655 |
| RTN4 | reticulon 4 | 0.0229806 |
| CPE | carboxypeptidase E | 0.0229417 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0221159 |
| KIF5B | kinesin family member 5B | 0.021991 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0219775 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0216297 |
| ECT2 | epithelial cell transforming 2 | 0.0215859 |
| FAM13A | family with sequence similarity 13, member A | 0.0215411 |
| PPME1 | protein phosphatase methylesterase 1 | 0.021437 |
| GOLIM4 | golgi integral membrane protein 4 | 0.0212283 |
| CCNL1 | cyclin L1 | 0.0210994 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0209279 |
| NUF2 | NUF2, NDC80 kinetochore complex component | 0.0204446 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.020166 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0201506 |
| FAT1 | FAT atypical cadherin 1 | 0.0200656 |
| PAPOLA | poly(A) polymerase alpha | 0.0199747 |
| CHGB | chromogranin B | 0.019973 |
| PKM | pyruvate kinase, muscle | 0.0196776 |
| YTHDC1 | YTH domain containing 1 | 0.0196723 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0196586 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0196347 |
| RPL4 | ribosomal protein L4 | 0.0194969 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.019482 |
| USP37 | ubiquitin specific peptidase 37 | 0.0193801 |
| AHR | aryl hydrocarbon receptor | 0.0191953 |
| HMGB2 | high mobility group box 2 | 0.0191076 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.01909 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0190765 |
| NUP58 | nucleoporin 58 | 0.0188895 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0187702 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0186156 |
| NCKAP1 | NCK-associated protein 1 | 0.0184459 |
| RNF145 | ring finger protein 145 | 0.0184181 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0181083 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0179281 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0177154 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0176637 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0175731 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0175224 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0175189 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0173173 |
| TPD52 | tumor protein D52 | 0.0172472 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0171984 |
| RLF | rearranged L-myc fusion | 0.0171474 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.017052 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0170382 |
| LMNB1 | lamin B1 | 0.0170205 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0169643 |
| MATR3 | matrin 3 | 0.0167333 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0166096 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0165447 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0165259 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0164847 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0164599 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0161516 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0159627 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0157343 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.0157126 |
| TPX2 | TPX2, microtubule-associated | 0.0156915 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0155552 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.015544 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0154678 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0154038 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0153591 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.015281 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.130061 |
| NRG1 | neuregulin 1 | -0.115213 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0816843 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0772721 |
| SMYD3 | SET and MYND domain containing 3 | -0.0715432 |
| GPC6 | glypican 6 | -0.0659249 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0618827 |
| FGF14 | fibroblast growth factor 14 | -0.0599055 |
| GPC5 | glypican 5 | -0.0568616 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0554071 |
| SNTG1 | syntrophin, gamma 1 | -0.0551071 |
| SYT1 | synaptotagmin I | -0.0544119 |
| CNKSR3 | CNKSR family member 3 | -0.0530409 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0512574 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0491414 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0479671 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0461011 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0442285 |
| KIF26B | kinesin family member 26B | -0.0432028 |
| NBEA | neurobeachin | -0.0429307 |
| TOX | thymocyte selection-associated high mobility group box | -0.0402381 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.040002 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0387186 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0380097 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0371634 |
| ACTG1 | actin gamma 1 | -0.0369103 |
| MAP1B | microtubule-associated protein 1B | -0.0368925 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0361563 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0350914 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.034266 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0333598 |
| EPHA6 | EPH receptor A6 | -0.0320078 |
| TXNRD1 | thioredoxin reductase 1 | -0.0319724 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.031732 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0313048 |
| RAD51B | RAD51 paralog B | -0.0309568 |
| RALYL | RALY RNA binding protein-like | -0.0298327 |
| ZNF804A | zinc finger protein 804A | -0.0296332 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0294111 |
| PTCHD4 | patched domain containing 4 | -0.0294018 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0290319 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0286273 |
| ZFHX3 | zinc finger homeobox 3 | -0.0280195 |
| RPS21 | ribosomal protein S21 | -0.0277771 |
| RNF213 | ring finger protein 213 | -0.027256 |
| SCFD2 | sec1 family domain containing 2 | -0.0270585 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0270523 |
| MT2A | metallothionein 2A | -0.0268836 |
| NCKAP5 | NCK-associated protein 5 | -0.0262685 |
| EFNA5 | ephrin-A5 | -0.0261515 |
| WWOX | WW domain containing oxidoreductase | -0.0261409 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0260179 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0255282 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0252726 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0251606 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0250406 |
| RIGI | RNA sensor RIG-I | -0.0248944 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0247547 |
| KCNH7 | potassium channel, voltage gated eag related subfamily H, member 7 | -0.0245539 |
| CNTNAP5 | contactin associated protein-like 5 | -0.0245033 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0244104 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0241737 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | -0.0240141 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0239514 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0236605 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0236179 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0233553 |
| TENM1 | teneurin transmembrane protein 1 | -0.0233163 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0222564 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0221951 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0221896 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0218306 |
| KLHL29 | kelch-like family member 29 | -0.0216392 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.0212888 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0206284 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0205477 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0205163 |
| MX2 | MX dynamin-like GTPase 2 | -0.0203393 |
| ADAR | adenosine deaminase, RNA-specific | -0.0203373 |
| RORA | RAR-related orphan receptor A | -0.0202702 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0202251 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0200409 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0200298 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.0198612 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.0196973 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0194194 |
| AUTS2 | autism susceptibility candidate 2 | -0.0193352 |
| PLSCR1 | phospholipid scramblase 1 | -0.0191843 |
| PCSK2 | proprotein convertase subtilisin/kexin type 2 | -0.0190576 |
| RPS8 | ribosomal protein S8 | -0.0190085 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0189959 |
| HM13 | histocompatibility (minor) 13 | -0.0189708 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.018831 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0187626 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0186059 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0185555 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0185515 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0184923 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0184628 |
| SP100 | SP100 nuclear antigen | -0.0184436 |
