Phenylephrine (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.164791
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.158616
FNDC3B fibronectin type III domain containing 3B 0.145899
LSAMP limbic system-associated membrane protein 0.130701
NLGN1 neuroligin 1 0.100071
NRG3 neuregulin 3 0.0872368
FMNL2 formin-like 2 0.0861322
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0797564
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0757297
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0673082
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0660596
LAMP2 lysosomal-associated membrane protein 2 0.0579768
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0535521
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0520124
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0515135
ENO1 enolase 1, (alpha) 0.0507998
MSN moesin 0.0491706
B2M beta-2-microglobulin 0.0488601
MSI2 musashi RNA-binding protein 2 0.0487534
BBX bobby sox homolog (Drosophila) 0.0477446
MMP12 matrix metallopeptidase 12 0.0464717
SLC39A11 solute carrier family 39, member 11 0.0463224
SBF2 SET binding factor 2 0.0451696
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0435914
PTK2 protein tyrosine kinase 2 0.0431083
SPAG9 sperm associated antigen 9 0.0429377
ARHGAP5 Rho GTPase activating protein 5 0.0427745
ZFAND3 zinc finger, AN1-type domain 3 0.0420016
DST dystonin 0.0412651
KTN1 kinectin 1 (kinesin receptor) 0.0403829
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0400354
CDK19 cyclin-dependent kinase 19 0.0399615
TPM3 tropomyosin 3 0.0397233
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0394519
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0392416
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0389261
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0387087
CFAP20DC CFAP20 domain containing 0.0385995
PHF21A PHD finger protein 21A 0.0384688
CXCL8 chemokine (C-X-C motif) ligand 8 0.0360622
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0358749
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0358206
RPS3 ribosomal protein S3 0.0357408
PRELID2 PRELI domain containing 2 0.0350562
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0347039
AFF3 AF4/FMR2 family, member 3 0.0346314
ARRDC3 arrestin domain containing 3 0.034407
PTPRM protein tyrosine phosphatase, receptor type, M 0.0341535
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0336731
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0327515
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0325097
DSCAM Down syndrome cell adhesion molecule 0.0320421
RAD51B RAD51 paralog B 0.0318432
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0317098
ZNF292 zinc finger protein 292 0.0316814
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0311532
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0305446
SEPTIN9 septin 9 0.0301792
KMT2E lysine (K)-specific methyltransferase 2E 0.0301477
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0296769
SFTPA2 surfactant protein A2 0.0296619
CHD4 chromodomain helicase DNA binding protein 4 0.0295418
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0294607
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0293137
CADM1 cell adhesion molecule 1 0.0292798
CNKSR3 CNKSR family member 3 0.0289371
ESYT2 extended synaptotagmin-like protein 2 0.028924
SREBF2 sterol regulatory element binding transcription factor 2 0.0288562
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0278688
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0277954
RYBP RING1 and YY1 binding protein 0.027794
ELL2 elongation factor, RNA polymerase II, 2 0.0277647
CENPF centromere protein F, 350/400kDa 0.0276614
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0275674
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0274639
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0274534
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0272496
PDE8A phosphodiesterase 8A 0.0272412
ANXA5 annexin A5 0.0270723
NGLY1 N-glycanase 1 0.0268222
SMAD3 SMAD family member 3 0.0268009
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0266408
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.026597
CD109 CD109 molecule 0.0260359
SOD2 superoxide dismutase 2, mitochondrial 0.0259491
SETD5 SET domain containing 5 0.0255831
PGK1 phosphoglycerate kinase 1 0.0255497
FAM13A family with sequence similarity 13, member A 0.0253335
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0252303
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0251696
SEC24A SEC24 family member A 0.0250709
HSPA4 heat shock 70kDa protein 4 0.0249958
FHIT fragile histidine triad 0.0249792
KAZN kazrin, periplakin interacting protein 0.0249581
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0249499
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0246816
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0246578
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0246248
CRYBG3 beta-gamma crystallin domain containing 3 0.0246169
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0245445

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.182712
FMN1 formin 1 -0.15183
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0847436
FRMD4A FERM domain containing 4A -0.0712705
TXNRD1 thioredoxin reductase 1 -0.0606589
FRMD5 FERM domain containing 5 -0.0549258
EEF2 eukaryotic translation elongation factor 2 -0.0536462
FN1 fibronectin 1 -0.0534708
FLNA filamin A, alpha -0.0532843
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0478502
LOC112694756 uncharaterized LOC112694756 -0.0478164
ANKRD28 ankyrin repeat domain 28 -0.0411064
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.040759
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0404732
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0380728
ERBIN erbb2 interacting protein -0.034835
WWTR1 WW domain containing transcription regulator 1 -0.0335079
RPLP1 ribosomal protein, large, P1 -0.0315852
NF1 neurofibromin 1 -0.0313234
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0307987
ACTG1 actin gamma 1 -0.029952
TMSB10 thymosin beta 10 -0.0278524
SNX24 sorting nexin 24 -0.0277368
PLSCR1 phospholipid scramblase 1 -0.0276662
PLEC plectin -0.0246736
GARS1 glycyl-tRNA synthetase 1 -0.0243744
RBM25 RNA binding motif protein 25 -0.0240788
BICD1 bicaudal D homolog 1 (Drosophila) -0.0239217
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0235889
SP100 SP100 nuclear antigen -0.0224421
EVI5 ecotropic viral integration site 5 -0.021754
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0217228
CCND1 cyclin D1 -0.0211807
RPS6 ribosomal protein S6 -0.0208903
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0206593
DNAH14 dynein, axonemal, heavy chain 14 -0.0205345
PMP22 peripheral myelin protein 22 -0.0205013
ZBTB20 zinc finger and BTB domain containing 20 -0.019896
FBXW11 F-box and WD repeat domain containing 11 -0.0197033
PRRC2B proline-rich coiled-coil 2B -0.0195333
RIGI RNA sensor RIG-I -0.0193011
EP300 E1A binding protein p300 -0.0192533
PCNX4 pecanex 4 -0.0189951
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0188368
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.018811
GLS2 glutaminase 2 (liver, mitochondrial) -0.0186285
FTL ferritin, light polypeptide -0.0185737
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.018418
ULK4 unc-51 like kinase 4 -0.0183664
WSB1 WD repeat and SOCS box containing 1 -0.018365
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0183459
RPL36A ribosomal protein L36a -0.0183403
RASAL2 RAS protein activator like 2 -0.0183207
RPL34 ribosomal protein L34 -0.0183039
EXT1 exostosin glycosyltransferase 1 -0.018132
HDAC9 histone deacetylase 9 -0.01795
ZNFX1 zinc finger, NFX1-type containing 1 -0.0178016
TENM1 teneurin transmembrane protein 1 -0.0176824
VDAC1 voltage-dependent anion channel 1 -0.0176733
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0174776
RPL13A ribosomal protein L13a -0.0171956
DMXL1 Dmx-like 1 -0.0171479
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.0171452
RPLP2 ribosomal protein, large, P2 -0.0169725
SOX6 SRY (sex determining region Y)-box 6 -0.016817
RACK1 receptor for activated C kinase 1 -0.0167638
SPPL3 signal peptide peptidase like 3 -0.016447
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.015863
LMNA lamin A/C -0.0157664
ACTN4 actinin, alpha 4 -0.0155961
ZEB2 zinc finger E-box binding homeobox 2 -0.0154343
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0154342
RPL35 ribosomal protein L35 -0.0151911
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0149934
SENP6 SUMO1/sentrin specific peptidase 6 -0.0148612
ZC3H15 zinc finger CCCH-type containing 15 -0.014655
PMEL premelanosome protein -0.0146318
KIAA0232 KIAA0232 -0.0144541
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0143866
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0143355
PEX5L peroxisomal biogenesis factor 5-like -0.0141229
OXSR1 oxidative stress responsive 1 -0.0140525
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0140246
RABGAP1L RAB GTPase activating protein 1-like -0.0139737
RBBP6 retinoblastoma binding protein 6 -0.013929
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0137878
MELTF melanotransferrin -0.0137707
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0137034
PCNX2 pecanex 2 -0.0136834
RPL28 ribosomal protein L28 -0.0134929
PRRC2A proline-rich coiled-coil 2A -0.0133081
EGR1 early growth response 1 -0.0132877
PUM2 pumilio RNA-binding family member 2 -0.0132162
TBC1D32 TBC1 domain family, member 32 -0.0131178
RPL39 ribosomal protein L39 -0.0130949
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.013077
RAD21 RAD21 homolog (S. pombe) -0.0130463
CEP128 centrosomal protein 128kDa -0.0130377
ZNF655 zinc finger protein 655 -0.0129766
ETV6 ets variant 6 -0.0129465