Phenylephrine (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.110065
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0864064
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0812725
GOLGA4 golgin A4 0.0804248
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0754175
WAC WW domain containing adaptor with coiled-coil 0.0740994
TPX2 TPX2, microtubule-associated 0.0728053
TXNRD1 thioredoxin reductase 1 0.0680159
SMYD3 SET and MYND domain containing 3 0.0657499
TAS2R14 taste receptor, type 2, member 14 0.0594738
MED13 mediator complex subunit 13 0.0588719
CKAP2 cytoskeleton associated protein 2 0.0558831
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0541796
CANX calnexin 0.0531295
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0525159
NUP58 nucleoporin 58 0.0509148
SAFB2 scaffold attachment factor B2 0.049258
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0489032
CKAP5 cytoskeleton associated protein 5 0.0486253
GOLT1B golgi transport 1B 0.0479298
NKTR natural killer cell triggering receptor 0.047658
BZW1 basic leucine zipper and W2 domains 1 0.0472279
B2M beta-2-microglobulin 0.0453606
FBXL5 F-box and leucine-rich repeat protein 5 0.0448975
SDC4 syndecan 4 0.0445527
RAB6A RAB6A, member RAS oncogene family 0.0443635
PICALM phosphatidylinositol binding clathrin assembly protein 0.0441881
RABGAP1 RAB GTPase activating protein 1 0.0435752
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0434255
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0434162
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0433242
HMGB2 high mobility group box 2 0.0428632
SPAG9 sperm associated antigen 9 0.0428188
ATXN2 ataxin 2 0.0424469
KDM2A lysine (K)-specific demethylase 2A 0.0418362
NAMPT nicotinamide phosphoribosyltransferase 0.0413555
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0401142
SRP54 signal recognition particle 54kDa 0.0394479
BIRC3 baculoviral IAP repeat containing 3 0.0391344
BIRC2 baculoviral IAP repeat containing 2 0.0389939
TBC1D5 TBC1 domain family, member 5 0.0387949
SEC24A SEC24 family member A 0.038053
AFTPH aftiphilin 0.037942
QKI QKI, KH domain containing, RNA binding 0.0373599
RDX radixin 0.037274
SEC31A SEC31 homolog A (S. cerevisiae) 0.0367357
KIF5B kinesin family member 5B 0.0363944
UBAC2 UBA domain containing 2 0.0363815
SMC4 structural maintenance of chromosomes 4 0.0355195
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0355023
RSF1 remodeling and spacing factor 1 0.0352805
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0352374
KIAA1328 KIAA1328 0.0348633
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0346606
MARCHF7 membrane associated ring-CH-type finger 7 0.0346343
TENT2 terminal nucleotidyltransferase 2 0.0344502
DCAF7 DDB1 and CUL4 associated factor 7 0.0344388
SEPTIN7 septin 7 0.0342772
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0342465
TNIP1 TNFAIP3 interacting protein 1 0.0334208
TMEM167A transmembrane protein 167A 0.0330592
RNF145 ring finger protein 145 0.0329519
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0324364
KIF4A kinesin family member 4A 0.0323576
ALKBH5 AlkB family member 5, RNA demethylase 0.0323324
TTC17 tetratricopeptide repeat domain 17 0.0321703
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0315159
WDPCP WD repeat containing planar cell polarity effector 0.0313226
TPR translocated promoter region, nuclear basket protein 0.0312043
BTBD7 BTB (POZ) domain containing 7 0.031154
RAB10 RAB10, member RAS oncogene family 0.0310355
NIN ninein (GSK3B interacting protein) 0.0305561
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0302566
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0302256
DENND4A DENN/MADD domain containing 4A 0.0301591
PDE8A phosphodiesterase 8A 0.0301448
CAPRIN2 caprin family member 2 0.0299943
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.029978
LRRC58 leucine rich repeat containing 58 0.0298295
YME1L1 YME1-like 1 ATPase 0.0297015
YBX3 Y box binding protein 3 0.0296807
CCNL1 cyclin L1 0.0295596
COG6 component of oligomeric golgi complex 6 0.0295493
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.029479
GSK3B glycogen synthase kinase 3 beta 0.0294706
TM9SF2 transmembrane 9 superfamily member 2 0.0291893
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0288085
GOLGA2 golgin A2 0.0288057
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0286562
RPL12 ribosomal protein L12 0.0286286
CENPF centromere protein F, 350/400kDa 0.0284408
PANK3 pantothenate kinase 3 0.0281729
NIPBL Nipped-B homolog (Drosophila) 0.0280979
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0280879
PHF3 PHD finger protein 3 0.0280253
PNISR PNN-interacting serine/arginine-rich protein 0.0279841
GARS1 glycyl-tRNA synthetase 1 0.0278653
CCDC88A coiled-coil domain containing 88A 0.0278223
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0278039
TMEM263 transmembrane protein 263 0.0277873

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.101252
FNDC3B fibronectin type III domain containing 3B -0.100406
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0738311
AKAP12 A kinase (PRKA) anchor protein 12 -0.0645469
MT2A metallothionein 2A -0.0633785
HMGA2 high mobility group AT-hook 2 -0.0619489
MACF1 microtubule-actin crosslinking factor 1 -0.0609284
VCL vinculin -0.0607265
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0593886
FLNB filamin B, beta -0.0589862
SVIL supervillin -0.0588404
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0586931
PRKCA protein kinase C, alpha -0.0562043
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.054905
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0538332
THSD4 thrombospondin, type I, domain containing 4 -0.0513297
EFNA5 ephrin-A5 -0.0510439
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0509584
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0492317
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0491951
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0471376
DPYD dihydropyrimidine dehydrogenase -0.0458254
SLC38A2 solute carrier family 38, member 2 -0.0446878
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0442096
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0430429
UGCG UDP-glucose ceramide glucosyltransferase -0.0421425
FMNL2 formin-like 2 -0.0414121
EGFR epidermal growth factor receptor -0.0396715
ELL2 elongation factor, RNA polymerase II, 2 -0.0390994
ATG7 autophagy related 7 -0.0387622
MBNL1 muscleblind-like splicing regulator 1 -0.0381653
IGF2 insulin-like growth factor 2 -0.0378522
DERA deoxyribose-phosphate aldolase (putative) -0.0375836
MYOF myoferlin -0.0374928
LDHA lactate dehydrogenase A -0.0368693
TRIO trio Rho guanine nucleotide exchange factor -0.0366538
NDRG1 N-myc downstream regulated 1 -0.0351199
BASP1 brain abundant, membrane attached signal protein 1 -0.0346473
ANGPTL4 angiopoietin-like 4 -0.0346223
IL1RAP interleukin 1 receptor accessory protein -0.0338445
PKM pyruvate kinase, muscle -0.0333325
SOD2 superoxide dismutase 2, mitochondrial -0.0330175
SKIL SKI-like proto-oncogene -0.0329556
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0328623
DOCK4 dedicator of cytokinesis 4 -0.0328182
IER3 immediate early response 3 -0.032432
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0317133
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.031679
ABR active BCR-related -0.0313608
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0312502
PTK2 protein tyrosine kinase 2 -0.0312352
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0311312
ZSWIM6 zinc finger, SWIM-type containing 6 -0.031095
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0307715
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0304969
DTNA dystrobrevin, alpha -0.0302441
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0302391
AKAP9 A kinase (PRKA) anchor protein 9 -0.0301068
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0299779
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0299574
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0299315
DNER delta/notch-like EGF repeat containing -0.0299243
TCF12 transcription factor 12 -0.0296696
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0293186
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0288655
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0288136
ZBTB38 zinc finger and BTB domain containing 38 -0.0286313
SH3KBP1 SH3-domain kinase binding protein 1 -0.0286096
MT1X metallothionein 1X -0.0285236
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0284366
NPAS2 neuronal PAS domain protein 2 -0.0283985
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0283556
AHNAK AHNAK nucleoprotein -0.0282608
FLNA filamin A, alpha -0.0281925
PBX3 pre-B-cell leukemia homeobox 3 -0.0280518
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0280007
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0275346
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0274963
PRELID2 PRELI domain containing 2 -0.027494
HILPDA hypoxia inducible lipid droplet-associated -0.0266921
RUNX1 runt-related transcription factor 1 -0.0261369
TPT1 tumor protein, translationally-controlled 1 -0.0259318
NSD2 nuclear receptor binding SET domain protein 2 -0.0258474
VIM vimentin -0.0257015
PRKCE protein kinase C, epsilon -0.0256824
OSMR oncostatin M receptor -0.0256331
RPLP1 ribosomal protein, large, P1 -0.0255657
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0255225
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.025465
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0254202
DMXL1 Dmx-like 1 -0.0252829
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0252401
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0250446
MAP4 microtubule-associated protein 4 -0.0249235
ANXA2 annexin A2 -0.0248318
HLA-C major histocompatibility complex, class I, C -0.0247882
BABAM2 BRISC and BRCA1 A complex member 2 -0.02478
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0247427
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0247287
MAP1B microtubule-associated protein 1B -0.0244774