Phenylephrine (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.203403
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0855678
NAMPT nicotinamide phosphoribosyltransferase 0.0736942
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0681663
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0507141
ITGA1 integrin, alpha 1 0.0501425
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0465281
TXNIP thioredoxin interacting protein 0.0423211
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0418264
AHR aryl hydrocarbon receptor 0.0397695
EREG epiregulin 0.0378387
TMEM156 transmembrane protein 156 0.037159
CENPF centromere protein F, 350/400kDa 0.0368386
OSMR oncostatin M receptor 0.0364019
MCTP2 multiple C2 domains, transmembrane 2 0.0362728
CANX calnexin 0.0348107
MKI67 marker of proliferation Ki-67 0.0340156
CD109 CD109 molecule 0.0339845
SMOX spermine oxidase 0.0313731
NEK7 NIMA-related kinase 7 0.0290907
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0289982
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0271775
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0269464
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0268841
ETNK1 ethanolamine kinase 1 0.0268541
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0263819
AFDN afadin, adherens junction formation factor 0.0261661
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0254899
TXNRD1 thioredoxin reductase 1 0.025288
CDC73 cell division cycle 73 0.0251771
FNDC3B fibronectin type III domain containing 3B 0.0249085
TM9SF3 transmembrane 9 superfamily member 3 0.0246263
TPR translocated promoter region, nuclear basket protein 0.0244095
PAPOLA poly(A) polymerase alpha 0.0241673
SUCO SUN domain containing ossification factor 0.0234257
MIS18BP1 MIS18 binding protein 1 0.0234134
ATL2 atlastin GTPase 2 0.0233364
SOS1 son of sevenless homolog 1 (Drosophila) 0.0232516
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0230759
ANLN anillin, actin binding protein 0.0229909
EPS8 epidermal growth factor receptor pathway substrate 8 0.0229871
ZNF292 zinc finger protein 292 0.0225654
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0225524
SPAG9 sperm associated antigen 9 0.0224883
ZC3H11A zinc finger CCCH-type containing 11A 0.022186
CARD16 caspase recruitment domain family, member 16 0.0220719
VEGFC vascular endothelial growth factor C 0.0220531
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0219656
LIFR leukemia inhibitory factor receptor alpha 0.0219492
NIPBL Nipped-B homolog (Drosophila) 0.021657
PCNX1 pecanex 1 0.0215481
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0215274
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0213854
ATOSA atos homolog A 0.0212536
ZC3H12C zinc finger CCCH-type containing 12C 0.0212304
NRIP1 nuclear receptor interacting protein 1 0.0210519
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0210321
CDCP1 CUB domain containing protein 1 0.0206662
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0205684
JMJD1C jumonji domain containing 1C 0.0201792
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201675
SMAD3 SMAD family member 3 0.0201479
OGA O-GlcNAcase 0.0201294
TENT2 terminal nucleotidyltransferase 2 0.019698
SFXN1 sideroflexin 1 0.019594
YBX3 Y box binding protein 3 0.0194168
EWSR1 EWS RNA-binding protein 1 0.0193942
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0193744
APP amyloid beta (A4) precursor protein 0.0193421
FNBP1 formin binding protein 1 0.019103
YME1L1 YME1-like 1 ATPase 0.0190932
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0190631
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0188823
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0186557
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0186545
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0185897
TAS2R14 taste receptor, type 2, member 14 0.0185724
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0185661
CSDE1 cold shock domain containing E1, RNA-binding 0.0185203
CLTC clathrin, heavy chain (Hc) 0.0184463
RUNX2 runt-related transcription factor 2 0.018375
PRRC2C proline-rich coiled-coil 2C 0.0183422
FNDC3A fibronectin type III domain containing 3A 0.0182558
APLP2 amyloid beta (A4) precursor-like protein 2 0.0182197
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0181734
IL6ST interleukin 6 signal transducer 0.0180627
SINHCAF SIN3-HDAC complex associated factor 0.0179888
NPC1 Niemann-Pick disease, type C1 0.0176741
TPX2 TPX2, microtubule-associated 0.0176589
ANKRD28 ankyrin repeat domain 28 0.0176569
FRYL FRY-like 0.0174861
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0174572
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0173128
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.017218
BZW1 basic leucine zipper and W2 domains 1 0.0172105
RAD21 RAD21 homolog (S. pombe) 0.0171212
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0170701
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.017031
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0170211
RLF rearranged L-myc fusion 0.0169708

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.263984
PTMA prothymosin, alpha -0.1454
TMSB10 thymosin beta 10 -0.136567
FTL ferritin, light polypeptide -0.105823
MT2A metallothionein 2A -0.103468
NRG1 neuregulin 1 -0.102862
NDRG1 N-myc downstream regulated 1 -0.0950915
FN1 fibronectin 1 -0.086304
VIM vimentin -0.0797827
RPS6 ribosomal protein S6 -0.0782639
RPL35A ribosomal protein L35a -0.0774865
TPT1 tumor protein, translationally-controlled 1 -0.0774852
IFI27 interferon, alpha-inducible protein 27 -0.0731306
HLA-B major histocompatibility complex, class I, B -0.0717188
RPL31 ribosomal protein L31 -0.0665353
ENO2 enolase 2 (gamma, neuronal) -0.0611955
FTH1 ferritin, heavy polypeptide 1 -0.0597014
STC2 stanniocalcin 2 -0.0582297
SQSTM1 sequestosome 1 -0.056812
RPL37 ribosomal protein L37 -0.0550709
RPL9 ribosomal protein L9 -0.0540895
S100A6 S100 calcium binding protein A6 -0.0540112
RPL37A ribosomal protein L37a -0.0529228
RPL23 ribosomal protein L23 -0.0519493
ACTG1 actin gamma 1 -0.051241
HILPDA hypoxia inducible lipid droplet-associated -0.0502632
RPS29 ribosomal protein S29 -0.0500279
RPLP1 ribosomal protein, large, P1 -0.0496644
RPS12 ribosomal protein S12 -0.0488687
RPS8 ribosomal protein S8 -0.0469747
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0459172
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0457725
RPL26 ribosomal protein L26 -0.0456244
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0448944
RACK1 receptor for activated C kinase 1 -0.0428108
INTS6 integrator complex subunit 6 -0.0424339
RPL28 ribosomal protein L28 -0.0421055
RPS24 ribosomal protein S24 -0.0416194
ZFP36L1 ZFP36 ring finger protein-like 1 -0.040665
RPS27 ribosomal protein S27 -0.0399908
RPS16 ribosomal protein S16 -0.0389813
RPS20 ribosomal protein S20 -0.0384926
GNAS GNAS complex locus -0.0383594
RPS11 ribosomal protein S11 -0.0383348
LMNA lamin A/C -0.0375903
WSB1 WD repeat and SOCS box containing 1 -0.0369758
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0362673
RPL38 ribosomal protein L38 -0.0362248
RPL34 ribosomal protein L34 -0.0361643
RPS19 ribosomal protein S19 -0.0358994
RPS5 ribosomal protein S5 -0.035592
ENO1 enolase 1, (alpha) -0.0351987
RPS25 ribosomal protein S25 -0.0350104
RPS3 ribosomal protein S3 -0.0348494
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0346626
HLA-A major histocompatibility complex, class I, A -0.0342195
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0327902
PLIN2 perilipin 2 -0.0323262
RPL11 ribosomal protein L11 -0.0311956
RAB7A RAB7A, member RAS oncogene family -0.0311252
PKM pyruvate kinase, muscle -0.0310618
S100A9 S100 calcium binding protein A9 -0.0308801
RPS23 ribosomal protein S23 -0.0306182
RPS27A ribosomal protein S27a -0.0303944
S100A10 S100 calcium binding protein A10 -0.0290431
B2M beta-2-microglobulin -0.0288646
RPL12 ribosomal protein L12 -0.0287538
RPS14 ribosomal protein S14 -0.027547
LOC102724023 ES1 protein homolog, mitochondrial -0.0274976
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0274007
HMGA2 high mobility group AT-hook 2 -0.0268503
RPS21 ribosomal protein S21 -0.0268319
AKAP12 A kinase (PRKA) anchor protein 12 -0.026552
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0265466
SOX4 SRY (sex determining region Y)-box 4 -0.0265216
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.026449
HMGA1 high mobility group AT-hook 1 -0.0262168
RPL30 ribosomal protein L30 -0.0261122
LIMCH1 LIM and calponin homology domains 1 -0.0260831
RPS15 ribosomal protein S15 -0.0259112
IGFBP3 insulin-like growth factor binding protein 3 -0.0257494
TPI1 triosephosphate isomerase 1 -0.0255845
RPL8 ribosomal protein L8 -0.0255683
RPL36 ribosomal protein L36 -0.0251512
FBXO11 F-box protein 11 -0.0250928
IFITM1 interferon induced transmembrane protein 1 -0.025014
ATF4 activating transcription factor 4 -0.0248426
CTSD cathepsin D -0.0247634
RPS17 ribosomal protein S17 -0.0245128
RPLP2 ribosomal protein, large, P2 -0.0244162
IER3 immediate early response 3 -0.0242062
RPL36A ribosomal protein L36a -0.0236645
NALF1 NALCN channel auxiliary factor 1 -0.0236581
CALR calreticulin -0.023518
MRPS6 mitochondrial ribosomal protein S6 -0.0234683
SERF2 small EDRK-rich factor 2 -0.0232829
LRRC23 leucine rich repeat containing 23 -0.0229438
RPLP0 ribosomal protein, large, P0 -0.0224454
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0223601
ASPH aspartate beta-hydroxylase -0.0219378