Phenylephrine (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenylephrine (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenylephrine (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.0612568
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0579785
EZR ezrin 0.0571789
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0558098
LMO7 LIM domain 7 0.0519694
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0473537
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0381697
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0358221
MACC1 metastasis associated in colon cancer 1 0.0355424
BCL2L1 BCL2-like 1 0.035243
ITGA6 integrin, alpha 6 0.0336347
ITPRID2 ITPR interacting domain containing 2 0.0316264
AHNAK AHNAK nucleoprotein 0.0305375
EFNB2 ephrin-B2 0.0287678
ERRFI1 ERBB receptor feedback inhibitor 1 0.0286105
CEMIP2 cell migration inducing hyaluronidase 2 0.027952
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0277561
USP9X ubiquitin specific peptidase 9, X-linked 0.0273695
ABHD2 abhydrolase domain containing 2 0.0262624
CD46 CD46 molecule, complement regulatory protein 0.0257984
NCEH1 neutral cholesterol ester hydrolase 1 0.0257165
ETNK1 ethanolamine kinase 1 0.0241903
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0229706
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.022412
PERP PERP, TP53 apoptosis effector 0.0221556
TJP1 tight junction protein 1 0.0220542
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.022046
USP34 ubiquitin specific peptidase 34 0.0218301
PGK1 phosphoglycerate kinase 1 0.0217989
SPRED2 sprouty-related, EVH1 domain containing 2 0.0217584
EMP1 epithelial membrane protein 1 0.0215889
DSPP dentin sialophosphoprotein 0.0213296
EGR1 early growth response 1 0.0212397
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210792
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0210292
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0209982
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0208027
PCLO piccolo presynaptic cytomatrix protein 0.0204934
AFDN afadin, adherens junction formation factor 0.0203681
SLC38A2 solute carrier family 38, member 2 0.0202416
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0200761
RBM39 RNA binding motif protein 39 0.0199003
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0197896
EPS8 epidermal growth factor receptor pathway substrate 8 0.0194305
ARHGAP5 Rho GTPase activating protein 5 0.019245
TXNIP thioredoxin interacting protein 0.0191457
DST dystonin 0.0191288
ECT2 epithelial cell transforming 2 0.0190529
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.019027
YAP1 Yes-associated protein 1 0.0190059
EIF4B eukaryotic translation initiation factor 4B 0.0189668
MACF1 microtubule-actin crosslinking factor 1 0.0189286
ANO6 anoctamin 6 0.0188844
ZMYM2 zinc finger, MYM-type 2 0.0188819
KDM7A lysine (K)-specific demethylase 7A 0.0187695
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0186545
EIF4A2 eukaryotic translation initiation factor 4A2 0.0184429
SVIL supervillin 0.0183319
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0182572
DSCAM Down syndrome cell adhesion molecule 0.0179597
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0179095
LRP6 low density lipoprotein receptor-related protein 6 0.0178345
ZC3H11A zinc finger CCCH-type containing 11A 0.0177436
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0177355
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0176738
STAG2 stromal antigen 2 0.0173993
MAST4 microtubule associated serine/threonine kinase family member 4 0.0173966
NIPBL Nipped-B homolog (Drosophila) 0.0173833
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0171584
TMEM41B transmembrane protein 41B 0.0171369
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0170531
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0168903
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0168817
AKAP13 A kinase (PRKA) anchor protein 13 0.0168675
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0167483
CEP95 centrosomal protein 95kDa 0.0166934
BRWD3 bromodomain and WD repeat domain containing 3 0.0166131
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0166088
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.016597
LAMA4 laminin, alpha 4 0.0165772
CAPRIN1 cell cycle associated protein 1 0.0165496
ANLN anillin, actin binding protein 0.0164512
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.016447
ARGLU1 arginine and glutamate rich 1 0.0164341
ZEB1 zinc finger E-box binding homeobox 1 0.0163494
MATR3 matrin 3 0.0160072
TMCC1 transmembrane and coiled-coil domain family 1 0.0159369
RPL4 ribosomal protein L4 0.0158591
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0156033
MYH9 myosin, heavy chain 9, non-muscle 0.0153864
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0151037
CUL3 cullin 3 0.0150253
STK24 serine/threonine kinase 24 0.0150025
RBM26 RNA binding motif protein 26 0.0149861
TXNRD1 thioredoxin reductase 1 0.0149174
JAG1 jagged 1 0.0147302
CSDE1 cold shock domain containing E1, RNA-binding 0.0147066
TES testin LIM domain protein 0.014663
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0146499
SFPQ splicing factor proline/glutamine-rich 0.0145611

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.133162
PTMA prothymosin, alpha -0.119418
NAV2 neuron navigator 2 -0.110939
RPL35A ribosomal protein L35a -0.106662
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.106282
RPS6 ribosomal protein S6 -0.0982016
TPT1 tumor protein, translationally-controlled 1 -0.0842674
RPS8 ribosomal protein S8 -0.065401
RPL23 ribosomal protein L23 -0.0646921
SDK1 sidekick cell adhesion molecule 1 -0.0641708
MT2A metallothionein 2A -0.0630949
RPLP1 ribosomal protein, large, P1 -0.0621114
CDH13 cadherin 13 -0.0620861
RPL37A ribosomal protein L37a -0.0556092
RPL26 ribosomal protein L26 -0.055455
CCND1 cyclin D1 -0.0553915
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0544166
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0534917
VIM vimentin -0.0519148
HMGA1 high mobility group AT-hook 1 -0.0498235
RPS19 ribosomal protein S19 -0.0446044
RPS24 ribosomal protein S24 -0.0443784
RPS12 ribosomal protein S12 -0.0419375
NDRG1 N-myc downstream regulated 1 -0.0419069
ACTG1 actin gamma 1 -0.0416106
RPLP2 ribosomal protein, large, P2 -0.0409787
NKD1 naked cuticle homolog 1 (Drosophila) -0.03932
RPS14 ribosomal protein S14 -0.0377856
RPS25 ribosomal protein S25 -0.0376525
AKAP12 A kinase (PRKA) anchor protein 12 -0.0375718
RPS21 ribosomal protein S21 -0.0370967
RPS3 ribosomal protein S3 -0.0359092
RPS17 ribosomal protein S17 -0.0353638
RPS13 ribosomal protein S13 -0.035071
MRPS6 mitochondrial ribosomal protein S6 -0.0346421
RPL34 ribosomal protein L34 -0.0334538
RPL36 ribosomal protein L36 -0.0329512
FTL ferritin, light polypeptide -0.0329027
RPL35 ribosomal protein L35 -0.0328309
RPL12 ribosomal protein L12 -0.0328121
MAML2 mastermind-like 2 (Drosophila) -0.0328088
PFN1 profilin 1 -0.0320442
RPL11 ribosomal protein L11 -0.0317282
RPS29 ribosomal protein S29 -0.0303395
ADGRL2 adhesion G protein-coupled receptor L2 -0.0297984
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297417
RPL9 ribosomal protein L9 -0.0294768
RPL5 ribosomal protein L5 -0.0279215
RPS27A ribosomal protein S27a -0.0278985
RPL31 ribosomal protein L31 -0.0276113
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0272039
INTS6 integrator complex subunit 6 -0.0267692
RPL38 ribosomal protein L38 -0.0267656
RPL28 ribosomal protein L28 -0.0265695
S100A9 S100 calcium binding protein A9 -0.0265567
S100A10 S100 calcium binding protein A10 -0.02655
BACE2 beta-site APP-cleaving enzyme 2 -0.0263247
VCL vinculin -0.02616
LDHA lactate dehydrogenase A -0.0259687
RPL36A ribosomal protein L36a -0.0259477
WWOX WW domain containing oxidoreductase -0.0249106
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.024879
RPS23 ribosomal protein S23 -0.0247392
FLNB filamin B, beta -0.0243222
RPL19 ribosomal protein L19 -0.0243111
RPS16 ribosomal protein S16 -0.0238304
RACK1 receptor for activated C kinase 1 -0.023818
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0234932
TUBB4B tubulin, beta 4B class IVb -0.0234731
RBP1 retinol binding protein 1, cellular -0.0233361
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0232283
RPS11 ribosomal protein S11 -0.0231968
RPS20 ribosomal protein S20 -0.0230251
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0226576
RPL27 ribosomal protein L27 -0.0226548
CUX1 cut-like homeobox 1 -0.0224393
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0223975
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0222115
SKAP1 src kinase associated phosphoprotein 1 -0.0222109
ANO1 anoctamin 1, calcium activated chloride channel -0.0221715
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0220009
NPAS2 neuronal PAS domain protein 2 -0.0219128
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0217422
SQSTM1 sequestosome 1 -0.0217418
TUBA1B tubulin, alpha 1b -0.021637
GMDS GDP-mannose 4,6-dehydratase -0.021584
HMGB1 high mobility group box 1 -0.0215466
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0212107
MSI2 musashi RNA-binding protein 2 -0.0210009
ACTN1 actinin, alpha 1 -0.0208119
ITGB4 integrin, beta 4 -0.0207591
POTEF POTE ankyrin domain family, member F -0.020574
CBX3 chromobox homolog 3 -0.0203306
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0202398
LMNA lamin A/C -0.0200116
GNAS GNAS complex locus -0.0199464
RPL27A ribosomal protein L27a -0.019449
PKM pyruvate kinase, muscle -0.0194075
RAD51B RAD51 paralog B -0.0192856
RPS2 ribosomal protein S2 -0.0192847